NO761217L - - Google Patents
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- Publication number
- NO761217L NO761217L NO761217A NO761217A NO761217L NO 761217 L NO761217 L NO 761217L NO 761217 A NO761217 A NO 761217A NO 761217 A NO761217 A NO 761217A NO 761217 L NO761217 L NO 761217L
- Authority
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- Norway
- Prior art keywords
- paper
- weight
- compounds
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- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims description 32
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims 1
- 239000000123 paper Substances 0.000 description 31
- 150000001875 compounds Chemical class 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 15
- 210000003097 mucus Anatomy 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 9
- 244000005700 microbiome Species 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000011885 synergistic combination Substances 0.000 description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000011272 standard treatment Methods 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 244000005706 microflora Species 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical class [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- JZFICWYCTCCINF-UHFFFAOYSA-N Thiadiazin Chemical compound S=C1SC(C)NC(C)N1CCN1C(=S)SC(C)NC1C JZFICWYCTCCINF-UHFFFAOYSA-N 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 231100001231 less toxic Toxicity 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000002731 mercury compounds Chemical class 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- 150000003567 thiocyanates Chemical class 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- NDSTUUPEXNCUNW-UHFFFAOYSA-N (5-nitrofuran-2-yl)methanol Chemical compound OCC1=CC=C([N+]([O-])=O)O1 NDSTUUPEXNCUNW-UHFFFAOYSA-N 0.000 description 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
- GSFSVEDCYBDIGW-UHFFFAOYSA-N 2-(1,3-benzothiazol-2-yl)-6-chlorophenol Chemical compound OC1=C(Cl)C=CC=C1C1=NC2=CC=CC=C2S1 GSFSVEDCYBDIGW-UHFFFAOYSA-N 0.000 description 1
- FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 239000008896 Opium Substances 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002289 effect on microbe Effects 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 229940066493 expectorants Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960001027 opium Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000002341 toxic gas Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
- D21H21/36—Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paper (AREA)
Description
Slimforhindringsmiddel.Mucus preventer.
Foreliggende oppfinnelse vedrorer et slimforhindringsmiddel, dvs. et middel for å kontrollere dannelse av slim. The present invention relates to a mucus prevention agent, i.e. a means to control the formation of mucus.
Det er velkjent at avlut og massevann i papirindustrien utgjor et utmerket vekstmedium for forskjellige mikroorganismer, såsom bakterier, sopp og alger. Noen av disse mikroorganismer er slimdannende. Slimavsetninger resulterer i alvorlige problemer , idet de påvirker papirkvaliteten som folge av hull og flekkdannelse. Produksjonen må ofte stoppes som folge av gjentetning av siler, munnstykker og virer. It is well known that waste liquor and mass water in the paper industry form an excellent growth medium for various microorganisms, such as bacteria, fungi and algae. Some of these microorganisms are mucus-forming. Slime deposits result in serious problems, as they affect the quality of the paper as a result of holes and staining. Production often has to be stopped as a result of the resealing of sieves, nozzles and wires.
Tilstedeværelse av mikroorganismer i ukontrollerte mengder resulterer også i luktproblemer og utgjor en helsefare for arbeiderene. Man har derfor forsokt å kontrollere bakterie-og soppveksten ved tilsetning til det sirkulerende vannsystem av visse kjemikalier som er toksiske overfor mikroorganismene. Organiske kvikksølvforbindelser har hatt en utstrakt anvendelse for dette formål, men er i dag forbudt i de fleste land. Det har vært mulig å erstatte disse kvikksolvforbindelser med forbindelser såsom klorerte fenoler, tiokarbamater, tiocya-nater, reaktive klor- og bromforbindelser (såsom bis-bromace-toksybuten), samt kvarternære ammoniumforbindelser. Alle disse forbindelser er beheftet med en eller flere ulemper. Presence of microorganisms in uncontrolled quantities also results in odor problems and constitutes a health hazard for the workers. Attempts have therefore been made to control bacterial and fungal growth by adding to the circulating water system certain chemicals that are toxic to the microorganisms. Organic mercury compounds have had extensive use for this purpose, but are currently banned in most countries. It has been possible to replace these mercury compounds with compounds such as chlorinated phenols, thiocarbamates, thiocyanates, reactive chlorine and bromine compounds (such as bis-bromace-toxybutene), as well as quaternary ammonium compounds. All these connections are subject to one or more disadvantages.
