PE20050036A1 - COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR - Google Patents
COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULARInfo
- Publication number
- PE20050036A1 PE20050036A1 PE2003000933A PE2003000933A PE20050036A1 PE 20050036 A1 PE20050036 A1 PE 20050036A1 PE 2003000933 A PE2003000933 A PE 2003000933A PE 2003000933 A PE2003000933 A PE 2003000933A PE 20050036 A1 PE20050036 A1 PE 20050036A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- aza
- cell proliferation
- ige
- imidazo
- Prior art date
Links
- BVNWQSXXRMNYKH-UHFFFAOYSA-N 4-phenyl-2h-benzotriazole Chemical class C1=CC=CC=C1C1=CC=CC2=C1NN=N2 BVNWQSXXRMNYKH-UHFFFAOYSA-N 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-CYCLOHEXYLAMINOPHENYL Chemical class 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UNA COMPOSICION FARMACEUTICA TAL COMO I, II Y III; ENTRE OTROS DONDE Q, T, X Y Z SON N O C, Y AL MENOS UNO DE ELLOS ES N; A ES H, HALOGENOS Y CONHR1; n ES 1-4; R ES H, ALQUILO C1-C5, BENZILO, ENTRE OTROS; R1 Y R2 SON CADA UNO H, ALQUILO, CICLOALQUILO C3-C9, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[2-(4-CICLOHEXILAMINOFENIL)-3H-IMIDAZO[4,5-b]PIRIDIN-6-IL]-CICLOHEXILAMIDA; N-[2-(4-ADAMANTILAMINOFENIL)-3H-IMIDAZO[4,5-b]PIRIDIN-6-IL]-ADAMANTILAMIDA Y ACIDO ADAMANTANE-1-CARBOXILICO[2-(4-(4-CETOADAMANTANOCARBONIL-FENIL)-3H-IMIDAZO[4,5-c]PIRIDINA-6-IL]-AMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION DE DICHOS COMPUESTOS FARMACEUTICOS LOS CUALES SON INHIBIDORES DE BAJO PESO MOLECULAR DE LA RESPUESTA DE IgE A ALERGENOS UTILES EN EL TRATAMIENTO DE ALERGIA Y/O ASMA O CUALQUIER ENFERMEDAD EN LA QUE IgE ES PATOGENA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41076102P | 2002-09-12 | 2002-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050036A1 true PE20050036A1 (es) | 2005-01-24 |
Family
ID=31994198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000933A PE20050036A1 (es) | 2002-09-12 | 2003-09-12 | COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR |
Country Status (17)
Country | Link |
---|---|
US (1) | US7256287B2 (es) |
EP (1) | EP1546157A4 (es) |
JP (1) | JP2006503048A (es) |
KR (1) | KR20050050102A (es) |
CN (1) | CN1694889A (es) |
AR (1) | AR041252A1 (es) |
AU (1) | AU2003279729A1 (es) |
BR (1) | BR0314235A (es) |
CA (1) | CA2498495A1 (es) |
MX (1) | MXJL05000010A (es) |
NZ (1) | NZ538547A (es) |
PE (1) | PE20050036A1 (es) |
PL (1) | PL375811A1 (es) |
RU (1) | RU2005109911A (es) |
TW (1) | TWI276631B (es) |
WO (1) | WO2004024897A2 (es) |
ZA (1) | ZA200502738B (es) |
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US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
PT1368028E (pt) * | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
JP2007501618A (ja) * | 2003-08-08 | 2007-02-01 | アバニール・ファーマシューティカルズ | タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法 |
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GB201302927D0 (en) | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
JP6599852B2 (ja) | 2013-06-21 | 2019-10-30 | ゼニス・エピジェネティクス・リミテッド | ブロモドメイン阻害剤としての新規の置換された二環式化合物 |
NZ714669A (en) | 2013-06-21 | 2021-07-30 | Zenith Epigenetics Ltd | Novel bicyclic bromodomain inhibitors |
AU2014298051B2 (en) | 2013-07-31 | 2018-11-15 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
MA39186A1 (fr) | 2013-12-19 | 2017-11-30 | Novartis Ag | Dérivés de [1,2,4]triazolo[1,5-a]pyrimidine utilisés comme inhibiteurs du protéasome des protozoaires pour le traitement de maladies parasitaires comme la leishmaniose |
CN103819398B (zh) * | 2014-01-24 | 2016-05-04 | 河北科技大学 | 4-氨基-2-氯-3-硝基吡啶的合成方法 |
US10494376B2 (en) | 2014-09-03 | 2019-12-03 | Ctxt Pty. Ltd. | Tetrahydroisoquinoline derived PRMT5-inhibitors |
GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
