NO20060733L - Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases - Google Patents

Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases

Info

Publication number
NO20060733L
NO20060733L NO20060733A NO20060733A NO20060733L NO 20060733 L NO20060733 L NO 20060733L NO 20060733 A NO20060733 A NO 20060733A NO 20060733 A NO20060733 A NO 20060733A NO 20060733 L NO20060733 L NO 20060733L
Authority
NO
Norway
Prior art keywords
pyrazolines
treatment
par
antagonists
cardiovascular diseases
Prior art date
Application number
NO20060733A
Other languages
Norwegian (no)
Inventor
Elisabeth Perzborn
Walter Huebsch
Christoph Gerdes
Verena Vohringer
Elke Stahl
Swen Allerheiligen
Nicole Diedrichs
Dirk Brohm
Britta-Nicole Frohlen
Mark Jean Gnoth
Heike Heckroth
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004010545A external-priority patent/DE102004010545A1/en
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of NO20060733L publication Critical patent/NO20060733L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår pyrazoliner med formel (I) hvor E er metylen, NH, O eller S, og R2 er en gruppe med formel (II), fremgangsmåte for fremstilling og anvendelse derav for fremstilling av medikamenter for behandling og/eller profylakse av sykdommer, særlig kardiovaskulære sykdommer slik som tromboemboliske sykdommer.The invention relates to pyrazolines of formula (I) wherein E is methylene, NH, O or S, and R 2 is a group of formula (II), a process for the preparation and use thereof for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular diseases such as thromboembolic diseases.

NO20060733A 2003-07-15 2006-02-15 Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases NO20060733L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10331951 2003-07-15
DE102004010545A DE102004010545A1 (en) 2003-07-15 2004-03-04 pyrazolines
PCT/EP2004/007227 WO2005007157A1 (en) 2003-07-15 2004-07-02 Pyrazolines as par-1 antagonists for treatment of cardiovascular diseases

Publications (1)

Publication Number Publication Date
NO20060733L true NO20060733L (en) 2006-04-10

Family

ID=34081645

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060733A NO20060733L (en) 2003-07-15 2006-02-15 Pyrazolines as PAR-1 antagonists for the treatment of cardiovascular diseases

Country Status (8)

Country Link
EP (1) EP1648447A1 (en)
AU (1) AU2004257406A1 (en)
BR (1) BRPI0412554A (en)
CA (1) CA2532316A1 (en)
MA (1) MA27905A1 (en)
MX (1) MXPA06000507A (en)
NO (1) NO20060733L (en)
WO (1) WO2005007157A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061747A1 (en) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Thiophene-substituted pyrazolines
DE102004061751A1 (en) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Cyanoguanidine-substituted pyrazolines
DE102004061748A1 (en) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Azetidine-substituted pyrazolines
CA2969771A1 (en) * 2014-12-08 2016-06-16 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
EP3283478A1 (en) * 2015-04-17 2018-02-21 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
WO2016166186A1 (en) 2015-04-17 2016-10-20 Bayer Pharma Aktiengesellschaft Novel aryl-cyanoguanidine compounds
EP3109237A1 (en) 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN111892585A (en) * 2020-08-05 2020-11-06 杭州维坦医药科技有限公司 N-formamido pyrazoline derivative as P2X3 receptor antagonist and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2143459T3 (en) * 1990-07-13 2000-05-16 Rohm & Haas 4,5-DIHIDRO-1H-PIRAZOL-1-CARBOXAMIDAS N-ARIL-3-ARIL-4 SUBSTITUTED AND PROCEDURES FOR ITS PRODUCTION.
DE4217863A1 (en) * 1991-08-28 1993-03-04 Bayer Ag SUBSTITUTED PYRAZOLINE
DE4217862A1 (en) * 1991-08-28 1993-03-04 Bayer Ag SUBSTITUTED PYRAZOLINE
DE4217864A1 (en) * 1992-05-29 1993-12-02 Bayer Ag Substituted pyrazolines
DE4233713A1 (en) * 1992-10-07 1994-04-14 Bayer Ag Substituted 4,5-dihydro-1-pyrazolecarboxanilides

Also Published As

Publication number Publication date
MA27905A1 (en) 2006-05-02
WO2005007157A1 (en) 2005-01-27
CA2532316A1 (en) 2005-01-27
MXPA06000507A (en) 2006-04-05
AU2004257406A1 (en) 2005-01-27
EP1648447A1 (en) 2006-04-26
BRPI0412554A (en) 2006-09-19

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Legal Events

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