NO313754B1 - Endothelin-reseptor-antagonister, anvendelse og fremstilling derav samt farmasöytiske preparater - Google Patents

Endothelin-reseptor-antagonister, anvendelse og fremstilling derav samt farmasöytiske preparater Download PDF

Info

Publication number: NO313754B1
Authority: NO; Norway
Prior art keywords: allar; yloxy; prop; alkyl; mmol
Prior art date: 1993-04-27

Application number

NO19954291A

Other languages

English (en)

Norwegian (no)

Other versions

NO954291L (no

NO954291D0 (no

Inventor

Russell Donovan Cousins

John Duncan Elliott

Maria Amparo Lago

Jack Dale Leber

Catherine Elizabeth Peishoff

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-27

Filing date

1995-10-26

Publication date

2002-11-25

1995-10-26 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1995-10-26 Publication of NO954291D0 publication Critical patent/NO954291D0/no

1995-12-21 Publication of NO954291L publication Critical patent/NO954291L/no

2002-11-25 Publication of NO313754B1 publication Critical patent/NO313754B1/no

Links

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-1 (+)(1 S, 2R, 3S)-3-[2-(2-hydroxyethyl-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy )indane-2-carboxylic acid Chemical class 0.000 claims description 12
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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NO19954291A 1993-04-27 1995-10-26 Endothelin-reseptor-antagonister, anvendelse og fremstilling derav samt farmasöytiske preparater NO313754B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6681893A	1993-04-27	1993-04-27
PCT/US1994/004603 WO1994025013A1 (en)	1993-04-27	1994-04-26	Endothelin receptor antagonists

Publications (3)

Publication Number	Publication Date
NO954291D0 NO954291D0 (no)	1995-10-26
NO954291L NO954291L (no)	1995-12-21
NO313754B1 true NO313754B1 (no)	2002-11-25

Family

ID=22071916

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19954291A NO313754B1 (no)	1993-04-27	1995-10-26	Endothelin-reseptor-antagonister, anvendelse og fremstilling derav samt farmasöytiske preparater

Country Status (29)

Country	Link
EP (1)	EP0699069B9 (cs)
JP (1)	JP3346571B2 (cs)
KR (1)	KR100331667B1 (cs)
CN (1)	CN1129428C (cs)
AP (1)	AP573A (cs)
AT (1)	ATE213156T1 (cs)
AU (1)	AU682038B2 (cs)
BR (1)	BR9406572A (cs)
CA (1)	CA2160914A1 (cs)
CZ (1)	CZ291189B6 (cs)
DE (1)	DE69429861T2 (cs)
DK (1)	DK0699069T3 (cs)
DZ (1)	DZ1773A1 (cs)
ES (1)	ES2172535T3 (cs)
FI (1)	FI955103A (cs)
HK (1)	HK1012252A1 (cs)
HU (2)	HUT73763A (cs)
IL (1)	IL109443A0 (cs)
MA (1)	MA23172A1 (cs)
NO (1)	NO313754B1 (cs)
NZ (1)	NZ266314A (cs)
PL (1)	PL175392B1 (cs)
PT (1)	PT699069E (cs)
RU (1)	RU2130920C1 (cs)
SG (1)	SG49667A1 (cs)
SI (1)	SI9400195B (cs)
SK (1)	SK130595A3 (cs)
TW (1)	TW330204B (cs)
WO (1)	WO1994025013A1 (cs)

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EP0763035A4 (en) *	1994-06-09	1997-10-01	Smithkline Beecham Corp	ENDOTHELIN RECEPTOR ANTAGONISTS
EP0768878A4 (en) *	1994-06-20	1999-02-17	Smithkline Beecham Corp	ENDOTHELINE RECEPTOR ANTAGONISTS
JPH10512855A (ja) *	1994-12-23	1998-12-08	スミスクライン・ビーチャム・コーポレイション	化合物および方法
ZA969363B (en) *	1995-11-08	1997-11-18	Smithkline Beecham Corp	An improved process for preparing aromatic ring-fused cyclopentane derivatives.
US6080862A (en) *	1995-11-08	2000-06-27	Smithkline Beecham Corporation	Stereoselective synthesis of endothelin receptor antagonists
CA2236924A1 (en) *	1995-11-08	1997-05-15	Smithkline Beecham Corporation	Stereoselective synthesis of endothelin receptor antagonists
US6162932A (en) *	1995-11-08	2000-12-19	Smithkline Beecham Corporation	Stereoselective synthesis of endothelin receptor antagonists
US5977117A (en) *	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5932553A (en)	1996-07-18	1999-08-03	The Regents Of The University Of California	Illudin analogs useful as antitumor agents
US5723632A (en)	1996-08-08	1998-03-03	Mgi Pharma, Inc.	Total synthesis of antitumor acylfulvenes
KR100343832B1 (ko)	1996-08-27	2002-07-20	시오노기세이야쿠가부시키가이샤	크로멘-3-카르복실산 유도체
US5929106A (en) *	1997-10-27	1999-07-27	Smithkline Beecham Corporation	Endothelin receptor antagonists
US7141603B2 (en)	1999-02-19	2006-11-28	The Regents Of The University California	Antitumor agents
US6025328A (en)	1998-02-20	2000-02-15	The Regents Of The University Of California	Antitumor agents
US6410554B1 (en)	1998-03-23	2002-06-25	Merck & Co., Inc.	Combination therapy for the treatment of benign prostatic hyperplasia
ATE244214T1 (de) *	1998-04-09	2003-07-15	Merck & Co Inc	Phosphat-vermittelte cyclisierung
AR022228A1 (es)	1999-01-12	2002-09-04	Abbott Gmbh & Co Kg	Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
TW200605867A (en)	2004-03-17	2006-02-16	Novartis Ag	Use of organic compounds
US7423176B2 (en)	2004-04-13	2008-09-09	Cephalon, Inc.	Bicyclic aromatic sulfinyl derivatives
AU2005318598B2 (en)	2004-12-21	2010-08-26	F. Hoffmann-La Roche Ag	Tetralin and indane derivatives and uses thereof as 5-HT antagonists
US20100040666A1 (en) *	2005-06-24	2010-02-18	Hiroshi Azuma	Method for Control of Drug Elution Rate and Composition for Coating of Drug-Eluting Stent
JP4989648B2 (ja)	2005-08-03	2012-08-01	ザリージェンツオブザユニバーシティオブカリフォルニア	抗癌剤として有用なイルジン類似体

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL176250B1 (pl) *	1991-11-05	1999-05-31	Smithkline Beecham Corp	Sposób wytwarzania pochodnych indanu

1994
- 1994-04-26 BR BR9406572A patent/BR9406572A/pt not_active Application Discontinuation
- 1994-04-26 JP JP52449694A patent/JP3346571B2/ja not_active Expired - Fee Related
- 1994-04-26 PL PL94311272A patent/PL175392B1/pl unknown
- 1994-04-26 NZ NZ266314A patent/NZ266314A/xx not_active IP Right Cessation
- 1994-04-26 HU HU9501931A patent/HUT73763A/hu unknown
- 1994-04-26 DZ DZ940038A patent/DZ1773A1/fr active
- 1994-04-26 SK SK1305-95A patent/SK130595A3/sk unknown
- 1994-04-26 HU HU9503067A patent/HU9503067D0/hu unknown
- 1994-04-26 AP APAP/P/1994/000636A patent/AP573A/en active
- 1994-04-26 DK DK94915903T patent/DK0699069T3/da active
- 1994-04-26 KR KR1019950704682A patent/KR100331667B1/ko not_active IP Right Cessation
- 1994-04-26 AU AU67750/94A patent/AU682038B2/en not_active Ceased
- 1994-04-26 WO PCT/US1994/004603 patent/WO1994025013A1/en active IP Right Grant
- 1994-04-26 ES ES94915903T patent/ES2172535T3/es not_active Expired - Lifetime
- 1994-04-26 AT AT94915903T patent/ATE213156T1/de not_active IP Right Cessation
- 1994-04-26 SI SI9400195A patent/SI9400195B/sl not_active IP Right Cessation
- 1994-04-26 EP EP94915903A patent/EP0699069B9/en not_active Expired - Lifetime
- 1994-04-26 RU RU95122388A patent/RU2130920C1/ru active
- 1994-04-26 IL IL10944394A patent/IL109443A0/xx unknown
- 1994-04-26 MA MA23478A patent/MA23172A1/fr unknown
- 1994-04-26 CN CN94192388A patent/CN1129428C/zh not_active Expired - Fee Related
- 1994-04-26 PT PT94915903T patent/PT699069E/pt unknown
- 1994-04-26 DE DE69429861T patent/DE69429861T2/de not_active Expired - Fee Related
- 1994-04-26 CA CA002160914A patent/CA2160914A1/en not_active Abandoned
- 1994-04-26 SG SG1996003492A patent/SG49667A1/en unknown
- 1994-04-26 CZ CZ19952835A patent/CZ291189B6/cs not_active IP Right Cessation
- 1994-07-01 TW TW083106015A patent/TW330204B/zh not_active IP Right Cessation
1995
- 1995-10-26 FI FI955103A patent/FI955103A/fi not_active Application Discontinuation
- 1995-10-26 NO NO19954291A patent/NO313754B1/no unknown
1998
- 1998-12-15 HK HK98113510A patent/HK1012252A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69429861T2 (de)	2002-09-19
HK1012252A1 (en)	1999-07-30
HU9503067D0 (en)	1995-12-28
KR100331667B1 (ko)	2002-11-08
SK130595A3 (en)	1996-06-05
AU6775094A (en)	1994-11-21
ATE213156T1 (de)	2002-02-15
TW330204B (en)	1998-04-21
CZ283595A3 (en)	1996-03-13
JP3346571B2 (ja)	2002-11-18
PL175392B1 (pl)	1998-12-31
CA2160914A1 (en)	1994-11-10
MA23172A1 (fr)	1994-12-31
SI9400195A (en)	1994-12-31
EP0699069A4 (cs)	1996-04-03
CN1124923A (zh)	1996-06-19
AP9400636A0 (en)	1994-04-30
BR9406572A (pt)	1996-01-30
FI955103A0 (fi)	1995-10-26
RU2130920C1 (ru)	1999-05-27
IL109443A0 (en)	1994-07-31
DE69429861D1 (de)	2002-03-21
SI9400195B (sl)	2003-10-31
HUT73763A (en)	1996-09-30
CZ291189B6 (cs)	2003-01-15
SG49667A1 (en)	1998-06-15
DZ1773A1 (fr)	2002-02-17
NZ266314A (en)	1998-10-28
PT699069E (pt)	2002-07-31
EP0699069B9 (en)	2003-10-22
AP573A (en)	1997-01-30
DK0699069T3 (da)	2002-05-27
AU682038B2 (en)	1997-09-18
NO954291L (no)	1995-12-21
PL311272A1 (en)	1996-02-05
ES2172535T3 (es)	2002-10-01
EP0699069B1 (en)	2002-02-13
JPH08510211A (ja)	1996-10-29
NO954291D0 (no)	1995-10-26
CN1129428C (zh)	2003-12-03
WO1994025013A1 (en)	1994-11-10
FI955103A (fi)	1995-10-26
HU9501931D0 (en)	1995-09-28
EP0699069A1 (en)	1996-03-06

Publication	Publication Date	Title
NO313754B1 (no)	2002-11-25	Endothelin-reseptor-antagonister, anvendelse og fremstilling derav samt farmasöytiske preparater
AP433A (en)	1995-11-17	Endothelin receptor antagonistis.
EP0650484B1 (en)	2000-01-26	Endothelin receptor antagonists
US5736564A (en)	1998-04-07	Endothelin receptor antagonists
CA1132983A (fr)	1982-10-05	Procedes de preparation de nouvelles piperazines monosubstituees
EP0723449A1 (en)	1996-07-31	Endothelin receptor antagonists
US5929106A (en)	1999-07-27	Endothelin receptor antagonists
EP0817782B1 (en)	2002-09-25	Phenyl derivatives useful as endothelin receptor antagonists
EP0841916B1 (en)	2003-07-02	Endothelin receptor antagonists
EP0693051B1 (en)	1999-11-03	Cyclopentene and cyclopentane derivatives as endothelin receptor antagonists
WO1995013817A1 (en)	1995-05-26	Endothelin converting enzyme inhibitors
EP0711157A1 (en)	1996-05-15	Endothelin receptor antagonists
US5716985A (en)	1998-02-10	Endothelin receptor antagonists
US5929116A (en)	1999-07-27	Cyclopentene derivatives as endothelin receptor antagonists
JPS58135850A (ja)	1983-08-12	トランス−１−（ベンゼンスルホニルオキシ）−２−シクロヘキシル−２−エタノン誘導体及びこれを含有する抗脂血症剤
GB2202222A (en)	1988-09-21	Fluoroxirane carboxylates