PE20010327A1 - Derivados de aminopirrolidina heterociclica como agentes melatonergicos - Google Patents

Derivados de aminopirrolidina heterociclica como agentes melatonergicos

Info

Publication number
PE20010327A1
PE20010327A1 PE2000000652A PE0006522000A PE20010327A1 PE 20010327 A1 PE20010327 A1 PE 20010327A1 PE 2000000652 A PE2000000652 A PE 2000000652A PE 0006522000 A PE0006522000 A PE 0006522000A PE 20010327 A1 PE20010327 A1 PE 20010327A1
Authority
PE
Peru
Prior art keywords
heterociclic
melatonergic agents
aminopyrrolidine derivatives
custom
character
Prior art date
Application number
PE2000000652A
Other languages
English (en)
Inventor
Katherine S Takaki
Guanglin Luo
Stephen R Bertenshaw
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20010327A1 publication Critical patent/PE20010327A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)

Abstract

SE REFIERE A DERIVADOS DE AMINOPIRROLIDINA HETEROCICLICA DONDE R1 Y R2 SON H, HALOGENO; W ES CR5, CR5R6, (CH2)n; n ES 1-2; Z ES CH2, CH, O; R3 ES H, ALQUILO C1-C4; R4 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, HALOALQUILO C1-C3, ALQUENILO C2-C6, ALQUILAMINO C1-C6, CICLOALQUILAMINO C3-C6, ENTRE OTROS; R5 Y R6 SON H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS (S)-N-[N-(2,3-DIHIDROBENZOFURAN-4-IL)-PIRROLIDIN-3-IL]ACETAMIDA; (R)-N-[N-(2,3-METILENDIOXIFEN-1-IL)-PIRROLIDIN-3-IL]PROPANAMIDA, (S)-N-[N-(2,3-DIHIDROBENZOFURAN-4-IL)-PIRROLIDIN-3-IL]BUTIRAMINA, (S)-N-[N-(2,3-DIHIDRO-1,4-BENZODIOXIN-5-IL)-PIRROLIDIN-3-IL]CICLOPROPAN CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS TIENEN AFINIDAD POR LOS RECEPTORES DE LA HORMONA PINEAL ENDOGENA MELATONINA POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE DESORDENES RELACIONADOS CON EL RITMO CIRCADIANO, DESORDENES DE SUENO, GLAUCOMA
PE2000000652A 1999-06-30 2000-06-28 Derivados de aminopirrolidina heterociclica como agentes melatonergicos PE20010327A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14189499P 1999-06-30 1999-06-30

Publications (1)

Publication Number Publication Date
PE20010327A1 true PE20010327A1 (es) 2001-06-10

Family

ID=22497702

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000652A PE20010327A1 (es) 1999-06-30 2000-06-28 Derivados de aminopirrolidina heterociclica como agentes melatonergicos

Country Status (13)

Country Link
US (1) US6211225B1 (es)
EP (1) EP1189900B1 (es)
JP (2) JP4767463B2 (es)
AT (1) ATE257834T1 (es)
AU (1) AU763963B2 (es)
CA (1) CA2376949C (es)
DE (1) DE60007745T2 (es)
DK (1) DK1189900T3 (es)
ES (1) ES2213022T3 (es)
PE (1) PE20010327A1 (es)
PT (1) PT1189900E (es)
UY (1) UY26226A1 (es)
WO (1) WO2001002392A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) 2002-03-12 2004-05-18 Bristol-Myers Squibb Company Benzoxazole derivatives as novel melatonergic agents
BR0313405A (pt) 2002-08-12 2005-07-12 Takeda Pharmaceutical Compostos, métodos para preparar um composto e para prevenir e/ou tratar câncer, prodroga, medicamento, modulador do receptor de androgênio, agente para prevenir e/ou tratar hipogonadismo ou pertubação climatérica masculina, osteoporose e câncer, e, uso de um composto
BRPI0610037A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de dihidrobenzofurano e uso dos mesmos
WO2006116136A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
EP2029564A4 (en) * 2006-05-22 2010-01-13 Vanda Pharmaceuticals Inc TREATMENT OF DEPRESSIVE DISORDERS
BRPI0810997A2 (pt) * 2007-04-26 2015-01-27 Takeda Pharmaceutical Composto, pró-droga, composição farmacêutica, método para prevenir ou tratar distúrbio do sono em um mamífero, e, uso do composto
ES2331276B1 (es) * 2007-10-25 2010-10-21 Ferrer Internacional, S.A. Compuestos de fenilpirrolidina.
EP2266975A1 (en) * 2009-06-15 2010-12-29 Ferrer Internacional, S.A. 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds
ES2897671T3 (es) 2012-01-26 2022-03-02 Vanda Pharmaceuticals Inc Sincronización del ritmo circadiano desincrónico del cortisol
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
PT2925745T (pt) 2012-11-29 2018-08-08 Chemocentryx Inc Antagonistas de cxcr7
CN105142630A (zh) 2012-12-18 2015-12-09 万达制药公司 昼夜节律紊乱的治疗
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
BR112021011222A2 (pt) 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
CN109574970A (zh) * 2018-12-27 2019-04-05 上海毕得医药技术有限公司 一种5-溴苯并二氢吡喃的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518273A (en) * 1966-08-03 1970-06-30 Warner Lambert Pharmaceutical Benzopyranquinolinol derivatives and process for their production
US3485835A (en) * 1968-04-10 1969-12-23 Haessle Ab 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives
US5071875A (en) 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2674524B1 (fr) 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680366B1 (fr) 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5449683A (en) 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
GB9326192D0 (en) 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9407919D0 (en) 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
FR2725985B1 (fr) 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
TR199802318T2 (xx) 1996-05-14 1999-03-22 Glaxo Group Limited Kronobiyolojik maddeler olarak benzofuranlar ve benzopiranlar.
NZ335910A (en) * 1996-12-10 2000-11-24 Bristol Myers Squibb Co Benzodioxole, benzofuran, dihydrobenzofuran and benzodioxane melatonergic agents useful in treating sleep disorders and circadian rhthym related disorders
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
JP2011137043A (ja) 2011-07-14
JP4767463B2 (ja) 2011-09-07
WO2001002392A1 (en) 2001-01-11
AU763963B2 (en) 2003-08-07
EP1189900B1 (en) 2004-01-14
UY26226A1 (es) 2001-01-31
DE60007745D1 (de) 2004-02-19
ATE257834T1 (de) 2004-01-15
AU5324000A (en) 2001-01-22
CA2376949C (en) 2009-05-26
EP1189900A1 (en) 2002-03-27
EP1189900A4 (en) 2002-07-31
JP2003503492A (ja) 2003-01-28
PT1189900E (pt) 2004-05-31
US6211225B1 (en) 2001-04-03
ES2213022T3 (es) 2004-08-16
DK1189900T3 (da) 2004-04-26
DE60007745T2 (de) 2005-03-10
JP5248647B2 (ja) 2013-07-31
CA2376949A1 (en) 2001-01-11

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