NO20065057L - benzoxazocines and their therapeutic use as monoamine reuptake inhibitors - Google Patents
benzoxazocines and their therapeutic use as monoamine reuptake inhibitorsInfo
- Publication number
- NO20065057L NO20065057L NO20065057A NO20065057A NO20065057L NO 20065057 L NO20065057 L NO 20065057L NO 20065057 A NO20065057 A NO 20065057A NO 20065057 A NO20065057 A NO 20065057A NO 20065057 L NO20065057 L NO 20065057L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- unsubstituted
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Forbindelser som er terapeutisk anvendelige har den generelle formel (1) hvor R1 er H, C1-C6 alkyl eventuelt substituert med F eller C3-C6 cykloalkyl eller C2-C4 alkenyl; A er O, CH2 eller S(O)n hvor n er 0-2; en av W, X, Y og Z er N, CH eller CR3 og de andre er CH; R2 er C5-C6 heteroaryl, C5-C10 cykloalkyl eller cykloalkenyl eventuelt inneholdende ett eller flere heteroatomer valgt fra O, N og S(O)n hvor n er 0-2 og eventuelt substituert med R3; eller en fenylgruppe eventuelt substituert i en eller flere stillinger med en eller flere substituenter uavhengig valgt fra halogen, CN, CF3, C1-C6 alkyl og OR1 eller fenylgruppen er kondensert til en fem- eller seksleddet ring som kan være karbosyklisk, heterosyklisk (inneholdende 1-2 heteroatomer valgt fra O, N og S), aromatisk eller heteroaromatisk (inneholdende 1-2 heteroatomer valgt fra O og N); R3 er valgt fra halogen; CF3; CN; OR5; SO2N(R5)2; COR5; CO2R5; CON(R5)2; NR1COR4; NR1SO2R4; NR1CO2R4; NR1CON(R5)2; OC1- C6 alkyl substituert med R3; C1-C6 alkyl eventuelt substituert med usubstituert R3; C3-C6 cykloalkyl eventuelt substituert med usubstituert R3; C2-C6 alkenyl eventuelt substituert med usubstituert R3; C2-C6 alkynyl eventuelt substituert med usubstituert R3; aryl eventuelt substituert med usubstituert R3; og fem- eller seksleddet aromatiske heterocykliske grupper inneholdende 1-4 heteroatomer valgt fra N og 0; R4 er C1- C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cykloalkyl, aryl og heteroaryl; og R5 er H, C1- C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cykloalkyl, aryl eller heteroaryl og er like som eller forskjellige fra en annen R5; eller et farmasøytisk akseptabelt salt derav.Compounds which are therapeutically useful have the general formula (1) wherein R 1 is H, C 1 -C 6 alkyl optionally substituted with F or C 3 -C 6 cycloalkyl or C 2 -C 4 alkenyl; A is O, CH2 or S (O) n where n is 0-2; one of W, X, Y and Z is N, CH or CR3 and the others are CH; R2 is C5-C6 heteroaryl, C5-C10 cycloalkyl or cycloalkenyl optionally containing one or more heteroatoms selected from O, N and S (O) n where n is 0-2 and optionally substituted with R3; or a phenyl group optionally substituted at one or more positions with one or more substituents independently selected from halogen, CN, CF3, C1-C6 alkyl and OR1 or the phenyl group is condensed into a five or six membered ring which may be carbocyclic, heterocyclic (containing 1 -2 heteroatoms selected from O, N and S), aromatic or heteroaromatic (containing 1-2 heteroatoms selected from O and N); R 3 is selected from halogen; CF3; CN; OR5; SO2N (R5) 2; COR5; CO2R5; CON (R5) 2; NR1COR4; NR1SO2R4; NR1CO2R4; NR1CON (R5) 2; OC1-C6 alkyl substituted with R3; C1-C6 alkyl optionally substituted with unsubstituted R3; C3-C6 cycloalkyl optionally substituted with unsubstituted R3; C2-C6 alkenyl optionally substituted with unsubstituted R3; C2-C6 alkynyl optionally substituted with unsubstituted R3; aryl optionally substituted with unsubstituted R 3; and five- or six-membered aromatic heterocyclic groups containing 1-4 heteroatoms selected from N and O; R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, aryl and heteroaryl; and R5 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, aryl or heteroaryl and are the same or different from another R5; or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0408863A GB0408863D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| GB0408862A GB0408862D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| PCT/GB2005/001519 WO2005103019A1 (en) | 2004-04-21 | 2005-04-21 | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20065057L true NO20065057L (en) | 2006-11-21 |
Family
ID=34965745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20065057A NO20065057L (en) | 2004-04-21 | 2006-11-02 | benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1740558A1 (en) |
| JP (1) | JP2007533718A (en) |
| AU (1) | AU2005235786A1 (en) |
| BR (1) | BRPI0510075A (en) |
| CA (1) | CA2558741A1 (en) |
| IL (1) | IL177750A0 (en) |
| NO (1) | NO20065057L (en) |
