DE69427332D1 - Galanthamin-Derivat, ein Verfahren zu seiner Herstellung und seine Verwendung als Medikament - Google Patents
Galanthamin-Derivat, ein Verfahren zu seiner Herstellung und seine Verwendung als MedikamentInfo
- Publication number
- DE69427332D1 DE69427332D1 DE69427332T DE69427332T DE69427332D1 DE 69427332 D1 DE69427332 D1 DE 69427332D1 DE 69427332 T DE69427332 T DE 69427332T DE 69427332 T DE69427332 T DE 69427332T DE 69427332 D1 DE69427332 D1 DE 69427332D1
- Authority
- DE
- Germany
- Prior art keywords
- medicament
- preparation
- alkylaminocarbonyloxy
- galanthamine derivative
- alkylaminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/137,443 US6323196B1 (en) | 1993-10-15 | 1993-10-15 | Galanthamine derivatives as acetylcholinesterase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69427332D1 true DE69427332D1 (de) | 2001-07-05 |
DE69427332T2 DE69427332T2 (de) | 2001-10-11 |
Family
ID=22477457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427332T Expired - Lifetime DE69427332T2 (de) | 1993-10-15 | 1994-10-10 | Galanthamin-Derivat, ein Verfahren zu seiner Herstellung und seine Verwendung als Medikament |
Country Status (24)
Country | Link |
---|---|
US (1) | US6323196B1 (de) |
EP (2) | EP0648771B1 (de) |
JP (1) | JP2718637B2 (de) |
KR (1) | KR100189043B1 (de) |
CN (1) | CN1039011C (de) |
AT (1) | ATE201687T1 (de) |
AU (1) | AU679560B2 (de) |
CA (1) | CA2118171C (de) |
CZ (1) | CZ283561B6 (de) |
DE (1) | DE69427332T2 (de) |
DK (1) | DK0648771T3 (de) |
EG (1) | EG20747A (de) |
ES (1) | ES2158876T3 (de) |
FI (1) | FI108724B (de) |
GR (1) | GR3036068T3 (de) |
IL (1) | IL111273A (de) |
NO (1) | NO307463B1 (de) |
NZ (1) | NZ264681A (de) |
PL (1) | PL177754B1 (de) |
PT (1) | PT648771E (de) |
RO (1) | RO114132B1 (de) |
RU (1) | RU2113438C1 (de) |
TW (1) | TW375615B (de) |
ZA (1) | ZA948060B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
EP1133230A4 (de) * | 1998-11-23 | 2004-05-26 | Bonnie M Davis | Dosisformulierungen für acetylcholinesterase-inhibitoren |
DE69912311T2 (de) | 1998-12-24 | 2004-07-29 | Janssen Pharmaceutica N.V. | Galantamin-zusammensetzung mit gesteuerter freisetzung |
WO2001043697A2 (en) * | 1999-12-10 | 2001-06-21 | Bonnie Davis | Analogs of galanthamine and lycoramine as modulators of nicotinic receptors |
PL202463B1 (pl) | 2000-03-31 | 2009-06-30 | Sanochemia Pharmazeutika Ag | Pochodne galantaminy, sposób ich wytwarzania, środek leczniczy zawierajacy te pochodne, zastosowanie pochodnej galantaminy do wytwarzania środków leczniczych, sposób wytwarzania środków leczniczych oraz sposób oddzielania (+)- i (-)-izomerów |
US20030162770A1 (en) * | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
US20040142970A1 (en) * | 2002-11-01 | 2004-07-22 | Kathryn Chung | Treatment of hyperkinetic movement disorder with donepezil |
US20050048543A1 (en) * | 2003-07-11 | 2005-03-03 | Jeroen Aerssens | CHRNA2 genetic markers associated with galantamine response |
WO2005042762A2 (en) * | 2003-10-28 | 2005-05-12 | Genaissance Pharmaceuticals, Inc. | Lrpap1 genetic markers associated with galantamine response |
US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
US7250258B2 (en) * | 2003-12-15 | 2007-07-31 | Pgxhealth Llc | CDK5 genetic markers associated with galantamine response |
CA2552114A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Solid dosage formulations of galantamine |
US20050191349A1 (en) * | 2003-12-31 | 2005-09-01 | Garth Boehm | Galantamine formulations |
US20080045500A1 (en) * | 2004-07-01 | 2008-02-21 | Eisai R&D Management Co., Ltd. | Nerve Regeneration Stimulator |
EP1895995A2 (de) * | 2005-05-13 | 2008-03-12 | Alza Corporation | Mehrschichtige transdermale systeme zur galantamine abgabe |
US20080188510A1 (en) * | 2005-05-23 | 2008-08-07 | Eisai R & D Management Co., Ltd. | Novel methods using zonisamide |
EP1777222A1 (de) * | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinesterase Inhibitoren mit erhöter Blut Hirn Schranke Permeabilität zur Behandlung von kognitiven Störungen |
US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
US20070104771A1 (en) * | 2005-09-23 | 2007-05-10 | Jay Audett | Transdermal galantamine delivery system |
KR100786371B1 (ko) * | 2006-12-07 | 2007-12-17 | 한국화학연구원 | 갈란타민의 제조방법 |
DK2137192T3 (da) | 2008-04-14 | 2014-05-26 | Neurodyn Life Sciences Inc | Derivater af galantamin som prodrugs til behandling af humane hjernesygdomme |
AU2010275431A1 (en) * | 2009-07-23 | 2012-02-23 | Shire Llc | Galantamine amino acid and peptide prodrugs and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL122665B1 (en) | 1978-11-21 | 1982-08-31 | Edinen Zentar Chim | Process for preparing novel dienones of narvedine type and their derivatives |
US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
US6150354A (en) * | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
ATE411026T1 (de) * | 1987-05-04 | 2008-10-15 | Bonnie Davis | Mittel zur behandlung der alzheimer-krankheit |
NL8800350A (nl) | 1988-02-12 | 1989-09-01 | Stichting Biomedical Research | Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen. |
ATE183084T1 (de) | 1991-05-14 | 1999-08-15 | Ernir Snorrason | Behandlung des ermüdungssyndroms mit cholinesteraseinhibitoren |
US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
US5231093A (en) * | 1991-10-01 | 1993-07-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
US5153193A (en) | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
-
1993
- 1993-10-15 US US08/137,443 patent/US6323196B1/en not_active Expired - Lifetime
-
1994
- 1994-10-10 DK DK94115960T patent/DK0648771T3/da active
- 1994-10-10 AT AT94115960T patent/ATE201687T1/de active
- 1994-10-10 ES ES94115960T patent/ES2158876T3/es not_active Expired - Lifetime
- 1994-10-10 DE DE69427332T patent/DE69427332T2/de not_active Expired - Lifetime
- 1994-10-10 EP EP94115960A patent/EP0648771B1/de not_active Expired - Lifetime
- 1994-10-10 EP EP00107569A patent/EP1020469A3/de not_active Withdrawn
- 1994-10-10 PT PT94115960T patent/PT648771E/pt unknown
- 1994-10-12 EG EG63794A patent/EG20747A/xx active
- 1994-10-13 RU RU94036761A patent/RU2113438C1/ru active
- 1994-10-13 IL IL111273A patent/IL111273A/en not_active IP Right Cessation
- 1994-10-13 NZ NZ264681A patent/NZ264681A/en not_active IP Right Cessation
- 1994-10-13 FI FI944822A patent/FI108724B/fi not_active IP Right Cessation
- 1994-10-14 CZ CZ942547A patent/CZ283561B6/cs not_active IP Right Cessation
- 1994-10-14 KR KR1019940026304A patent/KR100189043B1/ko active IP Right Grant
- 1994-10-14 CA CA002118171A patent/CA2118171C/en not_active Expired - Lifetime
- 1994-10-14 CN CN94117061A patent/CN1039011C/zh not_active Expired - Lifetime
- 1994-10-14 NO NO943894A patent/NO307463B1/no not_active IP Right Cessation
- 1994-10-14 ZA ZA948060A patent/ZA948060B/xx unknown
- 1994-10-14 TW TW083109528A patent/TW375615B/zh not_active IP Right Cessation
- 1994-10-14 AU AU75812/94A patent/AU679560B2/en not_active Expired
- 1994-10-14 RO RO94-01668A patent/RO114132B1/ro unknown
- 1994-10-14 PL PL94305455A patent/PL177754B1/pl unknown
- 1994-10-17 JP JP6250776A patent/JP2718637B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-19 GR GR20010400911T patent/GR3036068T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |