NO20074710L - 1H-Imidazole derivatives as cannabinoid CB2 receptor modulators - Google Patents
1H-Imidazole derivatives as cannabinoid CB2 receptor modulatorsInfo
- Publication number
- NO20074710L NO20074710L NO20074710A NO20074710A NO20074710L NO 20074710 L NO20074710 L NO 20074710L NO 20074710 A NO20074710 A NO 20074710A NO 20074710 A NO20074710 A NO 20074710A NO 20074710 L NO20074710 L NO 20074710L
- Authority
- NO
- Norway
- Prior art keywords
- imidazole derivatives
- cannabinoid
- receptor modulators
- receptors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår en gruppe 1H-imidazolderivater som er modulatorer av cannabinoid-CB2-reseptorer, fremgangsmåter for fremstilling av disse forbindelsene, nye intermediater anvendelige ved syntese av nevnte imidazolderivater, fremgangsmåter for fremstilling av disse intermediatene, farmasøytiske sammensetninger som inneholder et eller flere av disse 1H-imidazolderivatene som aktiv ingredies, så vel som anvendelse av disse farmasøytiske sammensetningene for behandling av forstyrrelser hvori cannabinoid-CB2-reseptorer er involvert. Forbindelsene har den generelle formelen (I) hvori R1-R4 har betydningene gitt i foreliggende beskrivelse.The present invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid CB2 receptors, processes for the preparation of these compounds, novel intermediates useful in the synthesis of said imidazole derivatives, processes for preparing these intermediates, pharmaceutical compositions containing one or more of them. The 1H-imidazole derivatives as active ingredient, as well as the use of these pharmaceutical compositions for the treatment of disorders involving cannabinoid CB2 receptors. The compounds have the general formula (I) wherein R1-R4 has the meanings given in the present description.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65309105P | 2005-02-16 | 2005-02-16 | |
EP05101171 | 2005-02-16 | ||
PCT/EP2006/060009 WO2006087355A1 (en) | 2005-02-16 | 2006-02-16 | 1h-imidiazole derivatives as cannabinoid cb2 receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20074710L true NO20074710L (en) | 2007-09-14 |
Family
ID=36216936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20074710A NO20074710L (en) | 2005-02-16 | 2007-09-14 | 1H-Imidazole derivatives as cannabinoid CB2 receptor modulators |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1874734A1 (en) |
JP (1) | JP2008530179A (en) |
AU (1) | AU2006215567B2 (en) |
BR (1) | BRPI0607439A2 (en) |
CA (1) | CA2597896A1 (en) |
IL (1) | IL184006A0 (en) |
NO (1) | NO20074710L (en) |
RU (1) | RU2410377C2 (en) |
WO (1) | WO2006087355A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8273738B2 (en) * | 2006-09-05 | 2012-09-25 | Kyowa Hakko Kirin Co., Ltd. | Imidazole derivatives |
FR2908766B1 (en) * | 2006-11-20 | 2009-01-09 | Sanofi Aventis Sa | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS. |
CA2696429A1 (en) * | 2007-08-22 | 2009-02-26 | Allergan, Inc. | Pyrrole compounds having sphingosine-1-phosphate receptor agonist or antagonist biological activity |
WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
US20110237528A1 (en) * | 2008-09-19 | 2011-09-29 | Institute For Oneworld Health | Compositions and methods comprising imidazole and triazole derivatives |
RU2012136451A (en) | 2010-01-28 | 2014-03-10 | Президент Энд Феллоуз Оф Гарвард Колледж | COMPOSITIONS AND METHODS FOR IMPROVING PROTEASOMIC ACTIVITY |
DK2707101T3 (en) | 2011-05-12 | 2019-05-13 | Proteostasis Therapeutics Inc | PROTEOSTASE REGULATORS |
AU2012317424B2 (en) * | 2011-09-28 | 2017-05-18 | Fujifilm Corporation | Crystal of 5-hydroxy-1h-imidazole-4-carboxamide 3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1h-imidazole-4-carboxamide hydrate |
JPWO2013147160A1 (en) * | 2012-03-29 | 2015-12-14 | 東レ株式会社 | Cyclic amine derivatives and their pharmaceutical use |
US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
MX369804B (en) * | 2013-06-12 | 2019-11-21 | Kaken Pharma Co Ltd | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient. |
WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
CN107922348A (en) | 2015-06-22 | 2018-04-17 | 大日本住友制药株式会社 | Bicyclic heterocycle amide derivatives |
RU2741000C2 (en) | 2015-06-22 | 2021-01-22 | Сумитомо Дайниппон Фарма Ко., Лтд. | 1,4-disubstituted imidazole derivative |
US10898469B2 (en) | 2016-02-26 | 2021-01-26 | Sumitomo Dainippon Pharma Co., Ltd. | Imidazolylamide derivative |
TW201803869A (en) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 6-aminopyridin-3-yl thiazoles as modulators of ROR[gamma]t |
CA3103771A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | 6-aminopyridin-3-yl pyrazoles as modulators of roryt |
JP2021529161A (en) | 2018-06-18 | 2021-10-28 | ヤンセン ファーマシューティカ エヌ.ベー. | Pyridinepyrazole as a modulator of RORγt |
US11345666B2 (en) | 2018-06-18 | 2022-05-31 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT |
CN112566901A (en) | 2018-06-18 | 2021-03-26 | 詹森药业有限公司 | Phenyl-substituted pyrazoles as modulators of ROR γ t |
RU2725878C1 (en) * | 2019-12-30 | 2020-07-07 | Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" | Chiral myrtanyl sulphonamides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004502642A (en) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | Cannabinoid receptor modulators, methods for their production, and use of cannabinoid receptor modulators for the treatment of respiratory and non-respiratory diseases |
US20110144128A1 (en) * | 2005-01-10 | 2011-06-16 | Exelixis, Inc. | Heterocyclic Carboxamide Compounds as Steroid Nuclear Receptors Ligands |
-
2006
- 2006-02-16 AU AU2006215567A patent/AU2006215567B2/en not_active Expired - Fee Related
- 2006-02-16 WO PCT/EP2006/060009 patent/WO2006087355A1/en active Application Filing
- 2006-02-16 RU RU2007134428/04A patent/RU2410377C2/en not_active IP Right Cessation
- 2006-02-16 JP JP2007555612A patent/JP2008530179A/en not_active Withdrawn
- 2006-02-16 CA CA002597896A patent/CA2597896A1/en not_active Abandoned
- 2006-02-16 EP EP06708303A patent/EP1874734A1/en not_active Withdrawn
- 2006-02-16 BR BRPI0607439-1A patent/BRPI0607439A2/en not_active IP Right Cessation
-
2007
- 2007-06-18 IL IL184006A patent/IL184006A0/en unknown
- 2007-09-14 NO NO20074710A patent/NO20074710L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2008530179A (en) | 2008-08-07 |
CA2597896A1 (en) | 2006-08-24 |
AU2006215567A1 (en) | 2006-08-24 |
RU2410377C2 (en) | 2011-01-27 |
WO2006087355A1 (en) | 2006-08-24 |
AU2006215567B2 (en) | 2011-05-12 |
IL184006A0 (en) | 2007-10-31 |
BRPI0607439A2 (en) | 2010-04-06 |
RU2007134428A (en) | 2009-03-27 |
EP1874734A1 (en) | 2008-01-09 |
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