NO343403B1 - Kinazolinderivat med tyrosinkinase-inhiberende aktivitet og farmasøytisk sammensetning - Google Patents
Kinazolinderivat med tyrosinkinase-inhiberende aktivitet og farmasøytisk sammensetningInfo
- Publication number
- NO343403B1 NO343403B1 NO20074311A NO20074311A NO343403B1 NO 343403 B1 NO343403 B1 NO 343403B1 NO 20074311 A NO20074311 A NO 20074311A NO 20074311 A NO20074311 A NO 20074311A NO 343403 B1 NO343403 B1 NO 343403B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical composition
- tyrosine kinase
- inhibitory activity
- quinazoline derivative
- kinase inhibitory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005047383 | 2005-02-23 | ||
| JP2005156828 | 2005-05-30 | ||
| PCT/JP2006/303125 WO2006090717A1 (ja) | 2005-02-23 | 2006-02-22 | チロシンキナーゼ阻害作用を有するキナゾリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20074311L NO20074311L (no) | 2007-11-23 |
| NO343403B1 true NO343403B1 (no) | 2019-02-25 |
Family
ID=36927355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20074311A NO343403B1 (no) | 2005-02-23 | 2007-08-23 | Kinazolinderivat med tyrosinkinase-inhiberende aktivitet og farmasøytisk sammensetning |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8202879B2 (no) |
| EP (1) | EP1854789B1 (no) |
| JP (1) | JP4137174B2 (no) |
| KR (1) | KR100910333B1 (no) |
| CN (1) | CN101163684B (no) |
| AU (1) | AU2006216266C1 (no) |
| BR (1) | BRPI0606905B1 (no) |
| CA (1) | CA2599328C (no) |
| DK (1) | DK1854789T3 (no) |
| ES (1) | ES2431843T3 (no) |
| NO (1) | NO343403B1 (no) |
| PL (1) | PL1854789T3 (no) |
| PT (1) | PT1854789E (no) |
| RU (1) | RU2414457C2 (no) |
| TW (1) | TWI372147B (no) |
| WO (1) | WO2006090717A1 (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1854789B1 (en) * | 2005-02-23 | 2013-10-09 | Shionogi & Co., Ltd. | Quinazoline derivative having tyrosine kinase inhibitory activity |
| CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
| JP5580592B2 (ja) | 2006-09-11 | 2014-08-27 | キュリス，インコーポレイテッド | 亜鉛結合部分を含むキナゾリン系ｅｇｆｒインヒビター |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CA3006395C (en) | 2008-11-07 | 2022-05-31 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| TWI466872B (zh) * | 2008-12-25 | 2015-01-01 | Shionogi & Co | 喹唑啉衍生物之製造方法 |
| MX363734B (es) | 2011-10-27 | 2019-03-29 | Massachusetts Inst Technology | Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco. |
| CN103288756B (zh) * | 2012-02-29 | 2016-04-20 | 江苏先声药物研究有限公司 | 一种喹唑啉中间体的甲醇溶剂合物及其制备方法 |
| MX367420B (es) | 2013-03-14 | 2019-08-21 | Convergene Llc | Metodos y composiciones para inhibicion de proteinas que contienen bromodominio. |
| EP3150573A4 (en) * | 2014-05-29 | 2018-02-21 | Shionogi & Co., Ltd. | Method for producing alkynyl ketone derivative |
| DK3330267T3 (da) * | 2015-07-29 | 2022-03-14 | Shionogi & Co | Salt af quinazolinderivat eller crystal deraf samt fremgangsmåde til fremstilling af salt af quinazolinderivat eller crystal deraf |
| KR20180086187A (ko) | 2015-10-05 | 2018-07-30 | 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료 |
| CN115806550A (zh) * | 2015-11-25 | 2023-03-17 | 康威基内有限公司 | 双环bet布罗莫结构域抑制剂及其用途 |
| US20180030403A1 (en) | 2016-07-28 | 2018-02-01 | Bobban Subhadra | Devices, systems and methods for the production of humanized gut commensal microbiota |
| WO2018139626A1 (ja) | 2017-01-30 | 2018-08-02 | 塩野義製薬株式会社 | キナゾリン誘導体を含有する固形製剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002434A1 (en) * | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| US20030018029A1 (en) * | 1996-02-14 | 2003-01-23 | Zeneca Limited | Quinazoline derivatives |
| WO2004026307A1 (en) * | 2002-09-18 | 2004-04-01 | Pfizer Products Inc. | Triazole derivatives as transforming growth factor (tgf) inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69222637T2 (de) | 1991-05-10 | 1998-02-26 | Rhone Poulenc Rorer Int | Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| WO1996030347A1 (en) * | 1995-03-30 | 1996-10-03 | Pfizer Inc. | Quinazoline derivatives |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| PL354923A1 (en) | 1999-09-21 | 2004-03-22 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
| EP1369418B1 (en) * | 2001-02-21 | 2010-07-28 | Mitsubishi Tanabe Pharma Corporation | Quinazoline derivatives |
| AU2002342051B2 (en) | 2001-10-12 | 2009-06-11 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
| WO2004069145A2 (en) | 2003-02-07 | 2004-08-19 | Dr. Reddy's Laboratories Ltd. | Anticancer compounds, process for their preparation and pharmaceutical compositions containing them |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| US20100190150A1 (en) | 2004-01-07 | 2010-07-29 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
| US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| EP1854789B1 (en) * | 2005-02-23 | 2013-10-09 | Shionogi & Co., Ltd. | Quinazoline derivative having tyrosine kinase inhibitory activity |
-
2006
- 2006-02-22 EP EP06714265.3A patent/EP1854789B1/en active Active
- 2006-02-22 RU RU2007135023/04A patent/RU2414457C2/ru active
- 2006-02-22 US US11/884,819 patent/US8202879B2/en active Active
- 2006-02-22 KR KR1020077019256A patent/KR100910333B1/ko active IP Right Grant
- 2006-02-22 DK DK06714265.3T patent/DK1854789T3/da active
- 2006-02-22 PT PT67142653T patent/PT1854789E/pt unknown
- 2006-02-22 CA CA2599328A patent/CA2599328C/en active Active
- 2006-02-22 JP JP2007504734A patent/JP4137174B2/ja active Active
- 2006-02-22 BR BRPI0606905-3A patent/BRPI0606905B1/pt active IP Right Grant
- 2006-02-22 PL PL06714265T patent/PL1854789T3/pl unknown
- 2006-02-22 AU AU2006216266A patent/AU2006216266C1/en active Active
- 2006-02-22 WO PCT/JP2006/303125 patent/WO2006090717A1/ja active Application Filing
- 2006-02-22 ES ES06714265T patent/ES2431843T3/es active Active
- 2006-02-22 CN CN2006800136753A patent/CN101163684B/zh active Active
- 2006-02-23 TW TW095106013A patent/TWI372147B/zh active
-
2007
- 2007-08-23 NO NO20074311A patent/NO343403B1/no unknown
-
2012
- 2012-01-26 US US13/359,326 patent/US8349857B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030018029A1 (en) * | 1996-02-14 | 2003-01-23 | Zeneca Limited | Quinazoline derivatives |
| WO1998002434A1 (en) * | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| US20020147214A1 (en) * | 1996-07-13 | 2002-10-10 | Cockerill George Stuart | Heterocyclic compounds |
| WO2004026307A1 (en) * | 2002-09-18 | 2004-04-01 | Pfizer Products Inc. | Triazole derivatives as transforming growth factor (tgf) inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0606905B1 (pt) | 2021-06-01 |
| DK1854789T3 (da) | 2013-10-21 |
| AU2006216266A8 (en) | 2009-04-02 |
| RU2007135023A (ru) | 2009-03-27 |
| US20090143414A1 (en) | 2009-06-04 |
| TWI372147B (en) | 2012-09-11 |
| WO2006090717A1 (ja) | 2006-08-31 |
| AU2006216266C1 (en) | 2010-08-26 |
| CN101163684A (zh) | 2008-04-16 |
| CN101163684B (zh) | 2012-08-29 |
| JPWO2006090717A1 (ja) | 2008-07-24 |
| RU2414457C2 (ru) | 2011-03-20 |
| JP4137174B2 (ja) | 2008-08-20 |
| BRPI0606905A2 (pt) | 2009-07-28 |
| KR20070098941A (ko) | 2007-10-05 |
| US8349857B2 (en) | 2013-01-08 |
| EP1854789A4 (en) | 2009-06-17 |
| AU2006216266A1 (en) | 2006-08-31 |
| CA2599328C (en) | 2012-04-17 |
| US20120123114A1 (en) | 2012-05-17 |
| EP1854789A1 (en) | 2007-11-14 |
| PT1854789E (pt) | 2013-10-23 |
| TW200640880A (en) | 2006-12-01 |
| AU2006216266B2 (en) | 2010-02-18 |
| PL1854789T3 (pl) | 2014-03-31 |
| KR100910333B1 (ko) | 2009-07-31 |
| AU2006216266A2 (en) | 2006-08-31 |
| CA2599328A1 (en) | 2006-08-31 |
| EP1854789B1 (en) | 2013-10-09 |
| US8202879B2 (en) | 2012-06-19 |
| NO20074311L (no) | 2007-11-23 |
| ES2431843T3 (es) | 2013-11-28 |
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