PE20061370A1 - Proceso para preparar oxindoles y tio-oxindoles 3,3- disustituidos - Google Patents

Proceso para preparar oxindoles y tio-oxindoles 3,3- disustituidos

Info

Publication number
PE20061370A1
PE20061370A1 PE2006000446A PE2006000446A PE20061370A1 PE 20061370 A1 PE20061370 A1 PE 20061370A1 PE 2006000446 A PE2006000446 A PE 2006000446A PE 2006000446 A PE2006000446 A PE 2006000446A PE 20061370 A1 PE20061370 A1 PE 20061370A1
Authority
PE
Peru
Prior art keywords
oxindoles
thio
oxindol
sodium
disilazide
Prior art date
Application number
PE2006000446A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20061370A1 publication Critical patent/PE20061370A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE OXINDOL Y TIO-OXINDOL QUE COMPRENDE A) SUSTITUIR UN FLUOROARENO DE FORMULA (I) CON UN NITRILO SECUNDARIO EN PRESENCIA DE UNA BASE TAL COMO HEXAMETILDISILAZIDA DE SODIO O HALURO DE ISOPROPIL MAGNESIO DONDE X ES HALOGENO; R1, R2, R3 Y R4 SON H, HALOGENO, CN, ALQUILO(C1-C6), ENTRE OTROS; A, D, E Y G SON C O N; B) CONVERTIR EL SUSTITUYENTE NITRILO DEL PRODUCTO DEL PASO (A) EN UNA AMIDA UTILIZANDO PEROXIDO DE HIDROGENO; C) CICLAR EL PRODUCTO DEL PASO (B) A DICHO OXINDOL EN PRESENCIA DE UNA BASE FUERTE; Y D) CONVERTIR DICHO OXINDOL A TIO-OXINDOL. DICHO PROCEDIMIENTO SE REALIZA A UNA TEMPERATURA DE -40°C A 0°C. DICHOS OXINDOLES Y TIO-OXINDOLES SON UTILES COMO PRECURSORES DE COMPUESTOS FARMACEUTICOS
PE2006000446A 2005-04-29 2006-04-27 Proceso para preparar oxindoles y tio-oxindoles 3,3- disustituidos PE20061370A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67638105P 2005-04-29 2005-04-29

Publications (1)

Publication Number Publication Date
PE20061370A1 true PE20061370A1 (es) 2007-01-08

Family

ID=36937284

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000446A PE20061370A1 (es) 2005-04-29 2006-04-27 Proceso para preparar oxindoles y tio-oxindoles 3,3- disustituidos

Country Status (12)

Country Link
US (1) US7595338B2 (es)
EP (1) EP1877377A2 (es)
JP (1) JP2008540337A (es)
CN (1) CN101166722A (es)
AU (1) AU2006242542A1 (es)
BR (1) BRPI0608221A2 (es)
CA (1) CA2603818A1 (es)
GT (1) GT200600179A (es)
MX (1) MX2007013450A (es)
PE (1) PE20061370A1 (es)
TW (1) TW200716517A (es)
WO (1) WO2006118955A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY158766A (en) * 2005-04-11 2016-11-15 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
PE20070220A1 (es) * 2005-07-29 2007-03-19 Wyeth Corp Proceso para la sintesis de moduladores del receptor de progesterona
WO2008060789A2 (en) * 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
EP2076518A1 (en) * 2006-10-12 2009-07-08 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
CA2666143A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
US20080312306A1 (en) * 2007-06-15 2008-12-18 Wyeth Polymorphs, solvates, and hydrate of 5-(4'-fluoro-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-yl)-1-methyl-1h-pyrrole-2-carbonitrile
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
AU2008341138A1 (en) * 2007-12-20 2009-07-02 Teva Women's Health, Inc. Dosage regimens and pharmaceutical compositions and packages for emergency contraception
EP2350091B1 (en) * 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
US8263606B2 (en) 2008-10-17 2012-09-11 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
WO2010130794A1 (en) 2009-05-15 2010-11-18 Novartis Ag 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1
JP5654572B2 (ja) 2009-05-15 2015-01-14 ノバルティス アーゲー アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
RU2015103694A (ru) 2009-10-14 2015-06-27 Ксенон Фармасьютикалз Инк. Способы синтеза спиро-оксиндольных соединений
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
MX343215B (es) 2010-02-26 2016-10-27 Xenon Pharmaceuticals Inc Composiciones farmacéuticas del compuesto espiro-oxindol para administración tópica y sus usos como agentes terapéuticos.
ES2557559T3 (es) * 2010-09-16 2016-01-27 F. Hoffmann-La Roche Ag Proceso para preparar un derivado de ciclohexanocarbonitrilo
US8933248B2 (en) 2012-06-21 2015-01-13 Council Of Scientific & Industrial Research 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
CN103936649B (zh) * 2014-03-29 2016-05-04 贵州大学 3-(2-丙烯酸酯)-3-硫代氧化吲哚化合物及其制备方法
ES2738630T3 (es) 2015-01-22 2020-01-24 Sanofi Aventis Deutschland Procedimiento para la producción de 2-[4-(ciclopropanocarbonil)fenil]-2-metil-propanonitrilo
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
RU2601749C1 (ru) * 2015-09-08 2016-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Способ получения 4'-фторспиро[циклопропан-1,3'-индол]-2'(1'н)-она
US11806333B2 (en) * 2017-11-16 2023-11-07 University Of Houston System Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732278A (en) 1970-12-02 1973-05-08 Us Navy Ethyl(4-trifluoromethyl-2,3,5,6-tetra-fluorophenyl)cyanoacetate
EP0010879B2 (en) 1978-10-27 1991-12-11 Imperial Chemical Industries Plc Halogenated esters of cyclopropane acids, their preparation, compositions and use as pesticides
DE3015587A1 (de) 1980-04-23 1981-10-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acylcyaniden
FR2482955A1 (fr) 1980-05-23 1981-11-27 Roussel Uclaf Nouveaux derives de l'acide cyclopropane carboxylique, leur procede de preparation et leur application a la lutte contre les parasites
US4783547A (en) 1986-04-18 1988-11-08 Ici Americas Inc. Polyfluoroaromatic nitriles
US4866185A (en) 1986-04-18 1989-09-12 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
US4965394A (en) 1986-04-18 1990-10-23 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
US5288732A (en) 1986-09-10 1994-02-22 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
DE3630732A1 (de) 1986-09-10 1988-03-17 Bayer Ag 2-cyano-2-alkoximino-acetamide
US5231109A (en) 1986-09-10 1993-07-27 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
FR2610624B1 (fr) 1987-02-06 1989-06-09 Roussel Uclaf Nouveaux esters d'acides cyclopropanecarboxyliques apparentes a l'acide pyrethrique, leur procede de preparation et leur application a la lutte contre les parasites
DE3735821A1 (de) 1987-10-22 1989-05-03 Peroxid Chemie Gmbh Verfahren zur polymerisation von ethylen unter erhoehtem druck
DE3909213A1 (de) 1989-03-21 1990-10-11 Bayer Ag Halogenbenzolderivate
GB9125791D0 (en) 1991-12-04 1992-02-05 Schering Agrochemicals Ltd Herbicides
WO1994008982A1 (en) 1992-10-13 1994-04-28 Nippon Soda Co., Ltd. Oxazole and thiazole derivatives
US5545769A (en) 1994-09-29 1996-08-13 E. I. Du Pont De Nemours And Company Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
PT805148E (pt) 1994-12-19 2004-12-31 Nippon Soda Co Derivado de benzamidoxima, processo para a sua producao e bactericida agro-horticola
FR2734564B1 (fr) 1995-05-24 1997-07-04 Rhone Poulenc Chimie Procede d'hydroxyalkylation d'un ether aromatique
AU6643696A (en) 1995-08-01 1997-02-26 E.I. Du Pont De Nemours And Company Process for the manufacture of halocarbons and selected compounds and azeotropes with hf
DE19529089A1 (de) 1995-08-08 1997-02-13 Bayer Ag Mercapto-triazolyl-nitrile
FR2739098B1 (fr) 1995-09-25 1997-11-28 Rhone Poulenc Chimie Procede d'acylation d'un compose aromatique
FR2745285B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouveau catalyseur de c-alkylation d'un compose aromatique et son utilisation
FR2745287B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouvelle composition catalytique et sa mise en oeuvre dans un procede d'acylation d'un compose aromatique
US6005118A (en) 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
US6040487A (en) 1996-07-31 2000-03-21 E. I. Du Pont De Nemours And Company Process for the manufacture of halocarbons
IT1284926B1 (it) 1996-10-08 1998-05-28 Isagro Spa Composizioni fungicide e loro utilizzo per il controllo di funghi fitopatogeni
DE19835943A1 (de) 1998-08-08 2000-02-10 Bayer Ag Substituierte Triazinone
US6303782B1 (en) 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
IL154418A0 (en) 2000-09-19 2003-09-17 Sumitomo Chemical Co Pyrimidine compounds and their use
WO2003006015A1 (en) 2001-07-13 2003-01-23 Bristol-Myers Squibb Pharma Company Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
US6482983B1 (en) 2001-07-31 2002-11-19 Millennium Specialty Chemicals Process for obtaining N-monosubstituted amides
AR039208A1 (es) 2002-04-03 2005-02-09 Syngenta Participations Ag Compuestos de fenil- y piridilalquinos, composicion herbicida que los contiene, procedimiento de preparacion de aquellos y procedimiento para combatir el crecimiento de plantas indeseadas
US6977131B2 (en) 2002-05-30 2005-12-20 Kodak Polychrome Graphics Llc Selected polymeric sulfonate acid generators and their use in processes for imaging radiation-sensitive elements
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
TW200602293A (en) 2004-04-05 2006-01-16 Merck & Co Inc Process for the preparation of enantiomerically enriched beta amino acid derivatives

