NO20072078L - Indolderivater som inhibitorer av loselig adenylsyklase - Google Patents

Indolderivater som inhibitorer av loselig adenylsyklase

Info

Publication number
NO20072078L
NO20072078L NO20072078A NO20072078A NO20072078L NO 20072078 L NO20072078 L NO 20072078L NO 20072078 A NO20072078 A NO 20072078A NO 20072078 A NO20072078 A NO 20072078A NO 20072078 L NO20072078 L NO 20072078L
Authority
NO
Norway
Prior art keywords
inhibitors
soluble
indole derivatives
adenyl cyclase
adenyl
Prior art date
Application number
NO20072078A
Other languages
English (en)
Inventor
Bernd Buchmann
Bernd Menzenbach
Knut Eis
Duy Nguyen
Anne Mengel
Martin Fritsch
Gernot Langer
Ulf Boemer
Seock-Kyu Khim
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004047272A external-priority patent/DE102004047272A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of NO20072078L publication Critical patent/NO20072078L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen angår forbindelser med generell formel (I) samt fremstilling av disse og anvendelse av disse som medikamenter.
NO20072078A 2004-09-24 2007-04-23 Indolderivater som inhibitorer av loselig adenylsyklase NO20072078L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004047272A DE102004047272A1 (de) 2004-09-24 2004-09-24 Inhibitoren der löslichen Adenylatzyklase
PCT/EP2005/010629 WO2006032541A1 (de) 2004-09-24 2005-09-23 Indol derivative als inhibitoren der löslichen adenylatzyklase

Publications (1)

Publication Number Publication Date
NO20072078L true NO20072078L (no) 2007-05-31

Family

ID=37600950

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072078A NO20072078L (no) 2004-09-24 2007-04-23 Indolderivater som inhibitorer av loselig adenylsyklase

Country Status (24)

Country Link
US (1) US20080004268A1 (no)
EP (1) EP1802572B1 (no)
JP (1) JP2008514572A (no)
KR (1) KR20070054685A (no)
CN (1) CN101084189A (no)
AR (1) AR051300A1 (no)
AT (1) ATE429419T1 (no)
AU (1) AU2005287481A1 (no)
BR (1) BRPI0516057A (no)
CA (1) CA2581492A1 (no)
CR (1) CR9058A (no)
DE (1) DE502005007158D1 (no)
EA (1) EA200700555A1 (no)
GT (1) GT200500268A (no)
IL (1) IL181739A0 (no)
MX (1) MX2007003287A (no)
MY (1) MY142839A (no)
NO (1) NO20072078L (no)
PA (1) PA8646301A1 (no)
PE (1) PE20060696A1 (no)
SV (1) SV2006002238A (no)
TW (1) TW200615260A (no)
UY (1) UY29141A1 (no)
ZA (1) ZA200703307B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase
CN102262159B (zh) 2010-05-27 2014-03-26 李建远 用于检测生育相关人睾丸和附睾表达305种***定位蛋白的方法
US10981899B2 (en) 2016-04-28 2021-04-20 Cornell University Inhibitors of soluble adenylyl cyclase
WO2019046465A2 (en) * 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey THERAPEUTIC INDOLES
EP3676255A1 (en) 2017-08-29 2020-07-08 Rutgers, The State University University Of New Jersey Therapeutic indazoles
CN108096244B (zh) * 2018-01-25 2020-11-24 昆明医科大学 1-氢-2-吲哚酮-3-苄基/取代苄基-3-甲酸酯类化合物的用途
EP3851853A1 (en) * 2020-01-17 2021-07-21 Biotechnologicky Ustav AV CR, v.v.i. Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69928260T2 (de) * 1998-07-08 2006-07-20 Sanofi-Aventis Deutschland Gmbh Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7417066B2 (en) * 2005-06-08 2008-08-26 Schering Ag Inhibitors of soluble adenylate cyclase
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase

Also Published As

Publication number Publication date
MX2007003287A (es) 2007-10-11
ZA200703307B (en) 2009-05-27
PA8646301A1 (es) 2006-09-08
AU2005287481A1 (en) 2006-03-30
US20080004268A1 (en) 2008-01-03
AR051300A1 (es) 2007-01-03
BRPI0516057A (pt) 2008-08-19
DE502005007158D1 (de) 2009-06-04
SV2006002238A (es) 2006-06-26
EP1802572B1 (de) 2009-04-22
PE20060696A1 (es) 2006-08-01
EP1802572A1 (de) 2007-07-04
CA2581492A1 (en) 2006-03-30
IL181739A0 (en) 2007-07-04
ATE429419T1 (de) 2009-05-15
JP2008514572A (ja) 2008-05-08
TW200615260A (en) 2006-05-16
CR9058A (es) 2007-10-04
UY29141A1 (es) 2006-04-28
CN101084189A (zh) 2007-12-05
MY142839A (en) 2011-01-14
EA200700555A1 (ru) 2007-10-26
KR20070054685A (ko) 2007-05-29
GT200500268A (es) 2006-10-10

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