PE20061055A1 - OCTAHYDROPIRROLO [3,4-c] PIRROL DERIVATIVES AS LIGANDS OF THE HISTAMINE H4 RECEPTOR - Google Patents

OCTAHYDROPIRROLO [3,4-c] PIRROL DERIVATIVES AS LIGANDS OF THE HISTAMINE H4 RECEPTOR

Info

Publication number
PE20061055A1
PE20061055A1 PE2005001360A PE2005001360A PE20061055A1 PE 20061055 A1 PE20061055 A1 PE 20061055A1 PE 2005001360 A PE2005001360 A PE 2005001360A PE 2005001360 A PE2005001360 A PE 2005001360A PE 20061055 A1 PE20061055 A1 PE 20061055A1
Authority
PE
Peru
Prior art keywords
histamine
ligands
receptor
octahydropirrolo
pyrrol
Prior art date
Application number
PE2005001360A
Other languages
Spanish (es)
Inventor
Charlotte Alice Louise Lane
David Anthony Price
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35985757&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20061055(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP04106044A external-priority patent/EP1671972A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20061055A1 publication Critical patent/PE20061055A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES H o ALQUILO(C1-C4); X ES N o C-R9 DONDE R9 ES H o METILO; Y ES O o NH; R6 ES H o METILO; R2, R3, R4 Y R5 SON H, HALO, CN, ALQUILO(C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{[(3aR,6aS)-5-METILHEXAHIDROPIRROLO[3,4-c]PIRROL-2(1H)-IL]CARBONIL}-1H-BENCIMIDAZOL, 5-METOXI-2-{[(3aR,6aS)-5-METILHEXAHIDROPIRROLO[3,4-c]PIRROL-2(1H)-IL]CARBONIL}-1H-BENCIMIDAZOL, 5-FLUORO-2-{[(3aR,6aS)-5-METILHEXAHIDROPIRROLO[3,4-c]PIRROL-2(1H)-IL]CARBONIL}-1H-BENCIMIDAZOL, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR DE HISTAMINA H4 SIENDO UTILES EN EL TRATAMIENTO DEL ASMA, RINITIS ALERGICAREFERS TO A COMPOUND OF FORMULA (I) WHERE R1 IS H or ALKYL (C1-C4); X IS NO. C-R9 WHERE R9 IS H or METHYL; Y IS O or NH; R6 IS H or METHYL; R2, R3, R4 AND R5 ARE H, HALO, CN, ALKYL (C1-C4), AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2 - {[(3aR, 6aS) -5-METHYLHEXAHYDROPYRROL [3,4-c] PYRROL-2 (1H) -YL] CARBONYL} -1H-BENZIMIDAZOLE, 5-METOXY-2 - {[(3aR , 6aS) -5-METHYLHEXAHYDROPYRRO [3,4-c] PYRROL-2 (1H) -IL] CARBONYL} -1H-BENZIMIDAZOLE, 5-FLUORO-2 - {[(3aR, 6aS) -5-METHYLHEXAHYDROPYRRO [3, 4-c] PYRROL-2 (1H) -IL] CARBONYL} -1H-BENZYMIDAZOLE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE HISTAMINE H4 RECEPTOR LIGANDS AND ARE USEFUL IN THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS

PE2005001360A 2004-11-24 2005-11-21 OCTAHYDROPIRROLO [3,4-c] PIRROL DERIVATIVES AS LIGANDS OF THE HISTAMINE H4 RECEPTOR PE20061055A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106044A EP1671972A1 (en) 2004-11-24 2004-11-24 Octahydropyrrolo[3,4-c]pyrrole derivatives
EP05100474 2005-01-26

Publications (1)

Publication Number Publication Date
PE20061055A1 true PE20061055A1 (en) 2006-11-09

Family

ID=35985757

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001360A PE20061055A1 (en) 2004-11-24 2005-11-21 OCTAHYDROPIRROLO [3,4-c] PIRROL DERIVATIVES AS LIGANDS OF THE HISTAMINE H4 RECEPTOR

Country Status (12)

Country Link
EP (1) EP1846409A1 (en)
JP (1) JP2008520644A (en)
AR (1) AR054707A1 (en)
CA (1) CA2587141A1 (en)
GT (1) GT200500340A (en)
NL (1) NL1030503C2 (en)
PA (1) PA8653801A1 (en)
PE (1) PE20061055A1 (en)
SV (1) SV2007002315A (en)
TW (1) TW200626600A (en)
UY (1) UY29221A1 (en)
WO (1) WO2006056848A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
JPWO2011013752A1 (en) * 2009-07-31 2013-01-10 塩野義製薬株式会社 Pharmaceutical composition containing a fused heterocyclic derivative
JP5848251B2 (en) 2009-10-23 2016-01-27 ヤンセン ファーマシューティカ エヌ．ベー． Fused heterocyclic compounds as orexin receptor modulators
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
JP5759470B2 (en) 2009-10-23 2015-08-05 ヤンセン ファーマシューティカ エヌ．ベー． Disubstituted octahydropyrrolo [3,4-c] pyrrole as an orexin receptor modulator
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
EP2858647B1 (en) 2012-06-08 2018-05-23 Sensorion H4 receptor inhibitors for treating tinnitus
HRP20220642T1 (en) 2016-03-10 2022-06-24 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
EP3746430A4 (en) * 2018-02-02 2021-11-03 Padforward LLC Inhibitors of protein arginine deiminases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2620341A (en) * 1949-03-24 1952-12-02 Burroughs Wellcome Co N,n-dialkyl-quinoline-4-carboxamidines
PT828741E (en) * 1995-05-11 2002-02-28 Upjohn Co OXAZOLIDINONES OF SPIROCYCLIC AND BICYCLE DIAZINYL AND CARBAZINYL
GB9902453D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2002070523A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1373204B1 (en) * 2001-03-09 2016-10-26 Janssen Pharmaceuticals, Inc. Heterocyclic compounds
CA2497788A1 (en) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. Use of histamine h4 receptor modulators for the treatment of allergy and asthma
CA2497827A1 (en) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
DK1543011T3 (en) * 2002-09-06 2006-08-07 Janssen Pharmaceutica Nv Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine H4 receptor ligands

Also Published As

Publication number Publication date
GT200500340A (en) 2006-07-13
NL1030503C2 (en) 2006-11-28
PA8653801A1 (en) 2006-06-02
EP1846409A1 (en) 2007-10-24
NL1030503A1 (en) 2006-05-29
WO2006056848A1 (en) 2006-06-01
TW200626600A (en) 2006-08-01
UY29221A1 (en) 2006-06-30
CA2587141A1 (en) 2006-06-01
SV2007002315A (en) 2007-02-16
JP2008520644A (en) 2008-06-19
AR054707A1 (en) 2007-07-11

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