Also Published As

Publication number Publication date
WO2006118955A3 (en) 2007-01-11
CN101166722A (zh) 2008-04-23
TW200716517A (en) 2007-05-01
JP2008540337A (ja) 2008-11-20
WO2006118955A2 (en) 2006-11-09
MX2007013450A (es) 2008-01-21
AU2006242542A1 (en) 2006-11-09
US20060247441A1 (en) 2006-11-02
US7595338B2 (en) 2009-09-29
EP1877377A2 (en) 2008-01-16
BRPI0608221A2 (pt) 2009-11-24
GT200600179A (es) 2006-11-22
CA2603818A1 (en) 2006-11-09

Similar Documents

Publication Publication Date Title
PE20061370A1 (es) Proceso para preparar oxindoles y tio-oxindoles 3,3- disustituidos
ES2568009T3 (es) Procedimiento para la absorción de CO2 a partir de una mezcla gaseosa con un medio de absorción que contiene aminas
CO5550421A2 (es) Derivados de indol utiles para el tratamiento de enfermeda- des
PE20071095A1 (es) Derivados policiclicos de indazol como inhibidores de erk
PE20061084A1 (es) Compuestos derivados de 2-ciano-3-(halo)alcoxi-bencenosulfonamida
AR034268A1 (es) Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion
CR8249A (es) Forma cristalina gamma del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que lo contienen
ECSP066375A (es) Forma cristalina gamma de clorhidrato de ivabradina, su procedimiento de preparación y composiciones farmacéuticas que la contienen
AR075084A1 (es) Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes
PE20091443A1 (es) Derivados bis-(sulfonilamino) como inhibidores de la enzima prostaglandina e sintasa-1 microsomal
MX2009005881A (es) Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.
PE20071236A1 (es) Derivados de piperidinilo como moduladores de la actividad del receptor de quimiocina
CR8246A (es) Forma cristalina gamma-d del clorhidrato de ivabradina, su procedimiento de preparacion y composiciones farmaceuticas que las contienen
MX2007013065A (es) Derivados de dihidrobenzofurano y usos de los mismos.
ES2313079T3 (es) Benzimidazol, benzotiazol, benzoxazol y su utilizacion como moduladores de lta4h.
MX2009009920A (es) Inhibidores no nucleosidos de transcriptasa inversa.
PE20091842A1 (es) Pirrolidinonas como activadores de glucoquinasa
CO6280399A2 (es) Peptidil nitrilos y uso de los mismos como inhibidores de peptidil peptidasa i
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
MX2010006202A (es) Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
AR051392A1 (es) Antagonistas no peptidicos de bradiquinina y composiciones farmaceuticas de los mismos
MX2009006730A (es) Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.
AR051373A1 (es) Procedimiento para la preparacion de analogos aciclicos de nucleotidos de fosfonatos
SA515360504B1 (ar) عملية لامتصاص ثاني اكسيد الكربون من خليط غاز باستخدام محلول مائي من داي أمين
BR0312882A (pt) Derivados de pleuromutilina como antimicrobianos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal