NO960309L - Agonists and antagonists of human interleukin-10 - Google Patents

Agonists and antagonists of human interleukin-10

Info

Publication number
NO960309L
NO960309L NO960309A NO960309A NO960309L NO 960309 L NO960309 L NO 960309L NO 960309 A NO960309 A NO 960309A NO 960309 A NO960309 A NO 960309A NO 960309 L NO960309 L NO 960309L
Authority
NO
Norway
Prior art keywords
agonists
antagonists
human
human interleukin
preparations
Prior art date
Application number
NO960309A
Other languages
Norwegian (no)
Other versions
NO960309D0 (en
Inventor
Chuan-Chu Chou
Xia-Yan Cai
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO960309D0 publication Critical patent/NO960309D0/en
Publication of NO960309L publication Critical patent/NO960309L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Agonister og antagonister for humant IL-10 er tilveiebrakt ved hjelp av denne oppfinnelsen som er basert på modifikasjon av endene til fullstendig, | humant IL-10. Det er også tilveiebrakt j preparater og fremgangsmåter for til- i førsel eller inhibering av den biolog- iske aktivitet av humant IL-10. Slike preparater kan være anvendbare ved be- handlingen av sykdommer kjennetegnet ved upassende Th-responser. Nuklein- syrer som koder for agonistene og antagonistene, rekombinante vektorer og : transformerte vertsceller som omfatter j slike nukleinsyrer, og fremgangsmåter i for fremstilling av agonistene og 1 antagonistene under anvendelse av de transformerte vertsceller, er også til- veiebrakt.Agonists and antagonists for human IL-10 are provided by this invention based on modification of the ends to complete, | human IL-10. Preparations and methods are also provided for the delivery or inhibition of the biological activity of human IL-10. Such preparations may be useful in the treatment of diseases characterized by inappropriate Th responses. Nucleic acids encoding the agonists and antagonists, recombinant vectors and: transformed host cells comprising such nucleic acids, and methods for preparing the agonists and 1 antagonists using the transformed host cells, are also provided.

NO960309A 1993-07-26 1996-01-25 Agonists and antagonists of human interleukin-10 NO960309L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9894393A 1993-07-26 1993-07-26
PCT/US1994/008052 WO1995003411A1 (en) 1993-07-26 1994-07-22 Agonists and antagonists of human interleukin-10

Publications (2)

Publication Number Publication Date
NO960309D0 NO960309D0 (en) 1996-01-25
NO960309L true NO960309L (en) 1996-01-25

Family

ID=22271670

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960309A NO960309L (en) 1993-07-26 1996-01-25 Agonists and antagonists of human interleukin-10

Country Status (17)

Country Link
EP (1) EP0711346A1 (en)
JP (1) JPH08507930A (en)
KR (1) KR960704041A (en)
CN (1) CN1127529A (en)
AU (1) AU681178B2 (en)
CA (1) CA2168110A1 (en)
CZ (1) CZ23396A3 (en)
FI (1) FI960353A0 (en)
HU (1) HUT73463A (en)
IL (1) IL110413A0 (en)
NO (1) NO960309L (en)
NZ (1) NZ269663A (en)
PL (1) PL312718A1 (en)
SG (1) SG43798A1 (en)
SK (2) SK150596A3 (en)
WO (1) WO1995003411A1 (en)
ZA (1) ZA945434B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159937A (en) 1994-07-05 2000-12-12 Steeno Research Group A/S Immunomodulators
GB2304047A (en) 1995-08-09 1997-03-12 Univ Manchester Pharmaceutical compositions containing cytokines
AUPN481295A0 (en) * 1995-08-16 1995-09-07 Medvet Science Pty. Ltd. Agonists of haemopoietic growth factors
AU4385696A (en) 1996-01-18 1997-08-11 Christian Gronhoj Larsen Synthetic il-10 analogues
DE19851675A1 (en) * 1998-11-10 2000-05-11 Bayer Ag Human interleukin-10 mutant proteins
AU8729101A (en) 2000-03-31 2001-10-15 Idec Pharma Corp Combined use of anti-cytokine antibodies or antagonists and anti-CD20 for the treatment of B cell lymphoma
EP2295450B1 (en) 2000-09-29 2015-01-28 Merck Sharp & Dohme Corp. Pegylated interleukin-10
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
EP1712241A1 (en) 2005-04-15 2006-10-18 Centre National De La Recherche Scientifique (Cnrs) Composition for treating cancer adapted for intra-tumoral administration and uses thereof
HUE041875T2 (en) 2005-05-31 2019-06-28 Univ Colorado Regents Methods for delivering genes
WO2008054585A2 (en) 2006-09-28 2008-05-08 Schering Corporation Use of pegylated il-10 to treat cancer
AU2009298131B2 (en) 2008-10-02 2016-07-14 Aptevo Research And Development Llc CD86 antagonist multi-target binding proteins
PT2379115T (en) 2008-12-17 2018-01-03 Merck Sharp & Dohme Mono- and di-peg il-10 production; and uses
EP2776460B1 (en) 2011-11-08 2018-05-02 UMC Utrecht Holding B.V. Fusion protein comprising an interleukin 4 and interleukin 10
AU2014254019B2 (en) 2013-04-18 2018-09-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
JP2016526014A (en) * 2013-04-24 2016-09-01 アルモ・バイオサイエンシーズ・インコーポレイテッド Interleukin-10 composition and use thereof
ES2688206T3 (en) 2013-06-17 2018-10-31 Armo Biosciences, Inc. Procedure for assessing protein identity and stability
CN105658232A (en) 2013-08-30 2016-06-08 阿尔莫生物科技股份有限公司 Methods of using interleukin-10 for treating diseases and disorders
ES2862139T3 (en) 2013-11-11 2021-10-07 Armo Biosciences Inc Procedures for the use of Interleukin 10 for the treatment of diseases and disorders
CN106573072A (en) 2014-06-02 2017-04-19 阿尔莫生物科技股份有限公司 Methods of lowering serum cholesterol
JP2017536098A (en) 2014-10-14 2017-12-07 アルモ・バイオサイエンシーズ・インコーポレイテッド Interleukin-15 composition and use thereof
KR20170084033A (en) 2014-10-22 2017-07-19 아르모 바이오사이언시스 인코포레이티드 Methods of using interleukin-10 for treating diseases and disorders
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN107847583A (en) 2015-05-28 2018-03-27 阿尔莫生物科技股份有限公司 PEGylated Interleukin 10 for treating cancer
US10398761B2 (en) 2015-08-25 2019-09-03 Armo Biosciences, Inc. Methods of using combinations of PEG-IL-10 and IL-15 for treating cancers
GB2620875B (en) 2019-04-19 2024-05-08 Synerkine Pharma B V A fusion protein comprising IL13

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01113229A (en) * 1987-10-27 1989-05-01 Inahata Kenkyusho:Kk Porous material of honeycomb structure
IL94878A (en) * 1989-06-28 2003-01-12 Schering Corp Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
ES2138976T3 (en) * 1991-08-06 2000-02-01 Schering Corp USE OF INTERLEUKIN-10 ANALOGS OR ANTAGONISTS TO TREAT ENDOTOXIN OR SUPERANTIGEN INDUCED TOXICITY.

Also Published As

Publication number Publication date
KR960704041A (en) 1996-08-31
HU9503983D0 (en) 1996-03-28
SK150596A3 (en) 1997-04-09
CN1127529A (en) 1996-07-24
PL312718A1 (en) 1996-05-13
EP0711346A1 (en) 1996-05-15
NO960309D0 (en) 1996-01-25
NZ269663A (en) 1997-09-22
SK8396A3 (en) 1997-03-05
WO1995003411A1 (en) 1995-02-02
ZA945434B (en) 1995-01-23
AU7399694A (en) 1995-02-20
IL110413A0 (en) 1994-10-21
FI960353A (en) 1996-01-26
JPH08507930A (en) 1996-08-27
CA2168110A1 (en) 1995-02-02
AU681178B2 (en) 1997-08-21
FI960353A0 (en) 1996-01-26
HUT73463A (en) 1996-08-28
CZ23396A3 (en) 1996-05-15
SG43798A1 (en) 1997-11-14

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