NO910201L - Borsyreaddukter av rheniumdioksim og technetium-99 m- dioksimkomplekser inneholdende en biokjemisk aktiv gruppe. - Google Patents

Borsyreaddukter av rheniumdioksim og technetium-99 m- dioksimkomplekser inneholdende en biokjemisk aktiv gruppe.

Info

Publication number
NO910201L
NO910201L NO91910201A NO910201A NO910201L NO 910201 L NO910201 L NO 910201L NO 91910201 A NO91910201 A NO 91910201A NO 910201 A NO910201 A NO 910201A NO 910201 L NO910201 L NO 910201L
Authority
NO
Norway
Prior art keywords
technetium
boric acid
dioxym
dioxim
rhenium
Prior art date
Application number
NO91910201A
Other languages
English (en)
Norwegian (no)
Other versions
NO910201D0 (no
Inventor
Adrian D Nunn
Karen E Linder
Silvia Jurisson
William C Eckelman
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of NO910201D0 publication Critical patent/NO910201D0/no
Publication of NO910201L publication Critical patent/NO910201L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO91910201A 1990-01-18 1991-01-17 Borsyreaddukter av rheniumdioksim og technetium-99 m- dioksimkomplekser inneholdende en biokjemisk aktiv gruppe. NO910201L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46688490A 1990-01-18 1990-01-18

Publications (2)

Publication Number Publication Date
NO910201D0 NO910201D0 (no) 1991-01-17
NO910201L true NO910201L (no) 1991-07-19

Family

ID=23853463

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91910201A NO910201L (no) 1990-01-18 1991-01-17 Borsyreaddukter av rheniumdioksim og technetium-99 m- dioksimkomplekser inneholdende en biokjemisk aktiv gruppe.

Country Status (18)

Country Link
US (1) US5387409A (pt)
EP (1) EP0441491A1 (pt)
JP (1) JPH04212099A (pt)
KR (1) KR100191568B1 (pt)
CN (3) CN1034078C (pt)
AU (2) AU651076B2 (pt)
CA (1) CA2034042C (pt)
FI (1) FI910274A (pt)
HU (1) HU910155D0 (pt)
IE (1) IE910133A1 (pt)
IL (1) IL96946A (pt)
MX (1) MX24177A (pt)
MY (1) MY105482A (pt)
NO (1) NO910201L (pt)
NZ (1) NZ236789A (pt)
PT (1) PT96518B (pt)
YU (1) YU26691A (pt)
ZA (1) ZA91300B (pt)

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US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
FR2690443B1 (fr) * 1992-04-10 1995-06-30 Wallone Region Marquage des hormones par le rhenium et le technetium.
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
AU8074294A (en) * 1993-10-04 1995-05-01 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs
DK0688313T3 (da) 1994-01-12 1998-05-11 Bracco Int Bv Ligander og metalkomplekser deraf
CA2170400A1 (en) * 1994-06-27 1996-01-04 M. Frederick Hawthorne Boron-containing hormone analogs and methods of their use in imaging or killing cells having hormone receptors
KR100430061B1 (ko) * 2000-03-21 2004-05-03 재단법인 아산사회복지재단 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트
US8909325B2 (en) * 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8565860B2 (en) * 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
WO2005119025A2 (en) 2004-06-01 2005-12-15 Spectrum Dynamics Llc Radioactive-emission-measurement optimization to specific body structures
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
EP2301587B1 (en) 2002-03-01 2014-06-25 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20040204646A1 (en) * 2002-11-04 2004-10-14 V-Target Technologies Ltd. Intracorporeal-imaging head
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
RU2006105644A (ru) * 2003-07-24 2006-08-10 Бракко Имэджинг С.П.А. (It) Стабильные радиофармацевтические композиции и способы их получения
US9470801B2 (en) * 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
US8586932B2 (en) * 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
US7176466B2 (en) * 2004-01-13 2007-02-13 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
WO2006054296A2 (en) * 2004-11-17 2006-05-26 Spectrum Dynamics Llc Methods of detecting prostate cancer
US9040016B2 (en) * 2004-01-13 2015-05-26 Biosensors International Group, Ltd. Diagnostic kit and methods for radioimaging myocardial perfusion
WO2007010534A2 (en) * 2005-07-19 2007-01-25 Spectrum Dynamics Llc Imaging protocols
US8571881B2 (en) * 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US8000773B2 (en) * 2004-11-09 2011-08-16 Spectrum Dynamics Llc Radioimaging
EP1827505A4 (en) * 2004-11-09 2017-07-12 Biosensors International Group, Ltd. Radioimaging
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
US8894974B2 (en) * 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
US9333272B2 (en) 2006-12-11 2016-05-10 Bracco Imaging Spa Fibrin binding peptide conjugates for diagnostic and therapeutic applications
US9275451B2 (en) * 2006-12-20 2016-03-01 Biosensors International Group, Ltd. Method, a system, and an apparatus for using and processing multidimensional data
US8521253B2 (en) * 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
WO2010107832A1 (en) 2009-03-17 2010-09-23 Bracco Imaging Spa Lhrh-ii peptide analogs
US8338788B2 (en) * 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
CN102030797B (zh) * 2009-09-24 2013-03-20 中国科学院上海应用物理研究所 锝标记***类衍生物及其参照化合物及其制备方法、应用和其中间体
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en) 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
CN108699130A (zh) 2016-02-09 2018-10-23 博莱科瑞士股份有限公司 用于选择素靶向的重组嵌合蛋白
CN115109120A (zh) 2016-04-04 2022-09-27 英蒂分子公司 Cd8-特异性捕获剂、组合物及使用和制备方法
WO2018064597A1 (en) 2016-09-29 2018-04-05 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
EP3638687A1 (en) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
CN107674098B (zh) * 2017-06-26 2021-12-07 中国医学科学院阜外医院 一类含芳基硼酸的99mTc配合物及其药盒配方和应用
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020186091A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
US20200371101A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
CN111377968B (zh) * 2020-03-09 2023-07-25 中国医学科学院阜外医院 一类含芳基硼酸的99mTc(Ⅲ)配合物及其药盒配方和应用
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
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CN115197261B (zh) * 2022-07-06 2024-05-03 重庆医科大学 噁二氮杂硼衍生物的合成方法

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US3369121A (en) 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
US3920995A (en) 1973-05-04 1975-11-18 Squibb & Sons Inc Radioactive material generator
US4431627A (en) * 1980-06-03 1984-02-14 Research Corporation Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same
US4705849A (en) * 1985-04-15 1987-11-10 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime complexes
US4871836A (en) 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
CN1022562C (zh) * 1989-04-08 1993-10-27 中国人民解放军第二军医大学 一种消瘤药——甲硝唑氨酸的合成方法

Also Published As

Publication number Publication date
EP0441491A1 (en) 1991-08-14
MX24177A (es) 1993-12-01
CN1034078C (zh) 1997-02-19
CA2034042C (en) 1999-08-17
AU651076B2 (en) 1994-07-14
FI910274A0 (fi) 1991-01-18
IL96946A (en) 1995-12-08
HU910155D0 (en) 1991-08-28
IL96946A0 (en) 1992-03-29
IE910133A1 (en) 1991-07-31
PT96518A (pt) 1991-10-15
CN1120437A (zh) 1996-04-17
AU6938591A (en) 1991-07-25
CN1111621A (zh) 1995-11-15
FI910274A (fi) 1991-07-19
NZ236789A (en) 1995-03-28
AU7914794A (en) 1995-02-16
NO910201D0 (no) 1991-01-17
YU26691A (sh) 1994-05-10
ZA91300B (en) 1991-11-27
KR100191568B1 (ko) 1999-06-15
CA2034042A1 (en) 1991-07-19
CN1054070A (zh) 1991-08-28
PT96518B (pt) 1998-06-30
US5387409A (en) 1995-02-07
JPH04212099A (ja) 1992-08-03
KR910014385A (ko) 1991-08-31
MY105482A (en) 1994-10-31

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