NO974257L - Immunomodulerende preparater fra galle for behandling av immunsystemsykdommer - Google Patents
Immunomodulerende preparater fra galle for behandling av immunsystemsykdommerInfo
- Publication number
- NO974257L NO974257L NO974257A NO974257A NO974257L NO 974257 L NO974257 L NO 974257L NO 974257 A NO974257 A NO 974257A NO 974257 A NO974257 A NO 974257A NO 974257 L NO974257 L NO 974257L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- immunomodulatory
- immunomodulator
- preparation
- immune system
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 210000000941 bile Anatomy 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 2
- 239000002955 immunomodulating agent Substances 0.000 abstract 2
- 230000002584 immunomodulator Effects 0.000 abstract 2
- 229940121354 immunomodulator Drugs 0.000 abstract 2
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 abstract 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
- 102100037850 Interferon gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 102000004388 Interleukin-4 Human genes 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 102000004889 Interleukin-6 Human genes 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 210000005087 mononuclear cell Anatomy 0.000 abstract 1
- 231100001083 no cytotoxicity Toxicity 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Foreliggende oppfinnelse gjelder et preparat for anvendelse som en immunomodulator som omfatter lav- molekylvektsbestanddeler på mindre enn 3 000 dalton, med følgende egenskaper: a) kan ekstraheres fra dyregalle, b) kan stimulere monocytter og makro- fager in vitro og in vlvo, c) kan modu- lere produksjonen av tumornekrosefak- tor, d) inneholder ikke målbare mengder av IL-la, IL-ip, TNF, lL-6, IL-8, IL-4, GM-CSF eller IFN-y, e) har antiproli- ferasjonsvirkning i en ondartet muse- hybridomcellelinje, f) viser ingen cytotoksisitet overfor mononukleære celler fra humant, perifert blod eller lymfocytter, og (g) er ikke et endotok- sin. Oppfinnelsen gjelder også en frem- gangsmåte for fremstilling av prepar- atet, dets anvendelse som en irmtiuno- modulator og dets anvendelse i behand- ling av sykdommer og tilstander med en immunologisk komponent, f.eks. cancer eller endometriose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40493295A | 1995-03-16 | 1995-03-16 | |
PCT/CA1996/000152 WO1996028175A1 (en) | 1995-03-16 | 1996-03-13 | Immunomodulating compositions from bile for the treatment of immune system disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
NO974257D0 NO974257D0 (no) | 1997-09-15 |
NO974257L true NO974257L (no) | 1997-11-17 |
Family
ID=23601619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974257A NO974257L (no) | 1995-03-16 | 1997-09-15 | Immunomodulerende preparater fra galle for behandling av immunsystemsykdommer |
Country Status (11)
Country | Link |
---|---|
US (1) | US6596319B2 (no) |
EP (1) | EP0814821A1 (no) |
JP (1) | JPH11501634A (no) |
KR (1) | KR19980703088A (no) |
CN (1) | CN1182368A (no) |
AU (1) | AU711294B2 (no) |
BR (1) | BR9607967A (no) |
CA (1) | CA2215339C (no) |
NO (1) | NO974257L (no) |
NZ (1) | NZ302638A (no) |
WO (1) | WO1996028175A1 (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040101569A1 (en) * | 1996-05-16 | 2004-05-27 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
CA2206047A1 (en) * | 1997-05-23 | 1998-11-23 | Romeo Rang (Deceased) | Immunomodulating compositions for the treatment of viral disorders |
US7799766B2 (en) * | 1998-04-08 | 2010-09-21 | Theta Biomedical Consulting & Development Co., Inc. | Composition for treating hormonally-dependent cancers |
WO1999063105A1 (de) * | 1998-06-03 | 1999-12-09 | Deutsches Krebsforschungszentrum Stiffung Des Öffentlichen Rechts | Glycosyl-inosit-phospho-ceramide (gipc), verfahren zu ihrer herstellung sowie ihre verwendung |
WO2002038164A1 (en) * | 2000-11-08 | 2002-05-16 | Lorus Therapeutics Inc. | Combination preparation of a biological response modifier and an anticancer agent and uses thereof |
WO2002102363A1 (en) * | 2001-06-20 | 2002-12-27 | Lorus Therapeutics Inc. | Biological response modifier composition and uses thereof |
WO2005016954A2 (en) * | 2003-08-14 | 2005-02-24 | Boston Medical Center Corporation | Immunologic activity measure(s) for t “helper” on-associated conditions |
US7136936B2 (en) * | 2003-10-03 | 2006-11-14 | Asoka Usa Corporation | Method and system for virtual powerline local area networks |
US7457885B2 (en) * | 2005-02-10 | 2008-11-25 | Asoka Usa Corporation | Powerline communication system and method using coupler design for additional users |
US20050220912A1 (en) * | 2004-03-30 | 2005-10-06 | Theoharides Theoharis C | Anti-inflammatory composition for treating pelvic endometriosis |
EP1863520B1 (en) | 2005-03-08 | 2014-12-31 | Aptose Biosciences Inc. | Use of interleukin 17e for the treatment of cancer |
WO2008085963A1 (en) * | 2007-01-05 | 2008-07-17 | University Of Florida Research Foundation, Inc. | Materials and methods for the detection, prevention and treatment of autoimmune disease |
US8042027B1 (en) | 2007-01-16 | 2011-10-18 | Marvell International Ltd. | BM/LLR computation for multi-dimensional TCM/BCM |
US8236354B1 (en) | 2012-02-17 | 2012-08-07 | ZOR Pharmaceuticals, LLC | Use of immunomodulators for the treatment of cancer |
US8338383B1 (en) | 2012-02-17 | 2012-12-25 | Gregory Jr Daniel Tyree | Use of immunomodulators for the treatment of cancer |
CL2014003632A1 (es) * | 2014-12-31 | 2015-06-26 | Pontificia Universidad Católica De Chile | Método que comprende el cultivo y expansión de células presentes en líquido ascítico de origen peritoneal, pleural, lavado peritoneal o lavados sistémicos que permite determinar el mejor tratamiento para pacientes con cáncer. |
CN113143936B (zh) * | 2021-02-10 | 2022-03-25 | 北京蕴汇医药科技有限公司 | 鹅去氧胆酸或其衍生物在制备egfr和/或stat3的抑制剂中的用途 |
CN114657125B (zh) * | 2022-04-29 | 2023-08-08 | 中国科学院海洋研究所 | 鲨鱼单个核细胞的分离方法、鲨鱼稀释液及其用途 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB337797A (en) | 1929-07-08 | 1930-11-10 | Henry Leitner | A specific for cancer |
GB2046092B (en) | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
US4562179A (en) | 1982-04-19 | 1985-12-31 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, and pharmaceutical composition of the same |
US4585762A (en) | 1982-07-30 | 1986-04-29 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same |
JPS5984824A (ja) | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
US4879226A (en) | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
US4767610A (en) | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
US4916249A (en) | 1985-07-03 | 1990-04-10 | Hans Brachwitz | Glycero-3(2)-phospho-L-serine derivatives and salts thereof |
IE59777B1 (en) | 1985-12-04 | 1994-04-06 | Max Planck Gesellschaft | Medicaments |
GB8706313D0 (en) | 1987-03-17 | 1987-04-23 | Health Lab Service Board | Treatment & prevention of viral infections |
US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
US5138067A (en) | 1987-12-17 | 1992-08-11 | Shionogi & Co. Ltd. | Lipid derivatives |
EP0356765A3 (en) | 1988-08-19 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Carboxylic acid derivatives, their production and use |
EP0378763A1 (en) | 1988-10-27 | 1990-07-25 | Takeda Chemical Industries, Ltd. | Lipids, their production and use |
GB8909022D0 (en) | 1989-04-20 | 1989-06-07 | Cortecs Ltd | Pharmaceutical compositions |
US5109118A (en) | 1989-07-06 | 1992-04-28 | Yutaka Mizushima | Modified biologically active proteins |
GB8928580D0 (en) | 1989-12-19 | 1990-02-21 | Scras | 3-(n-methyl-n-alkylamino)-methoxymethyl-propanol phosphocholine derivatives |
US5369097A (en) | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
US5352682A (en) * | 1993-03-08 | 1994-10-04 | Digestive Care Inc. | Compositions containing salts of bile acid-aminosalicylate conjugates |
ES2207639T3 (es) * | 1993-09-09 | 2004-06-01 | Lorus Therapeutics Inc. | Composiciones modulares inmunologicas a partir de las bilis. |
TW342436B (en) | 1996-08-14 | 1998-10-11 | Nippon Oxygen Co Ltd | Combustion type harm removal apparatus (1) |
-
1996
- 1996-03-13 AU AU48739/96A patent/AU711294B2/en not_active Ceased
- 1996-03-13 EP EP96904701A patent/EP0814821A1/en not_active Withdrawn
- 1996-03-13 NZ NZ302638A patent/NZ302638A/en unknown
- 1996-03-13 CA CA002215339A patent/CA2215339C/en not_active Expired - Fee Related
- 1996-03-13 BR BR9607967A patent/BR9607967A/pt not_active Application Discontinuation
- 1996-03-13 CN CN96193454A patent/CN1182368A/zh active Pending
- 1996-03-13 KR KR1019970706498A patent/KR19980703088A/ko not_active Application Discontinuation
- 1996-03-13 WO PCT/CA1996/000152 patent/WO1996028175A1/en not_active Application Discontinuation
- 1996-03-13 JP JP8527137A patent/JPH11501634A/ja active Pending
-
1997
- 1997-09-15 NO NO974257A patent/NO974257L/no not_active Application Discontinuation
-
2001
- 2001-01-17 US US09/764,010 patent/US6596319B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2215339C (en) | 1999-01-19 |
NZ302638A (en) | 2001-04-27 |
AU4873996A (en) | 1996-10-02 |
AU711294B2 (en) | 1999-10-07 |
CN1182368A (zh) | 1998-05-20 |
EP0814821A1 (en) | 1998-01-07 |
WO1996028175A1 (en) | 1996-09-19 |
JPH11501634A (ja) | 1999-02-09 |
KR19980703088A (ko) | 1998-09-05 |
CA2215339A1 (en) | 1996-09-19 |
US6596319B2 (en) | 2003-07-22 |
NO974257D0 (no) | 1997-09-15 |
BR9607967A (pt) | 1998-01-13 |
US20010009680A1 (en) | 2001-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |