NO902148L - Fremgangsmaate til fremstilling av sterkt vannopploeselige,stabile, krystallinske salter av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og2',3'-dideoksy-2'-fluorinosinhemihydrat. - Google Patents

Fremgangsmaate til fremstilling av sterkt vannopploeselige,stabile, krystallinske salter av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og2',3'-dideoksy-2'-fluorinosinhemihydrat.

Info

Publication number
NO902148L
NO902148L NO90902148A NO902148A NO902148L NO 902148 L NO902148 L NO 902148L NO 90902148 A NO90902148 A NO 90902148A NO 902148 A NO902148 A NO 902148A NO 902148 L NO902148 L NO 902148L
Authority
NO
Norway
Prior art keywords
dideoxy
salts
stable
water soluble
mononydryde
Prior art date
Application number
NO90902148A
Other languages
English (en)
Other versions
NO174102C (no
NO902148D0 (no
NO174102B (no
Inventor
Murray Arthur Kaplan
Robert Kevin Perrone
Joseph Ballard Bogardus
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO902148D0 publication Critical patent/NO902148D0/no
Publication of NO902148L publication Critical patent/NO902148L/no
Priority to NO933367A priority Critical patent/NO176609C/no
Publication of NO174102B publication Critical patent/NO174102B/no
Publication of NO174102C publication Critical patent/NO174102C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
NO902148A 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat NO174102C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (4)

Publication Number Publication Date
NO902148D0 NO902148D0 (no) 1990-05-15
NO902148L true NO902148L (no) 1990-11-16
NO174102B NO174102B (no) 1993-12-06
NO174102C NO174102C (no) 1994-03-16

Family

ID=26997373

Family Applications (2)

Application Number Title Priority Date Filing Date
NO902148A NO174102C (no) 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Country Status (16)

Country Link
EP (1) EP0398230B1 (no)
KR (1) KR970001160B1 (no)
CN (2) CN1027896C (no)
AT (1) ATE162528T1 (no)
AU (1) AU617614B2 (no)
BG (1) BG60517B1 (no)
DE (1) DE69031962T2 (no)
DK (1) DK0398230T3 (no)
EG (1) EG19154A (no)
ES (1) ES2113851T3 (no)
FI (1) FI95269C (no)
GR (1) GR3025984T3 (no)
HU (1) HU206628B (no)
IE (1) IE81107B1 (no)
NO (2) NO174102C (no)
PT (1) PT94040B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
CA2179987C (en) * 1994-01-07 1999-01-19 Richard E. Donaldson Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
WO2006007448A2 (en) * 2004-06-17 2006-01-19 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
WO2009125841A1 (ja) 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62501712A (ja) * 1985-08-26 1987-07-09 アメリカ合衆国 ２′、３′―ジデオキシイノシン、２′，３′―ジデオキシグアノシンまたは２′，３′―ジデオキシアデノシンを含有する抗ｈｔｌｖ―３／ｌａｖ剤
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
CA1312599C (en) * 1988-02-16 1993-01-12 Larry Wayne Hertel 2',3'dideoxy-2',2'difluoronucleosides
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
ES2113851T3 (es) 1998-05-16
KR970001160B1 (ko) 1997-01-29
EP0398230A2 (en) 1990-11-22
EP0398230B1 (en) 1998-01-21
IE81107B1 (en) 2000-03-08
AU617614B2 (en) 1991-11-28
CN1109755A (zh) 1995-10-11
CN1057443C (zh) 2000-10-18
DK0398230T3 (da) 1998-09-21
FI95269B (fi) 1995-09-29
NO176609C (no) 1995-05-03
PT94040B (pt) 1996-12-31
DE69031962T2 (de) 1998-09-17
KR900017591A (ko) 1990-12-19
BG60517B1 (bg) 1995-07-28
EP0398230A3 (en) 1991-06-26
ATE162528T1 (de) 1998-02-15
NO176609B (no) 1995-01-23
NO174102C (no) 1994-03-16
AU5501190A (en) 1990-11-15
HU206628B (en) 1992-12-28
NO933367D0 (no) 1993-09-22
NO902148D0 (no) 1990-05-15
FI902360A0 (fi) 1990-05-11
HU903038D0 (en) 1990-09-28
CN1047676A (zh) 1990-12-12
EG19154A (en) 1994-09-29
BG92000A (bg) 1993-12-24
NO174102B (no) 1993-12-06
NO933367L (no) 1990-11-16
IE901734L (en) 1990-11-15
HUT53528A (en) 1990-11-28
FI95269C (fi) 1996-01-10
GR3025984T3 (en) 1998-04-30
PT94040A (pt) 1991-01-08
DE69031962D1 (de) 1998-02-26
CN1027896C (zh) 1995-03-15

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