De klorerte fenoler er ikke biodegraderbare, tiokarbamatene og tiocyanatene er giftige og farlige å håndtere. De reaktive klor- og bromforbindelser er oralt mindre toksiske enn tio-forbindelsene, men p.g.a. deres alkylerende egenskaper er de farlige for hud og spesielt oynene. The chlorinated phenols are not biodegradable, the thiocarbamates and thiocyanates are toxic and dangerous to handle. The reactive chlorine and bromine compounds are orally less toxic than the thio compounds, but due to their alkylating properties are dangerous for the skin and especially the eyes.
Man har sokt etter mindre farlige kjemikalier, men som likevelA search has been made for less dangerous chemicals, but still
er effektive ved kontroll av mikroorganismer. I tysk utlegnings-skrift nr. 2.251.201 er det foreslått et middel omfattende en l:l-blanding av 5-nitrofurfuryl-alkohol og en annen mikrobiocid forbindelse såsom 8-hydroksykinolin opplost i et egnet opp-løsning smidde 1 . I henhold til utlegningsskriftet ligger det are effective in controlling microorganisms. In German publication No. 2,251,201, a remedy is proposed comprising a 1:1 mixture of 5-nitrofurfuryl alcohol and another microbiocidal compound such as 8-hydroxyquinoline dissolved in a suitable solution forge 1. According to the deed it is located
nye i anvendelse for slimkontroll av en forbindelse som er mindre farlig for mennesker enn de tidligere nevnte forbindelser. new in application for mucus control of a compound which is less dangerous to humans than the previously mentioned compounds.
I britisk patent nr. 1.167.08d er åpenbart en^forbindelsey^avIn British Patent No. 1,167,08d, a^connectiony^of
den generelle formel (i)the general formula (i)
HC CHHC CH
0-NC C- (CH=CH) -CH=A (i) 0-NC C-(CH=CH)-CH=A (i)
\./n\./n
0 0
hvori n er 0 eller 1.where n is 0 or 1.
^representtgfv ' ' formelen^ ^representtgfv ' ' the formula^
0=C—<1>N-Rj^0=C N0=C—<1>N-Rj^0=C N
I eller I I or I
=C C=X =C C-X-R2=C C=X =C C-X-R2
(II) (III)(II) (III)
hvori hver R X og R2er2-al^yl~eller allylgruppe,wherein each R X and R 2 is 2 -al-yl or allyl group,
X er oksygen, svovel eller gruppen =NR^, hvoriX is oxygen, sulfur or the group =NR^, wherein
R^j^ er hydrogen, en allyl- eller C1_3-alkylgruppe, ogR 2 is hydrogen, an allyl or C 1-3 alkyl group, and
Y er svovel eller gruppen =NR^ hvoriY is sulfur or the group =NR^ in which
R^er en C^^-alkylgruppe,R 2 is a C 2 -alkyl group,
samt terapeutisk akseptable salter av disse forbindelser.as well as therapeutically acceptable salts of these compounds.
Disse forbindelser er angitt å være nyttige medisinske midlerThese compounds are indicated to be useful medicinal agents
som utviser en effekt på mikroorganismer samtidig med at de fra et terapeutisk synspunkt er aksepterbare. Forbindel- which exhibit an effect on microorganisms while being acceptable from a therapeutic point of view. Connect-
sene er antibakterielle og antifungicide midler.tendons are antibacterial and antifungal agents.
