NZ526085A - Substituted imidazopyridines - Google Patents
Substituted imidazopyridinesInfo
- Publication number
- NZ526085A NZ526085A NZ526085A NZ52608501A NZ526085A NZ 526085 A NZ526085 A NZ 526085A NZ 526085 A NZ526085 A NZ 526085A NZ 52608501 A NZ52608501 A NZ 52608501A NZ 526085 A NZ526085 A NZ 526085A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- alkenyl
- aryl
- compounds
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Disclosed are compounds of formula (I), wherein: X is alkylene or alkenylene, Y is -CO-, -CS-, or -SO2-, Z is a bond, -O-, -S-, or -NR5-, R1 is optionally substituted aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, R2 is H, alkyl, alkenyl, -alkyl-O-alkyl, -alkyl-S-alkyl, -alkyl-O-aryl, -alkyl-S-aryl, -alkyl-O-alkenyl, -alkyl-S-alkenyl, or optionally substituted alkyl or alkenyl, R3 and R4 are independently alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialklyamino or alkylthio, each R5 is H or alkyl. The compounds are used in the manufacture of medicaments for inducing cytokine biosynthesis in animals, the treatment of viral diseases or neoplastic diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25422800P | 2000-12-08 | 2000-12-08 | |
| PCT/US2001/046915 WO2002046194A2 (en) | 2000-12-08 | 2001-12-06 | Substituted imidazopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ526085A true NZ526085A (en) | 2004-12-24 |
Family
ID=22963437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ526085A NZ526085A (en) | 2000-12-08 | 2001-12-06 | Substituted imidazopyridines |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1343783A2 (en) |
| JP (1) | JP2004525868A (en) |
| KR (1) | KR20030070048A (en) |
| CN (1) | CN1249062C (en) |
| AR (1) | AR035670A1 (en) |
| AU (2) | AU3954702A (en) |
| BR (1) | BR0116034A (en) |
| CA (1) | CA2431040A1 (en) |
| CZ (1) | CZ20031593A3 (en) |
| EE (1) | EE200300273A (en) |
| HK (1) | HK1063466A1 (en) |
| HR (1) | HRP20030465A2 (en) |
| HU (1) | HUP0600592A2 (en) |
| IL (1) | IL155885A0 (en) |
| MX (1) | MXPA03005013A (en) |
| NO (1) | NO20032453L (en) |
| NZ (1) | NZ526085A (en) |
| PL (1) | PL365739A1 (en) |
| RU (1) | RU2294934C2 (en) |
| SK (1) | SK7142003A3 (en) |
| TW (1) | TWI243819B (en) |
| UA (1) | UA74593C2 (en) |
| WO (1) | WO2002046194A2 (en) |
| ZA (1) | ZA200305238B (en) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741908A (en) | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| UA67760C2 (en) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines |
| US6541485B1 (en) | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6756382B2 (en) | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| UA75622C2 (en) | 2000-12-08 | 2006-05-15 | 3M Innovative Properties Co | Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon |
| US6664265B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US6677348B2 (en) | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
| US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US20020107262A1 (en) * | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
| US6545017B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6677347B2 (en) | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| US6660735B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
| US6664264B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6525064B1 (en) | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| NZ532769A (en) | 2001-11-29 | 2005-12-23 | 3M Innovative Properties Co | Pharmaceutical formulations comprising an immune response modifier |
| CA2365732A1 (en) | 2001-12-20 | 2003-06-20 | Ibm Canada Limited-Ibm Canada Limitee | Testing measurements |
| AU2003233519A1 (en) * | 2002-05-29 | 2003-12-19 | 3M Innovative Properties Company | Process for imidazo(4,5-c)pyridin-4-amines |
| EP2269632B1 (en) | 2002-08-15 | 2014-01-01 | 3M Innovative Properties Co. | Immunostimulatory compositions and methods of stimulating an immune response |
| AU2003299082A1 (en) | 2002-09-26 | 2004-04-19 | 3M Innovative Properties Company | 1h-imidazo dimers |
| NZ540826A (en) | 2002-12-20 | 2008-07-31 | 3M Innovative Properties Co | Aryl / hetaryl substituted imidazoquinolines |
| AU2003300184B8 (en) | 2002-12-30 | 2009-12-03 | 3M Innovative Properties Company | Immunostimulatory combinations |
| US8110582B2 (en) | 2003-03-04 | 2012-02-07 | 3M Innovative Properties Company | Prophylactic treatment of UV-induced epidermal neoplasia |
| CA2518082C (en) * | 2003-03-13 | 2013-02-12 | 3M Innovative Properties Company | Methods for diagnosing skin lesions |
| CA2518282C (en) | 2003-03-13 | 2012-11-06 | 3M Innovative Properties Company | Methods of improving skin quality |
| US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
| EP1617871A4 (en) | 2003-04-10 | 2010-10-06 | 3M Innovative Properties Co | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| WO2004110991A2 (en) | 2003-06-06 | 2004-12-23 | 3M Innovative Properties Company | PROCESS FOR IMIDAZO[4,5-c]PYRIDIN-4-AMINES |
| BRPI0412902A (en) | 2003-08-12 | 2006-09-26 | 3M Innovative Properties Co | oxime-substituted imidazo-containing compounds |
| CA2536249A1 (en) | 2003-08-25 | 2005-03-10 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| ES2406730T3 (en) | 2003-08-27 | 2013-06-07 | 3M Innovative Properties Company | Imidazoquinolines substituted with aryloxy and arylalkylenoxy |
| CA2537763A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
| RU2412942C2 (en) | 2003-10-03 | 2011-02-27 | 3М Инновейтив Пропертиз Компани | Oxy-substituted imidazoquinolines, capable of modulating biosynthesis of cytokines |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| EP1682544A4 (en) | 2003-11-14 | 2009-05-06 | 3M Innovative Properties Co | Hydroxylamine substituted imidazo ring compounds |
| AU2004291101A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
| MY161812A (en) | 2003-11-25 | 2017-05-15 | 3M Innovative Properties Co | Substituted imidazo ring systems and methods |
| WO2005055932A2 (en) | 2003-12-02 | 2005-06-23 | 3M Innovative Properties Company | Therapeutic combinations and methods including irm compounds |
| AU2004312510A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| EP1701955A1 (en) | 2003-12-29 | 2006-09-20 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| AU2004312508A1 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
| AU2005228150A1 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| WO2005123080A2 (en) | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| US8026366B2 (en) | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| US7897609B2 (en) | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| WO2006065280A2 (en) | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
| AU2005326708C1 (en) | 2004-12-30 | 2012-08-30 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| JP5543068B2 (en) | 2004-12-30 | 2014-07-09 | スリーエム イノベイティブ プロパティズ カンパニー | Chiral fused [1,2] imidazo [4,5-c] cyclic compound |
| US9248127B2 (en) | 2005-02-04 | 2016-02-02 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
| US7968563B2 (en) | 2005-02-11 | 2011-06-28 | 3M Innovative Properties Company | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
| EP1863814A1 (en) | 2005-04-01 | 2007-12-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| EP1869043A2 (en) | 2005-04-01 | 2007-12-26 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| BRPI0616338A2 (en) * | 2005-09-23 | 2011-06-14 | Coley Pharm Group Inc | Method for 1h-imidazo [4,5-c] pyridines and analogs thereof |
| CN100344325C (en) * | 2005-10-17 | 2007-10-24 | 华南师范大学 | Medicine for treating cervical cancer and preparation method and application thereof |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| WO2009034411A1 (en) * | 2007-09-12 | 2009-03-19 | Centre National De La Recherche Scientifique | Perharidines as cdk inhibitors |
| CN112587671A (en) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | Targeted immunotherapy for cancer |
| CN105814052B (en) * | 2013-12-09 | 2018-01-12 | Ucb生物制药私人有限公司 | Imidazopyridine derivatives as TNF active regulators |
| CN114716555A (en) | 2014-01-10 | 2022-07-08 | 博笛生物科技有限公司 | Compounds and compositions for targeting EGFR expressing tumors |
| AU2015286043B2 (en) | 2014-07-09 | 2020-08-20 | Birdie Biopharmaceuticals Inc. | Anti-PD-L1 combinations for treating tumors |
| CN105233291A (en) | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | Combined therapy composition and combined therapy method for treating cancers |
| CN112587672A (en) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | anti-PD-L1 conjugates for the treatment of tumors |
| CN115350279A (en) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | anti-HER 2 combinations for the treatment of tumors |
| CN115252792A (en) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | anti-EGFR combinations for the treatment of tumors |
| CN115554406A (en) | 2016-01-07 | 2023-01-03 | 博笛生物科技有限公司 | anti-CD 20 combinations for the treatment of tumors |
| CN108794467A (en) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2- amino-quinoline derivatives |
| MX2019015744A (en) | 2017-06-23 | 2020-02-20 | Birdie Biopharmaceuticals Inc | Pharmaceutical compositions. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL73534A (en) * | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US4929624A (en) * | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| CZ288182B6 (en) * | 1993-07-15 | 2001-05-16 | Minnesota Mining & Mfg | Imidazo[4,5-c]pyridine-4-amines and pharmaceutical preparations based thereon |
| EP0894797A4 (en) * | 1997-01-09 | 2001-08-16 | Terumo Corp | Novel amide derivatives and intermediates for the synthesis thereof |
| UA67760C2 (en) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines |
| US6541485B1 (en) * | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6451810B1 (en) * | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
-
2001
- 2001-06-12 UA UA2003042937A patent/UA74593C2/en unknown
- 2001-12-06 CZ CZ20031593A patent/CZ20031593A3/en unknown
- 2001-12-06 AU AU3954702A patent/AU3954702A/en active Pending
- 2001-12-06 KR KR10-2003-7007533A patent/KR20030070048A/en not_active Application Discontinuation
- 2001-12-06 CN CNB018198570A patent/CN1249062C/en not_active Expired - Fee Related
- 2001-12-06 WO PCT/US2001/046915 patent/WO2002046194A2/en active IP Right Grant
- 2001-12-06 IL IL15588501A patent/IL155885A0/en unknown
- 2001-12-06 AU AU2002239547A patent/AU2002239547B2/en not_active Ceased
- 2001-12-06 PL PL01365739A patent/PL365739A1/en not_active Application Discontinuation
- 2001-12-06 CA CA002431040A patent/CA2431040A1/en not_active Abandoned
- 2001-12-06 SK SK714-2003A patent/SK7142003A3/en unknown
- 2001-12-06 MX MXPA03005013A patent/MXPA03005013A/en active IP Right Grant
- 2001-12-06 NZ NZ526085A patent/NZ526085A/en unknown
- 2001-12-06 RU RU2003116648/04A patent/RU2294934C2/en active
- 2001-12-06 BR BR0116034-6A patent/BR0116034A/en not_active IP Right Cessation
- 2001-12-06 EP EP01987315A patent/EP1343783A2/en not_active Withdrawn
- 2001-12-06 HU HU0600592A patent/HUP0600592A2/en unknown
- 2001-12-06 JP JP2002547931A patent/JP2004525868A/en active Pending
- 2001-12-06 EE EEP200300273A patent/EE200300273A/en unknown
- 2001-12-07 TW TW090130400A patent/TWI243819B/en active
- 2001-12-10 AR ARP010105732A patent/AR035670A1/en unknown
-
2003
- 2003-05-28 NO NO20032453A patent/NO20032453L/en not_active Application Discontinuation
- 2003-06-06 HR HR20030465A patent/HRP20030465A2/en not_active Application Discontinuation
- 2003-07-07 ZA ZA200305238A patent/ZA200305238B/en unknown
-
2004
- 2004-08-18 HK HK04106187A patent/HK1063466A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2003116648A (en) | 2005-02-10 |
| AU3954702A (en) | 2002-06-18 |
| MXPA03005013A (en) | 2003-09-05 |
| NO20032453D0 (en) | 2003-05-28 |
| RU2294934C2 (en) | 2007-03-10 |
| ZA200305238B (en) | 2004-08-27 |
| HK1063466A1 (en) | 2004-12-31 |
| WO2002046194A3 (en) | 2003-02-06 |
| TWI243819B (en) | 2005-11-21 |
| NO20032453L (en) | 2003-07-16 |
| JP2004525868A (en) | 2004-08-26 |
| UA74593C2 (en) | 2006-01-16 |
| HUP0600592A2 (en) | 2006-11-28 |
| AU2002239547B2 (en) | 2006-11-30 |
| CZ20031593A3 (en) | 2004-01-14 |
| EE200300273A (en) | 2004-02-16 |
| SK7142003A3 (en) | 2003-10-07 |
| PL365739A1 (en) | 2005-01-10 |
| CN1249062C (en) | 2006-04-05 |
| EP1343783A2 (en) | 2003-09-17 |
| CN1478090A (en) | 2004-02-25 |
| CA2431040A1 (en) | 2002-06-13 |
| AR035670A1 (en) | 2004-06-23 |
| HRP20030465A2 (en) | 2004-06-30 |
| IL155885A0 (en) | 2003-12-23 |
| WO2002046194A2 (en) | 2002-06-13 |
| BR0116034A (en) | 2004-08-03 |
| KR20030070048A (en) | 2003-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |