NO20073493L - Anti-integrin immunkonjugater, fremgangsmater og anvendelser - Google Patents
Anti-integrin immunkonjugater, fremgangsmater og anvendelserInfo
- Publication number
- NO20073493L NO20073493L NO20073493A NO20073493A NO20073493L NO 20073493 L NO20073493 L NO 20073493L NO 20073493 A NO20073493 A NO 20073493A NO 20073493 A NO20073493 A NO 20073493A NO 20073493 L NO20073493 L NO 20073493L
- Authority
- NO
- Norway
- Prior art keywords
- conjugates
- integrin
- diseases
- applications
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sammendrag Oppfinnelsen relaterer til konjugater av anti-integrin spesifikke antistoffer med cytotoksiske sammensetninger, syntesen, seleksjonen og bruk av slike konjugater for bruk i kreftterapi eller andre sykdommer fremmet av celleproliferasjon, cellemigrering eller betennelse, og hvilken patologi involverer angiogenese eller neovaskularisering av nytt vev. I tillegg relaterer oppfinnelsen til kombinasjonsterapi av slike sykdommer hvori behandlingen omfatter bruk av konjugatene i kombinasjon med én eller flere andre behandlingsmodaliteter inkludert, men ikke begrenset til: kjemoterapi, kirurgi eller strålingsterapi. De foretrukne konjugatene inneholder maytansinoidsammensetninger koblet til antistoffet ved en disulfidkobling, og foretrukne kjemoterapeutiske virkemidler er doxorubicin, et taxan, en camptothecin, et podofyllotoxin, en nukleosid analog eller en pyrimidinanalog.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63444504P | 2004-12-09 | 2004-12-09 | |
PCT/US2005/043250 WO2006062779A2 (en) | 2004-12-09 | 2005-11-30 | Anti-integrin immunoconjugates, methods and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073493L true NO20073493L (no) | 2007-09-06 |
Family
ID=36578407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073493A NO20073493L (no) | 2004-12-09 | 2007-07-06 | Anti-integrin immunkonjugater, fremgangsmater og anvendelser |
Country Status (25)
Country | Link |
---|---|
US (2) | US8603483B2 (no) |
EP (1) | EP1819359B1 (no) |
JP (1) | JP5421532B2 (no) |
KR (1) | KR101281501B1 (no) |
CN (1) | CN101193916B (no) |
AR (1) | AR052041A1 (no) |
AU (1) | AU2005314392B2 (no) |
BR (1) | BRPI0515745A (no) |
CA (1) | CA2591148A1 (no) |
DK (1) | DK1819359T3 (no) |
EA (1) | EA013323B1 (no) |
ES (1) | ES2539126T3 (no) |
HK (1) | HK1107001A1 (no) |
HU (1) | HUE025449T2 (no) |
IL (1) | IL183695A0 (no) |
MX (1) | MX2007007011A (no) |
NO (1) | NO20073493L (no) |
NZ (1) | NZ555601A (no) |
PL (1) | PL1819359T3 (no) |
PT (1) | PT1819359E (no) |
SG (1) | SG158119A1 (no) |
TW (1) | TWI400087B (no) |
UA (1) | UA94388C2 (no) |
WO (1) | WO2006062779A2 (no) |
ZA (1) | ZA200705556B (no) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
PT1819359E (pt) * | 2004-12-09 | 2015-05-28 | Janssen Biotech Inc | Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização |
AU2006274698B2 (en) | 2005-08-02 | 2011-06-09 | Xbiotech, Inc. | Diagnosis, treatment, and prevention of vascular disorders using IL-1a autoantibodies |
MY159375A (en) * | 2006-03-21 | 2016-12-30 | Genentech Inc | Combinatorial therapy |
CA2658612C (en) | 2006-08-03 | 2015-11-17 | Astrazeneca Ab | Antibodies directed to .alpha.v.beta.6 and uses thereof |
WO2008042611A2 (en) * | 2006-09-29 | 2008-04-10 | Centocor, Inc. | Method of using il6 antagonists with mitoxantrone for prostate cancer |
US20090175784A1 (en) * | 2007-05-11 | 2009-07-09 | Joshua Goldstein | Anti-Alpha V Immunoliposome Composition, Methods, and Uses |
WO2008141276A1 (en) * | 2007-05-11 | 2008-11-20 | Centocor, Inc. | Anti-alpha-v immunoliposome composition, methods and uses |
US7973138B2 (en) | 2007-09-26 | 2011-07-05 | Genentech, Inc. | Antibodies |
KR20210100223A (ko) | 2008-04-30 | 2021-08-13 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
KR20150127300A (ko) | 2008-05-30 | 2015-11-16 | 엑스바이오테크, 인크. | 인터류킨-1 알파 항체 및 그의 사용 방법 |
BRPI0916365A2 (pt) * | 2008-07-21 | 2018-05-02 | Brigham & Womens Hospital Inc | métodos e composições relacionados aos oligossacarídeos de glicosina beta-1,6 sintéticos |
CN102209557A (zh) | 2008-09-12 | 2011-10-05 | 埃克斯生物科技公司 | 靶向病原性单核细胞 |
US20110207155A1 (en) * | 2008-10-13 | 2011-08-25 | Xeptagen Spa | Method for the preparation of immunoconjugates and use thereof |
EP2411411B1 (en) | 2009-03-25 | 2016-08-31 | F.Hoffmann-La Roche Ag | Novel anti-alpha5beta1 antibodies and uses thereof |
LT2437790T (lt) | 2009-06-03 | 2019-06-10 | Immunogen, Inc. | Konjugavimo būdai |
FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
CA2676946A1 (en) * | 2009-08-28 | 2011-02-28 | Lucie Peduto | Adam12 inhibitors and their use against inflammation-induced fibrosis |
JP2013506709A (ja) | 2009-10-06 | 2013-02-28 | イミュノジェン・インコーポレーテッド | 有効なコンジュゲートおよび親水性リンカー |
MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
CN107596365A (zh) | 2010-06-18 | 2018-01-19 | 埃克斯生物科技公司 | 关节炎治疗 |
KR20160062200A (ko) * | 2010-08-23 | 2016-06-01 | 엑스바이오테크, 인크. | 종양성 질병들에 대한 치료 |
WO2012057328A1 (ja) * | 2010-10-29 | 2012-05-03 | 株式会社ペルセウスプロテオミクス | 高い内在化能力を有する抗cdh3抗体 |
KR20220009505A (ko) | 2011-03-29 | 2022-01-24 | 이뮤노젠 아이엔씨 | 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조 |
WO2012135517A2 (en) | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Preparation of maytansinoid antibody conjugates by a one-step process |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
EP2699268A2 (de) | 2011-04-21 | 2014-02-26 | Seattle Genetics, Inc. | Neue binder-wirkstoff konjugate (adcs) und ihre verwendung |
RU2013154048A (ru) * | 2011-05-09 | 2015-06-20 | Юниверсити Оф Вирджиния Пэтент Фаундейшн | Композиции и способы лечения рака |
RU2622021C2 (ru) | 2011-09-23 | 2017-06-08 | ИксБиотеч, Инк. | Лечение кахексии |
KR20150009952A (ko) * | 2012-01-27 | 2015-01-27 | 에프. 호프만-라 로슈 아게 | 알파-v-베타-3 발현 세포로의 표적화 전달을 위한 인테그린 안타고니스트 접합체 |
SG11201404354UA (en) * | 2012-02-17 | 2014-10-30 | Seattle Genetics Inc | ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
EP3904358A1 (en) * | 2012-09-26 | 2021-11-03 | ImmunoGen, Inc. | Improved methods for the acylation of maytansinol |
SG11201502429YA (en) | 2012-10-04 | 2015-04-29 | Immunogen Inc | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
US9180203B2 (en) * | 2012-10-23 | 2015-11-10 | The Johns Hopkins University | Self-assembling drug amphiphiles and methods for synthesis and use |
CA2898239A1 (en) | 2013-01-23 | 2014-07-31 | Syddansk Universitet | Mfap4 binding antibodies blocking the interaction between mfap4 and integrin receptors |
EP2777714A1 (en) * | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
EP3021942A4 (en) * | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
EP3038624A1 (en) | 2013-08-26 | 2016-07-06 | Regeneron Pharmaceuticals, Inc. | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses |
NZ720736A (en) | 2013-12-23 | 2020-08-28 | Bayer Pharma AG | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) |
JP2017526682A (ja) * | 2014-09-02 | 2017-09-14 | イミュノジェン, インコーポレイテッド | 抗体薬物複合体組成物の製剤化方法 |
KR20170088905A (ko) | 2014-11-19 | 2017-08-02 | 이뮤노젠 아이엔씨 | 세포 결합 작용제-세포독성 작용제 접합체를 제조하기 위한 공정 |
WO2016090157A1 (en) | 2014-12-04 | 2016-06-09 | Celgene Corporation | Biomolecule conjugates |
WO2016102679A1 (en) | 2014-12-23 | 2016-06-30 | Nbe-Therapeutics Ag | Binding protein drug conjugates comprising anthracycline derivatives |
CN108025084A (zh) | 2015-06-22 | 2018-05-11 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物(adc)和抗体前药缀合物(apdc) |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
SG11201806478PA (en) | 2016-02-05 | 2018-08-30 | Immunogen Inc | Efficient process for preparing cell-binding agent-cytotoxic agent conjugates |
GB201602356D0 (en) * | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
WO2017162663A1 (de) | 2016-03-24 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
JP7022707B2 (ja) | 2016-06-15 | 2022-02-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ksp阻害剤および抗cd123抗体を含む特異的抗体-薬物-コンジュゲート(adc) |
WO2018114798A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
KR102583006B1 (ko) | 2016-12-21 | 2023-09-27 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc) |
CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
KR20190117579A (ko) | 2017-02-16 | 2019-10-16 | 엑스바이오테크, 인크. | 화농성 한선염의 치료 |
US10639382B2 (en) | 2017-04-13 | 2020-05-05 | National Guard Health Affairs | Method for treating leukemia |
CN110869051A (zh) * | 2017-05-30 | 2020-03-06 | 小利兰·斯坦福大学托管委员会 | 对神经炎症性疾病的治疗 |
EP3634485A4 (en) * | 2017-06-07 | 2021-07-21 | Silverback Therapeutics, Inc. | CONJUGATES OF ANTIBODIES CONTAINING IMMUNOMODULATOR COMPOUNDS AND THEIR USES |
US20200046737A1 (en) | 2018-08-09 | 2020-02-13 | Notable Labs, Inc. | Methods for treating cancer, and compositions therefor |
AU2020309570A1 (en) | 2019-07-10 | 2022-02-03 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
JP2022541747A (ja) | 2019-07-10 | 2022-09-27 | サイブレクサ 3,インコーポレイテッド | 治療薬としての微小管標的化剤のペプチドコンジュゲート |
WO2024001669A1 (zh) * | 2022-06-27 | 2024-01-04 | 昱言科技(北京)有限公司 | 靶向itga2的抗体和包含此抗体的抗体药物缀合物 |
CN115350187B (zh) * | 2022-08-30 | 2023-08-29 | 中山大学 | 异丙托溴铵在抑制肺癌骨转移中的应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
SE430062B (sv) | 1977-03-04 | 1983-10-17 | Pharmacia Fine Chemicals Ab | Kopplings- eller tioleringsreagens |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
PT627940E (pt) * | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
JP3161490B2 (ja) | 1993-07-30 | 2001-04-25 | 松下電器産業株式会社 | 金型装置 |
US6160099A (en) | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
GB9909392D0 (en) * | 1999-04-24 | 1999-06-23 | Imp Cancer Res Tech | Treatment, imaging and diagnosis of disease |
EP1191944A2 (en) | 1999-06-25 | 2002-04-03 | Genentech, Inc. | METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES |
US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
AR030612A1 (es) * | 2000-09-12 | 2003-08-27 | Smithkline Beecham Corp | Procedimiento e intermedios |
EP1389090A2 (en) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostic imaging compositions, their methods of synthesis and use |
US20030103985A1 (en) * | 2001-05-18 | 2003-06-05 | Boehringer Ingelheim International Gmbh | Cytotoxic CD44 antibody immunoconjugates |
EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US20050152913A1 (en) | 2002-05-13 | 2005-07-14 | Eldridge Ann M. | Process for preapring maytansinol |
DE60336149D1 (de) | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
BRPI0410260A (pt) * | 2003-05-14 | 2006-05-16 | Immunogen Inc | composição conjugada para medicamento |
US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
CN1956722A (zh) | 2003-05-20 | 2007-05-02 | 伊缪诺金公司 | 含有新的美登素类的改进的细胞毒剂 |
PT1819359E (pt) * | 2004-12-09 | 2015-05-28 | Janssen Biotech Inc | Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização |
-
2005
- 2005-11-30 PT PT58524844T patent/PT1819359E/pt unknown
- 2005-11-30 CA CA002591148A patent/CA2591148A1/en not_active Abandoned
- 2005-11-30 KR KR1020077015643A patent/KR101281501B1/ko not_active IP Right Cessation
- 2005-11-30 HU HUE05852484A patent/HUE025449T2/en unknown
- 2005-11-30 BR BRPI0515745-5A patent/BRPI0515745A/pt not_active IP Right Cessation
- 2005-11-30 US US11/290,249 patent/US8603483B2/en not_active Expired - Fee Related
- 2005-11-30 EP EP05852484.4A patent/EP1819359B1/en active Active
- 2005-11-30 JP JP2007545515A patent/JP5421532B2/ja not_active Expired - Fee Related
- 2005-11-30 NZ NZ555601A patent/NZ555601A/en not_active IP Right Cessation
- 2005-11-30 ES ES05852484.4T patent/ES2539126T3/es active Active
- 2005-11-30 UA UAA200706239A patent/UA94388C2/ru unknown
- 2005-11-30 PL PL05852484T patent/PL1819359T3/pl unknown
- 2005-11-30 CN CN2005800478135A patent/CN101193916B/zh not_active Expired - Fee Related
- 2005-11-30 MX MX2007007011A patent/MX2007007011A/es active IP Right Grant
- 2005-11-30 WO PCT/US2005/043250 patent/WO2006062779A2/en active Application Filing
- 2005-11-30 AU AU2005314392A patent/AU2005314392B2/en not_active Ceased
- 2005-11-30 DK DK05852484T patent/DK1819359T3/en active
- 2005-11-30 EA EA200701250A patent/EA013323B1/ru not_active IP Right Cessation
- 2005-11-30 SG SG200908161-3A patent/SG158119A1/en unknown
- 2005-12-07 AR ARP050105122A patent/AR052041A1/es not_active Application Discontinuation
- 2005-12-08 TW TW094143287A patent/TWI400087B/zh not_active IP Right Cessation
-
2007
- 2007-06-05 IL IL183695A patent/IL183695A0/en unknown
- 2007-07-06 NO NO20073493A patent/NO20073493L/no not_active Application Discontinuation
- 2007-07-06 ZA ZA200705556A patent/ZA200705556B/xx unknown
- 2007-11-15 HK HK07112495.8A patent/HK1107001A1/xx not_active IP Right Cessation
-
2013
- 2013-12-04 US US14/096,767 patent/US20140093523A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20073493L (no) | Anti-integrin immunkonjugater, fremgangsmater og anvendelser | |
Lau et al. | New and emerging targeted therapies for advanced breast cancer | |
PH12019502484A1 (en) | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof | |
JOP20210073A1 (ar) | مترافقات جسم مضاد وعقار أساسها إيريبولين وطرق استخدامها | |
MX2021014094A (es) | Conjugados de anticuerpo-farmaco inhibidores de mcl-1 y sus metodos de uso. | |
WO2004018000A3 (en) | Compositions and methods for treating cancer using maytansinoid cd44 antibody immonoconjugates and chemotherapeutic agents | |
WO2020056198A3 (en) | Substituted benzazepine compounds, conjugates, and uses thereof | |
MX2016010683A (es) | Terapia para tratar enfermedades mediante la induccion de respuesta inmune de las células que expresan trop-2. | |
DK1594542T3 (da) | Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer | |
MX2023004434A (es) | Anticuerpos anti-fgfr2 y metodos para usarlos. | |
WO2019234694A3 (en) | Therapeutic methods using antibody drug conjugates (adcs) | |
EA202193309A1 (ru) | Конъюгаты антитело к тканевому фактору-лекарственное средство и связанные способы | |
AU2020380603A8 (en) | Anti-mesothelin eribulin antibody-drug conjugates and methods of use | |
MX2020010408A (es) | Conjugados de anticuerpo-farmaco y sus usos para el tratamiento del cancer. | |
MX2020002266A (es) | Conjugados de fármaco-anticuerpo (adc) anti-egfr y sus usos. | |
Attoub et al. | PO-419 Use of origanum majorana oil in lung cancer therapy | |
Persaud et al. | CD45-ADC Plus Janus Kinase (JAK) Inhibitors As Conditioning for MHC-Mismatched Murine Hematopoietic Stem Cell Transplantation Is Associated with Minimal Toxicity and Graft Versus Host Disease | |
TW202421137A (zh) | 靶向NaPi2b之抗體—藥物結合物及使用方法 | |
EA202091688A1 (ru) | Конъюгаты антител к тканевому фактору с лекарственными средствами и их применение при лечении рака | |
Mawad et al. | hematopoietic bone marrow transplantation (BMT) for patients with high-risk acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS) using HLA-haploidentical related donors: a trial using radiolabeled anti-CD45 antibody combined with immunosuppression before and after BMT |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |