PA8609101A1 - Derivados de pirido [3,4-d] pirimidina como inhibidores de la metaloproteinasa-13 de la matriz - Google Patents

Derivados de pirido [3,4-d] pirimidina como inhibidores de la metaloproteinasa-13 de la matriz

Info

Publication number
PA8609101A1
PA8609101A1 PA20048609101A PA8609101A PA8609101A1 PA 8609101 A1 PA8609101 A1 PA 8609101A1 PA 20048609101 A PA20048609101 A PA 20048609101A PA 8609101 A PA8609101 A PA 8609101A PA 8609101 A1 PA8609101 A1 PA 8609101A1
Authority
PA
Panama
Prior art keywords
pirido
matrix
metaloproteinase
pyrimidine
inhibitors
Prior art date
Application number
PA20048609101A
Other languages
English (en)
Inventor
Joseph Armand Picard
Amy Mae Bunker
Rita Mayuri Lodaya
Michael Lane Waldo
Mark Eugene Marlatt
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PA8609101A1 publication Critical patent/PA8609101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

ESTA INVENCION SE REFIERE A UN DERIVADO DE PIRIDO [3,4-D] PIRIMIDINA DE LA FORMULA I O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN EL QUE R1, L1, L2, V L3, Y R2 SON COMO SE HAN DEFINIDO EN LA MEMORIA DESCRIPTIVA, QUE INHIBE UNA ENZIMA METALOPROTEINASA-13 DE LA MATRIZ Y ES POR TANTO UTIL PARA TRATAR ENFERMEDADES QUE RESULTAN DEL DETERIORO DE LOS TEJIDOS MEDIADO POR LA MMP-13, TALES COMO OSTEORTRITIS, ARTRITIS REUMATOIDE, DAÑO DEL CARTILAGO, ARTRITIS PSORIASICA, ESPONDILITIS ANQUILOSANTE, INSUFICIENCIA CARDIACA, ATEROSCLEROSIS, ENFERMEDAD INFLAMATORIA DEL INTESTINO, ESCLEROSIS MULTIPLE, DEGENERACION MACULAR RELACIONADA CON LA EDAD, ENFERMEDAD PULMONAR OBSTRUTIVA CRONICA, ASMA, ENFERMEDADES PERIODONTALES, PSORIASIS, CANCER Y OSTEOPOROSIS.
PA20048609101A 2003-08-19 2004-08-12 Derivados de pirido [3,4-d] pirimidina como inhibidores de la metaloproteinasa-13 de la matriz PA8609101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49616003P 2003-08-19 2003-08-19

Publications (1)

Publication Number Publication Date
PA8609101A1 true PA8609101A1 (es) 2005-03-03

Family

ID=34193370

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20048609101A PA8609101A1 (es) 2003-08-19 2004-08-12 Derivados de pirido [3,4-d] pirimidina como inhibidores de la metaloproteinasa-13 de la matriz

Country Status (5)

Country Link
US (1) US20050085447A1 (es)
AR (1) AR056247A1 (es)
NL (1) NL1026862C2 (es)
PA (1) PA8609101A1 (es)
WO (1) WO2005016926A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8704837B2 (en) * 2004-04-16 2014-04-22 Apple Inc. High-level program interface for graphics operations
US8134561B2 (en) 2004-04-16 2012-03-13 Apple Inc. System for optimizing graphics operations
EP3028703B1 (en) 2013-07-29 2019-12-04 Kyowa Kirin Co., Ltd. Piperidine derivatives as wnt signaling inhibitor
CN104130256B (zh) * 2014-08-01 2016-08-24 上海毕得医药科技有限公司 一种吡啶并[3,4-d]嘧啶-4（3H）-酮衍生物的制备方法
CN107903209B (zh) * 2017-12-29 2021-05-14 宁夏忠同生物科技有限公司 一种2-氨基-5-氟吡啶-3-甲酸甲酯的合成方法

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US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
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US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
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US6933298B2 (en) * 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
WO2003076416A1 (en) * 2002-03-08 2003-09-18 Warner-Lambert Company Llc Oxo azabicyclic compounds
US6747147B2 (en) * 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) * 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) * 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
WO2004014908A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
WO2004014388A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors
WO2004014354A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors
WO2004014378A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
MXPA05001642A (es) * 2002-08-13 2005-04-25 Warner Lambert Co Derivados de naftaleno como inhibidores de metaloproteinasas de matriz.
WO2004014869A2 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors
EP1530472A1 (en) * 2002-08-13 2005-05-18 Warner-Lambert Company LLC Isoquinoline derivatives as matrix metalloproteinase inhibitors
WO2004014880A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Chromone derivatives as matrix metalloproteinase inhibitors
WO2004014375A2 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused bicyclic metalloproteinase inhibitors
AU2003250482A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc Phthalimide derivatives as matrix metalloproteinase inhibitors
WO2004014923A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
WO2004014384A2 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
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WO2004014909A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
US20040142950A1 (en) * 2003-01-17 2004-07-22 Bunker Amy Mae Amide and ester matrix metalloproteinase inhibitors

Also Published As

Publication number Publication date
NL1026862C2 (nl) 2006-01-09
WO2005016926A1 (en) 2005-02-24
NL1026862A1 (nl) 2005-02-22
US20050085447A1 (en) 2005-04-21
AR056247A1 (es) 2007-10-03

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