NO921908L - AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES - Google Patents
AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINESInfo
- Publication number
- NO921908L NO921908L NO92921908A NO921908A NO921908L NO 921908 L NO921908 L NO 921908L NO 92921908 A NO92921908 A NO 92921908A NO 921908 A NO921908 A NO 921908A NO 921908 L NO921908 L NO 921908L
- Authority
- NO
- Norway
- Prior art keywords
- radical
- hydrogen atom
- lower alkyl
- group
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Abstract
Den foreliggende oppfinnelse angår forbindelsene som tilsvarer den generelle formel I og deres farmasøytiske akseptable salter, i hvilken X betegner et nitrogenatom eller et karbonatom bundet til et hydrogenatom, bundet til et halogenatom, et hydroksyl eller alkoksyradikal, et alkylradikal, et halogenert alkylradikal eller et alkylaminoradikal; Rj^ betegner et lavere alkyl eller cykloalkylradikal, et lavere haloalkyl- radikal, et hydroksyalkylradikal, et vinylradikal, et arylradikal eller et arylradikal substituert med en eller flere fluoratomer, eller et alkylamino- radikal; R2 betegner et hydrogenatom eller et lavere alkylradikal; R3 betegner et hydroksylradikal eller et C1-C4 lavere alkoksy- radikal; R4 betegner et hydrogenatom, et fluor- atom, et lavere alkylradikal, et nitroradlkal, et aminoradikal eller et substituert aminoradikal; RS, Rg og R7 betegner et hydrogenatom eller et lavere alkyl- radikal; n er et tall som kan være O eller 1; X og R! kan sammen danne en binding representert av en gruppe C-CH2-CH2-CH-Rg eller C-O-CH-CH2-CH-R9 eller C-S-CH2-CH- R9/ i hvilken R9 betegner et hydrogen- atom-, et lavere alkylradikal eller et lavere haloalkylradikal; R! og R2 kan sammen danne en binding representert av en gruppe -CHR^Q-S- i hvilken R^g betegner et hydrogenatom eller et lavere .alkylradikal eller et lavere haloalkylradikal; R2 og R3 kan sammen danne en binding representert av en gruppe -S-NH-; A er en oppløsende gruppe som er representert av en residual aminosyre eller en polypeptidkjede som består av to til fire eller mer aminosyrerester, som er bundet kovalent til hverandre ved peptidbindinger, og en fremgangsmåte for deres fremstilling.The present invention relates to the compounds corresponding to the general formula I and their pharmaceutically acceptable salts, wherein X represents a nitrogen atom or a carbon atom bonded to a hydrogen atom bonded to a halogen atom, a hydroxyl or alkoxy radical, an alkyl radical, a halogenated alkyl radical or an alkyl amino radical ; R 1 represents a lower alkyl or cycloalkyl radical, a lower haloalkyl radical, a hydroxyalkyl radical, a vinyl radical, an aryl radical or an aryl radical substituted by one or more fluorine atoms, or an alkylamino radical; R 2 represents a hydrogen atom or a lower alkyl radical; R 3 represents a hydroxyl radical or a C 1 -C 4 lower alkoxy radical; R4 represents a hydrogen atom, a fluorine atom, a lower alkyl radical, a nitro radical, an amino radical or a substituted amino radical; R5, R8 and R7 represent a hydrogen atom or a lower alkyl radical; n is a number which may be 0 or 1; X and R! may together form a bond represented by a group C-CH2-CH2-CH-Rg or CO-CH-CH2-CH-R9 or CS-CH2-CH-R9 / wherein R9 represents a hydrogen atom, a lower alkyl radical or a lower haloalkyl radical; R! and R 2 may together form a bond represented by a group -CHR 2 Q-S- in which R 2 g represents a hydrogen atom or a lower alkyl radical or a lower haloalkyl radical; R 2 and R 3 may together form a bond represented by a group -S-NH-; A is a solubilizing group represented by a residual amino acid or a polypeptide chain consisting of two to four or more amino acid residues covalently linked to each other by peptide bonds and a process for their preparation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9105937A FR2676445B1 (en) | 1991-05-16 | 1991-05-16 | SUBSTITUTED PYRIDONE AMINO ACID AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO921908D0 NO921908D0 (en) | 1992-05-14 |
| NO921908L true NO921908L (en) | 1992-11-17 |
Family
ID=9412841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92921908A NO921908L (en) | 1991-05-16 | 1992-05-14 | AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0514268A1 (en) |
| JP (1) | JPH05132479A (en) |
| KR (1) | KR920021528A (en) |
| CN (1) | CN1066656A (en) |
| AU (1) | AU660311B2 (en) |
| CA (1) | CA2068853A1 (en) |
| CZ (1) | CZ147992A3 (en) |
| ES (1) | ES2039192B1 (en) |
| FI (1) | FI922225A (en) |
| FR (1) | FR2676445B1 (en) |
| HU (1) | HUT61304A (en) |
| IL (1) | IL101886A0 (en) |
| IS (1) | IS3862A (en) |
| MA (1) | MA22526A1 (en) |
| MX (1) | MX9202273A (en) |
| NO (1) | NO921908L (en) |
| NZ (1) | NZ242733A (en) |
| OA (1) | OA09794A (en) |
| PL (1) | PL294561A1 (en) |
| ZA (1) | ZA923538B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE289999T1 (en) * | 1996-07-12 | 2005-03-15 | Daiichi Seiyaku Co | CIS-SUBSTITUTED AMINOCYCLOPROPANE DERIVATIVES |
| KR100613690B1 (en) * | 2004-07-30 | 2006-08-21 | 한국화학연구원 | 4-quinolinone derivative and fungicidal composition for agriculture and horticulture comprising same |
| KR100613688B1 (en) * | 2004-08-30 | 2006-08-21 | 한국화학연구원 | 2-amino-4-quinolinone derivative and fungicidal composition for agriculture and horticulture comprising same |
| CN101291683B (en) | 2004-11-24 | 2011-08-17 | 纽普罗研究有限公司 | Methods and compositions for treating conditions |
| CA2647835A1 (en) | 2006-03-28 | 2007-10-04 | Neopro Labs, Llc | Methods and compositions for treating conditions |
| CA2683288A1 (en) | 2007-05-17 | 2008-11-27 | Neopro Labs, Llc | Crystalline and amorphous forms of peptide |
| CN101898990B (en) * | 2009-06-01 | 2012-12-19 | 中国科学院化学研究所 | Method for catalyzing and synthesizing chirality azetidine amide and carboxylic acid compound by microorganism system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| DE3306771A1 (en) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
| JPH0665676B2 (en) * | 1984-04-26 | 1994-08-24 | アボツト ラボラトリーズ | Quinoline-benoxazine antibacterial compounds |
| US4617308A (en) * | 1985-01-25 | 1986-10-14 | Warner-Lambert Company | 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents |
| US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
| FR2634483B2 (en) * | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | DERIVATIVES OF ACIDS 7- (1-AZETIDINYL) -1,4-DIHYDRO-4-OXOQUINOLEINE-3-CARBOXYLIQUES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| IE76284B1 (en) * | 1988-09-22 | 1997-10-08 | Abbott Lab | Amino acid quinoline and naphthyridine derivatives |
| FI901201A0 (en) * | 1989-03-13 | 1990-03-09 | Bristol Myers Squibb Co | ANTIBAKTERIELLA 5-SUBSTITUERADE 1,4-DIHYDRO-4-OXONAFTYRIDIN-3-CARBOXYLATDERIVAT OCH DERAS FRAMSTAELLNING. |
| NO177302C (en) * | 1989-03-16 | 1995-08-23 | Esteve Labor Dr | Analogous Process for Preparing Therapeutically Active Substituted Azetidinyl Quinolone (Naphthyridone) Carboxylic Acid Derivatives |
| FR2645862B1 (en) * | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | SUBSTITUTED ISOTHIAZOLO-PYRYDONE AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| FR2649100B1 (en) * | 1989-06-29 | 1994-03-04 | Laboratorios Dr Esteve Sa | NOVEL AZETIDINES, THEIR PREPARATION AND THEIR APPLICATION AS INTERMEDIATES FOR THE PREPARATION OF COMPOUNDS WITH ANTIMICROBIAL ACTIVITY |
-
1991
- 1991-05-16 FR FR9105937A patent/FR2676445B1/en not_active Expired - Lifetime
-
1992
- 1992-05-14 EP EP92401318A patent/EP0514268A1/en not_active Withdrawn
- 1992-05-14 ES ES9200994A patent/ES2039192B1/en not_active Expired - Fee Related
- 1992-05-14 NO NO92921908A patent/NO921908L/en unknown
- 1992-05-14 IS IS3862A patent/IS3862A/en unknown
- 1992-05-14 MA MA22811A patent/MA22526A1/en unknown
- 1992-05-14 NZ NZ242733A patent/NZ242733A/en unknown
- 1992-05-14 AU AU16249/92A patent/AU660311B2/en not_active Ceased
- 1992-05-15 FI FI922225A patent/FI922225A/en not_active Application Discontinuation
- 1992-05-15 IL IL101886A patent/IL101886A0/en unknown
- 1992-05-15 HU HU9201621A patent/HUT61304A/en unknown
- 1992-05-15 PL PL29456192A patent/PL294561A1/en unknown
- 1992-05-15 CZ CS921479A patent/CZ147992A3/en unknown
- 1992-05-15 MX MX9202273A patent/MX9202273A/en unknown
- 1992-05-15 JP JP4123901A patent/JPH05132479A/en active Pending
- 1992-05-15 OA OA60208A patent/OA09794A/en unknown
- 1992-05-15 ZA ZA923538A patent/ZA923538B/en unknown
- 1992-05-15 CA CA002068853A patent/CA2068853A1/en not_active Abandoned
- 1992-05-16 CN CN92103602A patent/CN1066656A/en active Pending
- 1992-05-16 KR KR1019920008309A patent/KR920021528A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO921908D0 (en) | 1992-05-14 |
| IS3862A (en) | 1992-11-17 |
| MX9202273A (en) | 1993-05-01 |
| HU9201621D0 (en) | 1992-08-28 |
| MA22526A1 (en) | 1992-12-31 |
| FR2676445B1 (en) | 1995-02-03 |
| PL294561A1 (en) | 1993-05-04 |
| NZ242733A (en) | 1994-06-27 |
| IL101886A0 (en) | 1992-12-30 |
| KR920021528A (en) | 1992-12-18 |
| HUT61304A (en) | 1992-12-28 |
| ES2039192B1 (en) | 1994-04-01 |
| CN1066656A (en) | 1992-12-02 |
| AU660311B2 (en) | 1995-06-22 |
| CZ147992A3 (en) | 1993-09-15 |
| FI922225A (en) | 1992-11-17 |
| EP0514268A1 (en) | 1992-11-19 |
| CA2068853A1 (en) | 1992-11-17 |
| JPH05132479A (en) | 1993-05-28 |
| FR2676445A1 (en) | 1992-11-20 |
| OA09794A (en) | 1994-04-15 |
| AU1624992A (en) | 1992-11-19 |
| ES2039192A1 (en) | 1993-09-01 |
| ZA923538B (en) | 1993-01-27 |
| FI922225A0 (en) | 1992-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO951266L (en) | Imidazole-containing inhibitors of farnesyl protein transferase | |
| MY117527A (en) | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present | |
| DE3567870D1 (en) | Xanthine derivatives, processes for their preparation and pharmaceutical compositions containing them | |
| TW369533B (en) | Quinoline compounds, process for preparing them and pharmaceutical composition containing them | |
| MY101359A (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation | |
| DK0870765T3 (en) | Aminothiazole derivative, drug containing the same and intermediate for the preparation of the compound | |
| BG104716A (en) | Trisubstituted 1,3,5-triazine derivatives for the treatment of hiv infection | |
| UA27238C2 (en) | Indoline derivatives, their pharmaceutical acceptable salts which are antagonists of vasopressin vi-receptors, method for their synthesis, intermediate compounds and pharmaceutical composition | |
| HK1063781A1 (en) | Pyrazole derivatives for treating hiv | |
| HUP0101999A2 (en) | 4-hydroxyquinoline-3-carboxamides and hydrazides use of them and pharmaceutical compositions containing them | |
| HUP0401009A2 (en) | 1-aryl-or 1-alkylsulfonylbenzole derivatives as 5-hydroxytryptamine-6 ligands, process for their preparation and pharmaceutical compositions containing them | |
| ES8402559A1 (en) | Novel peptide compounds, a process for manufacturing them, pharmaceutical compositions containing them, and methods for treating ulcer and thrombus with them. | |
| NO964533L (en) | Novel quinolone 5- (N-hetero-substituted amino) antimicrobial compounds | |
| CA2330942A1 (en) | Piperazine derivatives and process for the preparation thereof | |
| NO904551L (en) | QUINOLONE COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION. | |
| NO921908L (en) | AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | |
| DK239788A (en) | BETA-D-PHENYL-THIOXYLOSIDES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS THERAPEUTICS | |
| NO961000L (en) | Piperidine derivatives, process for their preparation and drug and preparation containing them | |
| HU895268D0 (en) | Process for the preparation of quinoline derivatives and pharmaceutical compositions containing them | |
| AU1442297A (en) | Piperidone tachykinin antagonists | |
| NO812355L (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3,1-BENZOKSAZIN-2-ON DERIVATIVES | |
| NO983178L (en) | Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms | |
| IL115545A0 (en) | Oxime ethers their preparation and use | |
| CA2085171A1 (en) | Guanidinoalkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use | |
| DK0450420T3 (en) | Heterocyclic Substituted Dihydropyridines, Methods for their Preparation and Use in Drugs |