NO20054111L - Fremgangsmate for fremtilling av tibolon - Google Patents

Fremgangsmate for fremtilling av tibolon

Info

Publication number
NO20054111L
NO20054111L NO20054111A NO20054111A NO20054111L NO 20054111 L NO20054111 L NO 20054111L NO 20054111 A NO20054111 A NO 20054111A NO 20054111 A NO20054111 A NO 20054111A NO 20054111 L NO20054111 L NO 20054111L
Authority
NO
Norway
Prior art keywords
tibolone
procedure
producing
compound
formula
Prior art date
Application number
NO20054111A
Other languages
English (en)
Other versions
NO20054111D0 (no
Inventor
Alan Kenneth Greenwood
Derek Mchattie
Parveen Bhatarah
Original Assignee
Resolution Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Chemicals Ltd filed Critical Resolution Chemicals Ltd
Publication of NO20054111D0 publication Critical patent/NO20054111D0/no
Publication of NO20054111L publication Critical patent/NO20054111L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Fremgangsmåte for fremstilling av en forbindelse med formel (6): hvori R representerer Ci- til C2o-alkyl, C- til C-aryl, C-til C-cykloalkyl, C- til C-aralkyl eller C-til C-alkaryl, hvor fremgangsmåten omfatter trinnene: til å danne en forbindelse med formel (5a):. (i) metylering av karbonatomet i 7-stillingen i en forbindelse med formel (5): (ii) isomerisering av C=C dobbeltbindingen i forbindelsen med formel (5a).
NO20054111A 2003-03-04 2005-09-05 Fremgangsmate for fremtilling av tibolon NO20054111L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0304927.7A GB0304927D0 (en) 2003-03-04 2003-03-04 Process for the production of tibolone
PCT/GB2004/000887 WO2004078774A1 (en) 2003-03-04 2004-03-03 Process for the production of tibolone

Publications (2)

Publication Number Publication Date
NO20054111D0 NO20054111D0 (no) 2005-09-05
NO20054111L true NO20054111L (no) 2005-12-02

Family

ID=9954086

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054111A NO20054111L (no) 2003-03-04 2005-09-05 Fremgangsmate for fremtilling av tibolon

Country Status (12)

Country Link
US (1) US7884222B2 (no)
EP (2) EP1608670B1 (no)
JP (1) JP2006519248A (no)
CN (1) CN100420699C (no)
AU (1) AU2004218221C1 (no)
BR (1) BRPI0408104A (no)
CA (1) CA2517934A1 (no)
GB (1) GB0304927D0 (no)
NO (1) NO20054111L (no)
NZ (1) NZ542298A (no)
WO (1) WO2004078774A1 (no)
ZA (1) ZA200507281B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070942A1 (de) * 2007-12-13 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
JP5749261B2 (ja) * 2009-06-29 2015-07-15 メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー ３，３，５，５−テトラメチルシクロヘキサノンを調製する方法
US20130324748A1 (en) * 2011-02-17 2013-12-05 Lupin Limited Process for preparation of levonorgestrel
CN104292285A (zh) * 2014-09-30 2015-01-21 湖北三晶生物科技有限公司 一种高含量脱氢诺龙醋酸酯的合成工艺
CN107365340A (zh) * 2017-07-05 2017-11-21 湖北工业大学 一种3,5‑雌甾二烯‑3,17β‑二醋酸酯的制备方法
CN107200762A (zh) * 2017-07-12 2017-09-26 湖北共同生物科技有限公司 3,5‑雌甾二烯‑3,17β‑二醋酸酯的制备方法
CN109575094B (zh) * 2019-01-17 2021-01-26 浙江仙琚制药股份有限公司 替勃龙中间体的制备方法
CN110981930B (zh) * 2019-12-31 2021-04-20 浙江仙居君业药业有限公司 一种替勃龙的合成方法

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US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
BE665514A (no) * 1964-06-16
CH488682A (de) * 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) 1966-06-24 1975-08-15 Organon Nv Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) * 1967-03-15 1970-06-02 Upjohn Co 7-methyl-6,19-epoxy steroids of the androstane series
CH547268A (de) * 1968-10-25 1974-03-29 Merck Patent Gmbh Verfahren zur herstellung von n-disubstituierten 3-amino3,5-dien-19-nor-steroiden.
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US4000273A (en) * 1973-11-01 1976-12-28 Richardson-Merrell Inc. Method for the control of fertility
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DK24089D0 (da) 1989-01-20 1989-01-20 Hans Bundgaard Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
IE63051B1 (en) 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
CA2425841C (en) 1991-11-22 2006-01-10 Alcon Laboratories, Inc. Angiostatic steroids
JP2746041B2 (ja) 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体
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WO1999067270A1 (en) 1998-06-19 1999-12-29 Akzo Nobel N.V. Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone)
CN100378116C (zh) 1998-10-16 2008-04-02 欧加农股份有限公司 包含(7α,17α)-17-羟基-7-甲基-19-去甲-17-孕-5(10)-烯-20-炔-3-酮的高纯度组合物
CN1243767C (zh) 1999-03-23 2006-03-01 霍利斯-伊登医药公司 免疫调节性类固醇,特别是16α－溴表雄酮的半水合物
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TWI322813B (en) * 2002-01-21 2010-04-01 Organon Nv Process for the preparation of 7alpha-methylsteroids

Also Published As

Publication number Publication date
GB0304927D0 (en) 2003-04-09
US7884222B2 (en) 2011-02-08
AU2004218221C1 (en) 2011-07-07
BRPI0408104A (pt) 2006-03-01
CA2517934A1 (en) 2004-09-16
JP2006519248A (ja) 2006-08-24
CN100420699C (zh) 2008-09-24
WO2004078774A1 (en) 2004-09-16
EP1608670A1 (en) 2005-12-28
AU2004218221B2 (en) 2010-11-11
EP2497776A2 (en) 2012-09-12
NZ542298A (en) 2008-07-31
EP2497776A3 (en) 2013-01-02
AU2004218221A1 (en) 2004-09-16
CN1780849A (zh) 2006-05-31
ZA200507281B (en) 2006-12-27
NO20054111D0 (no) 2005-09-05
US20060173201A1 (en) 2006-08-03
EP1608670B1 (en) 2013-09-11

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