NO20091413L - WNT-antagonister og deres anvendelse i diagnostiseringen og behandlingen av WNT-medierte forstyrrelser - Google Patents
WNT-antagonister og deres anvendelse i diagnostiseringen og behandlingen av WNT-medierte forstyrrelserInfo
- Publication number
- NO20091413L NO20091413L NO20091413A NO20091413A NO20091413L NO 20091413 L NO20091413 L NO 20091413L NO 20091413 A NO20091413 A NO 20091413A NO 20091413 A NO20091413 A NO 20091413A NO 20091413 L NO20091413 L NO 20091413L
- Authority
- NO
- Norway
- Prior art keywords
- wnt
- diagnosis
- treatment
- mediated disorders
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Sammendrag Den foreliggende oppfinnelse tilveiebringer kimære Wnt-antagonister som omfatter en Frz-domenebestanddel avledet fra et Frizzledprotein, et utskilt Frizzled-relatert protein eller Ror-protein og en Fe-immunglobulinbestanddel, og deres anvendelse i behandlingen og den diagnostiske påvisning av cellulær Wntsignalisering og Wnt-medierte forstyrrelser, inkludert kreft.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82506306P | 2006-09-08 | 2006-09-08 | |
US95117507P | 2007-07-20 | 2007-07-20 | |
PCT/US2007/077845 WO2008031009A2 (en) | 2006-09-08 | 2007-09-07 | Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091413L true NO20091413L (no) | 2009-06-08 |
Family
ID=39092004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091413A NO20091413L (no) | 2006-09-08 | 2009-04-07 | WNT-antagonister og deres anvendelse i diagnostiseringen og behandlingen av WNT-medierte forstyrrelser |
Country Status (19)
Country | Link |
---|---|
US (5) | US7947277B2 (no) |
EP (1) | EP2061495A2 (no) |
JP (1) | JP2010504081A (no) |
KR (1) | KR20090060334A (no) |
AR (1) | AR062709A1 (no) |
AU (1) | AU2007292242A1 (no) |
BR (1) | BRPI0714751A2 (no) |
CA (1) | CA2662041A1 (no) |
CL (1) | CL2007002609A1 (no) |
CR (1) | CR10699A (no) |
IL (1) | IL197240A0 (no) |
MA (1) | MA31135B1 (no) |
MX (1) | MX2009002522A (no) |
NO (1) | NO20091413L (no) |
PE (3) | PE20120806A1 (no) |
RU (1) | RU2009113023A (no) |
SG (2) | SG174101A1 (no) |
TW (1) | TW200819463A (no) |
WO (1) | WO2008031009A2 (no) |
Families Citing this family (36)
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JP2009513708A (ja) * | 2005-10-31 | 2009-04-02 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
EP2235054A1 (en) * | 2007-12-13 | 2010-10-06 | Merck Serono S.A. | Sarp-1 fusion proteins and uses thereof |
CA2722485C (en) | 2008-04-30 | 2018-02-13 | F. Hoffmann-La Roche Ag | Use of sfrp-3 in the assessment of heart failure |
ES2334092B1 (es) * | 2008-07-02 | 2011-01-24 | Proyecto De Biomedicina Cima, S.L. | Agentes antiangiogenicos. |
AU2009296246B2 (en) | 2008-09-26 | 2015-07-30 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
EP2343080B1 (en) * | 2008-09-30 | 2017-11-08 | Kyowa Hakko Kirin Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN AND Fc PROTEIN |
AU2010238723A1 (en) | 2009-04-23 | 2011-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human ROR1 antibodies |
US8877199B2 (en) | 2009-05-15 | 2014-11-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | B cell surface reactive antibodies |
US20110189097A1 (en) * | 2009-11-09 | 2011-08-04 | Dritan Agalliu | Use of WNT inhibitor to inhibit angiogenesis in the CNS |
TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
CN102971337B (zh) * | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
EP2585098B1 (en) | 2010-06-28 | 2014-08-27 | Five Prime Therapeutics, Inc. | Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules for use in treating obesity and obesity-related disorders |
UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
WO2012054565A1 (en) | 2010-10-20 | 2012-04-26 | Genentech, Inc. | Methods and compositions for modulating the wnt pathway |
AU2011329854B2 (en) * | 2010-11-16 | 2017-03-30 | University Of Southern California | CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells |
WO2012075158A1 (en) | 2010-12-01 | 2012-06-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric rabbit/human ror1 antibodies |
AU2012271413B2 (en) | 2011-06-17 | 2017-07-13 | President And Fellows Of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
EP2725101B1 (en) | 2011-06-21 | 2017-09-27 | Kyowa Hakko Kirin Co., Ltd. | Protein comprising truncated form of extracellular domain protein of frizzled 2, and pharmaceutical composition for treating bone diseases which comprises said protein |
WO2013012747A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
US20130216546A1 (en) * | 2012-01-10 | 2013-08-22 | Ngm Biopharmaceuticals, Inc. | Methods of Treating Glucose Metabolism Disorders |
BR112014019741A2 (pt) | 2012-02-11 | 2020-12-22 | Genentech, Inc | Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado |
MY167232A (en) * | 2012-02-20 | 2018-08-14 | Swedish Orphan Biovitrum Ab Publ | Polypeptides binding to human complement c5 |
CA2887711A1 (en) * | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
WO2014096163A1 (en) * | 2012-12-19 | 2014-06-26 | Affibody Ab | New polypeptides |
CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
TW201610168A (zh) | 2013-12-02 | 2016-03-16 | 安可美德藥物股份有限公司 | 與Wnt途徑抑制劑有關之預測性生物標記之鑑別 |
EP3166627A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Notch pathway inhibition |
KR101572606B1 (ko) * | 2014-11-24 | 2015-11-27 | 강원대학교산학협력단 | Sfrp5 유래의 펩타이드 및 이를 포함하는 피부 미백용 화장료 조성물 |
KR101826841B1 (ko) | 2015-02-04 | 2018-02-08 | 주식회사 메드팩토 | 변형된 dkk2 단백질 또는 그 유전자를 포함하는 발기부전 예방 또는 치료용 조성물 및 이를 이용한 방법 |
US10913786B2 (en) * | 2016-03-21 | 2021-02-09 | Children's Medical Center Corporation | Compositions and methods for inhibiting Wnt signaling |
CN108310366A (zh) * | 2017-01-15 | 2018-07-24 | 复旦大学附属华山医院 | 重组sfrp5蛋白在制备治疗非酒精性脂肪性肝炎药物中的用途 |
JP2023502108A (ja) * | 2019-11-18 | 2023-01-20 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 抗ror-2抗体および使用方法 |
EP4065599A4 (en) * | 2019-11-26 | 2023-11-01 | Cedars-Sinai Medical Center | COMPOSITIONS AND METHODS FOR TREATING ILLNESSES AND CONDITIONS BY REMOVING MITOCHONDRIAL OR GENOMIC DNA FROM THE CIRCULATION |
Family Cites Families (20)
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WO1997039357A1 (en) * | 1996-04-12 | 1997-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt RECEPTOR COMPOSITIONS AND METHODS |
WO1998013493A2 (en) * | 1996-09-24 | 1998-04-02 | Lxr Biotechnology, Inc. | A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
ES2269366T3 (es) * | 2000-02-11 | 2007-04-01 | Merck Patent Gmbh | Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos. |
WO2001098354A2 (en) | 2000-06-21 | 2001-12-27 | Incyte Genomics, Inc. | Human receptors |
US7413873B2 (en) * | 2001-01-30 | 2008-08-19 | The Regents Of The University Of California | Method of detection and treatment of colon cancer |
US7713526B2 (en) | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US20030044409A1 (en) | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
AU2002308557A1 (en) * | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
AU2002317105A1 (en) | 2001-07-05 | 2003-01-21 | University Of British Columbia | Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors |
US20030108963A1 (en) * | 2001-07-25 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kit, and methods for identification, assessment, prevention and therapy of prostate cancer |
US20040247593A1 (en) * | 2002-10-04 | 2004-12-09 | Regents Of The University Of California, | Methods for treating cancer by inhibiting Wnt signaling |
US7803783B2 (en) * | 2002-12-06 | 2010-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Use of WNT inhibitors to augment therapeutic index of chemotherapy |
