NO341676B1 - Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI - Google Patents

Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI

Info

Publication number
NO341676B1
NO341676B1 NO20084411A NO20084411A NO341676B1 NO 341676 B1 NO341676 B1 NO 341676B1 NO 20084411 A NO20084411 A NO 20084411A NO 20084411 A NO20084411 A NO 20084411A NO 341676 B1 NO341676 B1 NO 341676B1
Authority
NO
Norway
Prior art keywords
trpvi
modulators
compounds
tetrahydro
pyrimidoazepines
Prior art date
Application number
NO20084411A
Other languages
English (en)
Other versions
NO20084411L (no
Inventor
Michael D Hack
Brett D Allison
Bryan James Branstetter
James Guy Breitenbucher
Natalie A Hawryluk
Alec D Lebsack
Kelly J Mcclure
Jeffrey E Merit
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20084411L publication Critical patent/NO20084411L/no
Publication of NO341676B1 publication Critical patent/NO341676B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Visse tetrahydro-pyrimidoazepinforbindelser er beskrevet, som er anvendelig som TRPV I -modulatorer. Slike forbindelser kan anvendes i farmasøytiske sammensetninger og fremgangsmåter for behandling av sykdomstilstander, forstyrrelser og tilstander mediert av TRPVI. Således kan forbindelsene administreres for å behandle for eksempel smerte, kløe, hoste, astma eller inflammatorisk tarmsykdom.
NO20084411A 2006-03-21 2008-10-21 Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI NO341676B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain

Publications (2)

Publication Number Publication Date
NO20084411L NO20084411L (no) 2008-11-03
NO341676B1 true NO341676B1 (no) 2017-12-18

Family

ID=38353855

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084411A NO341676B1 (no) 2006-03-21 2008-10-21 Tetrahydro-pyrimidoazepiner som modulatorer av TRPVI

Country Status (31)

Country Link
US (3) US8673895B2 (no)
EP (1) EP2024368B1 (no)
JP (1) JP5232768B2 (no)
KR (1) KR101461376B1 (no)
CN (1) CN101448835B (no)
AR (1) AR059985A1 (no)
AU (1) AU2007227203B2 (no)
BR (1) BRPI0709034B1 (no)
CA (1) CA2646977C (no)
CR (1) CR10387A (no)
DK (1) DK2024368T3 (no)
EA (1) EA017069B1 (no)
EC (1) ECSP088807A (no)
ES (1) ES2474152T3 (no)
HK (1) HK1129888A1 (no)
HR (1) HRP20140664T1 (no)
MX (1) MX2008012163A (no)
NI (1) NI200800253A (no)
NO (1) NO341676B1 (no)
NZ (1) NZ571343A (no)
PE (1) PE20080145A1 (no)
PL (1) PL2024368T3 (no)
PT (1) PT2024368E (no)
RS (1) RS53436B (no)
SG (1) SG177176A1 (no)
SI (1) SI2024368T1 (no)
TW (1) TWI440639B (no)
UA (1) UA92636C2 (no)
UY (1) UY30229A1 (no)
WO (1) WO2007109355A2 (no)
ZA (1) ZA200808975B (no)

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JP2010522156A (ja) * 2007-03-23 2010-07-01 ファイザー・リミテッド ５−ＨＴ２ｃ作動薬としてのピリミド［４，５−ｄ］アゼピン誘導体
CL2008003749A1 (es) * 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
WO2009079000A1 (en) * 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolopyrimidine modulators of trpv1
RU2473549C2 (ru) * 2008-07-31 2013-01-27 Дженентек, Инк. Пиримидиновые соединения, композиции и способы применения
EP2367826A4 (en) * 2008-11-06 2012-07-04 Astrazeneca Ab MODULATORS OF THE PROTEIN -AMYLOID
CN102480961A (zh) * 2009-06-24 2012-05-30 健泰科生物技术公司 与含氧杂环稠合的嘧啶化合物、组合物和使用方法
BR112012011147A2 (pt) * 2009-11-12 2021-09-08 F.Hoffmann-La Roche Ag Composto, composição farmacêutica e uso de um composto.
KR101469334B1 (ko) * 2009-11-12 2014-12-04 에프. 호프만-라 로슈 아게 Ｎ-9-치환된 퓨린 화합물, 조성물 및 사용 방법
WO2011161451A1 (en) 2010-06-23 2011-12-29 Johnson Matthey Plc Complexes
CN102154494B (zh) * 2011-03-14 2013-01-02 中国人民解放军军事医学科学院基础医学研究所 一种用于儿童哮喘检测的标志物
PL2958913T3 (pl) 2013-02-20 2019-03-29 Lg Chem, Ltd. Agoniści receptora sfingozyno-1-fosforanowego, sposoby ich przygotowania i zawierające je jako środek aktywny farmaceutyczne kompozycje
CN103641762A (zh) * 2013-12-18 2014-03-19 中国药科大学 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途
JP7427314B2 (ja) 2019-12-03 2024-02-05 エルジー・ケム・リミテッド スフィンゴシン－１－リン酸受容体アゴニスト、その製造方法、およびそれを活性成分として含有する医薬組成物

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