EP3189048B1 (en) | 2014-09-03 | 2021-03-17 | Ctxt Pty Ltd | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors |
WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
CN107207474B (zh) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | 被取代的杂环作为溴结构域抑制剂 |
EP3233846A4 (en) | 2014-12-17 | 2018-07-18 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
WO2017103670A1 (en) * | 2015-12-14 | 2017-06-22 | Zenith Epigenetics Lid. | 1h-imidazo[4,5-b]pyridinyl and 2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridinyl heterocyclic bet bromodomain inhibitors |
GB201604031D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604027D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604029D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604030D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
GB201604020D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
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US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
US6242461B1 (en) | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
PT1368028E (pt) | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
US6777442B2 (en) | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
DK1373255T3 (da) | 2001-03-12 | 2005-05-23 | Janssen Pharmaceutica Nv | Fremgangsmåde til fremstilling af imidazolforbindelser |
CN1638765A (zh) * | 2001-07-27 | 2005-07-13 | 柯里斯公司 | Hedgehog信号转导途径介质、其相关组合物以及应用 |
TW200304820A (en) | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
BRPI0409097A (pt) | 2003-04-10 | 2006-04-11 | Avanir Pharmaceuticals | derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos |
JP2007501618A (ja) * | 2003-08-08 | 2007-02-01 | アバニール・ファーマシューティカルズ | タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法 |
-
2003
- 2003-09-10 TW TW092124975A patent/TWI276631B/zh not_active IP Right Cessation
- 2003-09-12 US US10/661,296 patent/US7256287B2/en not_active Expired - Fee Related
- 2003-09-12 AR ARP030103321A patent/AR041252A1/es not_active Application Discontinuation
- 2003-09-12 MX MXJL05000010A patent/MXJL05000010A/es not_active Application Discontinuation
- 2003-09-12 JP JP2004536644A patent/JP2006503048A/ja not_active Withdrawn
- 2003-09-12 KR KR1020057004331A patent/KR20050050102A/ko not_active Application Discontinuation
- 2003-09-12 AU AU2003279729A patent/AU2003279729A1/en not_active Abandoned
- 2003-09-12 EP EP03773067A patent/EP1546157A4/en not_active Withdrawn
- 2003-09-12 PL PL03375811A patent/PL375811A1/xx not_active Application Discontinuation
- 2003-09-12 PE PE2003000933A patent/PE20050036A1/es not_active Application Discontinuation
- 2003-09-12 WO PCT/US2003/030962 patent/WO2004024897A2/en active Application Filing
- 2003-09-12 BR BR0314235-3A patent/BR0314235A/pt not_active IP Right Cessation
- 2003-09-12 CA CA002498495A patent/CA2498495A1/en not_active Abandoned
- 2003-09-12 NZ NZ538547A patent/NZ538547A/en unknown
- 2003-09-12 CN CNA038250934A patent/CN1694889A/zh active Pending
- 2003-09-12 RU RU2005109911/04A patent/RU2005109911A/ru not_active Application Discontinuation
-
2005
- 2005-04-05 ZA ZA200502738A patent/ZA200502738B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MXJL05000010A (es) | 2005-06-07 |
ZA200502738B (en) | 2007-04-25 |
TW200404784A (en) | 2004-04-01 |
RU2005109911A (ru) | 2006-04-27 |
EP1546157A2 (en) | 2005-06-29 |
CN1694889A (zh) | 2005-11-09 |
BR0314235A (pt) | 2005-08-09 |
CA2498495A1 (en) | 2004-03-25 |
TWI276631B (en) | 2007-03-21 |
NZ538547A (en) | 2007-05-31 |
US7256287B2 (en) | 2007-08-14 |
AR041252A1 (es) | 2005-05-11 |
JP2006503048A (ja) | 2006-01-26 |
PL375811A1 (en) | 2005-12-12 |
WO2004024897A3 (en) | 2004-08-26 |
AU2003279729A1 (en) | 2004-04-30 |
WO2004024897A2 (en) | 2004-03-25 |
KR20050050102A (ko) | 2005-05-27 |
EP1546157A4 (en) | 2007-02-28 |
US20040116466A1 (en) | 2004-06-17 |
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