PA8475001A1 - Composiciones estabilizadas - Google Patents
Composiciones estabilizadasInfo
- Publication number
- PA8475001A1 PA8475001A1 PA19998475001A PA8475001A PA8475001A1 PA 8475001 A1 PA8475001 A1 PA 8475001A1 PA 19998475001 A PA19998475001 A PA 19998475001A PA 8475001 A PA8475001 A PA 8475001A PA 8475001 A1 PA8475001 A1 PA 8475001A1
- Authority
- PA
- Panama
- Prior art keywords
- magnesium oxide
- ace inhibitor
- compositions containing
- stabilized compositions
- quinapril
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000005541 ACE inhibitor Substances 0.000 abstract 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 3
- 239000000395 magnesium oxide Substances 0.000 abstract 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 3
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 abstract 1
- 229960001455 quinapril Drugs 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSICIONES QUE CONTIENEN INHIBIDOR DE ACE ESTABILIZADAS MEDIANTE LA PRESENCIA DE OXIDO DE MAGNESIO. PREFERENTEMENTE, EL INHIBIDOR DE ACE, QUINAPRIL, ES PROTEGIDO DE CIERTAS FORMAS DE DEGRADACION CUANDO SE PREPARA EN UNA COMPOSICION FARMACEUTICA COMPUESTA ESENCIALMENTE POR OXIDO DE MAGNESIO COMO EL AGENTE ESTABILIZADOR. LA PRESENCIA DE OXIDO DE MAGNESIO TAMBIEN SE PRESTA PARA CONDICIONES DE PROCESAMIENTO FAVORABLES DURANTE LA FABRICACION DE LAS COMPOSICIONES QUE CONTIENEN INHIBIDOR DE ACE, ESPECIALMENTE PROCESAMIENTO MEDIANTE GRANULACION EN MEDIO HUMEDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8828098P | 1998-06-05 | 1998-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8475001A1 true PA8475001A1 (es) | 2000-09-29 |
Family
ID=22210458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA19998475001A PA8475001A1 (es) | 1998-06-05 | 1999-06-04 | Composiciones estabilizadas |
Country Status (32)
Country | Link |
---|---|
US (3) | US6417196B1 (es) |
EP (1) | EP1083931B1 (es) |
JP (1) | JP3727848B2 (es) |
KR (1) | KR20010052557A (es) |
CN (1) | CN1144598C (es) |
AR (1) | AR019150A1 (es) |
AT (1) | ATE295184T1 (es) |
AU (1) | AU755616B2 (es) |
BR (1) | BR9910947A (es) |
CA (1) | CA2330581A1 (es) |
CO (1) | CO5011043A1 (es) |
DE (1) | DE69925269T2 (es) |
ES (1) | ES2242398T3 (es) |
GT (1) | GT199900079A (es) |
HK (1) | HK1038879B (es) |
HN (1) | HN1999000088A (es) |
HU (1) | HUP0102260A3 (es) |
ID (1) | ID27398A (es) |
IL (1) | IL139590A0 (es) |
IS (1) | IS2270B (es) |
MY (1) | MY119667A (es) |
NO (1) | NO20006148D0 (es) |
NZ (1) | NZ508544A (es) |
PA (1) | PA8475001A1 (es) |
PE (1) | PE20000543A1 (es) |
PL (1) | PL344586A1 (es) |
SV (1) | SV1999000072A (es) |
TR (1) | TR200003600T2 (es) |
TW (1) | TW565455B (es) |
UY (1) | UY25546A1 (es) |
WO (1) | WO1999062560A1 (es) |
ZA (1) | ZA200006537B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69925269T2 (de) * | 1998-06-05 | 2006-02-23 | Warner-Lambert Co. Llc | Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid |
NZ333206A (en) | 1998-12-08 | 2000-07-28 | Bernard Charles Sherman | Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor |
GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
EP1300160B1 (en) * | 2000-05-24 | 2014-03-12 | Otsuka Pharmaceutical Co., Ltd. | Method of stabilizing preparation |
AU2003235579A1 (en) * | 2002-01-15 | 2003-07-30 | Delta Hf. | Formulations of quinapril and related ace inhibitors |
US20030157165A1 (en) * | 2002-02-01 | 2003-08-21 | Sherman Bernard Charles | Stable saccharide-free tablets comprising a salt of quinapril or moexipril |
US7638138B2 (en) * | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
CZ298224B6 (cs) * | 2003-04-29 | 2007-07-25 | Pliva Istrazivanje I Razvoj D.O.O. | Farmaceutická kompozice obsahující jako úcinnou látku ribavirin a zpusob její výroby |
DK1635792T3 (da) * | 2003-06-26 | 2009-06-15 | Teva Pharma | Stabile farmaceutiske sammensætninger af 2-aza-bicyklo-3.3.0-oktan-3-carboxylsyrederivater |
US8673360B2 (en) * | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
ITMI20060026A1 (it) * | 2006-01-10 | 2007-07-11 | Truffini & Regge Farmaceutici Srl | Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento |
EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
US20070232680A1 (en) * | 2006-04-04 | 2007-10-04 | Vijayabhaskar Bolugoddu | Preparation of ramipril and stable pharmaceutical compositions |
WO2007120930A2 (en) * | 2006-04-19 | 2007-10-25 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives |
EP2034966A1 (en) * | 2006-06-30 | 2009-03-18 | Alphapharm Pty Ltd. | A stabilised composition comprising ace inhibitors |
US20080071141A1 (en) * | 2006-09-18 | 2008-03-20 | Abhisuek Gattani | Method and apparatus for measuring attributes of an anatomical feature during a medical procedure |
US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
WO2008132756A1 (en) * | 2007-05-01 | 2008-11-06 | Lupin Limited | Stable pharmaceutical compositions of ramipril |
JP5113476B2 (ja) * | 2007-10-09 | 2013-01-09 | 沢井製薬株式会社 | 保存安定性に優れた塩酸テモカプリルの錠剤 |
US9101539B2 (en) * | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
TR200906322A2 (tr) | 2009-08-17 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Çözünürlük ve stabilite özellikleri geliştirilmiş granüller. |
ES2364011B1 (es) | 2009-11-20 | 2013-01-24 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares. |
TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
CN102512656B (zh) * | 2011-12-27 | 2013-11-27 | 天津市嵩锐医药科技有限公司 | 盐酸喹那普利药物组合物 |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3320029A (en) * | 1967-05-16 | Method of preparing magnesia | ||
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4425355A (en) * | 1981-02-17 | 1984-01-10 | Warner-Lambert Company | Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids |
US4830853A (en) * | 1986-10-20 | 1989-05-16 | Warner-Lambert Company | Drug compositions stabilized against oxidation |
US4793998A (en) * | 1986-10-20 | 1988-12-27 | Warner-Lambert Company | Stabilized drug compositions |
US4743450A (en) * | 1987-02-24 | 1988-05-10 | Warner-Lambert Company | Stabilized compositions |
US4830583A (en) * | 1988-03-02 | 1989-05-16 | Sri International | Fluid motor-pumping apparatus and system |
US5622985A (en) * | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
HU222489B1 (hu) | 1990-07-25 | 2003-07-28 | Novartis Ag. | Stabilizált gyógyszerkészítmények és eljárás az előállításukra |
IT1251153B (it) * | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
DE69925269T2 (de) * | 1998-06-05 | 2006-02-23 | Warner-Lambert Co. Llc | Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid |
NZ333206A (en) * | 1998-12-08 | 2000-07-28 | Bernard Charles Sherman | Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor |
-
1999
- 1999-05-10 DE DE69925269T patent/DE69925269T2/de not_active Revoked
- 1999-05-10 AT AT99922899T patent/ATE295184T1/de not_active IP Right Cessation
- 1999-05-10 BR BR9910947-6A patent/BR9910947A/pt not_active Application Discontinuation
- 1999-05-10 ID IDW20002515A patent/ID27398A/id unknown
- 1999-05-10 CN CNB998070262A patent/CN1144598C/zh not_active Expired - Fee Related
- 1999-05-10 US US09/700,883 patent/US6417196B1/en not_active Expired - Fee Related
- 1999-05-10 IL IL13959099A patent/IL139590A0/xx not_active IP Right Cessation
- 1999-05-10 EP EP99922899A patent/EP1083931B1/en not_active Revoked
- 1999-05-10 CA CA002330581A patent/CA2330581A1/en not_active Abandoned
- 1999-05-10 AU AU39793/99A patent/AU755616B2/en not_active Ceased
- 1999-05-10 HU HU0102260A patent/HUP0102260A3/hu unknown
- 1999-05-10 WO PCT/US1999/010189 patent/WO1999062560A1/en active IP Right Grant
- 1999-05-10 PL PL99344586A patent/PL344586A1/xx not_active Application Discontinuation
- 1999-05-10 JP JP2000551814A patent/JP3727848B2/ja not_active Expired - Fee Related
- 1999-05-10 ES ES99922899T patent/ES2242398T3/es not_active Expired - Lifetime
- 1999-05-10 NZ NZ508544A patent/NZ508544A/xx unknown
- 1999-05-10 KR KR1020007013714A patent/KR20010052557A/ko not_active Application Discontinuation
- 1999-05-10 TR TR2000/03600T patent/TR200003600T2/xx unknown
- 1999-05-18 TW TW088108107A patent/TW565455B/zh not_active IP Right Cessation
- 1999-06-03 HN HN1999000088A patent/HN1999000088A/es unknown
- 1999-06-03 MY MYPI99002229A patent/MY119667A/en unknown
- 1999-06-04 PA PA19998475001A patent/PA8475001A1/es unknown
- 1999-06-04 CO CO99035274A patent/CO5011043A1/es unknown
- 1999-06-04 SV SV1999000072A patent/SV1999000072A/es not_active Application Discontinuation
- 1999-06-04 AR ARP990102642A patent/AR019150A1/es not_active Application Discontinuation
- 1999-06-04 PE PE1999000475A patent/PE20000543A1/es not_active Application Discontinuation
- 1999-06-04 GT GT199900079A patent/GT199900079A/es unknown
- 1999-06-04 UY UY25546A patent/UY25546A1/es not_active IP Right Cessation
-
2000
- 2000-11-10 IS IS5712A patent/IS2270B/is unknown
- 2000-11-10 ZA ZA200006537A patent/ZA200006537B/en unknown
- 2000-12-04 NO NO20006148A patent/NO20006148D0/no unknown
-
2002
- 2002-01-18 HK HK02100407.5A patent/HK1038879B/zh not_active IP Right Cessation
- 2002-04-22 US US10/127,181 patent/US7015232B2/en not_active Expired - Fee Related
-
2005
- 2005-12-15 US US11/313,123 patent/US20060106057A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PA8475001A1 (es) | Composiciones estabilizadas | |
DK1487444T3 (da) | Anvendelse af pyridylamider som angiogeneseinhibitorer | |
BRPI0415121A (pt) | material particulado, forma de dosagem sólida, método para fabricar a mesma, e, uso de um material particulado ou de uma forma de dosagem sólida | |
WO2002000651A3 (en) | Factor xa inhibitors | |
BR0012752A (pt) | Benzofuril piperazinas e benzofuril homopiperazinas: agonistas de serotonina | |
PE20010126A1 (es) | Pirrolotriazinas como inhibidores de cinasas | |
BRPI0418251B8 (pt) | fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo | |
CY1109168T1 (el) | Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτητας | |
CR7034A (es) | Portador con fibrinogeno solido y trombina solida | |
DK1901755T3 (da) | Nye farmaceutiske sammensætninger indeholdende hyaluronsyre eller dens derivater og collagenase til topisk behandling af sår, forbrændinger og ulcera | |
EA201000089A1 (ru) | Применение гомо- и сополимеров для стабилизации составов активных ингредиентов | |
BRPI0412659A (pt) | isÈmero c de cci-779, seu processo de preparação, composição farmacêutica compreendendo o mesmo e pacote farmacêutico contendo o referido composto | |
RS53209B (en) | PHARMACEUTICAL COMPOSITION FOR VIRAL HEPATITIS C PROTEASE INHIBITOR | |
BR0014869A (pt) | Composição e método para estabilização da mesma | |
CO5040140A1 (es) | Composiciones detergentes para superficies duras que comp- prenden un polimero hidrofilo a nivel muy bajo que atenua el esfuerzo cortante | |
AR036652A1 (es) | Composiciones para el tratamiento del cabello que brindan cuerpo al cabello y que comprenden adhesivos sensibles a la presion de la silicona | |
MY120864A (en) | Composition for preventing creeping of a flux for soldering and use thereof. | |
NO20013966L (no) | Kombinasjoner for behandling av sykdommer som involverer angiogenese | |
DK1441769T3 (da) | Farmaceutiske formuleringer, der indeholder lave koncentrationer af peroxid, til behandling eller forebyggelse af vaginale infektioner | |
NO20043846L (no) | Oksa- og tiadiazoler og deres anvendelse som metalloproteinasehemmere | |
MXPA03010766A (es) | Nuevos compuestos y composiciones como inhibicores de las catepsinas. | |
BRPI0408299A (pt) | inibidores de catepsina s | |
NO20040153L (no) | Synergistisk farmasoytisk kombinasjon for profylakse eller behandling av diabetes | |
EE200200087A (et) | Kompositsioon hepatotsellulaarse kartsinoomi raviks | |
AR030416A1 (es) | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |