NO934271L - Anvendelse av rensede overflatemodifiseringsmidler for å hindre partikkelaggregering under sterilisering - Google Patents

Anvendelse av rensede overflatemodifiseringsmidler for å hindre partikkelaggregering under sterilisering

Info

Publication number
NO934271L
NO934271L NO934271A NO934271A NO934271L NO 934271 L NO934271 L NO 934271L NO 934271 A NO934271 A NO 934271A NO 934271 A NO934271 A NO 934271A NO 934271 L NO934271 L NO 934271L
Authority
NO
Norway
Prior art keywords
surface modifiers
particle aggregation
during sterilization
aggregation during
prevent particle
Prior art date
Application number
NO934271A
Other languages
English (en)
Other versions
NO934271D0 (no
Inventor
Kenneth Robert Hollister
David L Ladd
Gregory L Mcintire
George C Na
Natarajan Rajagopalan
Barbara O-Ching Yuan
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of NO934271D0 publication Critical patent/NO934271D0/no
Publication of NO934271L publication Critical patent/NO934271L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Preparat omfattende nanopartikler som har et renset polymert overflateaktivt middel som et overflatemodifi-serende middel adsorbert på deres overflate og et sløringspunkt-modiflserende middel forbundet dermed, hvilket sløringspunkt-modiflserende middel er tilstede i en mengde som er tilstrekkelig til å øke slørings-punktet til det overflatemodiflserende midlet. Det er også beskrevet en fremgangsmåte for fremstilling av slike nanopartikler. Foretrukne rensede polymere overflateaktive midlet er rensede polyalkylenoksyd-substituerte etylendiamin-overflateaktive midler og et foretrukket sløringspunkt-modiflserende middel er polyetylenglykol.
NO934271A 1992-12-16 1993-11-25 Anvendelse av rensede overflatemodifiseringsmidler for å hindre partikkelaggregering under sterilisering NO934271L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/991,639 US5352459A (en) 1992-12-16 1992-12-16 Use of purified surface modifiers to prevent particle aggregation during sterilization

Publications (2)

Publication Number Publication Date
NO934271D0 NO934271D0 (no) 1993-11-25
NO934271L true NO934271L (no) 1994-06-17

Family

ID=25537416

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934271A NO934271L (no) 1992-12-16 1993-11-25 Anvendelse av rensede overflatemodifiseringsmidler for å hindre partikkelaggregering under sterilisering

Country Status (17)

Country Link
US (1) US5352459A (no)
EP (1) EP0605024A3 (no)
JP (1) JPH06211647A (no)
KR (1) KR940013541A (no)
AU (1) AU663010B2 (no)
CA (1) CA2102356A1 (no)
CZ (1) CZ261693A3 (no)
FI (1) FI935306A (no)
HU (1) HUT65783A (no)
IL (1) IL107518A0 (no)
MY (1) MY110452A (no)
NO (1) NO934271L (no)
NZ (1) NZ250116A (no)
PH (1) PH30282A (no)
RU (1) RU2114612C1 (no)
SK (1) SK141693A3 (no)
TW (1) TW438606B (no)

Cited By (2)

* Cited by examiner, † Cited by third party
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EP0602700A3 (en) * 1992-12-17 1994-12-21 Sterling Winthrop Inc Preparation of X-ray contrasting formulations for blood containing high molecular weight surfactant nanoparticles.
EP0600532A3 (en) * 1992-12-04 1995-02-22 Sterling Winthrop Inc Use of ionic cloud point modifiers to prevent particle aggregation during sterilization.

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* Cited by examiner, † Cited by third party
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US5352459A (en) 1994-10-04
PH30282A (en) 1997-02-20
IL107518A0 (en) 1994-02-27
MY110452A (en) 1998-05-30
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TW438606B (en) 2001-06-07
FI935306A0 (fi) 1993-11-29
AU5046693A (en) 1994-06-30
KR940013541A (ko) 1994-07-15
EP0605024A3 (en) 1995-04-12
NO934271D0 (no) 1993-11-25
CA2102356A1 (en) 1994-06-17
HUT65783A (en) 1994-07-28
NZ250116A (en) 1994-09-27
HU9303604D0 (en) 1994-04-28
RU2114612C1 (ru) 1998-07-10
CZ261693A3 (en) 1994-07-13
EP0605024A2 (en) 1994-07-06
FI935306A (fi) 1994-06-17
SK141693A3 (en) 1994-09-07
AU663010B2 (en) 1995-09-21

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