DE69940969D1 - Detektion von neoplasien durch speichelanalyse - Google Patents

Detektion von neoplasien durch speichelanalyse

Info

Publication number
DE69940969D1
DE69940969D1 DE69940969T DE69940969T DE69940969D1 DE 69940969 D1 DE69940969 D1 DE 69940969D1 DE 69940969 T DE69940969 T DE 69940969T DE 69940969 T DE69940969 T DE 69940969T DE 69940969 D1 DE69940969 D1 DE 69940969D1
Authority
DE
Germany
Prior art keywords
detection
neoplasia
storage analysis
nucleic acids
mutant nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940969T
Other languages
English (en)
Inventor
David Sidransky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
School of Medicine of Johns Hopkins University
Original Assignee
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69940969D1 publication Critical patent/DE69940969D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69940969T 1998-03-10 1999-03-10 Detektion von neoplasien durch speichelanalyse Expired - Lifetime DE69940969D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/038,637 US6235470B1 (en) 1993-11-12 1998-03-10 Detection of neoplasia by analysis of saliva
PCT/US1999/005220 WO1999046408A1 (en) 1998-03-10 1999-03-10 Detection of neoplasia by analysis of saliva

Publications (1)

Publication Number Publication Date
DE69940969D1 true DE69940969D1 (de) 2009-07-23

Family

ID=21901047

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940969T Expired - Lifetime DE69940969D1 (de) 1998-03-10 1999-03-10 Detektion von neoplasien durch speichelanalyse

Country Status (10)

Country Link
US (4) US6235470B1 (de)
EP (1) EP1062366B1 (de)
JP (2) JP2002505888A (de)
AT (1) ATE433498T1 (de)
AU (1) AU769035B2 (de)
CA (1) CA2323060A1 (de)
DE (1) DE69940969D1 (de)
HK (1) HK1033765A1 (de)
NO (1) NO20004504L (de)
WO (1) WO1999046408A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235470B1 (en) * 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
EP0956365A4 (de) * 1996-08-28 2004-08-25 Univ Johns Hopkins Med Verfahren zur detektion zellproliferativer deregulationen
US7407943B2 (en) * 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7888324B2 (en) * 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
EP1463838A4 (de) * 2001-12-14 2006-06-07 Zila Inc Färbungsgesteuerte molekulare analyse zur krebsprognose und -diagnose
US7511131B2 (en) * 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20060009410A1 (en) * 2002-11-13 2006-01-12 Crooke Rosanne M Effects of apolipoprotein B inhibition on gene expression profiles in animals
JP5686493B2 (ja) 2003-01-24 2015-03-18 ユニバーシティ・オブ・ユタＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｕｔａｈ テロメアの長さを決定することによって死亡の危険性を予測する方法
WO2005089414A2 (en) * 2004-03-17 2005-09-29 The Johns Hopkins University Neoplasia diagnostic compositions and methods of use
US20050287558A1 (en) * 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
PT2409713E (pt) * 2004-08-10 2015-10-09 Genzyme Corp Oligonucleótidos para utilização em modulação dos níveis de lipoproteínas e colesterol em humanos
EP2019692B1 (de) 2006-05-05 2014-06-04 Isis Pharmaceuticals, Inc. Verbindungen und verfahren zur modulation der expression von gccr
EP2032716A4 (de) * 2006-05-12 2010-03-17 Univ Miami Biomarker zum nachweis und zur diagnose von plattenepithelkarzinomen im kopf- und halsbereich
JP2010522245A (ja) * 2007-03-24 2010-07-01 ゲンザイム コーポレイション ヒトアポリポタンパク質ｂと相補的なアンチセンスオリゴヌクレオチドの投与
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
US8012678B2 (en) 2007-07-24 2011-09-06 Wisconsin Alumni Research Foundation Biomarkers for human papilloma virus-associated cancer
EP2379747B1 (de) 2008-12-22 2013-07-03 University of Utah Research Foundation Monochrome quantitative multiplex-pcr
EP2408796B1 (de) 2009-03-16 2020-04-22 Ionis Pharmaceuticals, Inc. Targeting Apolipoprotein B für die Reduktion von Apolipoprotein C-III
ITBO20090554A1 (it) * 2009-08-27 2011-02-28 Maria Gabriella Fornaro Metodo per individuare la predisposizione al carcinoma della prostata.
ES2633111T3 (es) * 2010-03-26 2017-09-19 Hongzhi Zou Métodos y materiales para detectar neoplasia colorrectal
AU2012340441A1 (en) 2011-11-15 2014-05-29 University Of Miami Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma
AU2012362210A1 (en) * 2011-12-31 2014-08-21 Telomere Diagnostics, Inc. Saliva-derived measures of telomere abundance and sample collection device
US9506116B2 (en) 2013-03-14 2016-11-29 Mayo Foundation For Medical Education And Research Detecting neoplasm
EP2999800B1 (de) 2013-05-22 2019-09-25 Telomere Diagnostics Inc. Messung der menge kurzer telomere
EP4234722A3 (de) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detektion von kolorektalem neoplasma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US9944978B2 (en) 2014-12-30 2018-04-17 Telomere Diagnostics, Inc. Multiplex quantitative PCR
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
EP3344784A4 (de) 2015-08-31 2019-07-10 Mayo Foundation for Medical Education and Research Nachweis von gastrischen neoplasmen
CN116024334A (zh) 2016-04-14 2023-04-28 梅约医学教育与研究基金会 检测DMR试剂筛选IPMN-HGD、PanIN-3或PDAC的用途及试剂盒
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
US10934592B2 (en) 2017-02-28 2021-03-02 Mayo Foundation For Medical Education And Research Detecting prostate cancer
KR20200105661A (ko) 2017-11-30 2020-09-08 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 유방암 검출방법
CN114885938A (zh) * 2022-02-25 2022-08-12 厦门迈威生物科技有限公司 一种浆膜腔积液脱落细胞保存液及其生产方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0390323B2 (de) 1989-03-29 2012-08-08 Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
DK1013666T3 (da) 1990-06-27 2006-08-14 Univ Princeton Proteinkompleks p53/p90
AU662906B2 (en) 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
WO1993020235A1 (en) 1992-04-01 1993-10-14 The Johns Hopkins University School Of Medicine Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
WO1993022456A1 (en) 1992-04-27 1993-11-11 Trustees Of Dartmouth College Detection of gene sequences in biological fluids
US5561041A (en) 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5589579A (en) 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
CA2198702C (en) * 1994-08-31 2010-11-02 David Sidransky Detection of hypermutable nucleic acid sequence in tissue
EP0956365A4 (de) * 1996-08-28 2004-08-25 Univ Johns Hopkins Med Verfahren zur detektion zellproliferativer deregulationen
DE19712332A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik
AU6589698A (en) * 1997-03-28 1998-10-22 Epitope, Inc. Simultaneous collection of dna and non-nucleic analytes from oral fluids

Also Published As

Publication number Publication date
EP1062366A1 (de) 2000-12-27
EP1062366A4 (de) 2002-05-08
HK1033765A1 (en) 2001-09-21
ATE433498T1 (de) 2009-06-15
WO1999046408A1 (en) 1999-09-16
AU769035B2 (en) 2004-01-15
EP1062366B1 (de) 2009-06-10
US7279312B2 (en) 2007-10-09
JP2004159661A (ja) 2004-06-10
US7601521B2 (en) 2009-10-13
NO20004504L (no) 2000-11-08
NO20004504D0 (no) 2000-09-08
US20080124729A1 (en) 2008-05-29
CA2323060A1 (en) 1999-09-16
AU2996999A (en) 1999-09-27
US20050009040A1 (en) 2005-01-13
US6235470B1 (en) 2001-05-22
JP2002505888A (ja) 2002-02-26
US20020197608A1 (en) 2002-12-26
AU2003266475A1 (en) 2004-01-22

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