NO20082159L - Triazolopyridinderivater som inhibitorer av lipaser og fosfolipaser - Google Patents

Triazolopyridinderivater som inhibitorer av lipaser og fosfolipaser

Info

Publication number
NO20082159L
NO20082159L NO20082159A NO20082159A NO20082159L NO 20082159 L NO20082159 L NO 20082159L NO 20082159 A NO20082159 A NO 20082159A NO 20082159 A NO20082159 A NO 20082159A NO 20082159 L NO20082159 L NO 20082159L
Authority
NO
Norway
Prior art keywords
phospholipases
lipases
inhibitors
triazolopyridine derivatives
triazolopyridine
Prior art date
Application number
NO20082159A
Other languages
English (en)
Inventor
Gerhard Zoller
Hubert Heuer
Stefan Petry
Guenther Mueller
Karl-Heinz Baringhaus
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20082159L publication Critical patent/NO20082159L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
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Abstract

Foreliggende oppfinnelse angår triazolopyridinderivater med generell formel I, som er definert slik det er angitt i beskrivelsen, deres farmasøytisk anvendbare salter og deres anvendelse som medikamenter. (I)
NO20082159A 2005-10-19 2008-05-08 Triazolopyridinderivater som inhibitorer av lipaser og fosfolipaser NO20082159L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005049954A DE102005049954A1 (de) 2005-10-19 2005-10-19 Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
PCT/EP2006/009856 WO2007045392A1 (de) 2005-10-19 2006-10-12 Triazolopyridin-derivate als inhibitoren von lipasen und phospholipasen

Publications (1)

Publication Number Publication Date
NO20082159L true NO20082159L (no) 2008-05-08

Family

ID=37487398

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082159A NO20082159L (no) 2005-10-19 2008-05-08 Triazolopyridinderivater som inhibitorer av lipaser og fosfolipaser

Country Status (26)

Country Link
US (2) US7718669B2 (no)
EP (1) EP1940838B1 (no)
JP (1) JP2009512649A (no)
KR (1) KR20080057299A (no)
CN (1) CN101291932A (no)
AR (1) AR058095A1 (no)
AU (1) AU2006303551A1 (no)
BR (1) BRPI0617712A2 (no)
CA (1) CA2625442A1 (no)
CR (1) CR9851A (no)
DE (1) DE102005049954A1 (no)
DO (1) DOP2006000227A (no)
EC (1) ECSP088376A (no)
HN (1) HN2006035237A (no)
IL (1) IL190715A0 (no)
MA (1) MA29857B1 (no)
MY (1) MY140514A (no)
NO (1) NO20082159L (no)
NZ (1) NZ567574A (no)
PE (1) PE20070820A1 (no)
RU (1) RU2008119435A (no)
TN (1) TNSN08178A1 (no)
TW (1) TW200800987A (no)
UY (1) UY29878A1 (no)
WO (1) WO2007045392A1 (no)
ZA (1) ZA200802369B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005049954A1 (de) * 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
SI1976828T1 (sl) 2005-12-29 2017-07-31 Celtaxsys, Inc. Diaminski derivati kot inhibitorji levkotrien A4 hidrolaze
FR2915197B1 (fr) 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr) * 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
EP2351744B1 (en) 2008-10-17 2015-01-07 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase
JP5657566B2 (ja) * 2008-12-24 2015-01-21 バイアル ポルテラ アンド シーエイ エス エイＢＩＡＬ−Ｐｏｒｔｅｌａ ＆ Ｃａ， Ｓ．Ａ． 医薬品
CN102753545A (zh) 2009-12-15 2012-10-24 盐野义制药株式会社 具有血管内皮脂酶抑制活性的噁二唑衍生物
KR20130087002A (ko) 2010-06-04 2013-08-05 알바니 몰레큘라 리써치, 인크. 글리신 수송체-1 저해제, 그의 제조 방법 및 그의 용도
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2013166037A1 (en) 2012-05-01 2013-11-07 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of eye disorders
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
BR112015022227A2 (pt) 2013-03-14 2017-07-18 Celtaxsys Inc inibidores de leucotrieno a4 hidrolase
WO2014151936A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, their preparation and use
WO2014152018A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
WO2014152013A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
RU2678196C2 (ru) 2013-03-14 2019-01-24 Селтакссис, Инк. Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
BR112015022226A2 (pt) 2013-03-14 2017-07-18 Celtaxsys Inc inibidores de leucotrieno a4 hidrolase
US9580422B2 (en) * 2013-10-22 2017-02-28 Bristol-Myers Squibb Company Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP3137168B1 (en) 2014-04-30 2022-01-05 The Trustees of Columbia University in the City of New York Substituted 4-phenylpiperidines, their preparation and use
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
JP7386815B2 (ja) 2018-05-31 2023-11-27 セルタクシー、エルエルシー 呼吸器疾患患者の肺増悪を軽減する方法
CN117126134A (zh) * 2022-05-20 2023-11-28 中国科学院上海药物研究所 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0100624D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
DE10247680B4 (de) * 2002-10-12 2005-09-01 Aventis Pharma Deutschland Gmbh Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
DE102004005172A1 (de) * 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
DE102005049954A1 (de) * 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen

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CR9851A (es) 2008-07-29
AR058095A1 (es) 2008-01-23
ECSP088376A (es) 2008-05-30
DE102005049954A1 (de) 2007-05-31
MA29857B1 (fr) 2008-10-03
TNSN08178A1 (en) 2009-10-30
MY140514A (en) 2009-12-31
JP2009512649A (ja) 2009-03-26
US20100190801A1 (en) 2010-07-29
KR20080057299A (ko) 2008-06-24
IL190715A0 (en) 2008-11-03
DOP2006000227A (es) 2007-05-15
ZA200802369B (en) 2009-01-28
PE20070820A1 (es) 2007-09-04
TW200800987A (en) 2008-01-01
AU2006303551A1 (en) 2007-04-26
NZ567574A (en) 2010-03-26
EP1940838B1 (de) 2012-08-22
US7718669B2 (en) 2010-05-18
CN101291932A (zh) 2008-10-22
US20090030011A1 (en) 2009-01-29
UY29878A1 (es) 2007-05-31
EP1940838A1 (de) 2008-07-09
RU2008119435A (ru) 2009-11-27
HN2006035237A (es) 2010-03-11
WO2007045392A1 (de) 2007-04-26
CA2625442A1 (en) 2007-04-26
BRPI0617712A2 (pt) 2011-08-02

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