NO311112B1 - Fremgangsmåte for påvisning av en analytt i en pröve, et utstyrsett for denne, fremgangsmåte for fremstilling avsuperaggregat kompleks av et protein og en gull sol og etsuperaggregert kompleks - Google Patents
Fremgangsmåte for påvisning av en analytt i en pröve, et utstyrsett for denne, fremgangsmåte for fremstilling avsuperaggregat kompleks av et protein og en gull sol og etsuperaggregert kompleks Download PDFInfo
- Publication number
- NO311112B1 NO311112B1 NO19932320A NO932320A NO311112B1 NO 311112 B1 NO311112 B1 NO 311112B1 NO 19932320 A NO19932320 A NO 19932320A NO 932320 A NO932320 A NO 932320A NO 311112 B1 NO311112 B1 NO 311112B1
- Authority
- NO
- Norway
- Prior art keywords
- analyte
- gold
- complex
- protein
- superaggregated
- Prior art date
Links
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims description 104
- 239000010931 gold Substances 0.000 title claims description 82
- 229910052737 gold Inorganic materials 0.000 title claims description 82
- 239000012491 analyte Substances 0.000 title claims description 76
- 238000000034 method Methods 0.000 title claims description 56
- 102000004169 proteins and genes Human genes 0.000 title claims description 46
- 108090000623 proteins and genes Proteins 0.000 title claims description 46
- 239000006228 supernatant Substances 0.000 title description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 2
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- 102000004190 Enzymes Human genes 0.000 claims description 25
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 13
- 229940098773 bovine serum albumin Drugs 0.000 description 13
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
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- 210000002700 urine Anatomy 0.000 description 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
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- 101000942118 Homo sapiens C-reactive protein Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
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- 102000036675 Myoglobin Human genes 0.000 description 1
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- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
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- KAKKHKRHCKCAGH-UHFFFAOYSA-L disodium;(4-nitrophenyl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 KAKKHKRHCKCAGH-UHFFFAOYSA-L 0.000 description 1
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909028038A GB9028038D0 (en) | 1990-12-24 | 1990-12-24 | Test method and reagent kit therefor |
PCT/EP1991/002519 WO1992011537A1 (en) | 1990-12-24 | 1991-12-21 | Test method and reagent kit therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
NO932320D0 NO932320D0 (no) | 1993-06-23 |
NO932320L NO932320L (no) | 1993-06-23 |
NO311112B1 true NO311112B1 (no) | 2001-10-08 |
Family
ID=10687595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19932320A NO311112B1 (no) | 1990-12-24 | 1993-06-23 | Fremgangsmåte for påvisning av en analytt i en pröve, et utstyrsett for denne, fremgangsmåte for fremstilling avsuperaggregat kompleks av et protein og en gull sol og etsuperaggregert kompleks |
Country Status (15)
Country | Link |
---|---|
US (2) | US5691207A (de) |
EP (1) | EP0564494B1 (de) |
JP (1) | JP3174573B2 (de) |
AT (1) | ATE115729T1 (de) |
AU (1) | AU648625B2 (de) |
CA (1) | CA2093415C (de) |
DE (1) | DE69106002T2 (de) |
DK (1) | DK0564494T3 (de) |
ES (1) | ES2065158T3 (de) |
FI (1) | FI106984B (de) |
GB (1) | GB9028038D0 (de) |
GR (1) | GR3014996T3 (de) |
IE (1) | IE66474B1 (de) |
NO (1) | NO311112B1 (de) |
WO (1) | WO1992011537A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994021292A1 (en) * | 1993-03-23 | 1994-09-29 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
CA2105515A1 (en) * | 1993-09-03 | 1995-03-04 | Carlos A. Santizo Lescaille | Visual immunoassay method for the detection of ligands, based on the use of opaque plastic supports |
JPH08311100A (ja) * | 1995-03-13 | 1996-11-26 | Terumo Corp | ヒト肺腺癌に関するモノクローナル抗体および抗原、及びそれを用いた免疫測定方法 |
US5851777A (en) * | 1996-02-05 | 1998-12-22 | Dade Behring Inc. | Homogeneous sol-sol assay |
EP0882224A4 (de) * | 1996-02-22 | 1999-06-09 | Dexall Biochemical Labs Inc | Flüssigphaseimmunoassay mit nicht eingefangenem substrat |
US6410692B2 (en) * | 1998-02-02 | 2002-06-25 | Novadx, Inc. | Removal of abundant interfering proteins from a liquid sample using a collapsible affinity matrix |
US7297554B2 (en) * | 1998-11-18 | 2007-11-20 | Microdiagnostics, Inc. | Immunoassay system |
FR2810739B1 (fr) * | 2000-06-26 | 2007-01-26 | Centre Nat Rech Scient | Immunodosage electrochimiques a l'aide de marqueurs metalliques colloidaux |
DE10141691A1 (de) * | 2001-08-25 | 2003-03-13 | Friz Biochem Gmbh | Verdrängungsassay zur Detektion von Ligat-Ligand-Assoziationsereignissen |
EP1520037A4 (de) * | 2002-02-27 | 2006-06-07 | Miragene Inc | Verbesserte substratchemie für die immobilisierung von proteinen auf einem festen träger |
DE10211818B4 (de) * | 2002-03-16 | 2006-07-06 | peS Gesellschaft für medizinische Diagnose-Systeme mbH | Verfahren zur quantitativen Bestimmung mehrerer Analyten |
US6824776B2 (en) * | 2003-04-16 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Navy | Silica mesoporous aerogels having three-dimensional nanoarchitecture with colloidal gold-protein superstructures nanoglued therein |
EP1740951B1 (de) * | 2004-04-29 | 2008-03-05 | Marc Ramael | Verfahren und kit zum nachweis von bestandteilen in einer probe |
KR101255400B1 (ko) * | 2005-05-23 | 2013-04-17 | 파디아 에이비 | 2 단계 횡 유동 검사 방법 및 장치 |
ITUD20060177A1 (it) | 2006-07-14 | 2008-01-15 | Sire Analytical Systems Srl | Apparecchiatura integrata e metodo per la rilevazione di stati infiammatori presenti in un campione di sangue intero |
WO2008137910A2 (en) * | 2007-05-07 | 2008-11-13 | Massachusetts Instutute Of Technology | Matrix stabilization of aggregation-based assays |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
US10527628B2 (en) | 2015-05-01 | 2020-01-07 | Diagnostear, Ltd. | Method for measuring tear constituents in a tear sample |
US20190302028A1 (en) * | 2016-01-14 | 2019-10-03 | Diagnos Tear, Ltd. | Method for Measuring Tear Constituents in a Tear Sample |
CN112578109B (zh) * | 2020-12-08 | 2022-10-11 | 广东海洋大学深圳研究院 | 定性定量检测试剂、制备方法及定性定量检测试剂盒 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853987A (en) * | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
GB2045431B (en) * | 1979-02-26 | 1983-04-20 | Technicon Instr | Immunoassay utilising two particulate reagents |
US4434150A (en) * | 1981-10-19 | 1984-02-28 | Ortho Diagnostic Systems, Inc. | Immunological reagents employing polymeric backbone possessing reactive functional groups |
US4880751A (en) * | 1986-10-31 | 1989-11-14 | Board Of Regents, The University Of Texas System | Immunoglobulin adsorption |
US4859612A (en) * | 1987-10-07 | 1989-08-22 | Hygeia Sciences, Inc. | Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite |
ES2039025T3 (es) * | 1987-11-16 | 1993-08-16 | Janssen Pharmaceutica N.V. | Un agregado para determinar sustancias combinables. |
GB8800702D0 (en) * | 1988-01-13 | 1988-02-10 | Nycomed As | Test method & reagent kit therefor |
WO1991014707A2 (en) * | 1990-03-28 | 1991-10-03 | Board Of Regents, The University Of Texas System | Production of electrophoretically-uniform protein-colloidal gold complexes |
-
1990
- 1990-12-24 GB GB909028038A patent/GB9028038D0/en active Pending
-
1991
- 1991-12-21 AU AU90934/91A patent/AU648625B2/en not_active Ceased
- 1991-12-21 JP JP50117592A patent/JP3174573B2/ja not_active Expired - Fee Related
- 1991-12-21 US US08/039,426 patent/US5691207A/en not_active Expired - Lifetime
- 1991-12-21 AT AT92901060T patent/ATE115729T1/de not_active IP Right Cessation
- 1991-12-21 DK DK92901060.1T patent/DK0564494T3/da active
- 1991-12-21 DE DE69106002T patent/DE69106002T2/de not_active Expired - Fee Related
- 1991-12-21 EP EP92901060A patent/EP0564494B1/de not_active Expired - Lifetime
- 1991-12-21 WO PCT/EP1991/002519 patent/WO1992011537A1/en active IP Right Grant
- 1991-12-21 ES ES92901060T patent/ES2065158T3/es not_active Expired - Lifetime
- 1991-12-21 CA CA002093415A patent/CA2093415C/en not_active Expired - Fee Related
- 1991-12-23 IE IE453691A patent/IE66474B1/en not_active IP Right Cessation
-
1993
- 1993-06-23 NO NO19932320A patent/NO311112B1/no unknown
- 1993-06-23 FI FI932912A patent/FI106984B/fi active
-
1995
- 1995-02-08 GR GR950400237T patent/GR3014996T3/el unknown
- 1995-06-07 US US08/482,751 patent/US5650333A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5691207A (en) | 1997-11-25 |
JPH06503886A (ja) | 1994-04-28 |
WO1992011537A1 (en) | 1992-07-09 |
DE69106002T2 (de) | 1995-05-11 |
EP0564494A1 (de) | 1993-10-13 |
GR3014996T3 (en) | 1995-05-31 |
NO932320D0 (no) | 1993-06-23 |
US5650333A (en) | 1997-07-22 |
JP3174573B2 (ja) | 2001-06-11 |
FI106984B (fi) | 2001-05-15 |
ES2065158T3 (es) | 1995-02-01 |
ATE115729T1 (de) | 1994-12-15 |
CA2093415A1 (en) | 1992-06-25 |
FI932912A (fi) | 1993-06-23 |
DE69106002D1 (de) | 1995-01-26 |
NO932320L (no) | 1993-06-23 |
EP0564494B1 (de) | 1994-12-14 |
IE66474B1 (en) | 1995-12-27 |
AU9093491A (en) | 1992-07-22 |
GB9028038D0 (en) | 1991-02-13 |
IE914536A1 (en) | 1992-07-01 |
CA2093415C (en) | 2003-02-25 |
FI932912A0 (fi) | 1993-06-23 |
AU648625B2 (en) | 1994-04-28 |
DK0564494T3 (da) | 1995-03-06 |
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