NO2009024I2 - IUPAC (2'R)-2' -sykloheksyl-llbeta-hydroksy-21-isobutyryloksy-16bH-dioksolo[5',4'.16,17]pregna-1,4-dien-3,20-dion - Google Patents

IUPAC (2'R)-2' -sykloheksyl-llbeta-hydroksy-21-isobutyryloksy-16bH-dioksolo[5',4'.16,17]pregna-1,4-dien-3,20-dion

Info

Publication number: NO2009024I2
Authority: NO; Norway
Prior art keywords: cyclohexyl; 11beta; dioxolo; pregna; isobutyryloxy
Prior art date: 1997-05-21

Application number

NO2009024C

Other languages

English (en)

Other versions

NO2009024I1 (no

Original Assignee

3M Innovative Properties Co

Nycomed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-21

Filing date

2009-10-26

Publication date

2010-08-16

1997-05-21 Priority claimed from GBGB9710496.2A external-priority patent/GB9710496D0/en

1998-02-25 Priority claimed from GBGB9803990.2A external-priority patent/GB9803990D0/en

2009-10-26 Application filed by 3M Innovative Properties Co, Nycomed Gmbh filed Critical 3M Innovative Properties Co

2009-10-26 Publication of NO2009024I1 publication Critical patent/NO2009024I1/no

2010-08-16 Publication of NO2009024I2 publication Critical patent/NO2009024I2/no

Links

QIEPWCSVQYUPIY-LEKSSAKUSA-N Delta(1)-progesterone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 QIEPWCSVQYUPIY-LEKSSAKUSA-N 0.000 title 1
238000009472 formulation Methods 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
229960003728 ciclesonide Drugs 0.000 abstract 2
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
-1 isobutanoyl Chemical group 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
239000008249 pharmaceutical aerosol Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000003380 propellant Substances 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Materials For Medical Uses (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Thermotherapy And Cooling Therapy Devices (AREA)

NO2009024C 1997-05-21 2009-10-26 IUPAC (2'R)-2' -sykloheksyl-llbeta-hydroksy-21-isobutyryloksy-16bH-dioksolo[5',4'.16,17]pregna-1,4-dien-3,20-dion NO2009024I2 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9710496.2A GB9710496D0 (en)	1997-05-21	1997-05-21	Medicinal aerosol products
GBGB9803990.2A GB9803990D0 (en)	1998-02-25	1998-02-25	Medicinal aerosol products
PCT/US1998/010155 WO1998052542A1 (en)	1997-05-21	1998-05-18	Medicinal aerosol products

Publications (2)

Publication Number	Publication Date
NO2009024I1 NO2009024I1 (no)	2009-10-26
NO2009024I2 true NO2009024I2 (no)	2010-08-16

Family

ID=26311564

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO995667A NO327716B1 (no)	1997-05-21	1999-11-18	Farmasøytisk sammensetning, produkt og aerosolformulering
NO2009024C NO2009024I2 (no)	1997-05-21	2009-10-26	IUPAC (2'R)-2' -sykloheksyl-llbeta-hydroksy-21-isobutyryloksy-16bH-dioksolo[5',4'.16,17]pregna-1,4-dien-3,20-dion

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO995667A NO327716B1 (no)	1997-05-21	1999-11-18	Farmasøytisk sammensetning, produkt og aerosolformulering

Country Status (28)

Country	Link
US (1)	US6120752A (no)
EP (1)	EP0983058B1 (no)
JP (4)	JP2001526685A (no)
KR (1)	KR100527643B1 (no)
CN (1)	CN1149073C (no)
AT (1)	ATE245966T1 (no)
AU (1)	AU726835B2 (no)
BG (1)	BG64268B1 (no)
BR (1)	BR9809448A (no)
CA (1)	CA2290521C (no)
CZ (1)	CZ298253B6 (no)
DE (1)	DE69816811T2 (no)
DK (1)	DK0983058T3 (no)
EA (1)	EA002381B1 (no)
ES (1)	ES2205491T3 (no)
HK (1)	HK1027027A1 (no)
HU (1)	HU226694B1 (no)
IL (1)	IL132738A (no)
ME (1)	ME01631B (no)
NO (2)	NO327716B1 (no)
NZ (1)	NZ500874A (no)
PL (1)	PL191523B1 (no)
PT (1)	PT983058E (no)
RS (1)	RS49628B (no)
SK (1)	SK283930B6 (no)
TR (1)	TR199902863T2 (no)
UA (1)	UA58551C2 (no)
WO (1)	WO1998052542A1 (no)

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WO2004033478A2 (en) *	2002-10-08	2004-04-22	Sepracor Inc.	Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
KR101235583B1 (ko) *	2002-10-25	2013-02-22	허니웰 인터내셔널 인코포레이티드	플루오린 치환된 올레핀을 함유하는 조성물
ATE405275T1 (de) *	2002-12-12	2008-09-15	Nycomed Gmbh	Kombinationsarzneimittel aus r,r-formoterol und ciclesonide
MY143936A (en) *	2003-03-27	2011-07-29	Nycomed Gmbh	Process for preparing crystalline ciclesonide with defined particle size
WO2004103379A1 (en) *	2003-05-22	2004-12-02	Altana Pharma Ag	Salmeterol and ciclesonide combination
JP2006527237A (ja) *	2003-06-13	2006-11-30	アルタナ　ファルマ　アクチエンゲゼルシャフト	ホルモテロールと及びシクレソニドの組合せ物
EP1670482B2 (en) *	2003-09-16	2022-06-29	Covis Pharma B.V.	Use of ciclesonide for the treatment of respiratory diseases
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US9308199B2 (en)	2004-04-29	2016-04-12	Honeywell International Inc.	Medicament formulations
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JP2008512428A (ja) *	2004-09-10	2008-04-24	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	シクレソニドとＳｙｋインヒビターとの組合せ物並びにその使用方法
JP2008546634A (ja) *	2005-03-16	2008-12-25	ハネウェル・インターナショナル・インコーポレーテッド	医薬送達製剤、デバイス及び方法
WO2007068007A1 (en) *	2005-12-07	2007-06-14	Harm Benjamin Steyn	Use of a disinfectant for treating respiratory tract infections
PT2425820E (pt)	2007-02-11	2015-08-04	Map Pharmaceuticals Inc	Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
US20100120737A1 (en) *	2008-11-10	2010-05-13	Martin Feth	Amorphous ciclesonide
TWI465459B (zh) *	2009-03-09	2014-12-21	Mikasa Seiyaku Co Ltd	類固醇化合物
WO2011135585A2 (en)	2010-04-28	2011-11-03	Cadila Healthcare Limited	Aqueous pharmaceutical solution of ciclesonide
KR20180028563A (ko) *	2010-10-12	2018-03-16	시플라 리미티드	약학 조성물
CA2844944A1 (en)	2011-08-18	2013-02-21	Takeda Gmbh	Pharmaceutical aerosol product for administration by oral or nasal inhalation
CN102335132A (zh) *	2011-10-12	2012-02-01	中山大学	一种细辛脑吸入气雾剂及其制备方法
EP2809780B1 (en)	2012-02-01	2018-05-02	Protalix Ltd.	Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
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1998
- 1998-05-13 US US09/076,958 patent/US6120752A/en not_active Expired - Lifetime
- 1998-05-18 DK DK98922409T patent/DK0983058T3/da active
- 1998-05-18 PL PL336885A patent/PL191523B1/pl unknown
- 1998-05-18 EA EA199900991A patent/EA002381B1/ru not_active IP Right Cessation
- 1998-05-18 CN CNB98805261XA patent/CN1149073C/zh not_active Expired - Lifetime
- 1998-05-18 ES ES98922409T patent/ES2205491T3/es not_active Expired - Lifetime
- 1998-05-18 JP JP55049498A patent/JP2001526685A/ja active Pending
- 1998-05-18 CA CA002290521A patent/CA2290521C/en not_active Expired - Lifetime
- 1998-05-18 PT PT98922409T patent/PT983058E/pt unknown
- 1998-05-18 TR TR1999/02863T patent/TR199902863T2/xx unknown
- 1998-05-18 KR KR10-1999-7010773A patent/KR100527643B1/ko active IP Right Grant
- 1998-05-18 AT AT98922409T patent/ATE245966T1/de active
- 1998-05-18 DE DE69816811T patent/DE69816811T2/de not_active Expired - Lifetime
- 1998-05-18 RS YUP-598/99A patent/RS49628B/sr unknown
- 1998-05-18 UA UA99116244A patent/UA58551C2/uk unknown
- 1998-05-18 IL IL13273898A patent/IL132738A/en not_active IP Right Cessation
- 1998-05-18 BR BR9809448-3A patent/BR9809448A/pt not_active Application Discontinuation
- 1998-05-18 ME MEP-1999-598A patent/ME01631B/me unknown
- 1998-05-18 HU HU0002691A patent/HU226694B1/hu active Protection Beyond IP Right Term
- 1998-05-18 EP EP98922409A patent/EP0983058B1/en not_active Expired - Lifetime
- 1998-05-18 AU AU74962/98A patent/AU726835B2/en not_active Expired
- 1998-05-18 WO PCT/US1998/010155 patent/WO1998052542A1/en active IP Right Grant
- 1998-05-18 SK SK1576-99A patent/SK283930B6/sk not_active IP Right Cessation
- 1998-05-18 NZ NZ500874A patent/NZ500874A/en not_active IP Right Cessation
- 1998-05-18 CZ CZ0412499A patent/CZ298253B6/cs not_active IP Right Cessation
1999
- 1999-11-18 NO NO995667A patent/NO327716B1/no not_active IP Right Cessation
- 1999-11-19 BG BG103902A patent/BG64268B1/bg unknown
2000
- 2000-08-30 HK HK00105446A patent/HK1027027A1/xx not_active IP Right Cessation
2009
- 2009-10-26 NO NO2009024C patent/NO2009024I2/no unknown
2010
- 2010-12-03 JP JP2010270854A patent/JP2011102301A/ja not_active Withdrawn
2014
- 2014-09-16 JP JP2014187710A patent/JP6087882B2/ja not_active Expired - Lifetime
2016
- 2016-05-19 JP JP2016100499A patent/JP6178459B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO2009024I1 (no)	2009-10-26
CN1257421A (zh)	2000-06-21
IL132738A0 (en)	2001-03-19
AU726835B2 (en)	2000-11-23
NZ500874A (en)	2001-09-28
BG64268B1 (bg)	2004-08-31
ME01631B (me)	2007-08-03
JP2011102301A (ja)	2011-05-26
CZ298253B6 (cs)	2007-08-08
JP6178459B2 (ja)	2017-08-09
EP0983058B1 (en)	2003-07-30
UA58551C2 (uk)	2003-08-15
NO995667D0 (no)	1999-11-18
WO1998052542A1 (en)	1998-11-26
BR9809448A (pt)	2000-06-20
PT983058E (pt)	2003-12-31
KR100527643B1 (ko)	2005-11-15
ATE245966T1 (de)	2003-08-15
DE69816811D1 (de)	2003-09-04
KR20010012810A (ko)	2001-02-26
JP2015024999A (ja)	2015-02-05
CA2290521C (en)	2006-10-10
JP2016169222A (ja)	2016-09-23
HU226694B1 (en)	2009-06-29
NO995667L (no)	1999-11-18
EA199900991A1 (ru)	2000-08-28
AU7496298A (en)	1998-12-11
EA002381B1 (ru)	2002-04-25
CN1149073C (zh)	2004-05-12
SK157699A3 (en)	2000-05-16
HUP0002691A3 (en)	2001-04-28
JP6087882B2 (ja)	2017-03-01
BG103902A (en)	2000-05-31
ES2205491T3 (es)	2004-05-01
PL336885A1 (en)	2000-07-17
IL132738A (en)	2004-06-20
NO327716B1 (no)	2009-09-14
YU59899A (sh)	2002-06-19
RS49628B (sr)	2007-08-03
HUP0002691A2 (hu)	2001-02-28
HK1027027A1 (en)	2001-01-05
US6120752A (en)	2000-09-19
CA2290521A1 (en)	1998-11-26
DK0983058T3 (da)	2003-11-24
CZ412499A3 (cs)	2000-02-16
PL191523B1 (pl)	2006-06-30
JP2001526685A (ja)	2001-12-18
DE69816811T2 (de)	2004-04-15
SK283930B6 (sk)	2004-05-04
EP0983058A1 (en)	2000-03-08
TR199902863T2 (xx)	2000-05-22

Legal Events

Date	Code	Title	Description
2016-02-08	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: 3M INNOVATIVE PROPERTIES CO, DE

Publication	Publication Date	Title
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