NO326247B1 - Fremgangsmate for fremstilling av modent insulin eller et modent insulin derivat. - Google Patents

Fremgangsmate for fremstilling av modent insulin eller et modent insulin derivat. Download PDF

Info

Publication number: NO326247B1
Authority: NO; Norway
Prior art keywords: carboxypeptidase; precursor form; natural; isoform; sequence
Prior art date: 1999-04-09

Application number

NO20014815A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014815L (no

NO20014815D0 (no

Inventor

Paul Habermann

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2001-10-03

Publication date

2008-10-27

2001-10-03 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2001-10-03 Publication of NO20014815D0 publication Critical patent/NO20014815D0/no

2001-11-20 Publication of NO20014815L publication Critical patent/NO20014815L/no

2008-10-27 Publication of NO326247B1 publication Critical patent/NO326247B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 31
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims description 48
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO20014815A 1999-04-09 2001-10-03 Fremgangsmate for fremstilling av modent insulin eller et modent insulin derivat. NO326247B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19915938A DE19915938A1 (de)	1999-04-09	1999-04-09	Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
PCT/EP2000/002571 WO2000061727A2 (de)	1999-04-09	2000-03-23	Herstellung von pankreatischer procarboxypeptidase b, isoformen und muteinen davon und ihre verwendung

Publications (3)

Publication Number	Publication Date
NO20014815D0 NO20014815D0 (no)	2001-10-03
NO20014815L NO20014815L (no)	2001-11-20
NO326247B1 true NO326247B1 (no)	2008-10-27

Family

ID=7903951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014815A NO326247B1 (no)	1999-04-09	2001-10-03	Fremgangsmate for fremstilling av modent insulin eller et modent insulin derivat.

Country Status (17)

Country	Link
US (1)	US6531294B1 (zh)
EP (1)	EP1169461B1 (zh)
JP (1)	JP2002541793A (zh)
KR (1)	KR100714116B1 (zh)
CN (1)	CN100362105C (zh)
AT (1)	ATE341630T1 (zh)
AU (1)	AU777408B2 (zh)
BR (1)	BR0009636B1 (zh)
CA (1)	CA2369973C (zh)
DE (2)	DE19915938A1 (zh)
ES (1)	ES2270827T3 (zh)
HK (1)	HK1044566B (zh)
IL (2)	IL145646A0 (zh)
NO (1)	NO326247B1 (zh)
NZ (1)	NZ514657A (zh)
WO (1)	WO2000061727A2 (zh)
ZA (1)	ZA200108241B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7291587B2 (en)	2001-11-09	2007-11-06	Novo Nordisk Healthcare A/G	Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides
DE602004025192D1 (de) *	2003-12-05	2010-03-11	Roche Diagnostics Gmbh	Rekombinante Carboxypeptidase B und ihre Aufreinigung
EP1538203B1 (en) *	2003-12-05	2010-01-20	Roche Diagnostics GmbH	Recombinantly expressed carboxypeptidase B and purification thereof
ATE517181T1 (de) *	2004-09-27	2011-08-15	Sanofi Aventis Deutschland	Rekombinante carboxypeptidase b
WO2008062010A2 (en) *	2006-11-22	2008-05-29	Novo Nordisk A/S	Method for making activated carboxypeptidases
CN101058805B (zh) *	2007-03-21	2011-09-07	北京贯虹科技有限公司	突变羧肽酶原b及突变羧肽酶b的生产方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2061797T3 (es) *	1988-06-23	1994-12-16	Hoechst Ag	Mini-proinsulina, su preparacion y empleo.
IL95495A (en)	1989-08-29	1996-10-16	Hoechst Ag	Fusion proteins their preparation and use
KR960013134B1 (ko) *	1989-10-31	1996-09-30	쉐링 코포레이션	분비성 이.콜라이 균주, 이에 대한 플라스미드, 이의 제조 및 동정 방법 및 이를 이용하여 이질성 단백질을 제조하는 방법.
DE4009268A1 (de)	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten
FI103805B1 (fi) *	1990-09-05	1999-09-30	Hoechst Ag	Menetelmä preproinsuliinien hydroloimiseksi
DE4136389A1 (de)	1991-03-18	1992-10-08	Hoechst Ag	Verfahren zur herstellung von glutarylacylase in grossen mengen
CA2175834A1 (en)	1993-11-16	1995-05-26	Jeffrey Tobin Fayerman	Dna sequences encoding porcine pancreatic carboxypeptidase b
US5658755A (en)	1994-07-15	1997-08-19	Eli Lilly And Company	Method for extra-cellular expression of protein
IL116696A (en)	1995-01-25	1999-08-17	Bio Technology General Corp	Production of enzymatically active recombinant carboxypeptidase b

1999
- 1999-04-09 DE DE19915938A patent/DE19915938A1/de not_active Ceased
2000
- 2000-03-22 US US09/532,730 patent/US6531294B1/en not_active Expired - Lifetime
- 2000-03-23 CN CNB008060800A patent/CN100362105C/zh not_active Expired - Fee Related
- 2000-03-23 AU AU45394/00A patent/AU777408B2/en not_active Ceased
- 2000-03-23 CA CA2369973A patent/CA2369973C/en not_active Expired - Lifetime
- 2000-03-23 DE DE50013563T patent/DE50013563D1/de not_active Expired - Lifetime
- 2000-03-23 JP JP2000611652A patent/JP2002541793A/ja active Pending
- 2000-03-23 IL IL14564600A patent/IL145646A0/xx active IP Right Grant
- 2000-03-23 NZ NZ514657A patent/NZ514657A/en not_active IP Right Cessation
- 2000-03-23 KR KR1020017012888A patent/KR100714116B1/ko not_active IP Right Cessation
- 2000-03-23 ES ES00926751T patent/ES2270827T3/es not_active Expired - Lifetime
- 2000-03-23 BR BRPI0009636-9A patent/BR0009636B1/pt not_active IP Right Cessation
- 2000-03-23 AT AT00926751T patent/ATE341630T1/de active
- 2000-03-23 WO PCT/EP2000/002571 patent/WO2000061727A2/de active IP Right Grant
- 2000-03-23 EP EP00926751A patent/EP1169461B1/de not_active Expired - Lifetime
2001
- 2001-09-25 IL IL145646A patent/IL145646A/en not_active IP Right Cessation
- 2001-10-03 NO NO20014815A patent/NO326247B1/no not_active IP Right Cessation
- 2001-10-08 ZA ZA200108241A patent/ZA200108241B/xx unknown
2002
- 2002-08-22 HK HK02106158.3A patent/HK1044566B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2270827T3 (es)	2007-04-16
JP2002541793A (ja)	2002-12-10
WO2000061727A2 (de)	2000-10-19
HK1044566A1 (en)	2002-10-25
ATE341630T1 (de)	2006-10-15
NZ514657A (en)	2003-11-28
KR20010109348A (ko)	2001-12-08
NO20014815L (no)	2001-11-20
EP1169461A2 (de)	2002-01-09
CN100362105C (zh)	2008-01-16
IL145646A0 (en)	2002-06-30
AU777408B2 (en)	2004-10-14
NO20014815D0 (no)	2001-10-03
DE19915938A1 (de)	2000-10-19
ZA200108241B (en)	2002-11-27
KR100714116B1 (ko)	2007-05-07
WO2000061727A3 (de)	2001-02-01
CA2369973C (en)	2011-09-27
BR0009636A (pt)	2002-01-08
IL145646A (en)	2008-03-20
HK1044566B (zh)	2008-08-01
BR0009636B1 (pt)	2010-11-16
CA2369973A1 (en)	2000-10-19
AU4539400A (en)	2000-11-14
US6531294B1 (en)	2003-03-11
DE50013563D1 (de)	2006-11-16
EP1169461B1 (de)	2006-10-04
CN1346407A (zh)	2002-04-24

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2019-10-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
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