NO310223B1 - Anvendelse av kitosan og et polysakkarid i forbindelse med regenerering av hardt vev, samt implantat - Google Patents

Anvendelse av kitosan og et polysakkarid i forbindelse med regenerering av hardt vev, samt implantat Download PDF

Info

Publication number: NO310223B1
Authority: NO; Norway
Prior art keywords: chitosan; hard tissue; heparin; bone; implant
Prior art date: 1994-07-19

Application number

NO19970215A

Other languages

English (en)

Norwegian (no)

Other versions

NO970215D0 (no

NO970215L (no

Inventor

Hans-Arne Hansson

Gunilla Johansson-Ruden

Olle Larm

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-19

Filing date

1997-01-17

Publication date

2001-06-11

1997-01-17 Application filed by Astra Ab filed Critical Astra Ab

1997-01-17 Publication of NO970215D0 publication Critical patent/NO970215D0/no

1997-01-17 Publication of NO970215L publication Critical patent/NO970215L/no

2001-06-11 Publication of NO310223B1 publication Critical patent/NO310223B1/no

Links

229920001661 Chitosan Polymers 0.000 title claims abstract description 55
239000007943 implant Substances 0.000 title claims abstract description 29
150000004676 glycans Chemical class 0.000 title claims abstract description 15
229920001282 polysaccharide Polymers 0.000 title claims abstract description 15
239000005017 polysaccharide Substances 0.000 title claims abstract description 15
230000008929 regeneration Effects 0.000 title claims abstract description 11
238000011069 regeneration method Methods 0.000 title claims abstract description 11
210000000988 bone and bone Anatomy 0.000 claims abstract description 35
229920000669 heparin Polymers 0.000 claims abstract description 31
229960002897 heparin Drugs 0.000 claims abstract description 31
210000001519 tissue Anatomy 0.000 claims abstract description 30
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 29
239000003795 chemical substances by application Substances 0.000 claims abstract description 14
229920002971 Heparan sulfate Polymers 0.000 claims abstract description 9
229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 6
230000010354 integration Effects 0.000 claims abstract description 5
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 27
229910052719 titanium Inorganic materials 0.000 claims description 19
239000010936 titanium Substances 0.000 claims description 19
238000006640 acetylation reaction Methods 0.000 claims description 10
229960000633 dextran sulfate Drugs 0.000 claims description 8
229940107200 chondroitin sulfates Drugs 0.000 claims description 4
239000000843 powder Substances 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 3
238000010883 osseointegration Methods 0.000 abstract description 6
238000000034 method Methods 0.000 abstract description 4
238000004519 manufacturing process Methods 0.000 abstract description 2
229920002307 Dextran Polymers 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
229910021653 sulphate ion Inorganic materials 0.000 abstract 1
239000000243 solution Substances 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
239000012528 membrane Substances 0.000 description 13
230000007547 defect Effects 0.000 description 12
239000012153 distilled water Substances 0.000 description 8
230000002188 osteogenic effect Effects 0.000 description 7
210000003625 skull Anatomy 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
241000700159 Rattus Species 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000011164 ossification Effects 0.000 description 6
208000006735 Periostitis Diseases 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
210000002082 fibula Anatomy 0.000 description 5
239000000463 material Substances 0.000 description 5
210000003460 periosteum Anatomy 0.000 description 5
230000000638 stimulation Effects 0.000 description 5
229920002101 Chitin Polymers 0.000 description 4
238000004873 anchoring Methods 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 4
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
241000283973 Oryctolagus cuniculus Species 0.000 description 3
230000021736 acetylation Effects 0.000 description 3
229940094517 chondroitin 4-sulfate Drugs 0.000 description 3
KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 3
239000012634 fragment Substances 0.000 description 3
239000003102 growth factor Substances 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
210000003205 muscle Anatomy 0.000 description 3
238000001356 surgical procedure Methods 0.000 description 3
108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
230000001133 acceleration Effects 0.000 description 2
239000003513 alkali Substances 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
230000027455 binding Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
238000003381 deacetylation reaction Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
210000002454 frontal bone Anatomy 0.000 description 2
238000002683 hand surgery Methods 0.000 description 2
230000035876 healing Effects 0.000 description 2
ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
238000002513 implantation Methods 0.000 description 2
210000003127 knee Anatomy 0.000 description 2
210000000629 knee joint Anatomy 0.000 description 2
210000002414 leg Anatomy 0.000 description 2
230000007774 longterm Effects 0.000 description 2
210000003141 lower extremity Anatomy 0.000 description 2
239000004033 plastic Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
231100000241 scar Toxicity 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
208000006386 Bone Resorption Diseases 0.000 description 1
102000012286 Chitinases Human genes 0.000 description 1
108010022172 Chitinases Proteins 0.000 description 1
241000238557 Decapoda Species 0.000 description 1
241001269524 Dura Species 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
206010063560 Excessive granulation tissue Diseases 0.000 description 1
102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 1
102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
241000700201 Galea Species 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
206010072170 Skin wound Diseases 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
241000425571 Trepanes Species 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000002269 analeptic agent Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000011324 bead Substances 0.000 description 1
229920001222 biopolymer Polymers 0.000 description 1
210000002449 bone cell Anatomy 0.000 description 1
210000002805 bone matrix Anatomy 0.000 description 1
230000010478 bone regeneration Effects 0.000 description 1
230000024279 bone resorption Effects 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
210000002249 digestive system Anatomy 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
210000001126 granulation tissue Anatomy 0.000 description 1
210000004349 growth plate Anatomy 0.000 description 1
239000005457 ice water Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
208000014674 injury Diseases 0.000 description 1
XMBWDFGMSWQBCA-YPZZEJLDSA-N iodane Chemical compound [125IH] XMBWDFGMSWQBCA-YPZZEJLDSA-N 0.000 description 1
229940044173 iodine-125 Drugs 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
210000002418 meninge Anatomy 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000002278 reconstructive surgery Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
235000015170 shellfish Nutrition 0.000 description 1
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
235000019832 sodium triphosphate Nutrition 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
210000002303 tibia Anatomy 0.000 description 1
230000008733 trauma Effects 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Oral & Maxillofacial Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Plant Substances (AREA)
Saccharide Compounds (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Chemical Or Physical Treatment Of Fibers (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dental Preparations (AREA)

NO19970215A 1994-07-19 1997-01-17 Anvendelse av kitosan og et polysakkarid i forbindelse med regenerering av hardt vev, samt implantat NO310223B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9402528A SE9402528D0 (sv)	1994-07-19	1994-07-19	Hårdvävnadsstimulerande med el
PCT/SE1995/000857 WO1996002259A1 (en)	1994-07-19	1995-07-13	Hard tissue stimulating agent

Publications (3)

Publication Number	Publication Date
NO970215D0 NO970215D0 (no)	1997-01-17
NO970215L NO970215L (no)	1997-01-17
NO310223B1 true NO310223B1 (no)	2001-06-11

Family

ID=20394768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19970215A NO310223B1 (no)	1994-07-19	1997-01-17	Anvendelse av kitosan og et polysakkarid i forbindelse med regenerering av hardt vev, samt implantat

Country Status (22)

Country	Link
US (1)	US5894070A (sv)
EP (1)	EP0771206B1 (sv)
JP (1)	JP3492377B2 (sv)
KR (1)	KR100395724B1 (sv)
CN (1)	CN1081923C (sv)
AT (1)	ATE219678T1 (sv)
BR (1)	BR9508322A (sv)
CA (1)	CA2194462C (sv)
CZ (1)	CZ289981B6 (sv)
DE (1)	DE69527203T2 (sv)
DK (1)	DK0771206T3 (sv)
ES (1)	ES2178675T3 (sv)
FI (1)	FI970202A (sv)
HU (1)	HU220770B1 (sv)
IS (1)	IS1793B (sv)
MX (1)	MX9700443A (sv)
NO (1)	NO310223B1 (sv)
NZ (1)	NZ290219A (sv)
PL (1)	PL181764B1 (sv)
RU (1)	RU2153877C2 (sv)
SE (1)	SE9402528D0 (sv)
WO (1)	WO1996002259A1 (sv)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9402528D0 (sv) *	1994-07-19	1994-07-19	Astra Ab	Hårdvävnadsstimulerande med el
KR100237738B1 (ko) *	1997-04-26	2000-01-15	이용찬	생채 매식용 의료기구 임플란트의 기능 향상방법
DE19724869C2 (de) *	1997-06-12	1999-05-12	Henkel Kgaa	Verwendung von Citosanderivaten zur Oberflächenbeschichtung
US5993535A (en) *	1997-08-28	1999-11-30	Ngk Spark Plug Co., Ltd.	Calcium phosphate cement and calcium phosphate cement composition
JP4215884B2 (ja) *	1998-03-23	2009-01-28	日本特殊陶業株式会社	リン酸カルシウムセメント及びリン酸カルシウムセメント組成物
US20030147860A1 (en) *	2002-02-07	2003-08-07	Marchosky J. Alexander	Compositions and methods for forming and strengthening bone
CA2335058A1 (en)	1998-06-22	1999-12-29	Danforth Joslyn	Method, implant and delivery system for enhancing blood flow in tissue
US6806260B1 (en) *	1998-11-10	2004-10-19	Netech, Inc.	Functional chitosan derivative
FR2791262B1 (fr) *	1999-03-22	2001-09-28	Virbac Sa	Compositions a base de chondroitine et de chitosan pour la protection, le traitement ou le remplacement des tissus conjonctifs
EP1203074A4 (en)	1999-06-29	2003-09-10	J Alexander Marchosky	BONE FORMATION AND STRENGTHENING COMPOSITIONS AND METHOD
GB9920393D0 (en) *	1999-08-27	1999-11-03	Medix Scient Uk Limited	Plant extract mixtures and their uses
FI19991852A (sv)	1999-09-01	2001-03-01	Yli Urpo Antti	Nytt flerskiktsmaterial med ett biologiskt aktivt medel, och dess framställning
EP1229940B1 (en) *	1999-11-15	2014-05-14	Piramal Healthcare (Canada) Limited	Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US20030158302A1 (en) *	1999-12-09	2003-08-21	Cyric Chaput	Mineral-polymer hybrid composition
ATE243049T1 (de) *	1999-12-09	2003-07-15	Biosyntech Canada Inc	Mineral-polymer hybrid-zusammensetzung
WO2002000272A2 (en) *	2000-06-29	2002-01-03	Biosyntech Canada Inc.	Composition and method for the repair and regeneration of cartilage and other tissues
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1994
- 1994-07-19 SE SE9402528A patent/SE9402528D0/sv unknown
1995
- 1995-07-13 JP JP50495596A patent/JP3492377B2/ja not_active Expired - Fee Related
- 1995-07-13 HU HU9700160A patent/HU220770B1/hu not_active IP Right Cessation
- 1995-07-13 KR KR1019970700338A patent/KR100395724B1/ko not_active IP Right Cessation
- 1995-07-13 MX MX9700443A patent/MX9700443A/es unknown
- 1995-07-13 DK DK95926565T patent/DK0771206T3/da active
- 1995-07-13 CN CN95195024A patent/CN1081923C/zh not_active Expired - Fee Related
- 1995-07-13 CA CA002194462A patent/CA2194462C/en not_active Expired - Fee Related
- 1995-07-13 DE DE69527203T patent/DE69527203T2/de not_active Expired - Lifetime
- 1995-07-13 ES ES95926565T patent/ES2178675T3/es not_active Expired - Lifetime
- 1995-07-13 NZ NZ290219A patent/NZ290219A/en unknown
- 1995-07-13 RU RU97102352/14A patent/RU2153877C2/ru active
- 1995-07-13 US US08/505,353 patent/US5894070A/en not_active Expired - Lifetime
- 1995-07-13 BR BR9508322A patent/BR9508322A/pt not_active Application Discontinuation
- 1995-07-13 CZ CZ1997140A patent/CZ289981B6/cs not_active IP Right Cessation
- 1995-07-13 AT AT95926565T patent/ATE219678T1/de active
- 1995-07-13 PL PL95318326A patent/PL181764B1/pl unknown
- 1995-07-13 EP EP95926565A patent/EP0771206B1/en not_active Expired - Lifetime
- 1995-07-13 WO PCT/SE1995/000857 patent/WO1996002259A1/en active IP Right Grant
1997
- 1997-01-06 IS IS4409A patent/IS1793B/is unknown
- 1997-01-17 NO NO19970215A patent/NO310223B1/no unknown
- 1997-01-17 FI FI970202A patent/FI970202A/sv unknown

Also Published As

Publication number	Publication date
IS4409A (is)	1997-01-06
CA2194462C (en)	2007-07-10
AU3089595A (en)	1996-02-16
PL318326A1 (en)	1997-06-09
ATE219678T1 (de)	2002-07-15
JPH10502664A (ja)	1998-03-10
AU696183B2 (en)	1998-09-03
BR9508322A (pt)	1998-01-06
CA2194462A1 (en)	1996-02-01
SE9402528D0 (sv)	1994-07-19
NZ290219A (en)	1998-06-26
JP3492377B2 (ja)	2004-02-03
HU220770B1 (hu)	2002-05-28
KR100395724B1 (ko)	2004-02-18
CN1081923C (zh)	2002-04-03
NO970215D0 (no)	1997-01-17
KR970704459A (ko)	1997-09-06
DK0771206T3 (da)	2002-08-19
ES2178675T3 (es)	2003-01-01
CN1157568A (zh)	1997-08-20
NO970215L (no)	1997-01-17
DE69527203D1 (de)	2002-08-01
WO1996002259A1 (en)	1996-02-01
HU9700160D0 (en)	1997-03-28
FI970202A0 (sv)	1997-01-17
IS1793B (is)	2001-12-12
PL181764B1 (pl)	2001-09-28
RU2153877C2 (ru)	2000-08-10
CZ14097A3 (en)	1997-07-16
EP0771206B1 (en)	2002-06-26
HUT77607A (hu)	1998-06-29
US5894070A (en)	1999-04-13
EP0771206A1 (en)	1997-05-07
MX9700443A (es)	1997-04-30
CZ289981B6 (cs)	2002-05-15
DE69527203T2 (de)	2003-01-09
FI970202A (sv)	1997-01-17

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JP2008523870A (ja)	2008-07-10	キトサン組成物
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EP1941916B1 (en)	2012-08-15	Method for producing biomaterials from a bone tissue and the thus obtained material used for osteoplasty and tissue engineering
JP4551761B2 (ja)	2010-09-29	ケラチン由来の整形外科材料
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US6486140B2 (en)	2002-11-26	Agents, and methods employing them, for the prevention or reduction of tissue adhesion at a wound site
WO2003084571A1 (fr)	2003-10-16	Composition therapeutique destinee aux maladies infectieuses des os
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RU2278655C1 (ru)	2006-06-27	Способ получения биосовместимого материала для стоматологии
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