NO972881L - Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling - Google Patents
Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstillingInfo
- Publication number
- NO972881L NO972881L NO972881A NO972881A NO972881L NO 972881 L NO972881 L NO 972881L NO 972881 A NO972881 A NO 972881A NO 972881 A NO972881 A NO 972881A NO 972881 L NO972881 L NO 972881L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- methods
- piperazine derivatives
- drugs containing
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Det beskrives piperazinderivater med den generelle formel. hvor. Ra, Yi til Yog E er som definert i krav 1, deres tautomerer, deres stereoisomerer, inklusivt deres blandinger og deres salter, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, og som oppviser verdifulle farmakologiske egenskaper, fortrinnsvis. , aggregasjonshemmende virkninger, legemidler som inneholder disse forbindelsene, deres anvendelse samt fremgangsmåter fortleres fremstilling.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19944446301 DE4446301A1 (de) | 1994-12-23 | 1994-12-23 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE19526678A DE19526678A1 (de) | 1994-12-23 | 1995-07-21 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE1995133639 DE19533639A1 (de) | 1994-12-23 | 1995-09-12 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
PCT/EP1995/005031 WO1996020173A1 (de) | 1994-12-23 | 1995-12-19 | Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972881D0 NO972881D0 (no) | 1997-06-20 |
NO972881L true NO972881L (no) | 1997-06-20 |
Family
ID=27207101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972881A NO972881L (no) | 1994-12-23 | 1997-06-20 | Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling |
Country Status (20)
Country | Link |
---|---|
US (1) | US5922717A (no) |
EP (1) | EP0799202A1 (no) |
JP (1) | JPH10511374A (no) |
CN (1) | CN1183770A (no) |
AR (1) | AR002950A1 (no) |
AU (1) | AU4432496A (no) |
BG (1) | BG101582A (no) |
BR (1) | BR9510360A (no) |
CA (1) | CA2207618A1 (no) |
CZ (1) | CZ189197A3 (no) |
EE (1) | EE9700141A (no) |
FI (1) | FI972646A (no) |
HR (1) | HRP950609A2 (no) |
IL (1) | IL116517A0 (no) |
MX (1) | MX9704745A (no) |
NO (1) | NO972881L (no) |
PL (1) | PL321003A1 (no) |
SK (1) | SK79797A3 (no) |
TR (1) | TR199501634A2 (no) |
WO (1) | WO1996020173A1 (no) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10511359A (ja) * | 1994-12-22 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | フィブリノゲン受容体拮抗物質 |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
WO1997015567A1 (de) * | 1995-10-20 | 1997-05-01 | Dr. Karl Thomae Gmbh | 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung |
UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
WO1999052894A1 (fr) * | 1998-04-09 | 1999-10-21 | Meiji Seika Kaisha, Ltd. | Composes heterocycliques a base d'azote anti-agregation plaquettaire et leur utilisation medicale |
PL347976A1 (en) | 1999-09-29 | 2002-05-06 | Ortho Mcneil Pharm Inc | Isonipecotamides for the treatment of integrin−mediated disorders |
EP1533310A1 (en) * | 1999-09-29 | 2005-05-25 | Ortho-McNeil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
US7081460B2 (en) * | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
ES2335092T3 (es) | 2001-08-24 | 2010-03-22 | Yale University | Compuestos de piperazinona como agentes antitumorales y anticancer. |
FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
JP2005522436A (ja) | 2002-02-08 | 2005-07-28 | グラクソ グループ リミテッド | ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用 |
CN1946666A (zh) * | 2004-02-27 | 2007-04-11 | 埃姆艮股份有限公司 | 用于治疗代谢性疾病的化合物、药物组合物和方法 |
WO2007016496A2 (en) * | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
JP5175736B2 (ja) * | 2005-10-28 | 2013-04-03 | メルク・シャープ・エンド・ドーム・コーポレイション | ピペリジングリシン輸送体阻害剤 |
SG172685A1 (en) | 2006-06-28 | 2011-07-28 | Amgen Inc | Glycine transporter-1 inhibitors |
WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
DE602008002690D1 (de) * | 2007-01-16 | 2010-11-04 | Purdue Pharma Lp | Heterozyklische substituierte piperidine als orl-1-liganden |
RU2488585C2 (ru) * | 2007-08-31 | 2013-07-27 | Пэдью Фарма Л.П. | Замещенные пиперидиновые соединения хиноксалинового типа и их применение |
WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
WO2012177896A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
PE20140868A1 (es) | 2011-06-24 | 2014-07-18 | Amgen Inc | Antagonistas trpm8 y su uso en tratamientos |
JP2015508779A (ja) * | 2012-02-16 | 2015-03-23 | ニューヨーク・ユニバーシティ | 低酸素状態で誘導可能な遺伝子発現の、オリゴオキソピペラジン非ペプチド性へリックス模倣体による制御 |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
AU2014207311A1 (en) | 2013-01-19 | 2015-08-20 | New York University | Oligooxopiperazines for p53 reactivation |
WO2015179547A2 (en) | 2014-05-21 | 2015-11-26 | New York University | Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression |
WO2023122481A2 (en) * | 2021-12-20 | 2023-06-29 | Sigma-Aldrich Co. Llc | Chemical linkers |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
ZA825719B (en) * | 1981-09-03 | 1983-06-29 | Recordati Chem Pharm | Alkanoylanilides |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
US4895846A (en) * | 1984-04-11 | 1990-01-23 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties |
US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
EP0825184B1 (en) * | 1993-03-29 | 2001-06-20 | AstraZeneca AB | Heterocyclic derivatives as platelet aggregation inhibitors |
US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE4326344A1 (de) * | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5814636A (en) * | 1994-07-15 | 1998-09-29 | Meiji Seika Kabushiki Kaisha | Compounds with platelet aggregation inhibitor activity |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
-
1995
- 1995-12-19 BR BR9510360A patent/BR9510360A/pt not_active Application Discontinuation
- 1995-12-19 EE EE9700141A patent/EE9700141A/xx unknown
- 1995-12-19 JP JP8520188A patent/JPH10511374A/ja active Pending
- 1995-12-19 EP EP95943168A patent/EP0799202A1/de not_active Withdrawn
- 1995-12-19 CA CA002207618A patent/CA2207618A1/en not_active Abandoned
- 1995-12-19 PL PL95321003A patent/PL321003A1/xx unknown
- 1995-12-19 CZ CZ971891A patent/CZ189197A3/cs unknown
- 1995-12-19 SK SK797-97A patent/SK79797A3/sk unknown
- 1995-12-19 CN CN95196854A patent/CN1183770A/zh active Pending
- 1995-12-19 WO PCT/EP1995/005031 patent/WO1996020173A1/de not_active Application Discontinuation
- 1995-12-19 AU AU44324/96A patent/AU4432496A/en not_active Abandoned
- 1995-12-19 MX MX9704745A patent/MX9704745A/es unknown
- 1995-12-20 HR HR19533639.9A patent/HRP950609A2/hr not_active Application Discontinuation
- 1995-12-21 TR TR95/01634A patent/TR199501634A2/xx unknown
- 1995-12-21 US US08/576,528 patent/US5922717A/en not_active Expired - Fee Related
- 1995-12-22 AR ARP950100727A patent/AR002950A1/es unknown
- 1995-12-22 IL IL11651795A patent/IL116517A0/xx unknown
-
1997
- 1997-06-06 BG BG101582A patent/BG101582A/xx unknown
- 1997-06-19 FI FI972646A patent/FI972646A/fi not_active Application Discontinuation
- 1997-06-20 NO NO972881A patent/NO972881L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EE9700141A (et) | 1997-12-15 |
TR199501634A2 (tr) | 1996-07-21 |
BR9510360A (pt) | 1997-12-23 |
US5922717A (en) | 1999-07-13 |
AU4432496A (en) | 1996-07-19 |
JPH10511374A (ja) | 1998-11-04 |
FI972646A0 (fi) | 1997-06-19 |
AR002950A1 (es) | 1998-05-27 |
IL116517A0 (en) | 1996-03-31 |
CA2207618A1 (en) | 1996-07-04 |
SK79797A3 (en) | 1997-11-05 |
FI972646A (fi) | 1997-08-19 |
MX9704745A (es) | 1997-10-31 |
EP0799202A1 (de) | 1997-10-08 |
BG101582A (en) | 1998-01-30 |
NO972881D0 (no) | 1997-06-20 |
PL321003A1 (en) | 1997-11-24 |
HRP950609A2 (en) | 1997-10-31 |
CZ189197A3 (cs) | 1998-01-14 |
CN1183770A (zh) | 1998-06-03 |
WO1996020173A1 (de) | 1996-07-04 |
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