NZ541142A - Compositions and methods of delivery of pharmacological agents - Google Patents
Compositions and methods of delivery of pharmacological agentsInfo
- Publication number
- NZ541142A NZ541142A NZ541142A NZ54114203A NZ541142A NZ 541142 A NZ541142 A NZ 541142A NZ 541142 A NZ541142 A NZ 541142A NZ 54114203 A NZ54114203 A NZ 54114203A NZ 541142 A NZ541142 A NZ 541142A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pharmaceutical composition
- pharmaceutical
- composition
- agent
- albumin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 73
- 239000000203 mixture Substances 0.000 title claims description 185
- 238000012384 transportation and delivery Methods 0.000 title description 12
- 239000002831 pharmacologic agent Substances 0.000 title description 2
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- 239000008177 pharmaceutical agent Substances 0.000 claims abstract description 201
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 118
- 239000003937 drug carrier Substances 0.000 claims abstract description 77
- 102000008100 Human Serum Albumin Human genes 0.000 claims abstract description 69
- 108091006905 Human Serum Albumin Proteins 0.000 claims abstract description 69
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims abstract description 61
- 229960000958 deferoxamine Drugs 0.000 claims abstract description 59
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- 229960001592 paclitaxel Drugs 0.000 claims description 249
- 102000009027 Albumins Human genes 0.000 claims description 228
- 108010088751 Albumins Proteins 0.000 claims description 228
- 229930012538 Paclitaxel Natural products 0.000 claims description 199
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 199
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims description 108
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 49
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 30
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- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 11
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Abstract
Description
Claims (206)
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US22551903A | 2003-12-03 | 2003-12-03 | |
US22554903A | 2003-12-04 | 2003-12-04 | |
US22558503A | 2003-12-05 | 2003-12-05 | |
PCT/US2003/038941 WO2004052401A2 (en) | 2002-12-09 | 2003-12-09 | Compositions and methods of delivery of pharmacological agents |
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NZ541142A true NZ541142A (en) | 2008-07-31 |
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NZ541142A NZ541142A (en) | 2002-12-09 | 2003-12-09 | Compositions and methods of delivery of pharmacological agents |
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BR (1) | BR0317134A (en) |
MX (1) | MXPA05006169A (en) |
NZ (1) | NZ541142A (en) |
PT (1) | PT1585548T (en) |
WO (1) | WO2004052401A2 (en) |
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2003
- 2003-12-09 KR KR1020117011747A patent/KR20110079741A/en not_active Application Discontinuation
- 2003-12-09 BR BR0317134-5A patent/BR0317134A/en not_active Application Discontinuation
- 2003-12-09 WO PCT/US2003/038941 patent/WO2004052401A2/en active Application Filing
- 2003-12-09 KR KR1020197008420A patent/KR20190034694A/en not_active IP Right Cessation
- 2003-12-09 KR KR1020187024645A patent/KR20180098702A/en not_active Application Discontinuation
- 2003-12-09 MX MXPA05006169A patent/MXPA05006169A/en unknown
- 2003-12-09 PT PT03799876T patent/PT1585548T/en unknown
- 2003-12-09 NZ NZ541142A patent/NZ541142A/en not_active IP Right Cessation
- 2003-12-09 KR KR1020147003448A patent/KR20140027554A/en not_active Application Discontinuation
- 2003-12-09 KR KR1020127011409A patent/KR20120068035A/en not_active Application Discontinuation
- 2003-12-09 KR KR1020157025001A patent/KR20150108943A/en not_active Application Discontinuation
- 2003-12-09 KR KR1020147033814A patent/KR20140148502A/en not_active Application Discontinuation
- 2003-12-09 KR KR1020057010482A patent/KR20050095826A/en not_active Application Discontinuation
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KR20120068035A (en) | 2012-06-26 |
BR0317134A (en) | 2005-11-22 |
KR20110079741A (en) | 2011-07-07 |
KR20180098702A (en) | 2018-09-04 |
WO2004052401A2 (en) | 2004-06-24 |
KR20150108943A (en) | 2015-09-30 |
KR20190034694A (en) | 2019-04-02 |
WO2004052401A3 (en) | 2005-02-17 |
KR20140148502A (en) | 2014-12-31 |
MXPA05006169A (en) | 2006-03-30 |
KR20140027554A (en) | 2014-03-06 |
KR20050095826A (en) | 2005-10-04 |
PT1585548T (en) | 2018-10-17 |
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