NO20083000L - Tetomilast polymorfer - Google Patents
Tetomilast polymorferInfo
- Publication number
- NO20083000L NO20083000L NO20083000A NO20083000A NO20083000L NO 20083000 L NO20083000 L NO 20083000L NO 20083000 A NO20083000 A NO 20083000A NO 20083000 A NO20083000 A NO 20083000A NO 20083000 L NO20083000 L NO 20083000L
- Authority
- NO
- Norway
- Prior art keywords
- powder
- ray diffraction
- diffraction spectrum
- crystal
- tetomilast
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en tetomilast krystall som er industrielt enkelt å fremstille i en stort volum. (1) En tetomilast hydratkrystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret som er vist i fig. 2; (2) en vannfri tetomilast type A krystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret vist i fig. 4; (3) en vannfri tetomilast type C krystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret vist i fig. 8; (4) en tetomilast acetonitril solvatkrystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspektret vist i fig. 10; og (5) en blanding som består av den ovenfor nevnte vannfrie tetomilast type A krystallen og en vannfri tetomilast type B krystall. Disse krystallene er stabile overfor varme og fuktighet og er også svært tilfredsstillende når det gjelder desintegreringsegenskaper og oppløsningsegenskaper for tabletter. Følgelig blir disse krystallene foretrukket anvendt som farmasøytiske sammensetninger.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006075307 | 2006-03-17 | ||
PCT/JP2007/055931 WO2007119496A1 (en) | 2006-03-17 | 2007-03-15 | Tetomilast polymorphs |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083000L true NO20083000L (no) | 2008-09-30 |
Family
ID=38069222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083000A NO20083000L (no) | 2006-03-17 | 2008-07-07 | Tetomilast polymorfer |
Country Status (27)
Country | Link |
---|---|
US (4) | US8501949B2 (no) |
EP (4) | EP1999128B1 (no) |
JP (2) | JP4182363B2 (no) |
KR (6) | KR101118943B1 (no) |
CN (4) | CN101365697B (no) |
AR (1) | AR059911A1 (no) |
AT (1) | ATE476433T1 (no) |
AU (1) | AU2007239906B2 (no) |
BR (1) | BRPI0706224A2 (no) |
CA (4) | CA2725810C (no) |
CY (3) | CY1111046T1 (no) |
DE (1) | DE602007008212D1 (no) |
DK (3) | DK2311832T3 (no) |
ES (3) | ES2390926T3 (no) |
HK (3) | HK1124062A1 (no) |
IL (4) | IL192237A (no) |
MY (2) | MY143808A (no) |
NO (1) | NO20083000L (no) |
PH (1) | PH12015502374A1 (no) |
PL (3) | PL1999128T3 (no) |
PT (3) | PT2311832E (no) |
RU (2) | RU2408597C2 (no) |
SG (4) | SG172707A1 (no) |
SI (3) | SI2311832T1 (no) |
TW (1) | TWI394753B (no) |
WO (1) | WO2007119496A1 (no) |
ZA (2) | ZA200805235B (no) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11186605B2 (en) | 2016-10-06 | 2021-11-30 | Kyowa Hakko Bio Co., Ltd. | Crystal of cytidine diphosphate choline and production method thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3282731B2 (ja) * | 1990-06-15 | 2002-05-20 | メルク エンド カムパニー インコーポレーテッド | 結晶の構造および大きさを改良する結晶化方法 |
DE69132944T2 (de) | 1990-11-30 | 2002-11-21 | Otsuka Pharma Co Ltd | Azolederivate als Inhibitor von Superoxide-Radikalen |
MY128323A (en) * | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
JP4300373B2 (ja) | 1996-09-30 | 2009-07-22 | 大塚製薬株式会社 | サイトカイン産生抑制剤及び接着抑制剤 |
US6221153B1 (en) * | 1998-06-09 | 2001-04-24 | Trevor Percival Castor | Method for producing large crystals of complex molecules |
SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
GB9922963D0 (en) * | 1999-09-28 | 1999-12-01 | Pfizer Ltd | Polymorphic salt |
JP4336913B2 (ja) | 1999-02-12 | 2009-09-30 | 大塚製薬株式会社 | アミド誘導体の製造方法 |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
WO2003009844A1 (en) * | 2001-07-24 | 2003-02-06 | Otsuka Pharmaceutical Co., Ltd. | Use of thiazole deirvatives for the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease |
JP3713577B2 (ja) | 2001-07-24 | 2005-11-09 | 大塚製薬株式会社 | 慢性閉塞性肺疾患治療薬 |
AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
EP1613598B1 (en) * | 2003-12-16 | 2011-10-19 | Teva Pharmaceutical Industries, Ltd. | Methods of preparing aripiprazole crystalline forms |
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2007
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- 2007-03-15 DK DK11152502.8T patent/DK2311832T3/da active
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- 2007-03-15 PL PL07739373T patent/PL1999128T3/pl unknown
- 2007-03-15 SI SI200731066T patent/SI2311832T1/sl unknown
- 2007-03-15 DK DK07739373.4T patent/DK1999128T3/da active
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- 2007-03-15 ZA ZA200805235A patent/ZA200805235B/xx unknown
- 2007-03-15 KR KR1020107025457A patent/KR101118943B1/ko not_active IP Right Cessation
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- 2007-03-15 MY MYPI20082153A patent/MY143808A/en unknown
- 2007-03-15 WO PCT/JP2007/055931 patent/WO2007119496A1/en active Application Filing
- 2007-03-15 KR KR1020117016944A patent/KR101168630B1/ko not_active IP Right Cessation
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- 2007-03-15 SI SI200730386T patent/SI1999128T1/sl unknown
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- 2007-03-15 SI SI200731065T patent/SI2206711T1/sl unknown
- 2007-03-15 ES ES07739373T patent/ES2348630T3/es active Active
- 2007-03-15 KR KR20127033350A patent/KR101482374B1/ko not_active IP Right Cessation
- 2007-03-15 AT AT07739373T patent/ATE476433T1/de active
- 2007-03-15 BR BRPI0706224-9A patent/BRPI0706224A2/pt not_active IP Right Cessation
- 2007-03-15 CN CN201110065650.0A patent/CN102174044B/zh not_active Expired - Fee Related
- 2007-03-15 EP EP07739373A patent/EP1999128B1/en not_active Not-in-force
- 2007-03-15 PT PT11152502T patent/PT2311832E/pt unknown
- 2007-03-15 SG SG2011043304A patent/SG172707A1/en unknown
- 2007-03-15 AU AU2007239906A patent/AU2007239906B2/en not_active Ceased
- 2007-03-15 EP EP11152502A patent/EP2311832B1/en not_active Not-in-force
- 2007-03-15 RU RU2008127324/04A patent/RU2408597C2/ru not_active IP Right Cessation
- 2007-03-15 PT PT10160007T patent/PT2206711E/pt unknown
- 2007-03-15 EP EP11152503A patent/EP2311833A1/en not_active Withdrawn
- 2007-03-15 SG SG2011043312A patent/SG172708A1/en unknown
- 2007-03-15 RU RU2009147223/04A patent/RU2441002C2/ru not_active IP Right Cessation
- 2007-03-15 CN CN2011100656661A patent/CN102174045A/zh active Pending
- 2007-03-15 CA CA2725698A patent/CA2725698C/en not_active Expired - Fee Related
- 2007-03-15 PL PL11152502T patent/PL2311832T3/pl unknown
- 2007-03-15 ES ES11152502T patent/ES2390957T3/es active Active
- 2007-03-15 CN CN2011100656708A patent/CN102174046B/zh not_active Expired - Fee Related
- 2007-03-15 EP EP10160007A patent/EP2206711B1/en not_active Not-in-force
- 2007-03-15 PT PT07739373T patent/PT1999128E/pt unknown
- 2007-03-15 SG SG2011043296A patent/SG172706A1/en unknown
- 2007-03-15 KR KR1020117028260A patent/KR20110136902A/ko not_active Application Discontinuation
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