PE20050036A1 - COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR - Google Patents

COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR

Info

Publication number
PE20050036A1
PE20050036A1 PE2003000933A PE2003000933A PE20050036A1 PE 20050036 A1 PE20050036 A1 PE 20050036A1 PE 2003000933 A PE2003000933 A PE 2003000933A PE 2003000933 A PE2003000933 A PE 2003000933A PE 20050036 A1 PE20050036 A1 PE 20050036A1
Authority
PE
Peru
Prior art keywords
phenyl
aza
cell proliferation
ige
imidazo
Prior art date
Application number
PE2003000933A
Other languages
English (en)
Inventor
Jagadish Sircar
Richard J Thomas
Mark L Richards
Anjana Sinha
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of PE20050036A1 publication Critical patent/PE20050036A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA TAL COMO I, II Y III; ENTRE OTROS DONDE Q, T, X Y Z SON N O C, Y AL MENOS UNO DE ELLOS ES N; A ES H, HALOGENOS Y CONHR1; n ES 1-4; R ES H, ALQUILO C1-C5, BENZILO, ENTRE OTROS; R1 Y R2 SON CADA UNO H, ALQUILO, CICLOALQUILO C3-C9, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[2-(4-CICLOHEXILAMINOFENIL)-3H-IMIDAZO[4,5-b]PIRIDIN-6-IL]-CICLOHEXILAMIDA; N-[2-(4-ADAMANTILAMINOFENIL)-3H-IMIDAZO[4,5-b]PIRIDIN-6-IL]-ADAMANTILAMIDA Y ACIDO ADAMANTANE-1-CARBOXILICO[2-(4-(4-CETOADAMANTANOCARBONIL-FENIL)-3H-IMIDAZO[4,5-c]PIRIDINA-6-IL]-AMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION DE DICHOS COMPUESTOS FARMACEUTICOS LOS CUALES SON INHIBIDORES DE BAJO PESO MOLECULAR DE LA RESPUESTA DE IgE A ALERGENOS UTILES EN EL TRATAMIENTO DE ALERGIA Y/O ASMA O CUALQUIER ENFERMEDAD EN LA QUE IgE ES PATOGENA
PE2003000933A 2002-09-12 2003-09-12 COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR PE20050036A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41076102P 2002-09-12 2002-09-12

Publications (1)

Publication Number Publication Date
PE20050036A1 true PE20050036A1 (es) 2005-01-24

Family

ID=31994198

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000933A PE20050036A1 (es) 2002-09-12 2003-09-12 COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR

Country Status (17)

Country Link
US (1) US7256287B2 (es)
EP (1) EP1546157A4 (es)
JP (1) JP2006503048A (es)
KR (1) KR20050050102A (es)
CN (1) CN1694889A (es)
AR (1) AR041252A1 (es)
AU (1) AU2003279729A1 (es)
BR (1) BR0314235A (es)
CA (1) CA2498495A1 (es)
MX (1) MXJL05000010A (es)
NZ (1) NZ538547A (es)
PE (1) PE20050036A1 (es)
PL (1) PL375811A1 (es)
RU (1) RU2005109911A (es)
TW (1) TWI276631B (es)
WO (1) WO2004024897A2 (es)
ZA (1) ZA200502738B (es)

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Also Published As

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MXJL05000010A (es) 2005-06-07
ZA200502738B (en) 2007-04-25
TW200404784A (en) 2004-04-01
RU2005109911A (ru) 2006-04-27
EP1546157A2 (en) 2005-06-29
CN1694889A (zh) 2005-11-09
BR0314235A (pt) 2005-08-09
CA2498495A1 (en) 2004-03-25
TWI276631B (en) 2007-03-21
NZ538547A (en) 2007-05-31
US7256287B2 (en) 2007-08-14
AR041252A1 (es) 2005-05-11
JP2006503048A (ja) 2006-01-26
PL375811A1 (en) 2005-12-12
WO2004024897A3 (en) 2004-08-26
AU2003279729A1 (en) 2004-04-30
WO2004024897A2 (en) 2004-03-25
KR20050050102A (ko) 2005-05-27
EP1546157A4 (en) 2007-02-28
US20040116466A1 (en) 2004-06-17

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