NO20062579L - Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener - Google Patents

Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener

Info

Publication number
NO20062579L
NO20062579L NO20062579A NO20062579A NO20062579L NO 20062579 L NO20062579 L NO 20062579L NO 20062579 A NO20062579 A NO 20062579A NO 20062579 A NO20062579 A NO 20062579A NO 20062579 L NO20062579 L NO 20062579L
Authority
NO
Norway
Prior art keywords
immune responses
malantigens
melittin
compositions
methods
Prior art date
Application number
NO20062579A
Other languages
English (en)
Inventor
Rinaldo Zurbriggen
Original Assignee
Pevion Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pevion Biotech Ltd filed Critical Pevion Biotech Ltd
Publication of NO20062579L publication Critical patent/NO20062579L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer nye adjuvanssystemer som reduserer risikoen for toksiske bivirkninger som er assosiert med anvendelsen av kjente adjuvanser, mens det tilveiebringes kraftig stimulering av immunresponser mot målantigenet. Disse nye adjuvanssystemene er basert på hormingbiegiften melittin eller spesiflkke kationiske peptider som er avledet flia melittin og som er i stand til å utløse sterke immunresponser mot målantigenet. For ytterligere å forsterke deres immunogenisitet kan de eventuelt kombineres med syntetiske oligonukleotider (ODN'er) som mangler immunstimulatoriske sekvenser, slik som CpG-motiver.
NO20062579A 2003-11-05 2006-06-02 Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener NO20062579L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51750203P 2003-11-05 2003-11-05
PCT/EP2004/012548 WO2005049647A2 (en) 2003-11-05 2004-11-05 Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens

Publications (1)

Publication Number Publication Date
NO20062579L true NO20062579L (no) 2006-06-02

Family

ID=34619323

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062579A NO20062579L (no) 2003-11-05 2006-06-02 Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener

Country Status (8)

Country Link
US (1) US7538083B2 (no)
EP (1) EP1680446B1 (no)
AT (1) ATE377023T1 (no)
AU (1) AU2004291277A1 (no)
CA (1) CA2543072A1 (no)
DE (1) DE602004009818T2 (no)
NO (1) NO20062579L (no)
WO (1) WO2005049647A2 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004291277A1 (en) * 2003-11-05 2005-06-02 Intercell Ag Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens
WO2007092315A2 (en) * 2006-02-03 2007-08-16 The Regents Of The University Of California Immunostimulation by cpg oligonucleotide-virus complexes
WO2007099387A1 (en) 2006-03-03 2007-09-07 Mymetics Corporation Virosome-like vesicles comprising gp41-derived antigens
US20090022799A1 (en) * 2006-10-06 2009-01-22 Shikha Pramanik Barman Compositions that contain beta-glucan to be used for the prevention and treatment of disease and methods for their use
JP5645408B2 (ja) 2006-11-16 2014-12-24 カイ ファーマシューティカルズ インコーポレーティッド 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド
AU2010278897B2 (en) 2009-07-29 2015-02-26 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
PT2717896T (pt) 2011-06-08 2016-12-23 Kai Pharmaceuticals Inc Agentes terapêuticos para a regulação do fósforo sérico
CN111801419A (zh) * 2017-12-15 2020-10-20 拜耳动物保健有限责任公司 免疫刺激性寡核苷酸
CN108129560B (zh) * 2017-12-15 2020-04-28 西安交通大学医学院第一附属医院 一种突变蜂毒肽MEL-pep及其应用
EP3789041A4 (en) * 2018-05-04 2022-07-13 Twinpigbiolab Inc. TARGETING MACROPHAGES ASSOCIATED WITH A TYPE M2 TUMOR USING A PRO-APOPTOTIC PEPTIDE BASED ON MELITIN
CN114288404A (zh) * 2021-12-20 2022-04-08 浙江洪晟生物科技股份有限公司 一种禽苗用免疫增强剂、二联灭活疫苗及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
US5235038A (en) * 1991-01-22 1993-08-10 Torry Pines Institute For Molecular Studies Deletion and substitution analogues of melittin peptide
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US5519114A (en) 1993-10-29 1996-05-21 University Of Florida Research Foundation, Inc. Retroviral superantigens, superantigen peptides, and methods of use
EP0725145A4 (en) * 1994-08-23 1997-06-11 Drug Delivery System Inst Ltd PROTEIN MODIFICATION PROCESS
WO1998056400A1 (en) * 1997-06-11 1998-12-17 Board Of Regents, The University Of Texas System Anti-inflammatory and other therapeutic, prophylactic or diagnostic uses of synthetic melittin and new related peptides
US6372471B1 (en) * 1998-10-01 2002-04-16 The Rockefeller University Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
EP1499349B1 (en) * 2001-03-02 2009-11-18 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
AU2004291277A1 (en) * 2003-11-05 2005-06-02 Intercell Ag Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens
WO2007099387A1 (en) * 2006-03-03 2007-09-07 Mymetics Corporation Virosome-like vesicles comprising gp41-derived antigens
EP1938835A1 (en) * 2006-12-29 2008-07-02 Pevion Biotech AG Non-specific immunostimulating agents

Also Published As

Publication number Publication date
US20050196383A1 (en) 2005-09-08
WO2005049647A2 (en) 2005-06-02
EP1680446A2 (en) 2006-07-19
CA2543072A1 (en) 2005-06-02
ATE377023T1 (de) 2007-11-15
US7538083B2 (en) 2009-05-26
AU2004291277A1 (en) 2005-06-02
DE602004009818D1 (de) 2007-12-13
DE602004009818T2 (de) 2008-09-18
WO2005049647A3 (en) 2005-08-11
EP1680446B1 (en) 2007-10-31

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