NO307463B1 - Galantaminderivater, en fremgangsmõte for fremstilling samt deres anvendelse som medikamenter - Google Patents

Galantaminderivater, en fremgangsmõte for fremstilling samt deres anvendelse som medikamenter

Info

Publication number
NO307463B1
NO307463B1 NO943894A NO943894A NO307463B1 NO 307463 B1 NO307463 B1 NO 307463B1 NO 943894 A NO943894 A NO 943894A NO 943894 A NO943894 A NO 943894A NO 307463 B1 NO307463 B1 NO 307463B1
Authority
NO
Norway
Prior art keywords
drugs
preparation
alkylaminocarbonyloxy
galantamine derivatives
alkylaminocarbonyl
Prior art date
Application number
NO943894A
Other languages
English (en)
Norwegian (no)
Other versions
NO943894L (no
NO943894D0 (no
Inventor
Raymond W Kosley Jr
Larry Davis
Veronica Taberna
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO943894D0 publication Critical patent/NO943894D0/no
Publication of NO943894L publication Critical patent/NO943894L/no
Publication of NO307463B1 publication Critical patent/NO307463B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO943894A 1993-10-15 1994-10-14 Galantaminderivater, en fremgangsmõte for fremstilling samt deres anvendelse som medikamenter NO307463B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,443 US6323196B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (3)

Publication Number Publication Date
NO943894D0 NO943894D0 (no) 1994-10-14
NO943894L NO943894L (no) 1995-04-18
NO307463B1 true NO307463B1 (no) 2000-04-10

Family

ID=22477457

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943894A NO307463B1 (no) 1993-10-15 1994-10-14 Galantaminderivater, en fremgangsmõte for fremstilling samt deres anvendelse som medikamenter

Country Status (24)

Country Link
US (1) US6323196B1 (de)
EP (2) EP1020469A3 (de)
JP (1) JP2718637B2 (de)
KR (1) KR100189043B1 (de)
CN (1) CN1039011C (de)
AT (1) ATE201687T1 (de)
AU (1) AU679560B2 (de)
CA (1) CA2118171C (de)
CZ (1) CZ283561B6 (de)
DE (1) DE69427332T2 (de)
DK (1) DK0648771T3 (de)
EG (1) EG20747A (de)
ES (1) ES2158876T3 (de)
FI (1) FI108724B (de)
GR (1) GR3036068T3 (de)
IL (1) IL111273A (de)
NO (1) NO307463B1 (de)
NZ (1) NZ264681A (de)
PL (1) PL177754B1 (de)
PT (1) PT648771E (de)
RO (1) RO114132B1 (de)
RU (1) RU2113438C1 (de)
TW (1) TW375615B (de)
ZA (1) ZA948060B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
WO2000030446A1 (en) * 1998-11-23 2000-06-02 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
CA2358062C (en) 1998-12-24 2006-12-19 Janssen Pharmaceutica N.V. Controlled release galantamine composition
US6670356B2 (en) * 1999-12-10 2003-12-30 Bonnie Davis Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
DE50101827D1 (de) 2000-03-31 2004-05-06 Sanochemia Pharmazeutika Ag Wi Neue derivate und analoga von galanthamin
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040142970A1 (en) * 2002-11-01 2004-07-22 Kathryn Chung Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) * 2003-07-11 2005-03-03 Jeroen Aerssens CHRNA2 genetic markers associated with galantamine response
WO2005042762A2 (en) * 2003-10-28 2005-05-12 Genaissance Pharmaceuticals, Inc. Lrpap1 genetic markers associated with galantamine response
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US7250258B2 (en) * 2003-12-15 2007-07-31 Pgxhealth Llc CDK5 genetic markers associated with galantamine response
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
WO2005065661A2 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galanthamine
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
PL1895994T3 (pl) * 2005-05-13 2011-02-28 Alza Corp Wielowarstwowy system podawania leków z barierą zabezpieczającą przed wypływaniem materiału ze zbiornika
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
EP1777222A1 (de) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinesterase Inhibitoren mit erhöter Blut Hirn Schranke Permeabilität zur Behandlung von kognitiven Störungen
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal galantamine delivery system
KR100786371B1 (ko) * 2006-12-07 2007-12-17 한국화학연구원 갈란타민의 제조방법
CN102007129B (zh) 2008-04-14 2014-05-07 神经动力生命科学公司 用作治疗人类脑疾病的前药的雪花胺衍生物
US20120184532A1 (en) * 2009-07-23 2012-07-19 Shire Llc Galantamine amino acid and peptide prodrugs and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
ATE411026T1 (de) * 1987-05-04 2008-10-15 Bonnie Davis Mittel zur behandlung der alzheimer-krankheit
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
EP0515301A3 (en) * 1991-05-14 1993-06-16 Ernir Snorrason Improvements in benzodiazepine treatment by cholinesterterase inhibitors
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
EP1020469A3 (de) 2000-07-26
DE69427332T2 (de) 2001-10-11
DK0648771T3 (da) 2001-08-27
FI944822A (fi) 1995-04-16
US6323196B1 (en) 2001-11-27
IL111273A (en) 1998-04-05
NO943894L (no) 1995-04-18
EP0648771A1 (de) 1995-04-19
RU94036761A (ru) 1996-09-10
PT648771E (pt) 2001-09-28
PL177754B1 (pl) 2000-01-31
CZ254794A3 (en) 1995-05-17
TW375615B (en) 1999-12-01
CA2118171A1 (en) 1995-04-16
AU7581294A (en) 1995-05-04
CZ283561B6 (cs) 1998-05-13
ES2158876T3 (es) 2001-09-16
EG20747A (en) 2000-01-31
ZA948060B (en) 1995-06-09
PL305455A1 (en) 1995-04-18
NO943894D0 (no) 1994-10-14
CN1039011C (zh) 1998-07-08
EP0648771B1 (de) 2001-05-30
ATE201687T1 (de) 2001-06-15
IL111273A0 (en) 1994-12-29
EP1020469A2 (de) 2000-07-19
FI108724B (fi) 2002-03-15
JPH07188238A (ja) 1995-07-25
JP2718637B2 (ja) 1998-02-25
RU2113438C1 (ru) 1998-06-20
AU679560B2 (en) 1997-07-03
KR100189043B1 (ko) 1999-06-01
DE69427332D1 (de) 2001-07-05
KR950011444A (ko) 1995-05-15
NZ264681A (en) 1997-12-19
FI944822A0 (fi) 1994-10-13
CN1108658A (zh) 1995-09-20
RO114132B1 (ro) 1999-01-29
CA2118171C (en) 1999-12-28
GR3036068T3 (en) 2001-09-28

Similar Documents

Publication Publication Date Title
NO307463B1 (no) Galantaminderivater, en fremgangsmõte for fremstilling samt deres anvendelse som medikamenter
NO943893D0 (no) Galantaminderivater, en fremgangsmåte for fremstilling samt deres anvendelse som medikamenter
LU91210I2 (fr) Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
AU7350694A (en) Remedy for nervous diseases
DK0850926T3 (da) Difluorprostaglandinderivater og deres anvendelse
DK1104760T3 (da) Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
AU1433588A (en) 1-phenyl-3-naphthalenyloxypropanamines
IE880960L (en) Organic salts of physostigmine derivatives
PT918776E (pt) Sintese total de acilfulvenos antitumorais
HU904956D0 (en) Process for producing benzopyrane derivatives and pharmaceutical preparatives containing such active agents
NO943895D0 (no) Galantaminderivater, en fremgangsmåte for fremstilling samt deres anvendelse som medikamenter
ES2123873T3 (es) Pirrolocarbazol.
ES2150613T3 (es) Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.
AU586867B2 (en) Biocidal mixture
ES2054806T3 (es) Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas.
NO20052360L (no) Forbedrede formuleringer inneholdende substituerte imidazolderivater
EP1034783A4 (de) Amidederivaten
AU654125B2 (en) Novel diphenylthyazole derivative
EP0555479A4 (de)
DK0998464T3 (da) Polyhydroxyalkylpyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelser
ATE194621T1 (de) Pyrazolothiazolopyrimidin-derivate

Legal Events

Date Code Title Description
MK1K Patent expired