US20040171559A1 (en) * | 2002-12-06 | 2004-09-02 | Irving Weissman | Protection of stem cells from cytotoxic agents by modulation of beta-catenin signaling pathways |
US20050096263A1 (en) * | 2003-10-30 | 2005-05-05 | Keay Susan K. | Novel antiproliferative factor and methods of use |
CA2580780A1 (en) | 2004-09-21 | 2006-04-06 | Rhode Island Hospital, A Lifespan-Partner | Frizzled proteins and detection and treatment of cancer |
KR101549245B1 (ko) | 2004-09-21 | 2015-09-01 | 로드아일랜드 하스피털, 에이 라이프스팬 파트너 | Wnt 단백질 및 암의 검출 및 치료 |
WO2006036175A2 (en) * | 2004-09-21 | 2006-04-06 | Rhode Island Hospital, A Lifespan-Partner | Wnt proteins and detection and treatment of cancer |
US8809287B2 (en) | 2004-11-15 | 2014-08-19 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for altering Wnt autocrine signaling |
US7723477B2 (en) * | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
-
2007
- 2007-09-07 CA CA002662041A patent/CA2662041A1/en not_active Abandoned
- 2007-09-07 US US11/851,596 patent/US7947277B2/en not_active Expired - Fee Related
- 2007-09-07 JP JP2009527577A patent/JP2010504081A/ja active Pending
- 2007-09-07 TW TW096133617A patent/TW200819463A/zh unknown
- 2007-09-07 SG SG2011061439A patent/SG174101A1/en unknown
- 2007-09-07 SG SG2011061421A patent/SG174100A1/en unknown
- 2007-09-07 PE PE2011001828A patent/PE20120806A1/es not_active Application Discontinuation
- 2007-09-07 AU AU2007292242A patent/AU2007292242A1/en not_active Abandoned
- 2007-09-07 RU RU2009113023/15A patent/RU2009113023A/ru not_active Application Discontinuation
- 2007-09-07 MX MX2009002522A patent/MX2009002522A/es unknown
- 2007-09-07 AR ARP070103967A patent/AR062709A1/es not_active Application Discontinuation
- 2007-09-07 CL CL200702609A patent/CL2007002609A1/es unknown
- 2007-09-07 KR KR1020097007144A patent/KR20090060334A/ko not_active Application Discontinuation
- 2007-09-07 BR BRPI0714751-1A2A patent/BRPI0714751A2/pt not_active IP Right Cessation
- 2007-09-07 PE PE2011001829A patent/PE20120807A1/es not_active Application Discontinuation
- 2007-09-07 PE PE2007001209A patent/PE20081217A1/es not_active Application Discontinuation
- 2007-09-07 WO PCT/US2007/077845 patent/WO2008031009A2/en active Application Filing
- 2007-09-07 EP EP07814736A patent/EP2061495A2/en not_active Ceased
-
2009
- 2009-02-25 IL IL197240A patent/IL197240A0/en unknown
- 2009-03-31 CR CR10699A patent/CR10699A/es unknown
- 2009-04-06 MA MA31763A patent/MA31135B1/fr unknown
- 2009-04-07 NO NO20091413A patent/NO20091413L/no not_active Application Discontinuation
-
2010
- 2010-06-29 US US12/826,194 patent/US20100266593A1/en not_active Abandoned
-
2011
- 2011-05-23 US US13/113,211 patent/US20110311534A1/en not_active Abandoned
-
2012
- 2012-02-07 US US13/367,760 patent/US20120141481A1/en not_active Abandoned
-
2016
- 2016-12-20 US US15/385,528 patent/US20170349639A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2007292242A1 (en) | 2008-03-13 |
SG174100A1 (en) | 2011-09-29 |
MX2009002522A (es) | 2009-06-19 |
US20170349639A1 (en) | 2017-12-07 |
WO2008031009A3 (en) | 2009-07-02 |
EP2061495A2 (en) | 2009-05-27 |
RU2009113023A (ru) | 2010-10-20 |
PE20081217A1 (es) | 2008-09-24 |
US7947277B2 (en) | 2011-05-24 |
MA31135B1 (fr) | 2010-02-01 |
BRPI0714751A2 (pt) | 2014-06-24 |
CL2007002609A1 (es) | 2008-04-18 |
PE20120806A1 (es) | 2012-07-25 |
JP2010504081A (ja) | 2010-02-12 |
CR10699A (es) | 2009-07-10 |
PE20120807A1 (es) | 2012-07-26 |
IL197240A0 (en) | 2011-08-01 |
KR20090060334A (ko) | 2009-06-11 |
US20100266593A1 (en) | 2010-10-21 |
US20080299136A1 (en) | 2008-12-04 |
US20120141481A1 (en) | 2012-06-07 |
US20110311534A1 (en) | 2011-12-22 |
AR062709A1 (es) | 2008-11-26 |
SG174101A1 (en) | 2011-09-29 |
CA2662041A1 (en) | 2008-03-13 |
WO2008031009A2 (en) | 2008-03-13 |
TW200819463A (en) | 2008-05-01 |
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