NO20084783L - Syntese av acylaminoalkenylenamider nyttige som substans P antagonister - Google Patents

Syntese av acylaminoalkenylenamider nyttige som substans P antagonister

Info

Publication number
NO20084783L
NO20084783L NO20084783A NO20084783A NO20084783L NO 20084783 L NO20084783 L NO 20084783L NO 20084783 A NO20084783 A NO 20084783A NO 20084783 A NO20084783 A NO 20084783A NO 20084783 L NO20084783 L NO 20084783L
Authority
NO
Norway
Prior art keywords
acylaminoalkenylenamides
antagonists
synthesis
substance
useful
Prior art date
Application number
NO20084783A
Other languages
English (en)
Inventor
Robert Portmann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607532A external-priority patent/GB0607532D0/en
Priority claimed from GB0610244A external-priority patent/GB0610244D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20084783L publication Critical patent/NO20084783L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En fremgangsmåte for fremstilling av forbindelser med formel I
NO20084783A 2006-04-13 2008-11-12 Syntese av acylaminoalkenylenamider nyttige som substans P antagonister NO20084783L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0607532A GB0607532D0 (en) 2006-04-13 2006-04-13 Organic compounds
GB0610244A GB0610244D0 (en) 2006-05-23 2006-05-23 Organic compounds
PCT/EP2007/003213 WO2007118651A1 (en) 2006-04-13 2007-04-11 Synthesis of acylaminoalkenylene amides useful as substance p antagonists

Publications (1)

Publication Number Publication Date
NO20084783L true NO20084783L (no) 2008-11-12

Family

ID=38324102

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084783A NO20084783L (no) 2006-04-13 2008-11-12 Syntese av acylaminoalkenylenamider nyttige som substans P antagonister

Country Status (29)

Country Link
US (2) US8008479B2 (no)
EP (1) EP2010498B1 (no)
JP (1) JP5208917B2 (no)
KR (1) KR20080108291A (no)
AR (1) AR060506A1 (no)
AT (1) ATE486853T1 (no)
AU (1) AU2007237482B2 (no)
CA (1) CA2645362C (no)
CL (1) CL2007001040A1 (no)
CY (1) CY1111294T1 (no)
DE (1) DE602007010269D1 (no)
DK (1) DK2010498T3 (no)
EC (1) ECSP088820A (no)
GT (1) GT200800209A (no)
HK (1) HK1125640A1 (no)
HR (1) HRP20110045T1 (no)
JO (1) JO2630B1 (no)
MA (1) MA30394B1 (no)
MX (1) MX2008013117A (no)
MY (1) MY145069A (no)
NO (1) NO20084783L (no)
NZ (1) NZ571142A (no)
PE (1) PE20071223A1 (no)
PL (1) PL2010498T3 (no)
PT (1) PT2010498E (no)
RU (1) RU2433122C2 (no)
SI (1) SI2010498T1 (no)
TW (1) TW200815358A (no)
WO (1) WO2007118651A1 (no)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790699B2 (en) 2004-10-12 2010-09-07 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
AU2006275595B2 (en) 2005-07-29 2012-08-16 Concert Pharmaceuticals Inc. Novel benzo [d] [1,3]-dioxol derivatives
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US8080549B2 (en) 2007-01-12 2011-12-20 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
WO2008088727A2 (en) 2007-01-12 2008-07-24 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
US8013007B2 (en) 2007-02-26 2011-09-06 Concert Pharmaceuticals, Inc. Alpha 1A-adrenoceptor antagonists
EP2139877B1 (en) 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Deuterated piperazine derivatives as anti-anginal compounds
EP2918578A1 (en) 2007-03-16 2015-09-16 Concert Pharmaceuticals, Inc. Inhibitors of cholesterol ester transfer protein
US8198305B2 (en) 2007-04-13 2012-06-12 Concert Pharmaceuticals Inc. 1,2-benzisoxazol-3-yl compounds
US20090042842A1 (en) 2007-04-25 2009-02-12 Concert Pharmaceuticals, Inc. Analogues of cilostazol
US8349817B2 (en) 2007-04-25 2013-01-08 Concert Pharmaceuticals, Inc. Analogues of cilostazol
ES2545617T3 (es) 2007-05-01 2015-09-14 Concert Pharmaceuticals Inc. Compuestos de morfinano
EP2152709B1 (en) 2007-05-01 2012-02-22 Concert Pharmaceuticals Inc. Morphinan compounds
WO2008141021A1 (en) 2007-05-08 2008-11-20 Concert Pharmaceuticals, Inc. Deuterated derivatives of tetrahydrotriazolopyrazine compounds and their use as dpp-iv inhibitors
EP2003120B9 (en) 2007-06-12 2010-06-02 CoNCERT Pharmaceuticals, Inc. Azapeptide derivatives as HIV protease inhibitors
WO2009009531A2 (en) 2007-07-09 2009-01-15 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives for the treatment of hiv infections
WO2009023233A1 (en) 2007-08-14 2009-02-19 Concert Pharmaceuticals, Inc. Substituted oxazolidinone derivatives
EP2192906A4 (en) 2007-08-28 2014-10-29 Fmc Corp DELAYED SELF-GELING ALGINATE SYSTEMS AND USES THEREOF
EP2197847B1 (en) 2007-09-12 2012-11-07 Concert Pharmaceuticals Inc. Deuterated 4 -oxoquinoline derivative for the treatment of hiv infection
AU2008299921B2 (en) 2007-09-13 2012-03-01 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
WO2009051782A1 (en) 2007-10-18 2009-04-23 Concert Pharmaceuticals Inc. Deuterated etravirine
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
US8084464B2 (en) 2007-12-18 2011-12-27 Concert Pharmaceuticals, Inc. Tetrahydroisoquinoline derivatives
WO2009094210A1 (en) 2008-01-22 2009-07-30 Concert Pharmaceuticals Inc. Vandetanib derivatives
JP2011510079A (ja) 2008-01-22 2011-03-31 コンサート ファーマシューティカルズ インコーポレイテッド ゲフィチニブ誘導体
CA2716788C (en) 2008-02-29 2016-08-16 Concert Pharmaceuticals, Inc. Deuterium-substituted xanthine derivatives
WO2009128947A1 (en) 2008-04-17 2009-10-22 Concert Pharmaceuticals, Inc. Piperazine derivatives
US8354557B2 (en) 2008-06-17 2013-01-15 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
DK2328414T3 (en) 2008-08-29 2014-03-10 Concert Pharmaceuticals Inc Substituted triazolopyridazine derivatives
US8704001B2 (en) 2008-09-16 2014-04-22 Concert Pharmaceuticals, Inc. Deuterated 2-amino-3-hydroxypropanoic acid derivatives
EA019343B1 (ru) 2008-09-19 2014-02-28 Консерт Фармасьютикалз Инк. Дейтерированные морфинановые соединения
US9045453B2 (en) 2008-11-14 2015-06-02 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
EP2400953A1 (en) * 2009-02-24 2012-01-04 Novartis AG Uses of nk receptor antagonists
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
DE102009001446A1 (de) 2009-03-10 2010-09-23 Evonik Rohmax Additives Gmbh Verwendung von Kammpolymeren als Antifatigue-Additive
AP2909A (en) 2009-03-17 2014-05-31 Concert Pharmaceuticals Inc Pyrazinoisoquinoline Compounds
WO2010108103A1 (en) * 2009-03-19 2010-09-23 Concert Pharmaceuticals, Inc. Azepan-2-one derivatives
EP2421808B1 (en) 2009-04-23 2013-07-31 Concert Pharmaceuticals Inc. 4-hydroxybutyric acid analogs
US8410082B2 (en) 2009-05-22 2013-04-02 Concert Pharmaceuticals, Inc. Fluorinated diaryl urea derivatives
PL2443089T3 (pl) 2009-06-18 2014-09-30 Concert Pharmaceuticals Inc Deuterowane pochodne izoindolino-1,3-dionu jako inhibitory pde4 i tnf-alfa
EP2454259A1 (en) 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
EP2464355A4 (en) 2009-08-14 2013-01-02 Concert Pharmaceuticals Inc SUBSTITUTED TRIAZOLPHTHALAZINE DERIVATIVES
MX2012002704A (es) 2009-09-02 2012-03-21 Concert Pharmaceuticals Inc Derivados de xantina sustituidos.
WO2011028820A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
US8471034B2 (en) 2009-11-18 2013-06-25 Concert Pharmaceuticals, Inc. Niacin prodrugs and deuterated versions thereof
DE102010001040A1 (de) 2010-01-20 2011-07-21 Evonik RohMax Additives GmbH, 64293 (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes
EP2542534A1 (en) 2010-03-02 2013-01-09 Concert Pharmaceuticals Inc. Deuterated tetrahydronaphthalene derivatives
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
US9226801B2 (en) * 2010-03-08 2016-01-05 Ibur, Llc Custom linkable imaging and multifunctional tray
US8575221B2 (en) 2010-03-17 2013-11-05 Concert Pharmaceuticals, Inc. Derivatives of dimethylcurcumin
US9107922B2 (en) 2010-07-16 2015-08-18 Concert Pharmaceuticals, Inc. Pyrimidinecarboxamide derivatives
US9085788B2 (en) 2010-09-01 2015-07-21 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031073A1 (en) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
ES2804540T3 (es) 2011-02-14 2021-02-08 Concert Pharmaceuticals Inc Análogos deuterados de ácido 4–hidroxibutírico
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
WO2012122028A2 (en) 2011-03-04 2012-09-13 Concert Pharmaceuticals Inc. Pyrazinoisoquinoline compounds
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
MX2014012384A (es) 2012-04-13 2014-11-26 Concert Pharmaceuticals Inc Derivados sustituidos de xantina.
US9249093B2 (en) 2012-04-20 2016-02-02 Concert Pharmaceuticals, Inc. Deuterated rigosertib
US20150197525A1 (en) 2012-06-15 2015-07-16 Concert Pharmaceuticals, Inc. Deuterated derivatives of ruxolitinib
US9181190B2 (en) 2012-07-04 2015-11-10 Concert Pharmaceuticals, Inc. Deuterated vercirnon
CA2908929C (en) 2012-07-12 2021-01-26 Concert Pharmaceuticals, Inc. Deuterated idebenone
CA2879400A1 (en) 2012-07-30 2014-02-06 Concert Pharmaceuticals, Inc. Deuterated ibrutinib
BR112015003153A2 (pt) 2012-08-17 2017-07-04 Concert Pharmaceuticals Inc baricitinib deuterado
JP2015534989A (ja) 2012-10-22 2015-12-07 コンサート ファーマシューティカルズ インコーポレイテッド {s−3−(4−アミノ−1−オキソ−イソインドリン−2−イル)(ピペリジン−3,4,4,5,5−d5)−2,6−ジオン}の固体形態
US9518027B2 (en) 2013-01-09 2016-12-13 Concert Pharmaceuticals, Inc. Deuterated momelotinib
AU2014237569B2 (en) 2013-03-15 2019-03-14 Concert Pharmaceuticals Inc. Inhibitors of the enzyme UDP-glucose: N-acyl-sphingosine glucosyltransferase
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9676790B2 (en) 2013-08-30 2017-06-13 Concert Pharmaceuticals, Inc. Substituted thienotriazolodiazapines
US9694017B2 (en) 2014-02-10 2017-07-04 Concert Pharmaceuticals, Inc. Substituted triazolobenzodiazepines
WO2016069630A1 (en) 2014-10-27 2016-05-06 Concert Pharmaceuticals, Inc. Pyrimidine phosphonic acid esters bearing at least one deuterium atom
CA2981495C (en) 2015-03-31 2023-09-26 Vertex Pharmaceuticals (Europe) Limited Deuterated vx-661
US10683305B2 (en) 2015-04-27 2020-06-16 Concert Pharmaceuticals, Inc. Deuterated OTX-015
US10759721B2 (en) 2015-09-25 2020-09-01 Vertex Pharmaceuticals (Europe) Limited Deuterated CFTR potentiators
US11267777B2 (en) 2015-11-19 2022-03-08 Concert Pharmaceuticals, Inc. Deuterated EPI-743
US10442761B2 (en) 2016-02-16 2019-10-15 Concert Pharmaceuticals, Inc. Deuterated GFT-505
CA3082834A1 (en) 2017-11-22 2019-05-31 Concert Pharmaceuticals, Inc. Deuterated analogs of d-serine and uses thereof
SG11202004264VA (en) 2017-12-01 2020-06-29 Vertex Pharma Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701560B2 (en) 1995-02-22 1999-01-28 Novartis Ag 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
MY132550A (en) * 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ATE486853T1 (de) 2010-11-15
CY1111294T1 (el) 2015-08-05
HRP20110045T1 (hr) 2011-02-28
PT2010498E (pt) 2011-02-08
PL2010498T3 (pl) 2011-04-29
DK2010498T3 (da) 2011-02-14
GT200800209A (es) 2008-12-15
MA30394B1 (fr) 2009-05-04
KR20080108291A (ko) 2008-12-12
JP2009533369A (ja) 2009-09-17
DE602007010269D1 (de) 2010-12-16
SI2010498T1 (sl) 2011-03-31
JP5208917B2 (ja) 2013-06-12
CA2645362C (en) 2013-07-16
EP2010498B1 (en) 2010-11-03
TW200815358A (en) 2008-04-01
JO2630B1 (en) 2012-06-17
US20090137797A1 (en) 2009-05-28
AU2007237482B2 (en) 2011-03-17
CL2007001040A1 (es) 2008-03-14
RU2433122C2 (ru) 2011-11-10
US20110282053A1 (en) 2011-11-17
AR060506A1 (es) 2008-06-25
EP2010498A1 (en) 2009-01-07
HK1125640A1 (en) 2009-08-14
MX2008013117A (es) 2008-10-21
US8008479B2 (en) 2011-08-30
AU2007237482A1 (en) 2007-10-25
CA2645362A1 (en) 2007-10-25
NZ571142A (en) 2011-02-25
PE20071223A1 (es) 2008-01-22
RU2008145102A (ru) 2010-05-27
WO2007118651A1 (en) 2007-10-25
MY145069A (en) 2011-12-15
ECSP088820A (es) 2008-11-27

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