| WO (1) | WO2005103019A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504960D0 (en) * | 2005-03-10 | 2005-04-20 | Arakis Ltd | Benzoxazocines |
| GB0506835D0 (en) * | 2005-04-04 | 2005-05-11 | Arakis Ltd | Therapeutic use of nefopam |
| BR112012014471A2 (en) | 2009-12-15 | 2017-06-06 | Hospital For Sick Children | Method for treating scars and beta-catenin-mediated disorders using nefopam compounds |
| ES2603032T3 (en) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | 3-Pyridyl-heteroarylcarboxamide compounds as pesticides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830803A (en) * | 1965-05-10 | 1974-08-20 | Riker Laboratories Inc | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
| US3978085A (en) * | 1975-03-07 | 1976-08-31 | Riker Laboratories, Inc. | Process for benz[f]-2,5-oxazocines |
| JPS5913770A (en) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | Novel 1-phenyl-2,5-benzothiazocine derivative and its preparation |
| JPS5913760A (en) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | Novel benzazocine derivative and its preparation |
| JP4907818B2 (en) * | 1999-11-03 | 2012-04-04 | エーエムアール テクノロジー インコーポレイテッド | Aryl and heteroaryl substituted tetrahydroisoquinolines and their use to prevent reuptake of norepinephrine, dopamine and serotonin |
| EP1572672B1 (en) * | 2002-12-20 | 2008-08-13 | Sosei R&D Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
-
2005
- 2005-04-21 CA CA002558741A patent/CA2558741A1/en not_active Abandoned
- 2005-04-21 EP EP05736028A patent/EP1740558A1/en not_active Withdrawn
- 2005-04-21 JP JP2007508968A patent/JP2007533718A/en not_active Withdrawn
- 2005-04-21 AU AU2005235786A patent/AU2005235786A1/en not_active Abandoned
- 2005-04-21 WO PCT/GB2005/001519 patent/WO2005103019A1/en not_active Application Discontinuation
- 2005-04-21 BR BRPI0510075-5A patent/BRPI0510075A/en not_active IP Right Cessation
-
2006
- 2006-08-29 IL IL177750A patent/IL177750A0/en unknown
- 2006-11-02 NO NO20065057A patent/NO20065057L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007533718A (en) | 2007-11-22 |
| AU2005235786A1 (en) | 2005-11-03 |
| CA2558741A1 (en) | 2005-11-03 |
| WO2005103019A1 (en) | 2005-11-03 |
| IL177750A0 (en) | 2006-12-31 |
| BRPI0510075A (en) | 2007-10-16 |
| EP1740558A1 (en) | 2007-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2017001603A2 (en) | Jak inhibitor aminopyrimidinyl compounds | |
| RS51471B (en) | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | |
| MX2015015893A (en) | 2-phenylimidazo[1,2-a]pyrimidines as imaging agents. | |
| NO20072116L (en) | Pharmaceutical compounds | |
| AR054560A1 (en) | SPIROPIPERIDINE AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | |
| NO20092770L (en) | Novel aminopyrimidine derivatives as PLK1 inhibitors | |
| NO20054095L (en) | Pyridyloxymethyl and benzioxazolazabicyclic derivatives | |
| HRP20090280T1 (en) | Phenoxyacetic acid derivatives | |
| NO20063330L (en) | Amide derivatives with a cyclopropylaminocarbonyl substituent useful as cytokine inhibitors | |
| AR046297A1 (en) | DPP INHIBITORS - IV METHODS TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AS ACTIVE AGENTS | |
| DE602004014347D1 (en) | CHINAZOLIN DERIVATIVES AS TGF BETA INHIBITORS | |
| NO20092692L (en) | MAPK / ERK kinase inhibitors | |
| NO20053449L (en) | 3-substituted 4-pyrimidone derivatives | |
| AR041297A1 (en) | DERIVATIVES OF 4-PIRROLIDINO- FENIL- BENCIL ETER | |
| NZ601967A (en) | Pde10 inhibitors and related compositions and methods | |
| JOP20190239A1 (en) | Vmat2 inhibitor compounds and compositions thereof | |
| DK1961734T3 (en) | Amine compound and its use for medical purposes | |
| PE20070212A1 (en) | 1,4-DIHYDROPYRIDINE-CONDENSED HETEROCYCLES, PROCESSES TO PREPARE THE SAME, USE AND COMPOSITIONS CONTAINING THEM | |
| YU40998A (en) | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | |
| AR040489A1 (en) | COMPOUNDS DERIVED FROM 3-PHENYL-PROPIONAMIDE, 3-PHENYL-ACRYLAMIDE AND 3-PHENYL-PROPINAMID, ITS USE FOR THE PREPARATION OF MEDICINES, A PROCESS TO PREPARE THE COMPOUNDS AND MEDICINES CONTAINING THEM | |
| HUP0304101A2 (en) | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates | |
| ATE535241T1 (en) | USE OF 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE DERIVATIVES IN THE TREATMENT OF LEUKEMIA | |
| TW200510377A (en) | Novel compound having 4-pyridylalkylthio group as substituent | |
| NO20065057L (en) | benzoxazocines and their therapeutic use as monoamine reuptake inhibitors | |
| HUP0401883A2 (en) | Muscarinic agonists and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |