NO991677D0 - Aspartate ester inhibitors for interleukin-1 <beta> conversion enzyme - Google Patents
Aspartate ester inhibitors for interleukin-1 <beta> conversion enzymeInfo
- Publication number
- NO991677D0 NO991677D0 NO991677A NO991677A NO991677D0 NO 991677 D0 NO991677 D0 NO 991677D0 NO 991677 A NO991677 A NO 991677A NO 991677 A NO991677 A NO 991677A NO 991677 D0 NO991677 D0 NO 991677D0
- Authority
- NO
- Norway
- Prior art keywords
- interleukin
- beta
- conversion enzyme
- aspartate ester
- ester inhibitors
- Prior art date
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2832296P | 1996-10-11 | 1996-10-11 | |
PCT/US1997/018514 WO1998016502A1 (en) | 1996-10-11 | 1997-10-09 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
Publications (2)
Publication Number | Publication Date |
---|---|
NO991677D0 true NO991677D0 (en) | 1999-04-09 |
NO991677L NO991677L (en) | 1999-06-09 |
Family
ID=21842807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO991677A NO991677L (en) | 1996-10-11 | 1999-04-09 | Aspartate ester inhibitors for interleukin 1- <beta> conversion enzyme |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0932598A1 (en) |
JP (1) | JP2001506974A (en) |
KR (1) | KR20000049048A (en) |
AU (1) | AU738341B2 (en) |
BR (1) | BR9712530A (en) |
CA (1) | CA2268098A1 (en) |
IL (1) | IL129091A0 (en) |
NO (1) | NO991677L (en) |
WO (1) | WO1998016502A1 (en) |
Families Citing this family (45)
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DE69914200T2 (en) * | 1998-07-08 | 2004-10-14 | Harbor Branch Oceanographic Institution, Inc., Fort Pierce | AMINOIMINOCHINONE AND AMINOCHINONE ALKALOID COMPOUNDS AS CASPASE INHIBITORS |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
DE60035037T2 (en) * | 1999-04-09 | 2008-01-31 | Cytovia, Inc., San Diego | CASPASE INHIBITORS AND ITS USE |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
KR100767199B1 (en) * | 1999-05-07 | 2007-10-17 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
AR026748A1 (en) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | A CASPASE INHIBITING COMPOUND, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A METHOD FOR THE SYNTHESIS OF THE SAME AND AN INTERMEDIATE COMPOUND PARADICHA SYNTHESIS |
SI1268425T1 (en) | 2000-03-29 | 2008-04-30 | Vertex Pharma | Carbamate caspase inhibitors and uses thereof |
AR027993A1 (en) | 2000-03-29 | 2003-04-23 | Vertex Pharma | CASPASA CARBONATE INHIBITORS AND USES OF THE SAME |
PE20011350A1 (en) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE) |
WO2001094351A1 (en) * | 2000-06-07 | 2001-12-13 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
US6355666B1 (en) | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
JP2004521080A (en) | 2000-09-08 | 2004-07-15 | メルク フロスト カナダ アンド カンパニー | Gamma-keto acid dipeptides as caspase-3 inhibitors |
US6800619B2 (en) | 2000-09-13 | 2004-10-05 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
AU2007201841B2 (en) * | 2000-09-13 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Caspase Inhibitors and Uses Thereof |
DE60128709T2 (en) | 2000-09-15 | 2007-12-27 | Vertex Pharmaceuticals Inc., Cambridge | TRIAZOL COMPOUNDS AS PROTEIN KINASE INHIBITORS |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
KR100947185B1 (en) | 2000-12-21 | 2010-03-15 | 버텍스 파마슈티칼스 인코포레이티드 | Pyrazole compounds useful as protein kinase inhibitors and compositions comprising said compounds |
WO2002085899A1 (en) * | 2001-04-19 | 2002-10-31 | Vertex Pharmaceuticals Incorporated | Heterocyclyldicarbamides as caspase inhibitors |
CA2447999C (en) * | 2001-05-23 | 2011-04-26 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
US6878743B2 (en) | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
CN100503572C (en) | 2002-06-28 | 2009-06-24 | 沃泰克斯药物股份有限公司 | Caspase inhibitors and uses thereof |
CA2494100C (en) | 2002-08-02 | 2011-10-11 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
JP4675628B2 (en) | 2002-12-20 | 2011-04-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Esters and amide derivatives of 4-oxo-3- (1-oxo-1H-isoquinolin-2-ylacetylamino) -pentanoic acid and their use as caspase inhibitors |
PE20050159A1 (en) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS |
AU2005249503B2 (en) | 2003-11-10 | 2011-08-25 | Vertex Pharmaceuticals Incorporated | ICE inhibitors for the treatment of autoinflammatory diseases |
PT1725548E (en) | 2004-03-12 | 2015-04-16 | Vertex Pharma | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
ZA200610133B (en) | 2004-05-15 | 2008-05-28 | Vertex Pharma | Treating seizures using ice inhibitors |
RU2412936C2 (en) | 2004-11-24 | 2011-02-27 | Вертекс Фармасьютикалз Инкорпорейтед | Derivatives of 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentane acid and their application as caspase inhibitors |
ATE529430T1 (en) | 2005-07-28 | 2011-11-15 | Vertex Pharma | CASPASE INHIBITOR PROPHARMACIES |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
NZ594385A (en) | 2005-11-03 | 2013-02-22 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
CN101209976B (en) * | 2006-12-29 | 2012-01-11 | 中国人民解放军军事医学科学院毒物药物研究所 | Substituted tartaric acid derivatives and use thereof for preparing beta-secretase inhibitor |
MX2009011810A (en) | 2007-05-02 | 2010-01-14 | Vertex Pharma | Thiazoles and pyrazoles useful as kinase inhibitors. |
WO2009018415A1 (en) | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
EP2323622A1 (en) | 2008-09-03 | 2011-05-25 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
JP6006908B2 (en) | 2010-11-05 | 2016-10-12 | ブランダイス ユニバーシティBrandeis University | ICE inhibitory compounds and uses thereof |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
KR20190040931A (en) | 2016-01-11 | 2019-04-19 | 에피센트알엑스, 인코포레이티드 | Compositions and methods for intravenous administration of 2-bromo-1- (3,3-dinitroazetidin-1-yl) ethanone |
EP3526195A4 (en) * | 2016-10-14 | 2020-05-20 | EpicentRx, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
CN108997155A (en) * | 2018-09-17 | 2018-12-14 | 吉尔生化(上海)有限公司 | A kind of polypeptide raw material aspartic acid β-tert-butyl ester α-methyl ester hydrochloride preparation method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents. |
TW494094B (en) * | 1993-04-29 | 2002-07-11 | Vertex Pharma | Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same |
-
1997
- 1997-10-09 JP JP51851998A patent/JP2001506974A/en not_active Ceased
- 1997-10-09 IL IL12909197A patent/IL129091A0/en unknown
- 1997-10-09 WO PCT/US1997/018514 patent/WO1998016502A1/en not_active Application Discontinuation
- 1997-10-09 EP EP97911715A patent/EP0932598A1/en not_active Withdrawn
- 1997-10-09 KR KR1019990703117A patent/KR20000049048A/en not_active Application Discontinuation
- 1997-10-09 CA CA002268098A patent/CA2268098A1/en not_active Abandoned
- 1997-10-09 BR BR9712530-0A patent/BR9712530A/en not_active IP Right Cessation
- 1997-10-09 AU AU49023/97A patent/AU738341B2/en not_active Ceased
-
1999
- 1999-04-09 NO NO991677A patent/NO991677L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2268098A1 (en) | 1998-04-23 |
JP2001506974A (en) | 2001-05-29 |
AU738341B2 (en) | 2001-09-13 |
NO991677L (en) | 1999-06-09 |
IL129091A0 (en) | 2000-02-17 |
BR9712530A (en) | 1999-10-19 |
WO1998016502A1 (en) | 1998-04-23 |
AU4902397A (en) | 1998-05-11 |
EP0932598A1 (en) | 1999-08-04 |
KR20000049048A (en) | 2000-07-25 |
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