NO313186B1 - Dimer-selektive RXR modulatorer, farmasöytisk preparat omfattende samme og anvendelse derav for fremstilling avmedikament - Google Patents

Dimer-selektive RXR modulatorer, farmasöytisk preparat omfattende samme og anvendelse derav for fremstilling avmedikament Download PDF

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Publication number
NO313186B1
NO313186B1 NO19981501A NO981501A NO313186B1 NO 313186 B1 NO313186 B1 NO 313186B1 NO 19981501 A NO19981501 A NO 19981501A NO 981501 A NO981501 A NO 981501A NO 313186 B1 NO313186 B1 NO 313186B1
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Norway
Prior art keywords
tetramethyl
compound
tetrahydro
acid
benzoic acid
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NO19981501A
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English (en)
Norwegian (no)
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NO981501D0 (no
NO981501L (no
Inventor
Lin Zhang
Alex M Nadzan
Richard A Heyman
Ranjan Mukherjee
Deepak S Lala
Luc J Farmer
Stacie Canan-Koch
Chan Kou Hwang
Marcus F Boehm
Beth Ann Badea
Laura J Dardashti
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Ligand Pharm Inc
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Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of NO981501D0 publication Critical patent/NO981501D0/no
Publication of NO981501L publication Critical patent/NO981501L/no
Publication of NO313186B1 publication Critical patent/NO313186B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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  • Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
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  • Immunology (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
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  • Biomedical Technology (AREA)
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  • Communicable Diseases (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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NO19981501A 1995-10-06 1998-04-02 Dimer-selektive RXR modulatorer, farmasöytisk preparat omfattende samme og anvendelse derav for fremstilling avmedikament NO313186B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US489795P 1995-10-06 1995-10-06
US988496P 1996-01-10 1996-01-10
US1831896P 1996-05-24 1996-05-24
US2183996P 1996-07-10 1996-07-10
PCT/US1996/014876 WO1997012853A1 (en) 1995-10-06 1996-09-17 Dimer-selective rxr modulators and methods for their use

Publications (3)

Publication Number Publication Date
NO981501D0 NO981501D0 (no) 1998-04-02
NO981501L NO981501L (no) 1998-06-02
NO313186B1 true NO313186B1 (no) 2002-08-26

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ID=27485410

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Application Number Title Priority Date Filing Date
NO19981501A NO313186B1 (no) 1995-10-06 1998-04-02 Dimer-selektive RXR modulatorer, farmasöytisk preparat omfattende samme og anvendelse derav for fremstilling avmedikament

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US (2) US6545049B1 (es)
EP (2) EP0873295B1 (es)
JP (1) JP2002515025A (es)
KR (1) KR100625255B1 (es)
AT (1) ATE236115T1 (es)
AU (1) AU726450B2 (es)
BR (1) BR9610875A (es)
CA (1) CA2233888A1 (es)
DE (1) DE69627193T2 (es)
DK (1) DK0873295T3 (es)
ES (1) ES2190479T3 (es)
NO (1) NO313186B1 (es)
PT (1) PT873295E (es)
WO (1) WO1997012853A1 (es)

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US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US7115728B1 (en) * 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
US6028052A (en) 1995-09-18 2000-02-22 Ligand Pharmaceuticals Incorporated Treating NIDDM with RXR agonists
AU725998B2 (en) * 1995-09-18 2000-10-26 Eisai R&D Management Co., Ltd. Treating NIDDM with RXR agonists
US6005007A (en) * 1997-07-18 1999-12-21 Farmer; Luc J. Retinoids, methods for their production and use
WO1999005161A1 (en) * 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
US5998654A (en) * 1997-07-25 1999-12-07 Ligand Pharmaceuticals Incorporated Retinoic acid receptor antagonist compounds and methods
ATE334673T1 (de) * 1997-11-12 2006-08-15 Hoffmann La Roche Behandlung von t-helfer zel typ 2 vermittelten immunkrankheiten mit retinoid antagonisten
JP4204657B2 (ja) * 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤
EP1077920A1 (en) * 1998-05-11 2001-02-28 Novo Nordisk A/S New compounds, their preparation and use
EP1077919A1 (en) * 1998-05-11 2001-02-28 Novo Nordisk A/S New compounds, their preparation and use
JP2003520758A (ja) * 1998-06-12 2003-07-08 リガンド・ファーマシューティカルズ・インコーポレイテッド 抗エストロゲン耐性乳癌のｒｘｒモジュレーターを用いた処置
FR2780512B1 (fr) * 1998-06-25 2003-10-17 Lipha Utilisation de recepteurs de la famille rev-erb pour le criblage de substances utiles dans le traitement des dysfonctionnements du metabolisme lipidique
US6048873A (en) * 1998-10-01 2000-04-11 Allergan Sales, Inc. Tetrahdroquinolin-2-one 6 or 7-yl, tetrahdroquinilin-2-thione 6 or 7-yl pentadienoic acid and related derivatives having retinoid-like biological activity
US6403638B1 (en) 1998-10-01 2002-06-11 Allergan Sales, Inc. 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
US6147224A (en) * 1998-10-01 2000-11-14 Allergan Sales, Inc. 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
WO2000026173A1 (en) * 1998-11-03 2000-05-11 Ligand Pharmaceuticals Incorporated Novel retinoids, methods for their production and use
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