NO329706B1 - Kodet mikrobaerer med bundne ligander, fremgangsmate for koding av slike samt anvendelse derav for pavisning av malanalytter i en prove - Google Patents

Kodet mikrobaerer med bundne ligander, fremgangsmate for koding av slike samt anvendelse derav for pavisning av malanalytter i en prove Download PDF

Info

Publication number: NO329706B1
Authority: NO; Norway
Prior art keywords: microcarrier; code; microcarriers; written; bound
Prior art date: 1999-04-16

Application number

NO20015019A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015019L (no

NO20015019D0 (no

Inventor

Stefan Cornelis De Smedt

Joseph Demeester

Christiaan Hubert Simon Roelant

Rudi Wilfred Jan Pauwels

Original Assignee

Biocartis Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-16

Filing date

2001-10-15

Publication date

2010-12-06

2001-10-15 Application filed by Biocartis Sa filed Critical Biocartis Sa

2001-10-15 Publication of NO20015019D0 publication Critical patent/NO20015019D0/no

2001-12-14 Publication of NO20015019L publication Critical patent/NO20015019L/no

2010-12-06 Publication of NO329706B1 publication Critical patent/NO329706B1/no

Links

238000000034 method Methods 0.000 title claims description 63
239000003446 ligand Substances 0.000 title claims description 48
238000001514 detection method Methods 0.000 title description 2
239000011325 microbead Substances 0.000 title 1
238000004061 bleaching Methods 0.000 claims description 49
239000000126 substance Substances 0.000 claims description 36
238000006243 chemical reaction Methods 0.000 claims description 35
239000004005 microsphere Substances 0.000 claims description 33
239000012491 analyte Substances 0.000 claims description 15
239000000463 material Substances 0.000 claims description 13
239000007787 solid Substances 0.000 claims description 10
108020004707 nucleic acids Proteins 0.000 claims description 7
102000039446 nucleic acids Human genes 0.000 claims description 7
150000007523 nucleic acids Chemical class 0.000 claims description 7
238000003486 chemical etching Methods 0.000 claims description 3
238000009396 hybridization Methods 0.000 claims description 3
238000010884 ion-beam technique Methods 0.000 claims description 3
230000000295 complement effect Effects 0.000 claims description 2
210000003527 eukaryotic cell Anatomy 0.000 claims description 2
210000001236 prokaryotic cell Anatomy 0.000 claims description 2
241000321461 Mycteroperca phenax Species 0.000 description 26
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 23
239000004816 latex Substances 0.000 description 17
229920000126 latex Polymers 0.000 description 17
238000002474 experimental method Methods 0.000 description 14
238000003556 assay Methods 0.000 description 13
239000000523 sample Substances 0.000 description 13
239000011324 bead Substances 0.000 description 9
150000001875 compounds Chemical class 0.000 description 8
238000009792 diffusion process Methods 0.000 description 8
230000003993 interaction Effects 0.000 description 8
238000011084 recovery Methods 0.000 description 8
229920002307 Dextran Polymers 0.000 description 7
239000007844 bleaching agent Substances 0.000 description 6
229920002521 macromolecule Polymers 0.000 description 5
238000012544 monitoring process Methods 0.000 description 5
239000000376 reactant Substances 0.000 description 5
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
230000002349 favourable effect Effects 0.000 description 4
238000002493 microarray Methods 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
238000001228 spectrum Methods 0.000 description 4
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 3
238000004166 bioassay Methods 0.000 description 3
238000004590 computer program Methods 0.000 description 3
239000003814 drug Substances 0.000 description 3
238000007876 drug discovery Methods 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
238000007654 immersion Methods 0.000 description 3
239000003550 marker Substances 0.000 description 3
238000000386 microscopy Methods 0.000 description 3
230000003287 optical effect Effects 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
-1 polypropylene Polymers 0.000 description 3
230000008569 process Effects 0.000 description 3
238000012545 processing Methods 0.000 description 3
230000004044 response Effects 0.000 description 3
238000012216 screening Methods 0.000 description 3
238000012360 testing method Methods 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
