NO20062579L - Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener - Google Patents
Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigenerInfo
- Publication number
- NO20062579L NO20062579L NO20062579A NO20062579A NO20062579L NO 20062579 L NO20062579 L NO 20062579L NO 20062579 A NO20062579 A NO 20062579A NO 20062579 A NO20062579 A NO 20062579A NO 20062579 L NO20062579 L NO 20062579L
- Authority
- NO
- Norway
- Prior art keywords
- immune responses
- malantigens
- melittin
- compositions
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer nye adjuvanssystemer som reduserer risikoen for toksiske bivirkninger som er assosiert med anvendelsen av kjente adjuvanser, mens det tilveiebringes kraftig stimulering av immunresponser mot målantigenet. Disse nye adjuvanssystemene er basert på hormingbiegiften melittin eller spesiflkke kationiske peptider som er avledet flia melittin og som er i stand til å utløse sterke immunresponser mot målantigenet. For ytterligere å forsterke deres immunogenisitet kan de eventuelt kombineres med syntetiske oligonukleotider (ODN'er) som mangler immunstimulatoriske sekvenser, slik som CpG-motiver.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51750203P | 2003-11-05 | 2003-11-05 | |
PCT/EP2004/012548 WO2005049647A2 (en) | 2003-11-05 | 2004-11-05 | Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20062579L true NO20062579L (no) | 2006-06-02 |
Family
ID=34619323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20062579A NO20062579L (no) | 2003-11-05 | 2006-06-02 | Preparater som omfatter melittin-avledede peptider og fremgangsmate for styrking av immunresponser mot malantigener |
Country Status (8)
Country | Link |
---|---|
US (1) | US7538083B2 (no) |
EP (1) | EP1680446B1 (no) |
AT (1) | ATE377023T1 (no) |
AU (1) | AU2004291277A1 (no) |
CA (1) | CA2543072A1 (no) |
DE (1) | DE602004009818T2 (no) |
NO (1) | NO20062579L (no) |
WO (1) | WO2005049647A2 (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004291277A1 (en) * | 2003-11-05 | 2005-06-02 | Intercell Ag | Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens |
WO2007092315A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Immunostimulation by cpg oligonucleotide-virus complexes |
WO2007099387A1 (en) | 2006-03-03 | 2007-09-07 | Mymetics Corporation | Virosome-like vesicles comprising gp41-derived antigens |
US20090022799A1 (en) * | 2006-10-06 | 2009-01-22 | Shikha Pramanik Barman | Compositions that contain beta-glucan to be used for the prevention and treatment of disease and methods for their use |
JP5645408B2 (ja) | 2006-11-16 | 2014-12-24 | カイ ファーマシューティカルズ インコーポレーティッド | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
AU2010278897B2 (en) | 2009-07-29 | 2015-02-26 | Kai Pharmaceuticals, Inc. | Therapeutic agents for reducing parathyroid hormone levels |
PT2717896T (pt) | 2011-06-08 | 2016-12-23 | Kai Pharmaceuticals Inc | Agentes terapêuticos para a regulação do fósforo sérico |
CN111801419A (zh) * | 2017-12-15 | 2020-10-20 | 拜耳动物保健有限责任公司 | 免疫刺激性寡核苷酸 |
CN108129560B (zh) * | 2017-12-15 | 2020-04-28 | 西安交通大学医学院第一附属医院 | 一种突变蜂毒肽MEL-pep及其应用 |
EP3789041A4 (en) * | 2018-05-04 | 2022-07-13 | Twinpigbiolab Inc. | TARGETING MACROPHAGES ASSOCIATED WITH A TYPE M2 TUMOR USING A PRO-APOPTOTIC PEPTIDE BASED ON MELITIN |
CN114288404A (zh) * | 2021-12-20 | 2022-04-08 | 浙江洪晟生物科技股份有限公司 | 一种禽苗用免疫增强剂、二联灭活疫苗及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683291A (en) * | 1985-10-28 | 1987-07-28 | Scripps Clinic And Research Foundation | Platelet binding inhibitors |
US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
US5235038A (en) * | 1991-01-22 | 1993-08-10 | Torry Pines Institute For Molecular Studies | Deletion and substitution analogues of melittin peptide |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US5519114A (en) | 1993-10-29 | 1996-05-21 | University Of Florida Research Foundation, Inc. | Retroviral superantigens, superantigen peptides, and methods of use |
EP0725145A4 (en) * | 1994-08-23 | 1997-06-11 | Drug Delivery System Inst Ltd | PROTEIN MODIFICATION PROCESS |
WO1998056400A1 (en) * | 1997-06-11 | 1998-12-17 | Board Of Regents, The University Of Texas System | Anti-inflammatory and other therapeutic, prophylactic or diagnostic uses of synthetic melittin and new related peptides |
US6372471B1 (en) * | 1998-10-01 | 2002-04-16 | The Rockefeller University | Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon |
EP1499349B1 (en) * | 2001-03-02 | 2009-11-18 | The Rockefeller University | Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen |
AU2004291277A1 (en) * | 2003-11-05 | 2005-06-02 | Intercell Ag | Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens |
WO2007099387A1 (en) * | 2006-03-03 | 2007-09-07 | Mymetics Corporation | Virosome-like vesicles comprising gp41-derived antigens |
EP1938835A1 (en) * | 2006-12-29 | 2008-07-02 | Pevion Biotech AG | Non-specific immunostimulating agents |
-
2004
- 2004-11-05 AU AU2004291277A patent/AU2004291277A1/en not_active Abandoned
- 2004-11-05 CA CA002543072A patent/CA2543072A1/en not_active Abandoned
- 2004-11-05 WO PCT/EP2004/012548 patent/WO2005049647A2/en active IP Right Grant
- 2004-11-05 US US10/983,169 patent/US7538083B2/en not_active Expired - Fee Related
- 2004-11-05 DE DE602004009818T patent/DE602004009818T2/de active Active
- 2004-11-05 EP EP04818758A patent/EP1680446B1/en not_active Not-in-force
- 2004-11-05 AT AT04818758T patent/ATE377023T1/de not_active IP Right Cessation
-
2006
- 2006-06-02 NO NO20062579A patent/NO20062579L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20050196383A1 (en) | 2005-09-08 |
WO2005049647A2 (en) | 2005-06-02 |
EP1680446A2 (en) | 2006-07-19 |
CA2543072A1 (en) | 2005-06-02 |
ATE377023T1 (de) | 2007-11-15 |
US7538083B2 (en) | 2009-05-26 |
AU2004291277A1 (en) | 2005-06-02 |
DE602004009818D1 (de) | 2007-12-13 |
DE602004009818T2 (de) | 2008-09-18 |
WO2005049647A3 (en) | 2005-08-11 |
EP1680446B1 (en) | 2007-10-31 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |