NO930059L - O-glykosylert ifn-alfa - Google Patents
O-glykosylert ifn-alfaInfo
- Publication number
- NO930059L NO930059L NO93930059A NO930059A NO930059L NO 930059 L NO930059 L NO 930059L NO 93930059 A NO93930059 A NO 93930059A NO 930059 A NO930059 A NO 930059A NO 930059 L NO930059 L NO 930059L
- Authority
- NO
- Norway
- Prior art keywords
- ifn
- glycosylert
- alfa
- glycosylated
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Formålet med den foreliggende oppfinnelse er O-glykosy- lert IFN-a, fremgangsmåter for fremstilling av det, så vel som anvendelse av de 0-glykosylerte proteiner som legemidler.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904021917 DE4021917A1 (de) | 1990-07-10 | 1990-07-10 | Glykosyliertes ifnalpha |
DE19904035877 DE4035877A1 (de) | 1990-11-12 | 1990-11-12 | O-glycosyliertes ifn-alfa2 |
PCT/EP1991/001266 WO1992001055A1 (de) | 1990-07-10 | 1991-07-06 | O-glycosyliertes ifn-alpha |
Publications (2)
Publication Number | Publication Date |
---|---|
NO930059D0 NO930059D0 (no) | 1993-01-08 |
NO930059L true NO930059L (no) | 1993-01-08 |
Family
ID=25894855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO93930059A NO930059L (no) | 1990-07-10 | 1993-01-08 | O-glykosylert ifn-alfa |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0538300B1 (no) |
JP (1) | JPH06502987A (no) |
KR (1) | KR930701601A (no) |
AT (1) | ATE104348T1 (no) |
AU (1) | AU650893B2 (no) |
CA (1) | CA2084514A1 (no) |
CZ (1) | CZ386392A3 (no) |
DE (1) | DE59101397D1 (no) |
DK (1) | DK0538300T3 (no) |
ES (1) | ES2063515T3 (no) |
FI (1) | FI930058A (no) |
HU (1) | HUT65846A (no) |
NO (1) | NO930059L (no) |
PL (1) | PL297610A1 (no) |
SK (1) | SK386392A3 (no) |
WO (1) | WO1992001055A1 (no) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5541071A (en) * | 1992-02-07 | 1996-07-30 | New England Medical Center Hospitals, Inc. | Assay for identifying antagonists of gastrin and CCK-B receptors |
NZ245771A (en) * | 1992-02-07 | 1994-08-26 | New England Medical Center Inc | Mammalian gastrin/cholecystokinin b (cck-b) receptor and antagonists |
EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
AU713611B2 (en) * | 1994-10-28 | 1999-12-09 | Delft Diagnostic Laboratory B.V. | New polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms |
EP0920522B1 (en) * | 1996-08-14 | 2003-10-29 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | A vector for polynucleotide vaccines |
GB9904695D0 (en) * | 1999-03-01 | 1999-04-21 | Imp Cancer Res Tech | Peptide |
US20030171267A1 (en) | 2000-04-12 | 2003-09-11 | Rosen Craig A. | Albumin fusion proteins |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
EP2305312B1 (en) * | 2001-10-10 | 2015-03-04 | ratiopharm GmbH | Remodelling and glycoconjugation of follicle-stimulating hormone (FSH) |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
EP1997829A1 (en) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
JP2006523211A (ja) | 2003-03-14 | 2006-10-12 | ネオス テクノロジーズ インコーポレイテッド | 分岐水溶性ポリマーとその複合物 |
EP2338333B1 (en) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylation methods and proteins/peptides produced by the methods |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US8361961B2 (en) | 2004-01-08 | 2013-01-29 | Biogenerix Ag | O-linked glycosylation of peptides |
EP1771066A2 (en) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
SI2586456T1 (sl) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
AU2006203792B2 (en) | 2005-01-10 | 2011-11-03 | Ratiopharm Gmbh | Glycopegylated Granulocyte Colony Stimulating Factor |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
AR078117A1 (es) | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
JP2009544327A (ja) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー/エス | O−結合型グリコシル化配列によるペプチドのグリコシル化 |
US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
EP2144923B1 (en) | 2007-04-03 | 2013-02-13 | BioGeneriX AG | Methods of treatment using glycopegylated g-csf |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
WO2014102101A1 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
WO2014102103A2 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within a signal peptide |
RU2610173C1 (ru) * | 2016-03-30 | 2017-02-08 | Илья Александрович Марков | Рекомбинантная плазмида pFM-IFN-17, обеспечивающая экспрессию интерферона альфа-2b человека, рекомбинантная плазмида pFM-АР, обеспечивающая экспрессию фермента метионинаминопептидазы E. coli, биплазмидный штамм Escherichia coli FM-IFN-АР (pFM-IFN-17, pFM-АР) - продуцент (Met-) рекомбинантного интерферона альфа-2b человека |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN150740B (no) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
JPS58501543A (ja) * | 1981-08-14 | 1983-09-16 | エイ/エス アルフレツド ベンツオン | ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良 |
DE3306060A1 (de) * | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
-
1991
- 1991-07-06 EP EP91912306A patent/EP0538300B1/de not_active Expired - Lifetime
- 1991-07-06 DK DK91912306.7T patent/DK0538300T3/da active
- 1991-07-06 JP JP3511638A patent/JPH06502987A/ja active Pending
- 1991-07-06 SK SK3863-92A patent/SK386392A3/sk unknown
- 1991-07-06 KR KR1019930700049A patent/KR930701601A/ko not_active Application Discontinuation
- 1991-07-06 WO PCT/EP1991/001266 patent/WO1992001055A1/de not_active Application Discontinuation
- 1991-07-06 CA CA002084514A patent/CA2084514A1/en not_active Abandoned
- 1991-07-06 ES ES91912306T patent/ES2063515T3/es not_active Expired - Lifetime
- 1991-07-06 PL PL29761091A patent/PL297610A1/xx unknown
- 1991-07-06 AT AT91912306T patent/ATE104348T1/de not_active IP Right Cessation
- 1991-07-06 HU HU9300036A patent/HUT65846A/hu unknown
- 1991-07-06 AU AU82082/91A patent/AU650893B2/en not_active Ceased
- 1991-07-06 DE DE59101397T patent/DE59101397D1/de not_active Expired - Fee Related
-
1992
- 1992-12-23 CZ CS923863A patent/CZ386392A3/cs unknown
-
1993
- 1993-01-08 NO NO93930059A patent/NO930059L/no unknown
- 1993-01-08 FI FI930058A patent/FI930058A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE59101397D1 (de) | 1994-05-19 |
CA2084514A1 (en) | 1992-01-11 |
SK386392A3 (en) | 1994-08-10 |
ES2063515T3 (es) | 1995-01-01 |
CZ386392A3 (en) | 1993-08-11 |
NO930059D0 (no) | 1993-01-08 |
KR930701601A (ko) | 1993-06-12 |
AU8208291A (en) | 1992-02-04 |
HU9300036D0 (en) | 1993-04-28 |
EP0538300B1 (de) | 1994-04-13 |
WO1992001055A1 (de) | 1992-01-23 |
EP0538300A1 (de) | 1993-04-28 |
DK0538300T3 (da) | 1994-10-10 |
AU650893B2 (en) | 1994-07-07 |
FI930058A0 (fi) | 1993-01-08 |
HUT65846A (en) | 1994-07-28 |
PL297610A1 (no) | 1992-07-13 |
JPH06502987A (ja) | 1994-04-07 |
ATE104348T1 (de) | 1994-04-15 |
FI930058A (fi) | 1993-01-08 |
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