NO20060733L - Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases - Google Patents
Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseasesInfo
- Publication number
- NO20060733L NO20060733L NO20060733A NO20060733A NO20060733L NO 20060733 L NO20060733 L NO 20060733L NO 20060733 A NO20060733 A NO 20060733A NO 20060733 A NO20060733 A NO 20060733A NO 20060733 L NO20060733 L NO 20060733L
- Authority
- NO
- Norway
- Prior art keywords
- pyrazolines
- treatment
- par
- antagonists
- cardiovascular diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oppfinnelsen angår pyrazoliner med formel (I) hvor E er metylen, NH, O eller S, og R2 er en gruppe med formel (II), fremgangsmåte for fremstilling og anvendelse derav for fremstilling av medikamenter for behandling og/eller profylakse av sykdommer, særlig kardiovaskulære sykdommer slik som tromboemboliske sykdommer.The invention relates to pyrazolines of formula (I) wherein E is methylene, NH, O or S, and R 2 is a group of formula (II), a process for the preparation and use thereof for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular diseases such as thromboembolic diseases.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10331951 | 2003-07-15 | ||
DE102004010545A DE102004010545A1 (en) | 2003-07-15 | 2004-03-04 | pyrazolines |
PCT/EP2004/007227 WO2005007157A1 (en) | 2003-07-15 | 2004-07-02 | Pyrazolines as par-1 antagonists for treatment of cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20060733L true NO20060733L (en) | 2006-04-10 |
Family
ID=34081645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060733A NO20060733L (en) | 2003-07-15 | 2006-02-15 | Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1648447A1 (en) |
AU (1) | AU2004257406A1 (en) |
BR (1) | BRPI0412554A (en) |
CA (1) | CA2532316A1 (en) |
MA (1) | MA27905A1 (en) |
MX (1) | MXPA06000507A (en) |
NO (1) | NO20060733L (en) |
WO (1) | WO2005007157A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004061747A1 (en) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Thiophene-substituted pyrazolines |
DE102004061751A1 (en) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Cyanoguanidine-substituted pyrazolines |
DE102004061748A1 (en) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Azetidine-substituted pyrazolines |
CA2969771A1 (en) * | 2014-12-08 | 2016-06-16 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
EP3283478A1 (en) * | 2015-04-17 | 2018-02-21 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
WO2016166186A1 (en) | 2015-04-17 | 2016-10-20 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
EP3109237A1 (en) | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
CN111892585A (en) * | 2020-08-05 | 2020-11-06 | 杭州维坦医药科技有限公司 | N-formamido pyrazoline derivative as P2X3 receptor antagonist and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2143459T3 (en) * | 1990-07-13 | 2000-05-16 | Rohm & Haas | 4,5-DIHIDRO-1H-PIRAZOL-1-CARBOXAMIDAS N-ARIL-3-ARIL-4 SUBSTITUTED AND PROCEDURES FOR ITS PRODUCTION. |
DE4217863A1 (en) * | 1991-08-28 | 1993-03-04 | Bayer Ag | SUBSTITUTED PYRAZOLINE |
DE4217862A1 (en) * | 1991-08-28 | 1993-03-04 | Bayer Ag | SUBSTITUTED PYRAZOLINE |
DE4217864A1 (en) * | 1992-05-29 | 1993-12-02 | Bayer Ag | Substituted pyrazolines |
DE4233713A1 (en) * | 1992-10-07 | 1994-04-14 | Bayer Ag | Substituted 4,5-dihydro-1-pyrazolecarboxanilides |
-
2004
- 2004-07-02 EP EP04740582A patent/EP1648447A1/en not_active Withdrawn
- 2004-07-02 CA CA002532316A patent/CA2532316A1/en not_active Abandoned
- 2004-07-02 BR BRPI0412554-1A patent/BRPI0412554A/en not_active Application Discontinuation
- 2004-07-02 WO PCT/EP2004/007227 patent/WO2005007157A1/en not_active Application Discontinuation
- 2004-07-02 AU AU2004257406A patent/AU2004257406A1/en not_active Abandoned
- 2004-07-02 MX MXPA06000507A patent/MXPA06000507A/en unknown
-
2006
- 2006-01-06 MA MA28710A patent/MA27905A1/en unknown
- 2006-02-15 NO NO20060733A patent/NO20060733L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA27905A1 (en) | 2006-05-02 |
WO2005007157A1 (en) | 2005-01-27 |
CA2532316A1 (en) | 2005-01-27 |
MXPA06000507A (en) | 2006-04-05 |
AU2004257406A1 (en) | 2005-01-27 |
EP1648447A1 (en) | 2006-04-26 |
BRPI0412554A (en) | 2006-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20074592L (en) | Acetylenyl-pyrazolo-pyrimidine derivatives as mGluR2 antagonists | |
NO20060733L (en) | Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases | |
NL300933I2 (en) | Letermovir | |
MX2007000505A (en) | Substituted oxindol derivatives and medicaments containing the same. | |
NO20055421L (en) | Quinoline derivatives as phosphodiesterase inhibitors | |
NO20060324L (en) | [1,8] Naphthyridin-2-ones and related compounds for the treatment of schizophrenia | |
NO20051962L (en) | Phenethanolamine derivatives for the treatment of respiratory diseases | |
NO20050828L (en) | indole-3-sulfur derivatives | |
NO20054905L (en) | 2-acylamino-4-phenylthiazole derivatives, methods for their preparation and use of the same as in therapeutics | |
NO20061363L (en) | Pyrazolo and imidazopyrimidine derivatives | |
NO20064201L (en) | Glucopyranosyl substituted benzene derivatives, drugs containing such compounds, their use and preparation | |
NO20025601L (en) | Arylmethylamine derivatives for use as tryptase inhibitors | |
ATE365720T1 (en) | AGONISTS OF BETA-ADRENORECEPTORS | |
NO20041041L (en) | Phenethanolamine derivatives for the treatment of respiratory diseases | |
NO20062335L (en) | New diazaspiroalkanes and their use in the treatment of CCR8 mediated diseases | |
NO20054414L (en) | Dihydropteridinones, methods for their preparation and their use as medicines | |
NO20056010L (en) | Biaryloksymetylaren acids | |
NO20074258L (en) | Pyridine-2-carboxamide derivatives as MGLUR5 antagonists | |
TW200504067A (en) | New substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions | |
NO20056192L (en) | Capase inhibitors and their use | |
NO20092342L (en) | Azaspiroderivativater | |
NO20066055L (en) | pyridine derivatives | |
NO20051600L (en) | 1,4-disubstituted piperidine derivatives and their use as 11-betaHSD1 inhibitors | |
MXPA03012013A (en) | Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives as medicaments for the treatment of pain. | |
NO20070089L (en) | DPP-IV inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |