NO983984L - Disintegrin-metalloprotease samt anvendelse derav - Google Patents
Disintegrin-metalloprotease samt anvendelse deravInfo
- Publication number
- NO983984L NO983984L NO983984A NO983984A NO983984L NO 983984 L NO983984 L NO 983984L NO 983984 A NO983984 A NO 983984A NO 983984 A NO983984 A NO 983984A NO 983984 L NO983984 L NO 983984L
- Authority
- NO
- Norway
- Prior art keywords
- disintegrin
- protein
- binding
- expression vector
- recombinant expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
Abstract
Det er beskrevet en fremgangsmåte for å identifisere forbindelser som er i stand til å binde til et disinte- grinprotein og bestemme mengden og affinitet av en for- bindelse som er i stand til å binde til disintegrinpro- teinet i en prøve. Det er også beskrevet en vertscelle omfattende en rekombinant ekspresjonsvektor for disintegrinproteinet og en rekombinant ekspresjons- vektor som koder for disintegrinproteinet og det humane disintegrinmetalloproteaseprotein, fragment eller mutant derav, som er anvendelig for disse formål. Det er også beskrevet en in vivo eller in vi tro metode for bestemmelse av osteoartritt og andre metalloprote- asebaserte sykdommer, og som er i stand til å bli frem- stilt og brukt i form av et sett.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1267996P | 1996-03-01 | 1996-03-01 | |
PCT/US1997/003217 WO1997031931A1 (en) | 1996-03-01 | 1997-02-28 | A novel disintegrin metalloprotease and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO983984D0 NO983984D0 (no) | 1998-08-28 |
NO983984L true NO983984L (no) | 1998-11-02 |
Family
ID=21756171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO983984A NO983984L (no) | 1996-03-01 | 1998-08-28 | Disintegrin-metalloprotease samt anvendelse derav |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0888375A4 (no) |
JP (1) | JPH11506023A (no) |
KR (1) | KR19990087444A (no) |
AU (1) | AU2061797A (no) |
CA (1) | CA2247827A1 (no) |
NO (1) | NO983984L (no) |
NZ (1) | NZ331844A (no) |
WO (1) | WO1997031931A1 (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255064B1 (en) | 1996-03-01 | 2001-07-03 | The Procter & Gamble Company | Disintegrin metalloprotease and its use |
US5935792A (en) * | 1996-08-29 | 1999-08-10 | The Regents Of The University Of California | KUZ, a novel family of metalloproteases |
EP0977775A2 (en) * | 1997-02-25 | 2000-02-09 | The Procter & Gamble Company | Use of a novel disintegrin metalloprotease, mutants, fragments and the like |
US6436629B1 (en) | 2000-10-27 | 2002-08-20 | The Regents Of The University Of California | Modulating angiogenesis |
US6294368B1 (en) | 2001-03-22 | 2001-09-25 | Applera Corporation | Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof |
PL371525A1 (en) * | 2002-01-31 | 2005-06-27 | Wyeth | Aggrecanase molecules |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5935792A (en) * | 1996-08-29 | 1999-08-10 | The Regents Of The University Of California | KUZ, a novel family of metalloproteases |
-
1997
- 1997-02-28 WO PCT/US1997/003217 patent/WO1997031931A1/en not_active Application Discontinuation
- 1997-02-28 AU AU20617/97A patent/AU2061797A/en not_active Abandoned
- 1997-02-28 EP EP97908799A patent/EP0888375A4/en not_active Withdrawn
- 1997-02-28 JP JP9531177A patent/JPH11506023A/ja active Pending
- 1997-02-28 NZ NZ331844A patent/NZ331844A/en unknown
- 1997-02-28 CA CA002247827A patent/CA2247827A1/en not_active Abandoned
- 1997-02-28 KR KR1019980706866A patent/KR19990087444A/ko not_active Application Discontinuation
-
1998
- 1998-08-28 NO NO983984A patent/NO983984L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2061797A (en) | 1997-09-16 |
EP0888375A1 (en) | 1999-01-07 |
KR19990087444A (ko) | 1999-12-27 |
JPH11506023A (ja) | 1999-06-02 |
CA2247827A1 (en) | 1997-09-04 |
NZ331844A (en) | 2000-06-23 |
NO983984D0 (no) | 1998-08-28 |
WO1997031931A1 (en) | 1997-09-04 |
EP0888375A4 (en) | 2001-04-11 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |