PA8628901A1 - Derivados de 4-alquil-y 4-alcanoil-piperidina sustituidos y su uso como antagonistas de neuroquininas - Google Patents

Derivados de 4-alquil-y 4-alcanoil-piperidina sustituidos y su uso como antagonistas de neuroquininas

Info

Publication number
PA8628901A1
PA8628901A1 PA20058628901A PA8628901A PA8628901A1 PA 8628901 A1 PA8628901 A1 PA 8628901A1 PA 20058628901 A PA20058628901 A PA 20058628901A PA 8628901 A PA8628901 A PA 8628901A PA 8628901 A1 PA8628901 A1 PA 8628901A1
Authority
PA
Panama
Prior art keywords
alcanoil
alquil
substituted
antagonist activity
derivatives
Prior art date
Application number
PA20058628901A
Other languages
English (en)
Inventor
Frans Eduard Janssens
Francois Maria Sommen
Boeck Benoit Christian Albert Ghislain De
Joseph Elisabeth Leenaerts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8628901A1 publication Critical patent/PA8628901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

LA INVENCION SE RELACIONA CON DERIVADOS DE 4-ALQUIL- Y 4-ALCANOIL-PIPERIDINA SUSTITUIDOS QUE TIENEN ACTIVIDAD ANTAGONISTA DE NEUROQUININA, EN PARTICULAR, ACTIVIDAD ANTAGONISTA DE NK1 Y ACTIVIDAD ANATAGONISTA COMBINADA NK1/NK3 CON COMPOSICIONES QUE COMPRENDEN DICHOS DERIVADOS Y CON SU USO COMO UN MEDICAMENTO, EN ESPECIAL, PARA EL TRATAMIENTO O PROFILAXIS DE LA ESQUIZOFRENIA; EL VOMITO; ANSIEDAD Y DEPRESION; SINDROME DEL INTESTINO IRRITABLE (SII); ALTERACIONES DEL RITMO CIRCADIANO; PREECLAMSIA; NOCIRREPCION; DOLOR, EN PARTICULAR, DOLOR VISCERAL Y NEUROPATICO; PANCREATITIS; INFLAMACION NEUROGENA; ASMA; ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA (EPOC); Y TRASTORNOS DE LA MICCION, TALES COMO INCONTINENCIA URINARIA. LOS COMPUESTOS DE ACUERDO CON LA INVENCION PUEDEN REPRESENTARSE POR LA FORMULA GENERAL (I): Y COMPRENDEN TAMBIEN SUS SALES DE ADICION DE BASE O ACIDO FARAMACEUTICAMENTE ACEPTABLES; SUS FORMAS ESTEREOQUIMICAMENTE ISOMERAS; SU FORMA DE N-OXIDO; Y SUS PROFARMACOS, EN DONDE TODOS LOS SUSTITUYENTES SE DEFINEN COMO EN LA REIVINDICACION 1.
PA20058628901A 2004-04-08 2005-04-05 Derivados de 4-alquil-y 4-alcanoil-piperidina sustituidos y su uso como antagonistas de neuroquininas PA8628901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04101467 2004-04-08

Publications (1)

Publication Number Publication Date
PA8628901A1 true PA8628901A1 (es) 2006-09-08

Family

ID=34928945

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058628901A PA8628901A1 (es) 2004-04-08 2005-04-05 Derivados de 4-alquil-y 4-alcanoil-piperidina sustituidos y su uso como antagonistas de neuroquininas

Country Status (23)

Country Link
US (1) US20070213346A1 (es)
EP (1) EP1737838B1 (es)
JP (1) JP2007532516A (es)
KR (1) KR20070007347A (es)
CN (1) CN1938291B (es)
AR (1) AR048532A1 (es)
AT (1) ATE396185T1 (es)
AU (1) AU2005231986B2 (es)
BR (1) BRPI0509720A (es)
CA (1) CA2561967A1 (es)
DE (1) DE602005007002D1 (es)
EA (1) EA010312B1 (es)
ES (1) ES2307169T3 (es)
IL (1) IL178461A0 (es)
JO (1) JO2525B1 (es)
MX (1) MXPA06011683A (es)
MY (1) MY142773A (es)
NO (1) NO20065022L (es)
NZ (1) NZ550098A (es)
PA (1) PA8628901A1 (es)
TW (1) TWI358298B (es)
WO (1) WO2005097774A1 (es)
ZA (1) ZA200608356B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070107085A (ko) * 2005-02-23 2007-11-06 쉐링 코포레이션 케모카인 수용체의 억제제로서 유용한 피페리디닐 피페라진유도체
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
CA2757368C (en) * 2009-04-02 2019-03-12 Merck Patent Gmbh Piperidine and piperazine derivatives as autotaxin inhibitors
WO2010114181A1 (en) 2009-04-02 2010-10-07 Shionogi & Co., Ltd. Acrylamide compounds and the use thereof
WO2011051478A1 (en) * 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
EP3044207B1 (en) * 2013-09-12 2017-10-18 F. Hoffmann-La Roche AG Indol-carboxamide derivatives
CN114306347A (zh) * 2015-05-18 2022-04-12 康堤医疗有限公司 用于治疗性激素依赖性疾病的双重nk-1/nk-3受体拮抗剂
SG11202008226YA (en) 2018-03-14 2020-09-29 Kandy Therapeutics Ltd Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists
US11976034B2 (en) 2019-06-12 2024-05-07 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
US11976035B2 (en) 2019-06-12 2024-05-07 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
EP3983340B1 (en) * 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6642226B2 (en) * 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
DE60322110D1 (de) * 2002-12-23 2008-08-21 Janssen Pharmaceutica Nv Substituierte 4-(4-piperidin-yl-piperazin-1-yl)-azntagonisten

Also Published As

Publication number Publication date
EP1737838B1 (en) 2008-05-21
AR048532A1 (es) 2006-05-03
WO2005097774A1 (en) 2005-10-20
MXPA06011683A (es) 2006-12-14
MY142773A (en) 2010-12-31
NO20065022L (no) 2006-11-03
EA200601880A1 (ru) 2007-02-27
CN1938291A (zh) 2007-03-28
TWI358298B (en) 2012-02-21
CN1938291B (zh) 2011-11-16
EA010312B1 (ru) 2008-08-29
BRPI0509720A (pt) 2007-09-25
DE602005007002D1 (de) 2008-07-03
NZ550098A (en) 2009-10-30
AU2005231986B2 (en) 2011-02-24
KR20070007347A (ko) 2007-01-15
ATE396185T1 (de) 2008-06-15
EP1737838A1 (en) 2007-01-03
US20070213346A1 (en) 2007-09-13
ES2307169T3 (es) 2008-11-16
JO2525B1 (en) 2010-03-17
JP2007532516A (ja) 2007-11-15
CA2561967A1 (en) 2005-10-20
ZA200608356B (en) 2008-07-30
IL178461A0 (en) 2007-02-11
TW200603797A (en) 2006-02-01
AU2005231986A1 (en) 2005-10-20

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