229910052786 argon Inorganic materials 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000003086 colorant Substances 0.000 description 2
238000010226 confocal imaging Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000013461 design Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000005670 electromagnetic radiation Effects 0.000 description 2
238000002376 fluorescence recovery after photobleaching Methods 0.000 description 2
239000007850 fluorescent dye Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
238000012203 high throughput assay Methods 0.000 description 2
238000011835 investigation Methods 0.000 description 2
238000002372 labelling Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
238000006552 photochemical reaction Methods 0.000 description 2
238000006303 photolysis reaction Methods 0.000 description 2
230000015843 photosynthesis, light reaction Effects 0.000 description 2
239000000049 pigment Substances 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
238000000926 separation method Methods 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
WRXNJTBODVGDRY-UHFFFAOYSA-N 2-pyrrolidin-1-ylethanamine Chemical compound NCCN1CCCC1 WRXNJTBODVGDRY-UHFFFAOYSA-N 0.000 description 1
JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
238000000429 assembly Methods 0.000 description 1
230000000712 assembly Effects 0.000 description 1
230000002238 attenuated effect Effects 0.000 description 1
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
230000009141 biological interaction Effects 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000004040 coloring Methods 0.000 description 1
238000001218 confocal laser scanning microscopy Methods 0.000 description 1
238000004624 confocal microscopy Methods 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
235000001671 coumarin Nutrition 0.000 description 1
150000004775 coumarins Chemical class 0.000 description 1
238000011161 development Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000001917 fluorescence detection Methods 0.000 description 1
238000001215 fluorescent labelling Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
238000013537 high throughput screening Methods 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
DLBFLQKQABVKGT-UHFFFAOYSA-L lucifer yellow dye Chemical compound [Li+].[Li+].[O-]S(=O)(=O)C1=CC(C(N(C(=O)NN)C2=O)=O)=C3C2=CC(S([O-])(=O)=O)=CC3=C1N DLBFLQKQABVKGT-UHFFFAOYSA-L 0.000 description 1
238000001634 microspectroscopy Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000013307 optical fiber Substances 0.000 description 1
238000000399 optical microscopy Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
244000052769 pathogen Species 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000010526 radical polymerization reaction Methods 0.000 description 1
238000001525 receptor binding assay Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
238000004621 scanning probe microscopy Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
238000012800 visualization Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K1/00—Methods or arrangements for marking the record carrier in digital fashion
- G06K1/12—Methods or arrangements for marking the record carrier in digital fashion otherwise than by punching
- G06K1/126—Methods or arrangements for marking the record carrier in digital fashion otherwise than by punching by photographic or thermographic registration
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00542—Alphanumeric characters
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Theoretical Computer Science (AREA)
Nanotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO20015019A 1999-04-16 2001-10-15 Kodet mikrobaerer med bundne ligander, fremgangsmate for koding av slike samt anvendelse derav for pavisning av malanalytter i en prove NO329706B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12955199P	1999-04-16	1999-04-16
PCT/EP2000/003280 WO2000063695A1 (en)	1999-04-16	2000-04-12	Encoding of microcarriers

Publications (3)

Publication Number	Publication Date
NO20015019D0 NO20015019D0 (no)	2001-10-15
NO20015019L NO20015019L (no)	2001-12-14
NO329706B1 true NO329706B1 (no)	2010-12-06

Family

ID=22440543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015019A NO329706B1 (no)	1999-04-16	2001-10-15	Kodet mikrobaerer med bundne ligander, fremgangsmate for koding av slike samt anvendelse derav for pavisning av malanalytter i en prove

Country Status (23)

Country	Link
US (4)	US8939376B1 (ko)
EP (1)	EP1173760B1 (ko)
JP (1)	JP4500455B2 (ko)
KR (1)	KR100660600B1 (ko)
CN (1)	CN1271410C (ko)
AR (1)	AR023504A1 (ko)
AT (1)	ATE298888T1 (ko)
AU (1)	AU771517B2 (ko)
CA (1)	CA2370315C (ko)
CZ (1)	CZ301174B6 (ko)
DE (1)	DE60021070T2 (ko)
DK (1)	DK1173760T3 (ko)
HU (1)	HU227484B1 (ko)
IL (2)	IL145970A0 (ko)
MY (1)	MY132268A (ko)
NO (1)	NO329706B1 (ko)
NZ (1)	NZ515214A (ko)
PL (1)	PL209100B1 (ko)
RU (1)	RU2242746C2 (ko)
SK (1)	SK287052B6 (ko)
TW (1)	TWI249033B (ko)
WO (1)	WO2000063695A1 (ko)
ZA (1)	ZA200108305B (ko)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7045049B1 (en)	1999-10-01	2006-05-16	Nanoplex Technologies, Inc.	Method of manufacture of colloidal rod particles as nanobar codes
US6919009B2 (en)	1999-10-01	2005-07-19	Nanoplex Technologies, Inc.	Method of manufacture of colloidal rod particles as nanobarcodes
US7225082B1 (en) *	1999-10-01	2007-05-29	Oxonica, Inc.	Colloidal rod particles as nanobar codes
JP2004537712A (ja) *	2000-10-18	2004-12-16	バーチャル・アレイズ・インコーポレーテッド	多重細胞分析システム
RU2285265C2 (ru) *	2000-10-19	2006-10-10	Тиботек Бвба	Способ и устройство манипулирования микроносителями для их идентификации
DE10117274B4 (de) *	2001-04-06	2005-03-03	Hte Ag The High Throughput Experimentation Company	Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
GB0109544D0 (en) *	2001-04-18	2001-06-06	Scient Generics Ltd	Chemical libraries based on coded particles
GB0111470D0 (en) *	2001-05-10	2001-07-04	Scient Generics Ltd	Homogenous photoresist functionalisation
DE10137864B4 (de) *	2001-08-02	2005-05-19	Picorapid Technologie Gmbh	Substanzträger mit Markierung
CN1295347C (zh) *	2004-07-13	2007-01-17	东南大学	利用光子微粒编码的微通道阵列式生物芯片及应用方法
US8124943B1 (en)	2006-04-06	2012-02-28	Lugade Ananda G	Methods and systems for altering fluorescent intensities of a plurality of particles
EP1903337B1 (en) *	2006-09-20	2015-07-22	Mycartis N.V.	Coating for microcarriers
KR100938491B1 (ko)	2007-10-24	2010-01-25	한국생명공학연구원	생체분자 표지용 수용성 광변색 화합물 및 이를 이용한생체분자의 검출방법
WO2009136309A2 (en) *	2008-05-06	2009-11-12	Koninklijke Philips Electronics N.V.	Illumination system and method for processing light
JP5535237B2 (ja) *	2008-12-23	2014-07-02	ビオカルティソシエテアノニム	アッセイ装置および生物学的アッセイを行う方法
US8932811B2 (en)	2009-02-27	2015-01-13	Koninklijke Philips N.V.	Genomic selection and sequencing using encoded microcarriers
CN101543755B (zh) *	2009-04-01	2011-07-27	中国科学院苏州纳米技术与纳米仿生研究所	编码微球的制备方法
EP2426214A1 (en)	2010-09-01	2012-03-07	Koninklijke Philips Electronics N.V.	Method for amplifying nucleic acids
CN102147872A (zh) *	2011-01-05	2011-08-10	东南大学	一种微载体的编码方法
EP2484447A1 (en)	2011-02-07	2012-08-08	Biocartis SA	Improved encoded microcarriers, assay system using them and method for performing an assay
CN102279261B (zh) *	2011-06-20	2013-09-18	东南大学	一种图案编码微载体的喷墨打印制备方法
EP2685262A1 (en)	2012-07-11	2014-01-15	Biocartis SA	Method and device for performing biological and/or chemical assays
EP2684605A1 (en)	2012-07-11	2014-01-15	Biocartis SA	Method for injecting microparticles into a microfluidic channel
EP2690057A1 (en)	2012-07-24	2014-01-29	Biocartis SA	Method for producing structured microcarriers
EP2690058A1 (en)	2012-07-24	2014-01-29	Biocartis SA	Method for producing microcarriers and for performing biological assays
EP2690059A1 (en) *	2012-07-24	2014-01-29	Biocartis SA	Method for producing microcarriers
TWI737614B (zh)	2015-06-11	2021-09-01	博錸生技股份有限公司	已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件
US10436776B2 (en)	2015-11-20	2019-10-08	Plexbio Co., Ltd.	Methods and systems for selection of detection area
US10019815B2 (en)	2016-03-17	2018-07-10	Plexbio Co., Ltd.	Methods and systems for image differentiated multiplex assays
JP7062002B2 (ja)	2016-09-16	2022-05-02	プレックスバイオカンパニー，リミテッド	マルチプレックスアッセイの方法及びシステム
US10894975B2 (en)	2016-12-09	2021-01-19	Plexbio Co., Ltd.	Image differentiated multiplex assays for multiplex detection of DNA mutations

