NO311692B1 - Sukkersubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler - Google Patents

Sukkersubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler Download PDF

Info

Publication number: NO311692B1
Authority: NO; Norway
Prior art keywords: phenyl; fluorophenyl; trans; oxo; azetidinyl
Prior art date: 1995-10-31

Application number

NO19981950A

Other languages

English (en)

Norwegian (no)

Other versions

NO981950L (no

NO981950D0 (no

Inventor

Nathan P Yumibe

Kevin B Alton

Margaret Van Heek

Harry R Davis

Wayne D Vaccaro

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-31

Filing date

1998-04-29

Publication date

2002-01-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26677904&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO311692(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-04-29 Application filed by Schering Corp filed Critical Schering Corp

1998-04-29 Publication of NO981950D0 publication Critical patent/NO981950D0/no

1998-06-26 Publication of NO981950L publication Critical patent/NO981950L/no

2002-01-07 Publication of NO311692B1 publication Critical patent/NO311692B1/no

Links

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QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
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REDSKZBUUUQMSK-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC.CCCC[Sn](CCCC)CCCC REDSKZBUUUQMSK-UHFFFAOYSA-N 0.000 description 1
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DFKDOZMCHOGOBR-NCSQYGPNSA-N zaragozic acid A Chemical compound C([C@@H](C)[C@H](OC(C)=O)C(=C)CC[C@]12[C@H](O)[C@H]([C@](O2)(C(O)=O)[C@@](O)([C@H](O1)C(O)=O)C(O)=O)OC(=O)/C=C/[C@@H](C)C[C@@H](C)CC)C1=CC=CC=C1 DFKDOZMCHOGOBR-NCSQYGPNSA-N 0.000 description 1
DFKDOZMCHOGOBR-UHFFFAOYSA-N zaragozic acid A Natural products O1C(C(O)(C(O2)C(O)=O)C(O)=O)(C(O)=O)C(OC(=O)C=CC(C)CC(C)CC)C(O)C21CCC(=C)C(OC(C)=O)C(C)CC1=CC=CC=C1 DFKDOZMCHOGOBR-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

NO19981950A 1995-10-31 1998-04-29 Sukkersubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler NO311692B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US818595P	1995-10-31	1995-10-31
US57084795A	1995-12-12	1995-12-12
PCT/US1996/016823 WO1997016455A1 (en)	1995-10-31	1996-10-29	Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents

Publications (3)

Publication Number	Publication Date
NO981950D0 NO981950D0 (no)	1998-04-29
NO981950L NO981950L (no)	1998-06-26
NO311692B1 true NO311692B1 (no)	2002-01-07

Family

ID=26677904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19981950A NO311692B1 (no)	1995-10-31	1998-04-29	Sukkersubstituerte 2-azetidinoner som er anvendbare som hypokolesterolemiske midler

Country Status (28)

Country	Link
EP (1)	EP0877750B1 (es)
JP (2)	JP3385031B2 (es)
KR (1)	KR100311554B1 (es)
CN (1)	CN1103780C (es)
AR (1)	AR004701A1 (es)
AT (1)	ATE219495T1 (es)
AU (1)	AU712158B2 (es)
BR (2)	BR9611401B1 (es)
CA (1)	CA2235943C (es)
CY (1)	CY2353B1 (es)
CZ (1)	CZ293957B6 (es)
DE (1)	DE69621952T2 (es)
DK (1)	DK0877750T3 (es)
ES (1)	ES2175141T3 (es)
GE (1)	GEP20033006B (es)
HK (1)	HK1012507A1 (es)
HU (1)	HU226822B1 (es)
ID (1)	ID16177A (es)
IL (1)	IL124268A (es)
MX (1)	MX9803447A (es)
MY (1)	MY114803A (es)
NO (1)	NO311692B1 (es)
NZ (1)	NZ321766A (es)
PL (1)	PL184698B1 (es)
PT (1)	PT877750E (es)
SK (1)	SK283552B6 (es)
TW (1)	TW448181B (es)
WO (1)	WO1997016455A1 (es)

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DE10042447A1 (de) *	2000-08-29	2002-03-28	Aventis Pharma Gmbh	Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
DK1347987T3 (da) *	2000-12-20	2005-01-31	Schering Corp	Sukkersubstituerede 2-azetidinoner, der er anvendelige som hypocholesterolæmiske midler
EP1510521A1 (en) *	2000-12-20	2005-03-02	Schering Corporation	Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
KR100833089B1 (ko) *	2000-12-21	2008-05-29	사노피-아벤티스 도이칠란트 게엠베하	신규한 1,2-디페닐아제티딘온 및 당해 화합물을 함유하는 지질 대사 장애를 치료하기 위한 약제학적 조성물
PL205343B1 (pl) *	2001-01-26	2010-04-30	Schering Corp	Zastosowanie inhibitora wchłaniania sterolu
AU2005246926B2 (en) *	2001-01-26	2008-02-28	Merck Sharp & Dohme Corp.	The use of substituted azetidinone compounds for the treatment of sitosterolemia
PT1353694E (pt) *	2001-01-26	2008-03-12	Schering Corp	Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares
TWI291957B (en) *	2001-02-23	2008-01-01	Kotobuki Pharmaceutical Co Ltd	Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
CN1275949C (zh)	2001-03-28	2006-09-20	先灵公司	2－吖丁啶酮中间体化合物的对映体选择性合成
ES2272776T3 (es) *	2001-09-21	2007-05-01	Schering Corporation	Tratamiento de xantomas con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7176193B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en)	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
DE10227506A1 (de) *	2002-06-19	2004-01-08	Aventis Pharma Deutschland Gmbh	Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7671047B2 (en)	2002-06-19	2010-03-02	Sanofi-Aventis Deutschland Gmbh	Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
AR041089A1 (es)	2003-05-15	2005-05-04	Merck & Co Inc	Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP2005015434A (ja)	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) *	2003-10-07	2005-04-13	Lipideon Biotechnology AG	Novel hypocholesterolemic compounds
EP1682117A1 (en) *	2003-10-30	2006-07-26	Merck & Co., Inc.	2-azetidinones as anti-hypercholesterolemic agents
DE602004029715D1 (de)	2003-12-23	2010-12-02	Astrazeneca Ab	Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US20080194494A1 (en) *	2005-04-26	2008-08-14	Microbia, Inc.	4-Biarylyl-1-Phenylazetidin-2-One Glucuronide Derivatives for Hypercholesterolemia
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
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1996
- 1996-10-29 DK DK96937702T patent/DK0877750T3/da active
- 1996-10-29 AT AT96937702T patent/ATE219495T1/de active
- 1996-10-29 BR BRPI9611401-0A patent/BR9611401B1/pt not_active IP Right Cessation
- 1996-10-29 CN CN96199226A patent/CN1103780C/zh not_active Expired - Lifetime
- 1996-10-29 NZ NZ321766A patent/NZ321766A/xx not_active IP Right Cessation
- 1996-10-29 PL PL96327987A patent/PL184698B1/pl not_active IP Right Cessation
- 1996-10-29 PT PT96937702T patent/PT877750E/pt unknown
- 1996-10-29 GE GEAP19966589A patent/GEP20033006B/en unknown
- 1996-10-29 EP EP96937702A patent/EP0877750B1/en not_active Expired - Lifetime
- 1996-10-29 MY MYPI96004488A patent/MY114803A/en unknown
- 1996-10-29 ES ES96937702T patent/ES2175141T3/es not_active Expired - Lifetime
- 1996-10-29 JP JP51738697A patent/JP3385031B2/ja not_active Expired - Fee Related
- 1996-10-29 KR KR1019980703155A patent/KR100311554B1/ko not_active IP Right Cessation
- 1996-10-29 WO PCT/US1996/016823 patent/WO1997016455A1/en active IP Right Grant
- 1996-10-29 BR BRPI9612998-0A patent/BR9612998B1/pt not_active IP Right Cessation
- 1996-10-29 AU AU75179/96A patent/AU712158B2/en not_active Ceased
- 1996-10-29 DE DE69621952T patent/DE69621952T2/de not_active Expired - Lifetime
- 1996-10-29 IL IL12426896A patent/IL124268A/xx not_active IP Right Cessation
- 1996-10-29 HU HU9802539A patent/HU226822B1/hu unknown
- 1996-10-29 TW TW085113142A patent/TW448181B/zh not_active IP Right Cessation
- 1996-10-29 CA CA002235943A patent/CA2235943C/en not_active Expired - Lifetime
- 1996-10-29 SK SK483-98A patent/SK283552B6/sk not_active IP Right Cessation
- 1996-10-29 AR ARP960104954A patent/AR004701A1/es not_active Application Discontinuation
- 1996-10-29 CZ CZ19981294A patent/CZ293957B6/cs not_active IP Right Cessation
- 1996-10-30 ID IDP963136A patent/ID16177A/id unknown
1998
- 1998-04-29 NO NO19981950A patent/NO311692B1/no not_active IP Right Cessation
- 1998-04-30 MX MX9803447A patent/MX9803447A/es unknown
- 1998-12-18 HK HK98114029A patent/HK1012507A1/xx unknown
2000
- 2000-07-17 JP JP2000216704A patent/JP2001048895A/ja not_active Withdrawn
2003
- 2003-01-29 CY CY0300007A patent/CY2353B1/xx unknown

Also Published As

Publication number	Publication date
HUP9802539A2 (hu)	1998-11-30
DE69621952D1 (de)	2002-07-25
MY114803A (en)	2003-01-31
HK1012507A1 (en)	1999-08-06
GEP20033006B (en)	2003-07-10
JPH10512592A (ja)	1998-12-02
DE69621952T2 (de)	2003-01-16
ES2175141T3 (es)	2002-11-16
CA2235943A1 (en)	1997-05-09
BR9612998B1 (pt)	2010-03-23
NO981950L (no)	1998-06-26
EP0877750A1 (en)	1998-11-18
CZ129498A3 (cs)	1998-10-14
PL327987A1 (en)	1999-01-04
CN1103780C (zh)	2003-03-26
MX9803447A (es)	1998-09-30
WO1997016455A1 (en)	1997-05-09
AU7517996A (en)	1997-05-22
CY2353B1 (en)	2004-06-04
ID16177A (id)	1997-09-11
JP3385031B2 (ja)	2003-03-10
CN1205707A (zh)	1999-01-20
HUP9802539A3 (en)	1999-12-28
HU226822B1 (en)	2009-11-30
BR9611401A (pt)	1999-01-05
PL184698B1 (pl)	2002-12-31
BR9611401B1 (pt)	2010-08-10
JP2001048895A (ja)	2001-02-20
AR004701A1 (es)	1999-03-10
NO981950D0 (no)	1998-04-29
KR100311554B1 (ko)	2002-06-20
DK0877750T3 (da)	2002-07-15
ATE219495T1 (de)	2002-07-15
CA2235943C (en)	2002-10-01
KR19990067202A (ko)	1999-08-16
EP0877750B1 (en)	2002-06-19
CZ293957B6 (cs)	2004-08-18
PT877750E (pt)	2002-09-30
SK283552B6 (sk)	2003-09-11
SK48398A3 (en)	1998-11-04
NZ321766A (en)	1999-07-29
IL124268A (en)	2005-08-31
AU712158B2 (en)	1999-10-28
TW448181B (en)	2001-08-01

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2012-09-24

CHAD

Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: MERCK SHARP AND DOHME CORP

Free format text: NEW ADDRESS: 126 EAST LINCOLN AVENUE, US-NJ07065 RAHWAY, US

2015-05-26

MM1K

Lapsed by not paying the annual fees

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US6982251B2 (en)	2006-01-03	Substituted 2-azetidinones useful as hypocholesterolemic agents
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