NO20071274L - Inhibitorer av hepatitt C virus RNA-avhengig RNA polymerase, og sammensetninger og behandlinger ved anvendelse av samme. - Google Patents

Inhibitorer av hepatitt C virus RNA-avhengig RNA polymerase, og sammensetninger og behandlinger ved anvendelse av samme.

Info

Publication number
NO20071274L
NO20071274L NO20071274A NO20071274A NO20071274L NO 20071274 L NO20071274 L NO 20071274L NO 20071274 A NO20071274 A NO 20071274A NO 20071274 A NO20071274 A NO 20071274A NO 20071274 L NO20071274 L NO 20071274L
Authority
NO
Norway
Prior art keywords
hepatitis
inhibitors
treatments
compositions
same
Prior art date
Application number
NO20071274A
Other languages
English (en)
Inventor
Javier Gonzales
Tanya Michelle Jewell
Hui Li
Angelica Linton
John Howard Tatlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20071274L publication Critical patent/NO20071274L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel (4), og deres farmasøytisk akseptable salter og solvater, som er anvendelige som inhibitorer av hepatitt C virus (HCV) polymeraseenzym og er også anvendelige for behandling av HCV infeksjoner i HCV-infiserte pattedyr. Foreliggende oppfinnelse tilveiebringer også farmasøytiske sammensetninger som innbefatter forbindelser med formel (4), deres farmasøytisk akseptable salter og solvater. Videre tilveiebringer foreliggende oppfinnelse intermediater og fremgangsmåter anvendelige ved fremstilling av forbindelser med formel (4).
NO20071274A 2004-08-18 2007-03-08 Inhibitorer av hepatitt C virus RNA-avhengig RNA polymerase, og sammensetninger og behandlinger ved anvendelse av samme. NO20071274L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60261804P 2004-08-18 2004-08-18
PCT/IB2005/002697 WO2006018725A1 (en) 2004-08-18 2005-08-05 Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same

Publications (1)

Publication Number Publication Date
NO20071274L true NO20071274L (no) 2007-05-14

Family

ID=35429645

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071274A NO20071274L (no) 2004-08-18 2007-03-08 Inhibitorer av hepatitt C virus RNA-avhengig RNA polymerase, og sammensetninger og behandlinger ved anvendelse av samme.

Country Status (43)

Country Link
US (3) US7151105B2 (no)
EP (1) EP1781662B1 (no)
JP (1) JP4372195B2 (no)
KR (1) KR100851178B1 (no)
CN (2) CN101538268B (no)
AP (1) AP2313A (no)
AR (1) AR050699A1 (no)
AT (1) ATE506364T1 (no)
AU (1) AU2005273619B2 (no)
BR (1) BRPI0514425A (no)
CA (1) CA2577525C (no)
CR (2) CR8935A (no)
CY (1) CY1111480T1 (no)
DE (1) DE602005027580D1 (no)
DK (1) DK1781662T3 (no)
EA (1) EA012605B1 (no)
EC (1) ECSP077264A (no)
ES (1) ES2361845T3 (no)
GE (2) GEP20094751B (no)
GT (1) GT200500221A (no)
HK (1) HK1109617A1 (no)
HN (1) HN2005000449A (no)
HR (1) HRP20110458T1 (no)
IL (2) IL180933A (no)
MA (1) MA28803B1 (no)
MX (1) MX2007001527A (no)
MY (1) MY146123A (no)
NI (1) NI200700043A (no)
NL (1) NL1029755C2 (no)
NO (1) NO20071274L (no)
NZ (1) NZ552874A (no)
PE (1) PE20060677A1 (no)
PL (1) PL1781662T3 (no)
PT (1) PT1781662E (no)
RS (1) RS51794B (no)
SI (1) SI1781662T1 (no)
SV (1) SV2007002202A (no)
TN (1) TNSN07066A1 (no)
TW (1) TWI376379B (no)
UA (1) UA88909C2 (no)
UY (1) UY29068A1 (no)
WO (1) WO2006018725A1 (no)
ZA (1) ZA200700779B (no)

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Publication number Publication date
EP1781662A1 (en) 2007-05-09
EP1781662B1 (en) 2011-04-20
HRP20110458T1 (hr) 2011-07-31
US8268835B2 (en) 2012-09-18
MY146123A (en) 2012-06-29
AP2313A (en) 2011-10-31
JP4372195B2 (ja) 2009-11-25
CR20110153A (es) 2011-04-26
CN101006092B (zh) 2013-04-17
GT200500221A (es) 2006-06-21
CA2577525A1 (en) 2006-02-23
CN101538268B (zh) 2011-07-27
WO2006018725A1 (en) 2006-02-23
SI1781662T1 (sl) 2011-07-29
KR20070044057A (ko) 2007-04-26
DE602005027580D1 (de) 2011-06-01
TWI376379B (en) 2012-11-11
JP2008509984A (ja) 2008-04-03
SV2007002202A (es) 2007-03-20
AU2005273619A1 (en) 2006-02-23
CY1111480T1 (el) 2015-08-05
IL192919A0 (en) 2009-02-11
NL1029755A1 (nl) 2006-02-21
CN101006092A (zh) 2007-07-25
BRPI0514425A (pt) 2008-06-10
ATE506364T1 (de) 2011-05-15
UA88909C2 (ru) 2009-12-10
DK1781662T3 (da) 2011-06-27
HK1109617A1 (en) 2008-06-13
PE20060677A1 (es) 2006-08-11
PL1781662T3 (pl) 2011-08-31
GEP20115305B (en) 2011-10-10
AP2007003918A0 (en) 2007-02-28
EA200700338A1 (ru) 2007-08-31
KR100851178B1 (ko) 2008-08-08
RS51794B (en) 2011-12-31
US20090281122A1 (en) 2009-11-12
HN2005000449A (es) 2009-10-30
PT1781662E (pt) 2011-07-01
IL180933A0 (en) 2007-07-04
GEP20094751B (en) 2009-08-10
AR050699A1 (es) 2006-11-15
TW200612898A (en) 2006-05-01
UY29068A1 (es) 2006-03-31
CA2577525C (en) 2010-03-30
MA28803B1 (fr) 2007-08-01
NZ552874A (en) 2010-04-30
NI200700043A (es) 2008-01-02
IL180933A (en) 2011-08-31
US7151105B2 (en) 2006-12-19
US7622605B2 (en) 2009-11-24
ECSP077264A (es) 2007-04-26
AU2005273619B2 (en) 2009-05-28
ZA200700779B (en) 2008-11-26
ES2361845T3 (es) 2011-06-22
NL1029755C2 (nl) 2006-10-18
US20070015764A1 (en) 2007-01-18
CR8935A (es) 2007-07-24
US20060122399A1 (en) 2006-06-08
TNSN07066A1 (fr) 2008-06-02
MX2007001527A (es) 2007-03-27
EA012605B1 (ru) 2009-10-30
CN101538268A (zh) 2009-09-23

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