NO983178L - Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms - Google Patents

Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms

Info

Publication number
NO983178L
NO983178L NO983178A NO983178A NO983178L NO 983178 L NO983178 L NO 983178L NO 983178 A NO983178 A NO 983178A NO 983178 A NO983178 A NO 983178A NO 983178 L NO983178 L NO 983178L
Authority
NO
Norway
Prior art keywords
prophylaxis
preparation
treatment
pharmaceutical composition
menopausal symptoms
Prior art date
Application number
NO983178A
Other languages
Norwegian (no)
Inventor
Michael Shalmi
Niels Korsgaard
Birgitte Hjort Guldhammer
James Robertson Piggott
Virender Mohan Labroo
Steven Bain
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO983178L publication Critical patent/NO983178L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Abstract

Foreliggende oppfinnelse til- veiebringer nye anvendelser av forbin- delser med den generelle formel (I) hvor R1, R* og R5 uavhengig av hverandre er hydrogen, hydroksy, halogen, tri- fluormetyl, Cj.6-alkyl, C^-alkoksy eller (tertiært aminoHC^-alkoksy); og R2 og R3 uavhengig av hverandre er hydrogen eller Cj.g-alkyl, eller som et farmasøytisk akseptabelt salt derav, i kombinasjon med en farmasøytisk aksep- tabel bærer til fremstilling av et far- masøytisk preparat for behandling eller profylakse av menopausesymptomer.The present invention provides new uses of compounds of the general formula (I) wherein R 1, R 4 and R 5 are independently hydrogen, hydroxy, halogen, trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxy or (tertiary amino HCl alkoxy); and R 2 and R 3 are independently hydrogen or C 1-6 alkyl, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier for the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms.

NO983178A 1996-01-11 1998-07-10 Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms NO983178L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US983496P 1996-01-11 1996-01-11
US67826196A 1996-07-11 1996-07-11
PCT/DK1997/000008 WO1997025035A1 (en) 1996-01-11 1997-01-09 Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms

Publications (1)

Publication Number Publication Date
NO983178L true NO983178L (en) 1998-07-10

Family

ID=26679921

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983178A NO983178L (en) 1996-01-11 1998-07-10 Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms

Country Status (12)

Country Link
EP (1) EP0873120A1 (en)
JP (1) JP2000506505A (en)
KR (1) KR19990077156A (en)
AU (1) AU1367297A (en)
BR (1) BR9706967A (en)
CA (1) CA2241623A1 (en)
CZ (1) CZ217298A3 (en)
HU (1) HUP9902683A3 (en)
IL (1) IL124882A0 (en)
NO (1) NO983178L (en)
PL (1) PL327831A1 (en)
WO (1) WO1997025035A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
KR20020075388A (en) * 1999-12-30 2002-10-04 시그널 파머슈티컬스 인크 Compounds and methods for modulation of estrogen receptors
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
EP2407462B1 (en) 2004-09-21 2014-07-30 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
CN106038572A (en) 2004-10-20 2016-10-26 恩多研究公司 Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 CGMP phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women
US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
CA2702710C (en) 2007-10-16 2013-05-07 Repros Therapeutics, Inc. Trans-clomiphene for metabolic syndrome
US20100317635A1 (en) 2009-06-16 2010-12-16 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
WO2011156908A1 (en) 2010-06-16 2011-12-22 Endorecherche, Inc. Methods of treating or preventing estrogen-related diseases
CA2816322A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
ES2681023T3 (en) 2012-02-29 2018-09-11 Repros Therapeutics Inc. Combination therapy to treat androgen deficit
MY195739A (en) 2014-02-07 2023-02-08 Novogen ltd Functionalised Benzopyran Compounds and use Thereof
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
CA2974123C (en) 2015-02-02 2023-08-01 Mei Pharma, Inc. Combination of benzopyran derivative and glycolytic inhibitors for cancer therapy
CN108348605B (en) 2015-11-10 2023-06-09 帕拉卡林治疗公司 Treatment of ER-negative breast cancer with PDGF-CC inhibitors and antiestrogens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency

Also Published As

Publication number Publication date
EP0873120A1 (en) 1998-10-28
HUP9902683A2 (en) 2001-04-28
JP2000506505A (en) 2000-05-30
CZ217298A3 (en) 1999-01-13
WO1997025035A1 (en) 1997-07-17
BR9706967A (en) 1999-05-04
AU1367297A (en) 1997-08-01
CA2241623A1 (en) 1997-07-17
HUP9902683A3 (en) 2001-08-28
PL327831A1 (en) 1999-01-04
IL124882A0 (en) 1999-01-26
KR19990077156A (en) 1999-10-25

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