PE20010291A1 - Procedimiento para preparar un derivado de 10,11-metanodibenzosuberano - Google Patents

Procedimiento para preparar un derivado de 10,11-metanodibenzosuberano

Info

Publication number
PE20010291A1
PE20010291A1 PE2000000540A PE0005402000A PE20010291A1 PE 20010291 A1 PE20010291 A1 PE 20010291A1 PE 2000000540 A PE2000000540 A PE 2000000540A PE 0005402000 A PE0005402000 A PE 0005402000A PE 20010291 A1 PE20010291 A1 PE 20010291A1
Authority
PE
Peru
Prior art keywords
prepare
methanodibenzosuberan
derivative
procedure
difluoromethanodibenzosuber
Prior art date
Application number
PE2000000540A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Bret Anthony Astleford
Michael Edward Kobierski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20010291A1 publication Critical patent/PE20010291A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA IVa, DONDE: HX ES UN ACIDO TAL COMO ACIDO CLORHIDRICO, ACIDO BROMHIDRICO, ACIDO PARATOLUENSULFONICO, ACIDO SULFURICO; QUE COMPRENDE: 1) a)DISOLVER UN COMPUESTO DE FORMULA II EN ACETONITRILO FORMANDO UNA DISOLUCION; b)CRISTALIZAR UN COMPUESTO ESTEREOISOMERO SIN, DE FORMULA III; EN LA SOLUCION DE II; c)ELIMINAR EL ACETONITRILO DEL FILTRADO PROPORCIONANDO UNA MEZCLA ENRIQUECIDA EN UN COMPUESTO ESTEREOISOMERO ANTI DE FORMULA (IV); d) ANADIR A DICHA MEZCLA ENRIQUECIDA UN ACIDO Y UN DISOLVENTE COMO CLORURO DE METILENO, ETANOL, ACETATO DE ETILO; e) CRISTALIZAR EL COMPUESTO ESTEREOISOMERO ANTI DE FORMULA (IVa); O 2)HACER REACCIONAR EL ESTEREOISOMERO (IVa) ANTI, EN FORMA DE BASE LIBRE, CON (R)-1-(5-QUINOLINILOXI)-2,3-EPOXIPROPANO, FORMANDO EL COMPUESTO V, EL QUE OPCIONALMENTE REACCIONA CON CLORURO DE HIDROGENO Y FORMA EL COMPUESTO I. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION DE COMPUESTOS INTERMEDIOS. EL COMPUESTO I ES LA SAL TRICLORHIDRATO DE (2R)-ANTI-5-{3-[4-(10,11-DIFLUOROMETANODIBENZOSUBER-5-IL)PIPERAZIN-1-IL]-2-HIDROXIPROPOXI}QUINOLINA. LOS COMPUESTOS 10,11-METANOBENZOSUBERANO PUEDEN SER UTILES PARA MEJORAR LA EFICACIA DE LOS AGENTES QUIMIOTERAPEUTICOS CONTRA EL CANCER
PE2000000540A 1999-06-03 2000-06-01 Procedimiento para preparar un derivado de 10,11-metanodibenzosuberano PE20010291A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13728499P 1999-06-03 1999-06-03

Publications (1)

Publication Number Publication Date
PE20010291A1 true PE20010291A1 (es) 2001-03-07

Family

ID=22476646

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000540A PE20010291A1 (es) 1999-06-03 2000-06-01 Procedimiento para preparar un derivado de 10,11-metanodibenzosuberano

Country Status (10)

Country Link
US (2) US6570016B1 (es)
EP (1) EP1198462B1 (es)
JP (1) JP2003501425A (es)
AT (1) ATE277922T1 (es)
AU (1) AU5125200A (es)
CA (1) CA2375283A1 (es)
DE (1) DE60014386T2 (es)
ES (1) ES2228534T3 (es)
PE (1) PE20010291A1 (es)
WO (1) WO2000075132A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
EP1198462B1 (en) * 1999-06-03 2004-09-29 Eli Lilly And Company Process for preparing a 10,11-methanodibenzosuberane derivative
JP2004527552A (ja) 2001-04-25 2004-09-09 イーライ・リリー・アンド・カンパニー （２ｒ）−アンチ−５−｛３−［４−（１０，１１−ジフルオロメタノジベンゾスベラ−５−イル）ピペラジン−１−イル］−２−ヒドロキシプロポキシ｝キノリンの新規な塩および結晶形態
DE602006018477D1 (de) * 2005-08-19 2011-01-05 Nanosphere Inc Dna und antikörpern sowie verwendungen davon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125285T3 (es) * 1992-07-31 1999-03-01 Bristol Myers Squibb Co Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles.
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
WO1996040664A2 (en) * 1995-06-07 1996-12-19 Dade Chemistry Systems Inc. Preparation of immunogens and other conjugates of drugs
CA2258556A1 (en) * 1996-06-17 1997-12-24 Julian Stanley Kroin Drug resistance and multidrug resistance modulators
WO1998022112A1 (en) * 1996-11-22 1998-05-28 Eli Lilly And Company Drug resistance and multidrug resistance modulators
TWI267511B (en) * 1999-06-03 2006-12-01 Lilly Co Eli Process for preparing 10,11-methanobenzosuberane derivatives
EP1198462B1 (en) * 1999-06-03 2004-09-29 Eli Lilly And Company Process for preparing a 10,11-methanodibenzosuberane derivative

Also Published As

Publication number Publication date
EP1198462A1 (en) 2002-04-24
US6624304B1 (en) 2003-09-23
EP1198462B1 (en) 2004-09-29
ES2228534T3 (es) 2005-04-16
CA2375283A1 (en) 2000-12-14
AU5125200A (en) 2000-12-28
WO2000075132A1 (en) 2000-12-14
US6570016B1 (en) 2003-05-27
DE60014386T2 (de) 2005-10-13
JP2003501425A (ja) 2003-01-14
ATE277922T1 (de) 2004-10-15
DE60014386D1 (de) 2004-11-04

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Legal Events

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