Det er nå uventet funnet at en viss kombinasjon av forbindelsene av den generelle formel (i) virker synergistisk og at denne kombinasjon er uhyre effektiv som et middel mot mikroflora i industrielle vandige væsker, spesielt mikroflora som er tilstede i vann som anvendes ved papirfremstilling. Den synergistiske effekt betyr i praksis at den nodvendige dose for å bekjempe mikrofloraen kan reduseres. Denne kombinasjon av forbindelser kan anvendes som slimbekjempningsmiddel ved papirfremstilling, It has now been unexpectedly found that a certain combination of the compounds of the general formula (i) acts synergistically and that this combination is extremely effective as an agent against microflora in industrial aqueous fluids, particularly microflora present in water used in papermaking. The synergistic effect means in practice that the necessary dose to combat the microflora can be reduced. This combination of compounds can be used as an anti-sliming agent in papermaking,
i en meget lav dose og med utmerket virkning, uten å være beheftet med den hoye toksitet eller andre farer som er forbundet med anvendelse av konvensjonelle slimbekjempningsmidler. in a very low dose and with excellent effect, without being encumbered with the high toxicity or other dangers associated with the use of conventional expectorants.
Disse forbindelser i kombinasjon er 2-metylamino-5-(5-nitro-2-furfuryliden)-tiazolin-4-on (Forbindelse A) og 3-metyl-2-imino-5-(5-nitro-2-furfuryliden)-tiazolidin-4-on (Forbindelse B). These compounds in combination are 2-methylamino-5-(5-nitro-2-furfurylidene)-thiazolin-4-one (Compound A) and 3-methyl-2-imino-5-(5-nitro-2-furfurylidene) -thiazolidin-4-one (Compound B).
De har formlene:They have the formulas:
2-metylamino-5-(5-nitro-2-furfuryliden)-tiazolin-4-on 2-Methylamino-5-(5-nitro-2-furfurylidene)-thiazolin-4-one
3-métyl-2-imino-5-(5-nitro-2-furfuryliden)-tiazolidin-4-on. 3-Methyl-2-imino-5-(5-nitro-2-furfurylidene)-thiazolidin-4-one.
At disse forbindelser virker synergistisk kan sees av de data angitt i tabell I. That these compounds act synergistically can be seen from the data indicated in Table I.
Oppfinnelsen tilveiebringer således et slimbekjempningsmiddel omfattende forbindelsen (A) og forbindelsen (B) i et vektforhold fra 1:4 til 4:1. Om onsket kan den ytterligere omfatte en bærer eller et fortynningsmiddel. The invention thus provides an expectorant comprising the compound (A) and the compound (B) in a weight ratio of from 1:4 to 4:1. If desired, it may further comprise a carrier or a diluent.
fe fairy
Hensikten med oppfinnelsen er således å kontrollere dannelse av slim og spesielt og forhindre eller redusere vekst av ytterligere slim. The purpose of the invention is thus to control the formation of mucus and in particular to prevent or reduce the growth of further mucus.
Den synergistiske effekt av de to nitrofuraner er av betydning, ikke bare fra et okonomisk synspunkt, men også av tek-niske hensyn. Den synergistiske effekt betyr at den nodvendige dose for å bekjempe veksten av mikroorganismer kan reduseres til 1/10 eller 1/20 ved å anvende en synergistisk kombinasjon istedenfor å anvende en ikke-synergistisk kombinasjon. The synergistic effect of the two nitrofurans is important, not only from an economic point of view, but also from technical considerations. The synergistic effect means that the necessary dose to combat the growth of microorganisms can be reduced to 1/10 or 1/20 by using a synergistic combination instead of using a non-synergistic combination.
Den synergistiske kombinasjon anvendes fortrinnsvis i form av en opplosning som kan innfores i papirmaskinens sirkula-sjonsvannsystem. Egnede opplosningsmidler er formamid, dimetylformamid, dimetylacetamid, dimetylsulfoksyd og heksa-metylfosforsyre-triamid. The synergistic combination is preferably used in the form of a solution that can be introduced into the paper machine's circulation water system. Suitable solvents are formamide, dimethylformamide, dimethylacetamide, dimethylsulfoxide and hexamethylphosphoric triamide.
Andre opplosningsmidler som kan anvendes er uorganiske syrer, av disse er fosforsyre i en konsentrasjon på ca. 75 vekt-% foretrukket. Den foretrukne konsentrasjon i et hvilket som helst opplosningsmiddel av den synergistiske kombinasjon er Other solvents that can be used are inorganic acids, of which phosphoric acid is in a concentration of approx. 75% by weight preferred. The preferred concentration in any solvent of the synergistic combination is
0,5 - 3%, fortrinnsvis 0,5 - 2%. Hoyere konsentrasjoner kan anvendes, men som folge av den hoye aktivitet for kombinasjo"-nen er det mere praktisk å anvende lavkonsentrasjoner. En spesielt foretrukket komposisjon består av ca. 98 vekt-% fosforsyre (passende konsentrasjon er 75 vekt-%) og ca 1 vekt-% 0.5 - 3%, preferably 0.5 - 2%. Higher concentrations can be used, but as a result of the high activity of the combination, it is more practical to use low concentrations. A particularly preferred composition consists of about 98% by weight phosphoric acid (suitable concentration is 75% by weight) and about 1 weight-%
av hver av forbindelsene (A) og (B).of each of compounds (A) and (B).
Komposisjonen lean eventuelt anvendes i form av en dispersjori hvor vann kan passende anvendes som dispergeringsmedium. For å fremstille dispersjonen vil det generelt være nodvendig å finfordele forbindelsene (A) og (B) og for dette formål anvendes fortrinnsvis maling i en strålemolle såsom en "Micronizer". Et disper-geringsmiddel, som generelt kan være ikke-ionisk, anionisk eller kationisk er vanligvis nodvendig for å fremstille og/eller sta-bilisere dispersjonen. Dispergeringsmidlet kan være et hvilket som helst av de vanlig overflateaktive midler eller kan være av en polymer type (ikke-ionisk, anionisk eller kationisk). Til-stedeværelsen av et fortykningsmiddel forbedrer stabiliteten av den vandige dispersjon. The composition lean is optionally used in the form of a dispersion where water can be suitably used as a dispersing medium. In order to prepare the dispersion, it will generally be necessary to finely distribute the compounds (A) and (B) and for this purpose paint is preferably used in a jet mold such as a "Micronizer". A dispersing agent, which can generally be non-ionic, anionic or cationic, is usually required to prepare and/or stabilize the dispersion. The dispersant can be any of the usual surfactants or can be of a polymeric type (non-ionic, anionic or cationic). The presence of a thickener improves the stability of the aqueous dispersion.
Oppfinnelsen innbefatter også en fremgangsmåte for å kontrollere dannelse av slim i industrielle (eller andre) vandige væsker, hvor fremgangsmåten omfatter å tilsette en komposisjon ifolge oppfinnelsen til væsken. En spesielt foretrukket utforelsesform er naturligvis tilsetning av komposisjonen til vann som sirku-lerer i eller gjennom en papirmaskin. The invention also includes a method for controlling the formation of slime in industrial (or other) aqueous liquids, where the method comprises adding a composition according to the invention to the liquid. A particularly preferred embodiment is naturally the addition of the composition to water that circulates in or through a paper machine.
Oppfinnelsen omfatter ytterligere en fremgangsmåte for å be-skytte papir mot angrep av mikroorganismer, som omfatter en imp-regnering av papiret med en komposisjon som har en egnet inert bærer eller fortynningsmiddel, dvs. et middel som ikke skader papiret. The invention further comprises a method for protecting paper against attack by microorganisms, which comprises an impregnation of the paper with a composition which has a suitable inert carrier or diluent, i.e. an agent which does not damage the paper.
Betegnelsen "papir" må forstås i den videste forstand, dvs. at det innbefatter forskjellige typer av kartong og papir fremstilt i en papirfabrikk. The term "paper" must be understood in the broadest sense, i.e. that it includes different types of cardboard and paper produced in a paper mill.
For å bestemme hvorledes den synergistiske kombinasjon virkerTo determine how the synergistic combination works
i praksis er det utfort fabrikkforsok i papirfabrikker.in practice, factory trials have been carried out in paper factories.
Eksempel 1Example 1
Det ble anvendt en papirmaskin med hvilken det ble fremstilt 60 tonn papir pr. dogn. Det fremstilte papir er elektrisk isola-sjonspapir. Det er viktig at for denne anvendelse må antall hull i papiret være ekstremt lavt. Dette kontrolleres ved hjelp av en elektronisk anordning. Standardbehandlingen for papirmaskinen innbefatter tilsetning av et slimbekjempningsmiddel bestående av en blanding av 120 g/l av dinatrium-1, :2-bisditio-karbamat og 120 g/l natriumdimetylditiokarbamat, som tilsettes i et mengdeforhold på 15 ml/min. i 2 timer hver 6. time. Dette resulterer i en tilsetning av 29 g av de aktive bestanddeler pr. tonn papir. A paper machine was used which produced 60 tonnes of paper per year. day and night. The paper produced is electrical insulation paper. It is important that for this application the number of holes in the paper must be extremely low. This is checked using an electronic device. The standard treatment for the paper machine includes the addition of a slime control agent consisting of a mixture of 120 g/l disodium 1, :2-bisdithiocarbamate and 120 g/l sodium dimethyldithiocarbamate, which is added at a rate of 15 ml/min. for 2 hours every 6 hours. This results in an addition of 29 g of the active ingredients per tons of paper.
Sammensetningen av den synergistiske blanding var 0,5 g av forbindelse (A) og 0,5 g av forbindelse (B) i 99 g dimetylformamid. Behandlingen fulgte det samme tidsskjema som for tiokarbamatene og ble utfort ved to dosenivåer, nemlig 1,2 og 0,6 g av aktive bestanddeler pr. tonn papir. Resultatene er vist i fig. 1, 2 og 3 i de vedlagte tegninger og er uttrykt som antall telte levende organismer. Telletallene er henholdsvis totale bakterier, koliforme bakterier og sopp. The composition of the synergistic mixture was 0.5 g of compound (A) and 0.5 g of compound (B) in 99 g of dimethylformamide. The treatment followed the same schedule as for the thiocarbamates and was carried out at two dose levels, namely 1.2 and 0.6 g of active ingredients per tons of paper. The results are shown in fig. 1, 2 and 3 in the attached drawings and is expressed as the number of living organisms counted. The counts are respectively total bacteria, coliform bacteria and fungi.
Det kunne ikke oppdages noe tegn tii ukontrollert slimdannelse i maskinen og vannsirkulasjonssystemet. No sign of uncontrolled slime formation in the machine and water circulation system could be detected.
Eksempel 2Example 2
Den anvendte papirmaskinen fremstilte 31,2 tonn dekkpapir for kartong. Standardbehandlingen ble utfort med bisbromacetoksy-2-buten som en 30%'ig opplosning i et organisk opplosningsmiddel. 312 ml av oppløsningen (dvs. 96 g av den aktive bestanddel) ble innfort en gang i dognet i 1 time. The paper machine used produced 31.2 tonnes of cover paper for cardboard. The standard treatment was carried out with bisbromoacetoxy-2-butene as a 30% solution in an organic solvent. 312 ml of the solution (ie 96 g of the active ingredient) was infused once a day for 1 hour.
I forsoket med den nye synergistiske kombinasjon ble det anvendt en 1 vekt-%'ig opplosning i fosforsyre. 312 ml av opp-løsningen (dvs. 5 g av de aktive bestanddeler) ble tilsatt på samme måte som ved standardbehandlingen. Behandlingen ble fulgt med telling av levende bakterier og sopp, og også ved visuell observasjon av papir og maskineri. Resultatene viste at behandlingen med den synergistiske kombinasjon var i det minste In the trial with the new synergistic combination, a 1% by weight solution in phosphoric acid was used. 312 ml of the solution (ie 5 g of the active ingredients) was added in the same way as in the standard treatment. The treatment was followed by counting live bacteria and fungi, and also by visual observation of paper and machinery. The results showed that the treatment with the synergistic combination was the least
like effektiv som standardbehandlingen.as effective as the standard treatment.
Eksempel 3Example 3
Forsok AAttempt A
Den anvendte papirmaksin fremstilte 80 tonn kartong pr. dogn. Systemet ble renset for slim. I mange uker for forsoket ble påbegynt ble det gitt doser med en kjent blanding bestående av: 20 vekt-% 3,5-dimetyl-l,3,5-2H-tetrahydroti diazin-2-tion 12 vekt-% av 92 vekt-%'ig vandig kaliumhydroksydopp-losning og The paper machine used produced 80 tonnes of cardboard per year. day and night. The system was cleaned of mucus. For many weeks before the experiment was started, doses were given with a known mixture consisting of: 20% by weight 3,5-dimethyl-1,3,5-2H-tetrahydrothidiazin-2-thione 12% by weight of 92% by weight % aqueous potassium hydroxide solution and
68 vekt-% vann.68% by weight water.
Dosene var 15 ml/min. i 2 timer for hver 6 timers periode til innlopskassen for midtlaget i kartongen. Forsoket ble deretter utfort og en dose på 1,9 ml/min. av komposisjonen i henhold til oppfinnelsen, som beskrevet i eksempel 1 ble tilfort i 4 timer i hver 6 timers periode til den samme innlopskasse. Forsoket ble avbrutt av forskjellige brudd som folge av meka-niske feil i utstyret, men dosene ble tilsatt og det oppstod ingen problemer som folge av slimdannelse. Figurene 4, 5 og 6 viser telletall for levende organismer for henholdsvis bakterier, koliforme bakterier og sopp (gjær og mugg). De hoye topper ble forårsaket av at et lengre tidsrom (ca. 4 timer) medgikk for provene ble inkubert enn for de andre prover. Denne tidsforsinkelse forårsaket vekst av bakterier. The doses were 15 ml/min. for 2 hours for every 6 hour period to the inlet box for the middle layer of the carton. The experiment was then continued and a dose of 1.9 ml/min. of the composition according to the invention, as described in example 1, was added for 4 hours in every 6 hour period to the same inlet box. The experiment was interrupted by various breaks as a result of mechanical faults in the equipment, but the doses were added and no problems arose as a result of mucus formation. Figures 4, 5 and 6 show counts of living organisms for bacteria, coliform bacteria and fungi (yeast and mould) respectively. The high peaks were caused by the fact that a longer period of time (approx. 4 hours) was allowed for the samples to be incubated than for the other samples. This time delay caused the growth of bacteria.
Forsok BAttempt B
Papirmaskinen som ble anvendt i forsok A ble stoppet for meka-nisk vedlikehold og forsoket ble utfort på en annen maskin. Dette var en Fourdinier-maskin med hvilken ble fremstilt 60 tonn pr. dag av liner-materiale og kartong. The paper machine used in experiment A was stopped for mechanical maintenance and the experiment was carried out on another machine. This was a Fourdinier machine with which 60 tonnes per year were produced. day of liner material and cardboard.
Slim ble ikke renset ut av systemet for forsoket startet. Det hadde vært visse problemer med slim i maskinen i de tidligere uker, til tross for doser av den kjente komposisjon beskrevet under "Forsok A" med 15 ml/min. i 2 timer i hver periode på 6 timer til innlopskassen og 15 ml/min. i 2 timer i lop av hver periode på 6 timer til det sirkulerende bakvann. Mucus was not cleared from the system before the experiment started. There had been some problems with mucus in the machine in the previous weeks, despite doses of the known composition described under "Experiment A" at 15 ml/min. for 2 hours in each period of 6 hours to the inlet box and 15 ml/min. for 2 hours during each 6-hour period to the circulating tailwater.
Forsoket ble påbegynt med en sjokkdose på 100 ppm (pr. vekt)The experiment was started with a shock dose of 100 ppm (per weight)
av den samme kjente komposisjon til innlopskassen. Deretter ble komposisjonen ifolge oppfinnelsen, slik som beskrevet i eksempel ljtilsatt med en dose på 2 ml/min. til innlopskassen i 4 timer i hver tidsperiode på 6 timer og 1,5 ml/min. i 4 timer pr. hver periode på 6 timer til bakvahnet. Tilsetningen av komposisjonen til bakvannet ble påbegynt uten forsinkelse, men tilsetningen til innlopskassen ble forsinket i 3 dager. of the same known composition to the inlet box. Then the composition according to the invention, as described in example 1, was added at a dose of 2 ml/min. to the inlet box for 4 hours in each time period of 6 hours and 1.5 ml/min. for 4 hours per every period of 6 hours until the hangover. The addition of the composition to the tailwater was started without delay, but the addition to the inlet box was delayed for 3 days.
Figurene 7-9 viser telletallene for mikroorganismer for henholdsvis totalt antall bakterier, koliforme bakterier bg sopp. Figures 7-9 show the count figures for micro-organisms for the total number of bacteria, coliform bacteria and fungi respectively.
De hoye tall i lopet av de forste par dager tilskrives den mang-lende dosering til innlopsgassen, men det vil sees at deretter avtar telletallene drastisk. Symbolene "a" og "b" angir må-linger utfort den forste dag en 1/2 time for (a) og 2 1/2 time etter (b) etter dosering til massen. En viss slimdannelse fant sted som forårsaket stopp, men ikke så hyppig som for forsoket startet. The high numbers in the course of the first couple of days are attributed to the lack of dosing of the inlet gas, but it will be seen that thereafter the count figures decrease drastically. The symbols "a" and "b" indicate measurements taken on the first day 1/2 hour for (a) and 2 1/2 hours after (b) after dosing to the mass. Some mucus formation took place which caused stoppage, but not as frequently as before the experiment started.
Forsok B utgjorde en meget alvorligere prove enn forsok A fordi slim ble ikke renset ut av systemet for forsok B startet, siik som i forsok A, og ytterligere fordi tilforselen til innlopskassen ble utelatt de forste dager av forsok B. Tar man hensyn til disse faktorer var effekten av komposisjonen ifolge oppfinnelsen minst like så god som sammenligningskomposisjonen. Omkostningen for komposisjonen vil være ca. den samme basert Experiment B was a much more severe test than experiment A because mucus was not cleared from the system before experiment B started, as in experiment A, and further because the supply to the inlet box was omitted in the first days of experiment B. Taking these factors into account the effect of the composition according to the invention was at least as good as the comparative composition. The cost of the composition will be approx. the same based
på vekten av det fremstilte papir.on the weight of the paper produced.
I andre henseende utviser komposisjonen ifolge oppfinnelsen frem-ragende fordeler. For det forste er den vesentlig mindre tok-.sisk. De aktive bestanddeler utviser omtrent den samme toksisi-tet, men sammenligningskomposisjonen inneholder 24% av den aktive bestanddel, mens komposisjonen ifolge oppfinnelsen kun inneholdt 2%. Fra disse tall og de anvendte doser vil det sees at komposisjoner ifolge oppfinnelsen har en meget lavere toksi-sitet. In other respects, the composition according to the invention exhibits outstanding advantages. Firstly, it is significantly less toxic. The active ingredients show approximately the same toxicity, but the comparative composition contains 24% of the active ingredient, while the composition according to the invention only contained 2%. From these figures and the doses used, it will be seen that compositions according to the invention have a much lower toxicity.
For det andre er tiadiazin, den aktive bestanddel i sammenligningskomposisjonen, meget labil og ved surgjbring avgives kar-bondisulfid, som er kjent som en toksisk gass. En alkalisk opplosning av tiadiazin, anvendt i forsok A, har en ubehagelig lukt (av aminer og svovelforbindelser). For det tredje kan sammenligningskomposisjonen ikke anvendes ved fremstilling av hvitt papir fordi den forårsaker alvorlig misfargning. Komposisjonen ifolge oppfinnelsen forårsaker praktisk talt ingen misfargning av papiret. Secondly, thiadiazine, the active ingredient in the comparative composition, is very labile and when acidified gives off carbon disulphide, which is known as a toxic gas. An alkaline solution of thiadiazine, used in experiment A, has an unpleasant odor (of amines and sulfur compounds). Thirdly, the comparative composition cannot be used in the manufacture of white paper because it causes severe discoloration. The composition according to the invention causes practically no discoloration of the paper.
Eksempel 4Example 4
For å bestemme hvorvidt den slimforhindrende komposisjon også To determine whether the anti-phlegm composition also
var egnet for å preservere papir ble de folgende laboratoriefor-søk utfort. Filterpapir ble neddykket i opplosninger inneholdende slimbekjempningsmidlene i forskjellige konsentrasjoner. (Det ble for dette formål anvendt en 2 vekt-%'ig forrådsoppiosning i fosforsyre av en 1:1 vektblanding av forbindelsene (A> og was suitable for preserving paper, the following laboratory tests were carried out. Filter paper was immersed in solutions containing the mucilage agents at various concentrations. (For this purpose, a 2% by weight stock opium solution in phosphoric acid of a 1:1 weight mixture of the compounds (A> and
(B) for de forskjellige uttynninger. Etter torking ble stykker (4 cm 2) av det behandlede papir plassert på overflaten av agar-plater og infisert med Staphylococcus aureus. Storrelsen av sonen på papiret hvor vekst ble inhibert ga en indikasjon på den baktericide effekt. Resultatene er vist i tabell II. (B) for the different dilutions. After drying, pieces (4 cm 2 ) of the treated paper were placed on the surface of agar plates and infected with Staphylococcus aureus. The size of the zone on the paper where growth was inhibited gave an indication of the bactericidal effect. The results are shown in Table II.
Claims (6)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1464075A GB1473752A (en) | 1975-04-09 | 1975-04-09 | Composition of nitrofurans and its use in controlling formation of slime |
Publications (1)
Publication Number | Publication Date |
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NO761217L true NO761217L (en) | 1976-10-12 |
Family
ID=10044906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO761217A NO761217L (en) | 1975-04-09 | 1976-04-08 |
Country Status (7)
Country | Link |
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DE (1) | DE2614798A1 (en) |
FI (1) | FI760961A (en) |
FR (1) | FR2307081A1 (en) |
GB (1) | GB1473752A (en) |
IT (1) | IT1058370B (en) |
NO (1) | NO761217L (en) |
SE (1) | SE7604170L (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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HU200177B (en) * | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
WO2009137133A2 (en) | 2008-02-14 | 2009-11-12 | University Of Washington | 5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection |
-
1975
- 1975-04-09 GB GB1464075A patent/GB1473752A/en not_active Expired
-
1976
- 1976-04-06 DE DE19762614798 patent/DE2614798A1/en active Pending
- 1976-04-08 NO NO761217A patent/NO761217L/no unknown
- 1976-04-08 FR FR7610283A patent/FR2307081A1/en active Granted
- 1976-04-08 IT IT22100/76A patent/IT1058370B/en active
- 1976-04-08 FI FI760961A patent/FI760961A/fi not_active Application Discontinuation
- 1976-04-08 SE SE7604170A patent/SE7604170L/en unknown
Also Published As
Publication number | Publication date |
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FR2307081A1 (en) | 1976-11-05 |
DE2614798A1 (en) | 1976-10-28 |
SE7604170L (en) | 1976-10-10 |
FI760961A (en) | 1976-10-10 |
IT1058370B (en) | 1982-04-10 |
GB1473752A (en) | 1977-05-18 |
FR2307081B3 (en) | 1979-01-05 |
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