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3786237A (en) *	1972-03-13	1974-01-15	R Postal	Mechanically readable system using premarked substrate
US4390452A (en) *	1979-08-20	1983-06-28	Minnesota Mining & Manufacturing Company	Microparticles with visual identifying means
JP2690297B2 (ja) *	1985-08-05	1997-12-10	東レ株式会社	有用たん白質の産生方法
US6248319B1 (en)	1989-10-16	2001-06-19	Krisztina M. Zsebo	Method for increasing hematopoietic progenitor cells by stem cell factor polypeptides
US5129974A (en) *	1990-08-23	1992-07-14	Colorcode Unlimited Corporation	Microlabelling system and method of making thin labels
WO1994008314A1 (en) *	1992-09-28	1994-04-14	Olympus Optical Co., Ltd.	Dot code and information recording/reproducing system for recording/reproducing dot code
US5565324A (en)	1992-10-01	1996-10-15	The Trustees Of Columbia University In The City Of New York	Complex combinatorial chemical libraries encoded with tags
US5721099A (en) *	1992-10-01	1998-02-24	Trustees Of Columbia University In The City Of New York	Complex combinatorial chemical libraries encoded with tags
US5492222A (en) *	1994-04-13	1996-02-20	Illinois Tool Works Inc.	Bar code blocking carrier
GB2289150B (en)	1994-04-25	1998-07-15	Univ Hertfordshire	Coded items for labelling objects
US6329139B1 (en) *	1995-04-25	2001-12-11	Discovery Partners International	Automated sorting system for matrices with memory
CN1181720A (zh) *	1995-04-25	1998-05-13	伊萝莉公司	可远程编程的存储器材料及其应用
US5961923A (en)	1995-04-25	1999-10-05	Irori	Matrices with memories and uses thereof
US5751629A (en)	1995-04-25	1998-05-12	Irori	Remotely programmable matrices with memories
GB9521943D0 (en)	1995-10-26	1996-01-03	Univ Hertfordshire	Coded particles for process sequence tracking in combinatorial compound library preparation
WO1997020074A1 (en) *	1995-11-30	1997-06-05	Wlodek Mandecki	Electronically-solid-phase assay biomolecules
US5736332A (en)	1995-11-30	1998-04-07	Mandecki; Wlodek	Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
US5838361A (en) *	1996-01-11	1998-11-17	Micron Technology, Inc.	Laser marking techniques
US6023540A (en)	1997-03-14	2000-02-08	Trustees Of Tufts College	Fiber optic sensor with encoded microspheres
JP4302780B2 (ja)	1997-05-23	2009-07-29	バイオアレイソリューションズエルエルシー	マトリックスで結合された化合物の色別コード化とインシトゥ探索
US20020084329A1 (en)	1997-07-16	2002-07-04	Kaye Paul H.	Coded items for labeling objects
US7115884B1 (en)	1997-10-06	2006-10-03	Trustees Of Tufts College	Self-encoding fiber optic sensor
US6168913B1 (en)	1997-10-14	2001-01-02	Abbott Laboratories	Coding combinatorial libraries with fluorine tags
JP4357112B2 (ja)	1997-10-14	2009-11-04	ルミネックスコーポレイション	精密蛍光染色された粒子及びその製造及び使用方法
AUPP032897A0 (en)	1997-11-12	1997-12-04	University Of Queensland, The	Oligomer libraries
JP3468750B2 (ja)	1998-01-22	2003-11-17	ルミネックスコーポレイション	多数の蛍光シグナルを有する微小粒子
US6844170B1 (en)	1998-03-19	2005-01-18	Human Genome Sciences, Inc.	Cytokine receptor common gamma chain like
US6214618B1 (en)	1998-04-07	2001-04-10	Solohill Engineering, Inc.	Microcarrier beads having a styrene copolymer core and a covalently linked tri-methylamine exterior
GB9820163D0 (en) *	1998-09-17	1998-11-11	Sentec Ltd	Micro-fabricated coded labels, reading systems and their applications
US6908737B2 (en) *	1999-04-15	2005-06-21	Vitra Bioscience, Inc.	Systems and methods of conducting multiplexed experiments
TWI220927B (en) *	2000-05-12	2004-09-11	Rong-Seng Chang	Method for producing a micro-carrier
RU2285265C2 (ru) *	2000-10-19	2006-10-10	Тиботек Бвба	Способ и устройство манипулирования микроносителями для их идентификации
US6365312B1 (en) *	2001-05-24	2002-04-02	Xerox Corporation	Marking particles
US7350711B2 (en) *	2006-02-28	2008-04-01	Symbol Technologies, Inc.	Ambient light shield and color filter for imaging-based bar code reader

2000
- 2000-04-12 CN CNB008090157A patent/CN1271410C/zh not_active Expired - Lifetime
- 2000-04-12 NZ NZ515214A patent/NZ515214A/xx not_active IP Right Cessation
- 2000-04-12 CA CA002370315A patent/CA2370315C/en not_active Expired - Lifetime
- 2000-04-12 EP EP00922629A patent/EP1173760B1/en not_active Expired - Lifetime
- 2000-04-12 RU RU2001130889/04A patent/RU2242746C2/ru active
- 2000-04-12 HU HU0200802A patent/HU227484B1/hu unknown
- 2000-04-12 CZ CZ20013706A patent/CZ301174B6/cs not_active IP Right Cessation
- 2000-04-12 US US09/958,655 patent/US8939376B1/en not_active Expired - Fee Related
- 2000-04-12 PL PL351793A patent/PL209100B1/pl unknown
- 2000-04-12 WO PCT/EP2000/003280 patent/WO2000063695A1/en active IP Right Grant
- 2000-04-12 JP JP2000612749A patent/JP4500455B2/ja not_active Expired - Lifetime
- 2000-04-12 DE DE60021070T patent/DE60021070T2/de not_active Expired - Lifetime
- 2000-04-12 IL IL14597000A patent/IL145970A0/xx active IP Right Grant
- 2000-04-12 DK DK00922629T patent/DK1173760T3/da active
- 2000-04-12 KR KR1020017012934A patent/KR100660600B1/ko active IP Right Grant
- 2000-04-12 AT AT00922629T patent/ATE298888T1/de not_active IP Right Cessation
- 2000-04-12 AU AU42952/00A patent/AU771517B2/en not_active Expired
- 2000-04-12 SK SK1445-2001A patent/SK287052B6/sk not_active IP Right Cessation
- 2000-04-14 AR ARP000101747A patent/AR023504A1/es active IP Right Grant
- 2000-04-14 TW TW089106948A patent/TWI249033B/zh not_active IP Right Cessation
- 2000-04-14 MY MYPI20001599A patent/MY132268A/en unknown
2001
- 2001-10-09 ZA ZA200108305A patent/ZA200108305B/xx unknown
- 2001-10-15 NO NO20015019A patent/NO329706B1/no not_active IP Right Cessation
- 2001-10-16 IL IL145970A patent/IL145970A/en not_active IP Right Cessation
2005
- 2005-12-27 US US11/319,153 patent/US20060097056A1/en not_active Abandoned
2014
- 2014-03-25 US US14/224,338 patent/US8967483B2/en not_active Expired - Fee Related
- 2014-10-31 US US14/529,589 patent/US20150057190A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60021070D1 (de)	2005-08-04
DE60021070T2 (de)	2006-04-20
TWI249033B (en)	2006-02-11
NZ515214A (en)	2003-06-30
HUP0200802A2 (en)	2002-06-29
CN1271410C (zh)	2006-08-23
AU4295200A (en)	2000-11-02
US8939376B1 (en)	2015-01-27
HU227484B1 (en)	2011-07-28
WO2000063695A1 (en)	2000-10-26
ATE298888T1 (de)	2005-07-15
CA2370315C (en)	2007-07-24
US20140206569A1 (en)	2014-07-24
AU771517B2 (en)	2004-03-25
CA2370315A1 (en)	2000-10-26
US20060097056A1 (en)	2006-05-11
PL351793A1 (en)	2003-06-16
SK14452001A3 (sk)	2002-10-08
AR023504A1 (es)	2002-09-04
US8967483B2 (en)	2015-03-03
NO20015019L (no)	2001-12-14
ZA200108305B (en)	2003-03-26
EP1173760B1 (en)	2005-06-29
DK1173760T3 (da)	2005-10-17
SK287052B6 (sk)	2009-10-07
JP4500455B2 (ja)	2010-07-14
CZ301174B6 (cs)	2009-11-25
KR100660600B1 (ko)	2006-12-22
KR20020021784A (ko)	2002-03-22
JP2002542484A (ja)	2002-12-10
CZ20013706A3 (cs)	2002-07-17
EP1173760A1 (en)	2002-01-23
IL145970A0 (en)	2002-07-25
IL145970A (en)	2007-05-15
CN1355883A (zh)	2002-06-26
NO20015019D0 (no)	2001-10-15
US20150057190A1 (en)	2015-02-26
MY132268A (en)	2007-09-28
RU2242746C2 (ru)	2004-12-20
PL209100B1 (pl)	2011-07-29
HUP0200802A3 (en)	2010-01-28

Legal Events

Date	Code	Title	Description
2014-11-24	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: MYCARTIS NV, BE
2020-05-11	MK1K	Patent expired

Publication	Publication Date	Title
US8967483B2 (en)	2015-03-03	Encoding of microcarriers
Braeckmans et al.	2002	Encoding microcarriers: present and future technologies
US6391562B2 (en)	2002-05-21	DNA probe array
RU2285265C2 (ru)	2006-10-10	Способ и устройство манипулирования микроносителями для их идентификации
US7499806B2 (en)	2009-03-03	Image processing in microsphere arrays
JP4583923B2 (ja)	2010-11-17	生体分子基板ならびにそれを利用した検査および診断の方法および装置
JP4477085B2 (ja)	2010-06-09	生物学的および生化学的サンプルの蛍光測定用低バックグラウンドマルチウェルプレート
US20030036096A1 (en)	2003-02-20	Chemical-library composition and method
JP2009080119A6 (ja)	2009-07-09	生物学的および生化学的サンプルの蛍光測定用低バックグラウンドマルチウェルプレート
US20100075859A1 (en)	2010-03-25	System and method for solution based multiparameter analysis of analytes
JP6925265B2 (ja)	2021-08-25	光ファイバーアレイ走査技術による親和性試薬および触媒の発見本発明は、ＳｐａｃｅａｎｄＮａｖａｌＷａｒｆａｒｅＳｙｓｔｅｍｓＣｏｍｍａｎｄＳｙｓｔｅｍｓＣｅｎｔｅｒＰａｃｉｆｉｃから授与された契約番号Ｎ６６００１−１４−Ｃ−４０５９に基づく国庫補助でなされたものである。政府は、本発明に関してある権利を有する。
JP2003185663A (ja)	2003-07-03	Ｄｎａプローブアレー製造方法、製造装置
JP2005345186A (ja)	2005-12-15	キャピラリービーズアレイ及び生体高分子の検出及び測定方法