NZ321370A - Polymorphic forms of a growth hormone secretagogue - Google Patents
Polymorphic forms of a growth hormone secretagogueInfo
- Publication number
- NZ321370A NZ321370A NZ321370A NZ32137096A NZ321370A NZ 321370 A NZ321370 A NZ 321370A NZ 321370 A NZ321370 A NZ 321370A NZ 32137096 A NZ32137096 A NZ 32137096A NZ 321370 A NZ321370 A NZ 321370A
- Authority
- NZ
- New Zealand
- Prior art keywords
- polymorphic forms
- growth hormone
- polymorphic
- forms
- methanesulfonylspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Fodder In General (AREA)
Abstract
Disclosed are polymorphic forms of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. Also disclosed are processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
| PCT/US1996/016955 WO1997015574A1 (en) | 1995-10-27 | 1996-10-23 | Polymorphic forms of a growth hormone secretagogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ321370A true NZ321370A (en) | 1999-11-29 |
Family
ID=26308741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ321370A NZ321370A (en) | 1995-10-27 | 1996-10-23 | Polymorphic forms of a growth hormone secretagogue |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1019402A1 (en) |
| JP (1) | JP3204266B2 (en) |
| KR (1) | KR19990067098A (en) |
| CN (1) | CN1067687C (en) |
| AU (1) | AU707946B2 (en) |
| BG (1) | BG102476A (en) |
| BR (1) | BR9611229A (en) |
| CA (1) | CA2235371A1 (en) |
| CO (1) | CO4770956A1 (en) |
| CZ (1) | CZ128098A3 (en) |
| EA (1) | EA000528B1 (en) |
| EE (1) | EE9800147A (en) |
| HK (1) | HK1017894A1 (en) |
| HU (1) | HUP9902208A3 (en) |
| IS (1) | IS4721A (en) |
| NO (1) | NO310556B1 (en) |
| NZ (1) | NZ321370A (en) |
| PL (1) | PL327511A1 (en) |
| SK (1) | SK51398A3 (en) |
| TR (1) | TR199800726T2 (en) |
| WO (1) | WO1997015574A1 (en) |
| YU (1) | YU56696A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO115804B1 (en) * | 1992-12-11 | 2000-06-30 | Merck & Co Inc | Spiropyperidine derivatives, processes for preparation and pharmaceutical compositions thereof |
-
1996
- 1996-10-23 WO PCT/US1996/016955 patent/WO1997015574A1/en not_active Application Discontinuation
- 1996-10-23 BR BR9611229A patent/BR9611229A/en not_active IP Right Cessation
- 1996-10-23 HU HU9902208A patent/HUP9902208A3/en unknown
- 1996-10-23 JP JP51673797A patent/JP3204266B2/en not_active Expired - Lifetime
- 1996-10-23 NZ NZ321370A patent/NZ321370A/en not_active IP Right Cessation
- 1996-10-23 KR KR1019980703038A patent/KR19990067098A/en not_active Application Discontinuation
- 1996-10-23 EA EA199800335A patent/EA000528B1/en not_active IP Right Cessation
- 1996-10-23 AU AU74686/96A patent/AU707946B2/en not_active Expired
- 1996-10-23 EE EE9800147A patent/EE9800147A/en unknown
- 1996-10-23 SK SK513-98A patent/SK51398A3/en unknown
- 1996-10-23 CN CN96199328A patent/CN1067687C/en not_active Expired - Lifetime
- 1996-10-23 CZ CZ981280A patent/CZ128098A3/en unknown
- 1996-10-23 CA CA002235371A patent/CA2235371A1/en not_active Abandoned
- 1996-10-23 EP EP96936869A patent/EP1019402A1/en not_active Withdrawn
- 1996-10-23 PL PL96327511A patent/PL327511A1/en unknown
- 1996-10-23 TR TR1998/00726T patent/TR199800726T2/en unknown
- 1996-10-25 CO CO96056663A patent/CO4770956A1/en unknown
- 1996-10-25 YU YU56696A patent/YU56696A/en unknown
-
1998
- 1998-04-21 IS IS4721A patent/IS4721A/en unknown
- 1998-04-24 NO NO19981867A patent/NO310556B1/en not_active IP Right Cessation
- 1998-05-21 BG BG102476A patent/BG102476A/en unknown
-
1999
- 1999-07-12 HK HK99102961A patent/HK1017894A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1017894A1 (en) | 1999-12-03 |
| CN1067687C (en) | 2001-06-27 |
| PL327511A1 (en) | 1998-12-21 |
| BR9611229A (en) | 1999-05-25 |
| AU7468696A (en) | 1997-05-15 |
| KR19990067098A (en) | 1999-08-16 |
| CN1205703A (en) | 1999-01-20 |
| JPH10512295A (en) | 1998-11-24 |
| NO981867L (en) | 1998-06-29 |
| NO310556B1 (en) | 2001-07-23 |
| EA199800335A1 (en) | 1998-12-24 |
| EA000528B1 (en) | 1999-10-28 |
| HUP9902208A2 (en) | 1999-10-28 |
| CZ128098A3 (en) | 1998-09-16 |
| AU707946B2 (en) | 1999-07-22 |
| HUP9902208A3 (en) | 2001-05-28 |
| SK51398A3 (en) | 1998-12-02 |
| BG102476A (en) | 1999-04-30 |
| NO981867D0 (en) | 1998-04-24 |
| WO1997015574A1 (en) | 1997-05-01 |
| IS4721A (en) | 1998-04-21 |
| TR199800726T2 (en) | 1998-08-21 |
| CO4770956A1 (en) | 1999-04-30 |
| CA2235371A1 (en) | 1997-05-01 |
| EE9800147A (en) | 1998-12-15 |
| EP1019402A1 (en) | 2000-07-19 |
| YU56696A (en) | 1999-09-27 |
| JP3204266B2 (en) | 2001-09-04 |
| MX9803351A (en) | 1998-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| ASS | Change of ownership |
Owner name: SCHERING CORPORATION, US Free format text: OLD OWNER(S): MERCK SHARP AND DOHME CORP. |
|
| EXPY | Patent expired |