NO20054371L - Somatostatin-dopamin kimaere analoger - Google Patents

Somatostatin-dopamin kimaere analoger

Info

Publication number
NO20054371L
NO20054371L NO20054371A NO20054371A NO20054371L NO 20054371 L NO20054371 L NO 20054371L NO 20054371 A NO20054371 A NO 20054371A NO 20054371 A NO20054371 A NO 20054371A NO 20054371 L NO20054371 L NO 20054371L
Authority
NO
Norway
Prior art keywords
somatostatin
dopamine chimeric
chimeric analogs
analogs
dopamine
Prior art date
Application number
NO20054371A
Other languages
English (en)
Other versions
NO20054371D0 (no
Inventor
Yeelana Shen
Michael Dewitt Culler
Zheng Xin Dong
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NO20054371D0 publication Critical patent/NO20054371D0/no
Publication of NO20054371L publication Critical patent/NO20054371L/no

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

Oppfinnelsen angår somatostatin-dopamin kimære analoger og metoder som angår deres terapeutiske anvendelse for behandling av neoplasi, akromegali og andre lidelser.
NO20054371A 2003-04-11 2005-09-21 Somatostatin-dopamin kimaere analoger NO20054371L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46237403P 2003-04-11 2003-04-11
PCT/US2004/010891 WO2004091490A2 (en) 2003-04-11 2004-04-08 Somatostatin-dopamine chimeric analogs

Publications (2)

Publication Number Publication Date
NO20054371D0 NO20054371D0 (no) 2005-09-21
NO20054371L true NO20054371L (no) 2005-12-19

Family

ID=33299939

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054371A NO20054371L (no) 2003-04-11 2005-09-21 Somatostatin-dopamin kimaere analoger

Country Status (19)

Country Link
US (2) US7517853B2 (no)
EP (1) EP1617856B1 (no)
JP (2) JP4579235B2 (no)
KR (3) KR101098323B1 (no)
CN (2) CN101653594A (no)
AR (1) AR041769A1 (no)
AU (1) AU2004229437B2 (no)
BR (1) BRPI0409359A (no)
CA (1) CA2521965A1 (no)
ES (1) ES2450645T3 (no)
IL (1) IL170742A0 (no)
MX (1) MXPA05010868A (no)
NO (1) NO20054371L (no)
NZ (2) NZ542297A (no)
RU (1) RU2329273C2 (no)
SG (1) SG175448A1 (no)
TW (2) TWI350838B (no)
WO (1) WO2004091490A2 (no)
ZA (1) ZA200508145B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2521965A1 (en) * 2003-04-11 2004-10-28 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Somatostatin-dopamine chimeric analogs
KR20090074806A (ko) * 2006-10-20 2009-07-07 입센 파마 에스.에이.에스 펩타이드-세포독성 접합체
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
CN102088998A (zh) * 2008-05-14 2011-06-08 益普生制药股份有限公司 生长激素释放抑制因子-多巴胺缀合物的药物组合物
WO2011104627A1 (en) 2010-02-24 2011-09-01 Ipsen Pharma S.A.S. Metabolites of dop2-d-lys(dop2)-cyclo[cys-tyr-d-trp-lys-abu-cys]-thr-nh2
RU2457215C1 (ru) * 2011-04-07 2012-07-27 Закрытое Акционерное Общество "Фарм-Синтез" Октапептид для получения радиофармацевтических средств, радиофармацевтическое средство на его основе и способ диагностики опухолей, экспрессирующих соматостатиновые рецепторы
MX350536B (es) * 2011-12-23 2017-09-08 Ipsen Mfg Ireland Limited Proceso para la sintesis de peptidos terapeuticos.
CN102898397B (zh) * 2012-09-26 2014-12-10 江苏华益科技有限公司 (4aR,10bR)-3,4,4a,5,6,10b-六氢-2H-萘并[1,2-b][1,4]噁嗪-9-醇类物质及其盐酸盐合成方法
TWI523863B (zh) * 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
US9777039B2 (en) 2012-11-01 2017-10-03 Ipsen Pharma S.A.S. Somatostatin analogs and dimers thereof
RU2528414C1 (ru) * 2013-01-25 2014-09-20 Закрытое Акционерное Общество "Фарм-Синтез" Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
BR112017015510A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
WO2018021447A1 (ja) * 2016-07-28 2018-02-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
BR112019025420A2 (pt) 2017-06-01 2020-06-16 Xoc Pharmaceuticals, Inc. Compostos policíclicos e usos destes
EP3744721A4 (en) 2018-01-26 2021-11-10 Shionogi & Co., Ltd CONDENSED CYCLIC COMPOUND WITH ANTAGONISM TO DOPAMINE D3 RECEPTOR
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
CN110105232A (zh) * 2019-05-10 2019-08-09 中国农业大学 一种金刚烷胺半抗原及其制备方法和应用
WO2021067897A1 (en) * 2019-10-04 2021-04-08 Tiburio Therapeutics Inc. Storage stable somatostatin-dopamine chimeric compounds and salt forms thereof
WO2023235232A2 (en) * 2022-05-31 2023-12-07 The Administrators Of The Tulane Educational Fund Glycosylated cyclic endomorphin analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE652720C (de) 1932-12-03 1937-11-09 Pirelli Elektrische OElkabelanlage mit Druckausgleichsbehaelter und zusaetzlichem hydrostatischem Speisebehaelter
CH652720A5 (en) * 1983-02-16 1985-11-29 Sandoz Ag Ergoline derivatives, their preparation and use
WO2000004916A1 (en) 1998-07-23 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Encapsulation of water soluble peptides
WO2002085902A1 (en) * 2001-04-16 2002-10-31 Finetech Laboratories Ltd. Process and intermediates for production of cabergoline and related compounds
CN1514843A (zh) * 2001-06-08 2004-07-21 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 生长激素释放抑制因子-多巴胺嵌合类似物
CA2521965A1 (en) * 2003-04-11 2004-10-28 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Somatostatin-dopamine chimeric analogs

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