PE20050435A1 - Derivados de fenil-piperazina como moduladores de receptores muscarinicos - Google Patents

Derivados de fenil-piperazina como moduladores de receptores muscarinicos

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Publication number
PE20050435A1
PE20050435A1 PE2004000936A PE2004000936A PE20050435A1 PE 20050435 A1 PE20050435 A1 PE 20050435A1 PE 2004000936 A PE2004000936 A PE 2004000936A PE 2004000936 A PE2004000936 A PE 2004000936A PE 20050435 A1 PE20050435 A1 PE 20050435A1
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PE
Peru
Prior art keywords
modulators
muscarinic receptors
phenyl
ring
piperazine
Prior art date
Application number
PE2004000936A
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English (en)
Inventor
Daniel Disepio
Gabriel Raffai
Lewis R Makings
Daniele Bergeron
Dennis Hurley
Akiko Nakatani
Peter D J Grootenhuis
Blanco Miguel Garcia-Guzman
Original Assignee
Vertex Pharma
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34393175&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050435(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20050435A1 publication Critical patent/PE20050435A1/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

SE REFIERE A DERIVADOS DE FENIL-PIPERAZINA DE FORMULA I DONDE B ES AL GRUPO a, ENTRE OTROS; D ES CF2, CH2, CHR9; C ES FENILO SUSTITUIDO CON 1 A 4 DE R1, R2, R3, R4 O R5; EL ANILLO A ES UN ANILLO CARBOCICLICO MONOCICLICO DE 3 A 8 MIEMBROS, UN ANILLO CARBOCICLICO BICICLICO DE 7 A 14 MIEMBROS, UN ANILLO CARBOCICLICO TRICICLICO DE 7 A 14 MIEMBROS, ENTRE OTROS; R1 ES OXO O (ALIFATICO C1-C4)m-Q1; Q1 ES HALO, CN, NO2, CF3, OCF3, OH, ENTRE OTROS; R2 ES ALIFATICO; R3 ES UN ANILLO CICLOALIFATICO, ARILO, HETEROCICLICO O HETEROARILO, ENTRE OTROS; R4 ES OR5, OR6, OC(O)R5, OC(O)OR6, ENTRE OTROS; R6 ES H, ALIFATICO SUSTITUIDO CON R7; R7 ES UN ANILLO CICLOALIFATICO, ARILO, HETEROCICLICO, ENTRE OTROS; Q2 ES HALO, CN, NO2, CF3, OH, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DE FORMULA I SON MODULADORES DE LOS RECEPTORES MUSCARINICOS
PE2004000936A 2003-09-26 2004-09-27 Derivados de fenil-piperazina como moduladores de receptores muscarinicos PE20050435A1 (es)

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US (2) US7563795B2 (es)
EP (1) EP1673089A2 (es)
JP (1) JP2007506776A (es)
KR (1) KR20060099513A (es)
CN (1) CN1886135A (es)
AR (1) AR047759A1 (es)
AU (1) AU2004275836A1 (es)
CA (1) CA2540186A1 (es)
IL (1) IL174419A0 (es)
MX (1) MXPA06003363A (es)
NO (1) NO20061845L (es)
PE (1) PE20050435A1 (es)
RU (1) RU2006114045A (es)
TW (1) TW200524890A (es)
UY (1) UY28538A1 (es)
WO (1) WO2005030188A2 (es)
ZA (1) ZA200602449B (es)

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